-
1
-
-
48249149059
-
Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance
-
Akman HO, Dorado B, Lopez LC, Garcıa-Cazorla A, Vila MR, Tanabe LM, Dauer WT, Bonilla E, Tanji K, Hirano M (2008) Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance. Hum Mol Genet 17: 2433-2440
-
(2008)
Hum Mol Genet
, vol.17
, pp. 2433-2440
-
-
Akman, H.O.1
Dorado, B.2
Lopez, L.C.3
Garcıa-Cazorla, A.4
Vila, M.R.5
Tanabe, L.M.6
Dauer, W.T.7
Bonilla, E.8
Tanji, K.9
Hirano, M.10
-
3
-
-
0003880161
-
-
(eds) Garland Science, New York
-
Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P (eds) (2008) The molecular biology of the cell. Garland Science, New York
-
(2008)
The molecular biology of the cell
-
-
Alberts, B.1
Johnson, A.2
Lewis, J.3
Raff, M.4
Roberts, K.5
Walter, P.6
-
4
-
-
0028035447
-
Regulation of cell proliferation under extreme and moderate hypoxia: The role of pyrimidine (deoxy)nucleotides
-
Amellem O, Löffler M, Pettersen EO (1994) Regulation of cell proliferation under extreme and moderate hypoxia: the role of pyrimidine (deoxy)nucleotides. Br J Cancer 70: 857-866
-
(1994)
Br J Cancer
, vol.70
, pp. 857-866
-
-
Amellem, O.1
Löffler, M.2
Pettersen, E.O.3
-
5
-
-
0031936129
-
The retinoblastoma protein-associated cell cycle arrest in S-phase under moderate hypoxia is disrupted in cells expressing HPV18 E7 oncoprotein
-
Amellem O, Sandvik JA, Stokke T, Pettersen EO (1998) The retinoblastoma protein-associated cell cycle arrest in S-phase under moderate hypoxia is disrupted in cells expressing HPV18 E7 oncoprotein. Br J Cancer 77: 862-872
-
(1998)
Br J Cancer
, vol.77
, pp. 862-872
-
-
Amellem, O.1
Sandvik, J.A.2
Stokke, T.3
Pettersen, E.O.4
-
6
-
-
0031925587
-
Adenovirus preterminal protein binds to the CAD enzyme at active sites of viral DNA replication on the nuclear matrix
-
Angeletti PC, Engler JA (1998) Adenovirus preterminal protein binds to the CAD enzyme at active sites of viral DNA replication on the nuclear matrix. J Virol 72: 2896-2904
-
(1998)
J Virol
, vol.72
, pp. 2896-2904
-
-
Angeletti, P.C.1
Engler, J.A.2
-
7
-
-
0029069747
-
Localization of dihydroorotate oxidase in myocardium and kidney cortex of the rat
-
Angermüller S, Löffler M (1995) Localization of dihydroorotate oxidase in myocardium and kidney cortex of the rat. Histochem Cell Biol 103: 287-292
-
(1995)
Histochem Cell Biol
, vol.103
, pp. 287-292
-
-
Angermüller, S.1
Löffler, M.2
-
8
-
-
1242272722
-
The equilibrative nucleoside transporter family, SLC29
-
Baldwin SA, Beal PR, Yao SY, King AE, Cass CE, Young JD (2004) The equilibrative nucleoside transporter family, SLC29. Eur J Physiol 447: 735-743
-
(2004)
Eur J Physiol
, vol.447
, pp. 735-743
-
-
Baldwin, S.A.1
Beal, P.R.2
Yao, S.Y.3
King, A.E.4
Cass, C.E.5
Young, J.D.6
-
9
-
-
0027385523
-
Regional mapping of the gene encoding dihydroorotate dehydrogenase, an enzyme involved in UMP synthesis, electron transport and superoxide generation, to human chromosome region 16q22
-
Barnes T, Parry P, Hart I, Jones C, Minet M, Patterson D (1993) Regional mapping of the gene encoding dihydroorotate dehydrogenase, an enzyme involved in UMP synthesis, electron transport and superoxide generation, to human chromosome region 16q22. Somat Cell Mol Genet 19: 405-411
-
(1993)
Somat Cell Mol Genet
, vol.19
, pp. 405-411
-
-
Barnes, T.1
Parry, P.2
Hart, I.3
Jones, C.4
Minet, M.5
Patterson, D.6
-
10
-
-
33144458560
-
Dual binding mode of a novel series of DHODH inhibitors
-
Baumgarten R, Walloschek M, Kralik M, Gotschlich A, Tasler S, Mies J, Leban J (2006) Dual binding mode of a novel series of DHODH inhibitors. J Med Chem 49: 1239-1247
-
(2006)
J Med Chem
, vol.49
, pp. 1239-1247
-
-
Baumgarten, R.1
Walloschek, M.2
Kralik, M.3
Gotschlich, A.4
Tasler, S.5
Mies, J.6
Leban, J.7
-
11
-
-
84874995247
-
Stimulation of de novo pyrimidine synthesis by growth signalling through mTOR and S6K1
-
Ben-Sahra I, Howell JJ, Asara JM, Manning BD (2013) Stimulation of de novo pyrimidine synthesis by growth signalling through mTOR and S6K1. Science 339: 1323-1328
-
(2013)
Science
, vol.339
, pp. 1323-1328
-
-
Ben-Sahra, I.1
Howell, J.J.2
Asara, J.M.3
Manning, B.D.4
-
12
-
-
0034656164
-
Indirect inhibition of mitochondrial dihydroorotate dehydrogenase activity by nitric oxide
-
Beuneu C, Auger R, Löffler M, Guissani A, Lemaire G, Lepoivre M (2000) Indirect inhibition of mitochondrial dihydroorotate dehydrogenase activity by nitric oxide. Free Radic Biol Med 28: 1206-1213
-
(2000)
Free Radic Biol Med
, vol.28
, pp. 1206-1213
-
-
Beuneu, C.1
Auger, R.2
Löffler, M.3
Guissani, A.4
Lemaire, G.5
Lepoivre, M.6
-
13
-
-
79953184249
-
Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors
-
Bijnsdorp V, Capriotti F, Kruyt FAE, Losekoot N, Fukushima M, Griffioen AW, Thijssen VL, Peters GJ (2011) Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors. Br J Cancer 104: 1185-1192
-
(2011)
Br J Cancer
, vol.104
, pp. 1185-1192
-
-
Bijnsdorp, V.1
Capriotti, F.2
Kruyt, F.A.E.3
Losekoot, N.4
Fukushima, M.5
Griffioen, A.W.6
Thijssen, V.L.7
Peters, G.J.8
-
14
-
-
13844317355
-
Synthesis of brequinar analogue inhibitors of malaria parasite dihydroorotate dehydrogenase
-
Boa AN, Canavan SP, Hirst RR, Ransey C, Stead AM, Mc Conkey GA (2005) Synthesis of brequinar analogue inhibitors of malaria parasite dihydroorotate dehydrogenase. Bioorg Med Chem 13: 1945-1967
-
(2005)
Bioorg Med Chem
, vol.13
, pp. 1945-1967
-
-
Boa, A.N.1
Canavan, S.P.2
Hirst, R.R.3
Ransey, C.4
Stead, A.M.5
Mc Conkey, G.A.6
-
15
-
-
0010118471
-
Carbamyl phosphate synthetase-aspartate transcarbamylase activity in regenerating rat liver
-
Calva E, Cohen PP (1959) Carbamyl phosphate synthetase-aspartate transcarbamylase activity in regenerating rat liver. Cancer Res 19: 679-683
-
(1959)
Cancer Res
, vol.19
, pp. 679-683
-
-
Calva, E.1
Cohen, P.P.2
-
16
-
-
84876725421
-
Neuroprotective effect of uridine in a rat model of neonatal hypoxic-ischemic encephalopathy
-
Cansev M, Minbay Z, Goren B, Yaylagul EO, Cetinkaya M, Koksal N, Alkan T (2013) Neuroprotective effect of uridine in a rat model of neonatal hypoxic-ischemic encephalopathy. Neurosci Lett 542: 65-70
-
(2013)
Neurosci Lett
, vol.542
, pp. 65-70
-
-
Cansev, M.1
Minbay, Z.2
Goren, B.3
Yaylagul, E.O.4
Cetinkaya, M.5
Koksal, N.6
Alkan, T.7
-
17
-
-
34547385847
-
Double regulation by UTP of the mammalian carbamoyl phosphate synthase II activity
-
Carrey EA (1989) Double regulation by UTP of the mammalian carbamoyl phosphate synthase II activity. Biochem Soc Trans 17: 761-762
-
(1989)
Biochem Soc Trans
, vol.17
, pp. 761-762
-
-
Carrey, E.A.1
-
18
-
-
0022435133
-
Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis
-
Carrey EA, Campbell DG, Hardie DG (1985) Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis. EMBO J 4: 3735-3742
-
(1985)
EMBO J
, vol.4
, pp. 3735-3742
-
-
Carrey, E.A.1
Campbell, D.G.2
Hardie, D.G.3
-
19
-
-
0036072433
-
Detection and location of the enzymes of de novo pyrimidine biosynthesis in mammalian spermatozoa
-
Carrey EA, Dietz C, Glubb DM, Löffler M, Lucocq JM, Watson PF (2002) Detection and location of the enzymes of de novo pyrimidine biosynthesis in mammalian spermatozoa. Reproduction 123: 757-768
-
(2002)
Reproduction
, vol.123
, pp. 757-768
-
-
Carrey, E.A.1
Dietz, C.2
Glubb, D.M.3
Löffler, M.4
Lucocq, J.M.5
Watson, P.F.6
-
20
-
-
0017134372
-
The cellular location of dihydroorotate dehydrogenase: Relation to de novo biosynthesis of pyrimidines
-
Chen JJ, Jones ME (1976) The cellular location of dihydroorotate dehydrogenase: relation to de novo biosynthesis of pyrimidines. Arch Biochem Biophys 176: 82-90
-
(1976)
Arch Biochem Biophys
, vol.176
, pp. 82-90
-
-
Chen, J.J.1
Jones, M.E.2
-
21
-
-
25144457125
-
Transcriptional repression of human cad gene by hypoxia inducible factor-1-alpha
-
Chen KF, Lai YY, Sun HAS, Tsai SJ (2005) Transcriptional repression of human cad gene by hypoxia inducible factor-1-alpha. Nucleic Acids Res 33: 5190-5198
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 5190-5198
-
-
Chen, K.F.1
Lai, Y.Y.2
Sun, H.A.S.3
Tsai, S.J.4
-
22
-
-
77955708527
-
Serum thymidine kinase 1 correlates to clinical stages and clinical reactions and monitors the outcome of therapy of 1, 247 cancer patients in routine clinical settings
-
Chen Y, Ying M, Chen YS, Minhua H, Lin Y, Den D, Li X, Zhnag M, Yun X, Zhou J, He E, Skog S (2010) Serum thymidine kinase 1 correlates to clinical stages and clinical reactions and monitors the outcome of therapy of 1, 247 cancer patients in routine clinical settings. Int J Clin Oncol 15: 359-368
-
(2010)
Int J Clin Oncol
, vol.15
, pp. 359-368
-
-
Chen, Y.1
Ying, M.2
Chen, Y.S.3
Minhua, H.4
Lin, Y.5
Den, D.6
Li, X.7
Zhnag, M.8
Yun, X.9
Zhou, J.10
He, E.11
Skog, S.12
-
23
-
-
48949120865
-
Identification of a putative mitochondrial thymidine monophosphate kinase-associated with monocytic/macrophage terminal differentiation
-
Chen YL, Lin DW, Chang ZF (2008) Identification of a putative mitochondrial thymidine monophosphate kinase-associated with monocytic/macrophage terminal differentiation. Genes Cells 13: 679-689
-
(2008)
Genes Cells
, vol.13
, pp. 679-689
-
-
Chen, Y.L.1
Lin, D.W.2
Chang, Z.F.3
-
24
-
-
0024590390
-
Channeling of urea cycle intermediates in situ in permeabilised hepatocytes
-
Cheung CW, Cohen NS, Raijman L (1989) Channeling of urea cycle intermediates in situ in permeabilised hepatocytes. J Biol Chem 264: 4038-4044
-
(1989)
J Biol Chem
, vol.264
, pp. 4038-4044
-
-
Cheung, C.W.1
Cohen, N.S.2
Raijman, L.3
-
25
-
-
0019321917
-
The overall synthesis of L-5, 6-dihydroorotate by multienzymatic protein pyr1-3 from hamster cells. Kinetic studies, substrate channeling, and the effects of inhibitors
-
Christopherson RI, Jones ME (1980) The overall synthesis of L-5, 6-dihydroorotate by multienzymatic protein pyr1-3 from hamster cells. Kinetic studies, substrate channeling, and the effects of inhibitors. J Biol Chem 255: 11381-95
-
(1980)
J Biol Chem
, vol.255
, pp. 11381-11395
-
-
Christopherson, R.I.1
Jones, M.E.2
-
27
-
-
0032992733
-
Uridine and its nucleotides: Biological actions, therapeutic potentials
-
Connolly GP, Duley JA (1999) Uridine and its nucleotides: biological actions, therapeutic potentials. Trends Pharmacol Sci 20: 218-225
-
(1999)
Trends Pharmacol Sci
, vol.20
, pp. 218-225
-
-
Connolly, G.P.1
Duley, J.A.2
-
28
-
-
0035863027
-
Activation of deoxycytidine kinase by inhibition of DNA synthesis in human lymphocytes
-
Csapó Z, Sasvári-Székely M, Spasokoukotskaja T, Talianidis I, Eriksson S, Staub M (2001) Activation of deoxycytidine kinase by inhibition of DNA synthesis in human lymphocytes. Biochem Pharmacol 61: 191-197
-
(2001)
Biochem Pharmacol
, vol.61
, pp. 191-197
-
-
Csapó, Z.1
Sasvári-Székely, M.2
Spasokoukotskaja, T.3
Talianidis, I.4
Eriksson, S.5
Staub, M.6
-
29
-
-
84864033445
-
Mitochondria in biology and medicine
-
Desler C, Rasmussen LJ (2012) Mitochondria in biology and medicine. Mitochondrion 12: 472-476
-
(2012)
Mitochondrion
, vol.12
, pp. 472-476
-
-
Desler, C.1
Rasmussen, L.J.2
-
30
-
-
35548983409
-
Mitochondria as determinant of nucleotide pools and chromosomal stability
-
Desler C, Munch-Petersen B, Stevnsner T, Matsui SI, Kulawiec M, Singh KK, Rasmussen LJ (2007) Mitochondria as determinant of nucleotide pools and chromosomal stability. Mutat Res 625: 112-124
-
(2007)
Mutat Res
, vol.625
, pp. 112-124
-
-
Desler, C.1
Munch-Petersen, B.2
Stevnsner, T.3
Matsui, S.I.4
Kulawiec, M.5
Singh, K.K.6
Rasmussen, L.J.7
-
31
-
-
52049104467
-
The mechanism of mitochondrial superoxide production by the cytochrome bc1 complex
-
Dröse S, Brandt U (2008) The mechanism of mitochondrial superoxide production by the cytochrome bc1 complex. J Biol Chem 283: 21649-21654
-
(2008)
J Biol Chem
, vol.283
, pp. 21649-21654
-
-
Dröse, S.1
Brandt, U.2
-
33
-
-
4043064372
-
Mammalian pyrimidine biosynthesis: Fresh insights into an ancient pathway
-
Evans DR, Guy HI (2004) Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway. J Biol Chem 279: 33035-33038
-
(2004)
J Biol Chem
, vol.279
, pp. 33035-33038
-
-
Evans, D.R.1
Guy, H.I.2
-
34
-
-
0029585361
-
Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans
-
Fairbanks LD, Bofill M, Ruckemann K, Simmonds HA (1995) Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans. J Biol Chem 270: 29682-29689
-
(1995)
J Biol Chem
, vol.270
, pp. 29682-29689
-
-
Fairbanks, L.D.1
Bofill, M.2
Ruckemann, K.3
Simmonds, H.A.4
-
35
-
-
21644445569
-
Mitochondrial deoxynucleotide pools in quiescent fibroblasts a possible model for mitochondrial neurogastrointestinal encephalomyopathy
-
Ferraro P, Pontarin G, Crocco L, Fabris S, Reichard P, Bianchi V (2005) Mitochondrial deoxynucleotide pools in quiescent fibroblasts a possible model for mitochondrial neurogastrointestinal encephalomyopathy. J Biol Chem 280: 24472-24480
-
(2005)
J Biol Chem
, vol.280
, pp. 24472-24480
-
-
Ferraro, P.1
Pontarin, G.2
Crocco, L.3
Fabris, S.4
Reichard, P.5
Bianchi, V.6
-
36
-
-
2642534227
-
Deoxyribonucleotides: The unusual chemistry and biochemistry of DNA precursors
-
Follmann H (2004) Deoxyribonucleotides: the unusual chemistry and biochemistry of DNA precursors. Chem Soc Rev 33: 225-233
-
(2004)
Chem Soc Rev
, vol.33
, pp. 225-233
-
-
Follmann, H.1
-
37
-
-
0016750459
-
Superoxide production and electron transport in mitochondrial oxidation of dihydroorotic acid
-
Forman HJ, Kennedy J (1975) Superoxide production and electron transport in mitochondrial oxidation of dihydroorotic acid. J Biol Chem 250: 4322-4326
-
(1975)
J Biol Chem
, vol.250
, pp. 4322-4326
-
-
Forman, H.J.1
Kennedy, J.2
-
38
-
-
84864813191
-
The pyrimidine nucleotide carrier PNC1 and mitochondrial trafficking of thymidine phosphates in cultured cells
-
Franzolin E, Miazzi C, Frangini M, Palumbo E, Rampazzo C, Bianchi V (2012) The pyrimidine nucleotide carrier PNC1 and mitochondrial trafficking of thymidine phosphates in cultured cells. Exp Cell Res 318: 2226-2236
-
(2012)
Exp Cell Res
, vol.318
, pp. 2226-2236
-
-
Franzolin, E.1
Miazzi, C.2
Frangini, M.3
Palumbo, E.4
Rampazzo, C.5
Bianchi, V.6
-
39
-
-
84883397529
-
The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells
-
Franzolin E, Pontarin G, Rampazzo C, Miazzi C, Ferraro P, Palumbo E, Reichard P, Bianchi V (2013) The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells. Proc Natl Acad Sci USA 110: 14272-14277
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 14272-14277
-
-
Franzolin, E.1
Pontarin, G.2
Rampazzo, C.3
Miazzi, C.4
Ferraro, P.5
Palumbo, E.6
Reichard, P.7
Bianchi, V.8
-
40
-
-
29044445144
-
Severe cytochrome c oxidase inhibition in vivo does not induce a pyrimidine deficiency: Neuroprotective action of oral uridine prodrug PN401 requires supraphysiological levels of uridine
-
Garcia RAG, Liu L, Hu Z, Gonzales A, von Borstel RW, Saydoff JA (2005) Severe cytochrome c oxidase inhibition in vivo does not induce a pyrimidine deficiency: neuroprotective action of oral uridine prodrug PN401 requires supraphysiological levels of uridine. Brain Res 1066: 164-171
-
(2005)
Brain Res
, vol.1066
, pp. 164-171
-
-
Garcia, R.A.G.1
Liu, L.2
Hu, Z.3
Gonzales, A.4
von Borstel, R.W.5
Saydoff, J.A.6
-
41
-
-
0034142678
-
From sideroblastic anemia to the role of mitochondrial DNA mutations in myelodysplastic syndromes
-
Gattermann N (1999) From sideroblastic anemia to the role of mitochondrial DNA mutations in myelodysplastic syndromes. Leuk Res 24: 141-151
-
(1999)
Leuk Res
, vol.24
, pp. 141-151
-
-
Gattermann, N.1
-
42
-
-
0742282012
-
Severe impairment of nucleotide synthesis through inhibition of mitochondrial respiration
-
Gattermann N, Dadak M, Hofhaus G, Wulfert M, Berneburg M, Löffler M, Simmonds HA (2004) Severe impairment of nucleotide synthesis through inhibition of mitochondrial respiration. Nucleosides Nucleotides Nucleic Acids 23: 1275-1279
-
(2004)
Nucleosides Nucleotides Nucleic Acids
, vol.23
, pp. 1275-1279
-
-
Gattermann, N.1
Dadak, M.2
Hofhaus, G.3
Wulfert, M.4
Berneburg, M.5
Löffler, M.6
Simmonds, H.A.7
-
43
-
-
0018786517
-
Deoxyguanosine kinase. Distinct molecular forms in mitochondria and cytosol
-
Gower WJ, Carr MC, Ives DH (1979) Deoxyguanosine kinase. Distinct molecular forms in mitochondria and cytosol. J Biol Chem 154: 2180-2183
-
(1979)
J Biol Chem
, vol.154
, pp. 2180-2183
-
-
Gower, W.J.1
Carr, M.C.2
Ives, D.H.3
-
44
-
-
18344413122
-
Regulation of carbamoyl phosphate synthetase by MAP kinase
-
Graves LM, Guy HI, Kozlowski P, Huang M, Lazarowski E, Pope RM, Collins MA, Dahlstrand EN, Earp HS 3rd, Evans DR (2000) Regulation of carbamoyl phosphate synthetase by MAP kinase. Nature 403: 328-332
-
(2000)
Nature
, vol.403
, pp. 328-332
-
-
Graves, L.M.1
Guy, H.I.2
Kozlowski, P.3
Huang, M.4
Lazarowski, E.5
Pope, R.M.6
Collins, M.A.7
Dahlstrand, E.N.8
Earp, H.S.9
Evans, D.R.10
-
45
-
-
0021144748
-
On auxotrophy for pyrimidines of respiration-deficient chick embryo cells
-
Grégoire M, Morais R, Quilliam MA, Gravel D (1984) On auxotrophy for pyrimidines of respiration-deficient chick embryo cells. Eur J Biochem 142: 9-55
-
(1984)
Eur J Biochem
, vol.142
, pp. 9-55
-
-
Grégoire, M.1
Morais, R.2
Quilliam, M.A.3
Gravel, D.4
-
47
-
-
77953555526
-
Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide induced reactive oxygen species production and apoptosis
-
Grove Hail N, Chen P, Kepa JJ, Bushman LR, Shearn C (2010) Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide induced reactive oxygen species production and apoptosis. Free Radic Biol Med 49: 109-116
-
(2010)
Free Radic Biol Med
, vol.49
, pp. 109-116
-
-
Grove Hail, N.1
Chen, P.2
Kepa, J.J.3
Bushman, L.R.4
Shearn, C.5
-
49
-
-
0034122123
-
Leflunomide: An immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases
-
Herrmann ML, Schleyerbach R, Kirschbaum BJ (2000) Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases. Immunopharmacology 47: 273-289
-
(2000)
Immunopharmacology
, vol.47
, pp. 273-289
-
-
Herrmann, M.L.1
Schleyerbach, R.2
Kirschbaum, B.J.3
-
50
-
-
84862685701
-
Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii
-
Hortua Triana MA, Huynh MH, Garavito MF, Fox BA, Bzik DJ, Carruthers VB, Löffler M, Zimmermann B (2012) Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii. Mol Biochem Parasitol 184: 71-81
-
(2012)
Mol Biochem Parasitol
, vol.184
, pp. 71-81
-
-
Hortua Triana, M.A.1
Huynh, M.H.2
Garavito, M.F.3
Fox, B.A.4
Bzik, D.J.5
Carruthers, V.B.6
Löffler, M.7
Zimmermann, B.8
-
51
-
-
0036182275
-
Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosis
-
Huang M, Kozlowski P, Collins M, Wang Y, Haystead TA, Graves LM (2002) Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosis. Mol Pharmacol 61: 569-577
-
(2002)
Mol Pharmacol
, vol.61
, pp. 569-577
-
-
Huang, M.1
Kozlowski, P.2
Collins, M.3
Wang, Y.4
Haystead, T.A.5
Graves, L.M.6
-
52
-
-
0030751062
-
A reciprocal allosteric mechanism for efficient transfer of labile intermediates between active sites in CAD, the mammalian pyrimidinebiosynthetic multienzyme polypeptide
-
Irvine HS, Shaw SM, Paton A, Carrey EA (1997) A reciprocal allosteric mechanism for efficient transfer of labile intermediates between active sites in CAD, the mammalian pyrimidinebiosynthetic multienzyme polypeptide. Eur J Biochem 247: 1063-1073
-
(1997)
Eur J Biochem
, vol.247
, pp. 1063-1073
-
-
Irvine, H.S.1
Shaw, S.M.2
Paton, A.3
Carrey, E.A.4
-
53
-
-
0017201832
-
Control of pyrimidine biosynthesis in human lymphocytes. Studies on lymphocytes from chronic lymphocytic leukemia patients
-
Ito K, Uchino H (1976) Control of pyrimidine biosynthesis in human lymphocytes. Studies on lymphocytes from chronic lymphocytic leukemia patients. Hiroshima J Med Sci 25: 23-7
-
(1976)
Hiroshima J Med Sci
, vol.25
, pp. 23-27
-
-
Ito, K.1
Uchino, H.2
-
54
-
-
0003081753
-
Evolutionary and functional families of dihydroorotate dehydrogenase
-
Jensen KF, Björnberg O (1998) Evolutionary and functional families of dihydroorotate dehydrogenase. Paths Pyrimidines 6: 20-28
-
(1998)
Paths Pyrimidines
, vol.6
, pp. 20-28
-
-
Jensen, K.F.1
Björnberg, O.2
-
55
-
-
0018823799
-
Pyrimidine nucleotide biosynthesis in animals: Genes, enzymes, and regulation of UMP biosynthesis
-
Jones ME (1980) Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis. Annu Rev Biochem 49: 253-279
-
(1980)
Annu Rev Biochem
, vol.49
, pp. 253-279
-
-
Jones, M.E.1
-
56
-
-
0032531668
-
Structural and functional comparison of agents interfering with dihydroorotate, succinate and NADH oxidation of rat liver mitochondria
-
Jöckel J, Wendt B, Löffler M (1998) Structural and functional comparison of agents interfering with dihydroorotate, succinate and NADH oxidation of rat liver mitochondria. Biochem Pharmacol 56: 1053-1060
-
(1998)
Biochem Pharmacol
, vol.56
, pp. 1053-1060
-
-
Jöckel, J.1
Wendt, B.2
Löffler, M.3
-
57
-
-
0017038049
-
Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis
-
Kempe TD, Swyryd EA, Bruist M, Stark GB (1976) Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis. Cell 9: 541-550
-
(1976)
Cell
, vol.9
, pp. 541-550
-
-
Kempe, T.D.1
Swyryd, E.A.2
Bruist, M.3
Stark, G.B.4
-
58
-
-
0002289568
-
Pyrimidine nucleotide metabolism and its compartmentation
-
Sies E (ed), Academic, London
-
Keppler D, Holstege A (1982) Pyrimidine nucleotide metabolism and its compartmentation. In: Sies E (ed) Metabolic compartmentation. Academic, London, pp 148-203
-
(1982)
Metabolic compartmentation
, pp. 148-203
-
-
Keppler, D.1
Holstege, A.2
-
60
-
-
24644518083
-
Neuroprotective effects of oral administration of triacetyluridine against MPTP neurotoxicity
-
Klivenyi P, Gardian G, Calingasan NY, Yang L, von Borstel R, Saydoff J, Browne SE, Beal MF (2004) Neuroprotective effects of oral administration of triacetyluridine against MPTP neurotoxicity. Neuromolecular Med 6: 87-92
-
(2004)
Neuromolecular Med
, vol.6
, pp. 87-92
-
-
Klivenyi, P.1
Gardian, G.2
Calingasan, N.Y.3
Yang, L.4
von Borstel, R.5
Saydoff, J.6
Browne, S.E.7
Beal, M.F.8
-
61
-
-
0033990195
-
Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives, brequinar sodium and polyporic acid
-
Knecht W, Henseling J, Löffler M (2000) Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives, brequinar sodium and polyporic acid. Chem Biol Interact 124: 61-76
-
(2000)
Chem Biol Interact
, vol.124
, pp. 61-76
-
-
Knecht, W.1
Henseling, J.2
Löffler, M.3
-
62
-
-
84863852687
-
Metabolic enzyme IMPDH is also a transcription factor regulated by cellular state
-
Kozhevnikova EN, van der Knaap JA, Pindyurin AV, Ozgur Z, van Ijcken WFJ, Moshkin YM, Verrijzer CP (2012) Metabolic enzyme IMPDH is also a transcription factor regulated by cellular state. Mol Cell 47: 133-139
-
(2012)
Mol Cell
, vol.47
, pp. 133-139
-
-
Kozhevnikova, E.N.1
van der Knaap, J.A.2
Pindyurin, A.V.3
Ozgur, Z.4
van Ijcken, W.F.J.5
Moshkin, Y.M.6
Verrijzer, C.P.7
-
63
-
-
0030791450
-
The human dUTPase gene encodes both nuclear and mitochondrial isoforms. Different expression of isoforms and characterization of a cDNA encoding the mitochondrial species
-
Ladner RD, Caradonna SJ (1997) The human dUTPase gene encodes both nuclear and mitochondrial isoforms. Different expression of isoforms and characterization of a cDNA encoding the mitochondrial species. J Biol Chem 272: 19072-19080
-
(1997)
J Biol Chem
, vol.272
, pp. 19072-19080
-
-
Ladner, R.D.1
Caradonna, S.J.2
-
64
-
-
1042301403
-
Mitochondrial expression of the human equilibrative nucleoside transporter 1 (HENT1) results in enhanced toxicity of antiviral drugs
-
Lai Y, Tse CM, Unadkat JD (2004) Mitochondrial expression of the human equilibrative nucleoside transporter 1 (HENT1) results in enhanced toxicity of antiviral drugs. J Biol Chem 279: 4490-4497
-
(2004)
J Biol Chem
, vol.279
, pp. 4490-4497
-
-
Lai, Y.1
Tse, C.M.2
Unadkat, J.D.3
-
65
-
-
0019311378
-
On the role of dihydroorotate dehydrogenase in growth cessation of Ehrlich ascites tumor cells cultured under oxygen deficiency
-
Löffler M (1980) On the role of dihydroorotate dehydrogenase in growth cessation of Ehrlich ascites tumor cells cultured under oxygen deficiency. Eur J Biochem 107: 207-215
-
(1980)
Eur J Biochem
, vol.107
, pp. 207-215
-
-
Löffler, M.1
-
66
-
-
0022355390
-
Towards a further understanding of the growth-inhibiting action of oxygen deficiency: Evaluation of the effect of antimycin on proliferating Ehrlich ascites tumour cells
-
Löffler M (1987) Towards a further understanding of the growth-inhibiting action of oxygen deficiency: evaluation of the effect of antimycin on proliferating Ehrlich ascites tumour cells. Exp Cell Res 157: 195-206
-
(1987)
Exp Cell Res
, vol.157
, pp. 195-206
-
-
Löffler, M.1
-
67
-
-
0024341665
-
The biosynthetic pathway of pyrimidine(deoxy)nucleotides: A sensor of oxygen tension necessary for maintaining cell proliferation
-
Löffler M (1989) The biosynthetic pathway of pyrimidine(deoxy)nucleotides: a sensor of oxygen tension necessary for maintaining cell proliferation? Exp Cell Res 182: 673-680
-
(1989)
Exp Cell Res
, vol.182
, pp. 673-680
-
-
Löffler, M.1
-
68
-
-
0030039060
-
Catalytic enzyme histochemistry and biochemical analysis of dihydroorotate dehydrogenase/oxidase and succinate dehydrogenase in mammalian tissues, cells and mitochondria
-
Löffler M, Becker C, Wegerle E (1996) Catalytic enzyme histochemistry and biochemical analysis of dihydroorotate dehydrogenase/oxidase and succinate dehydrogenase in mammalian tissues, cells and mitochondria. Histochem Cell Biol 105: 110-128
-
(1996)
Histochem Cell Biol
, vol.105
, pp. 110-128
-
-
Löffler, M.1
Becker, C.2
Wegerle, E.3
-
69
-
-
0030761388
-
Dihydroorotate-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides
-
Löffler M, Jöckel J, Schuster G, Becker C (1997) Dihydroorotate-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides. Mol Cell Biochem 174: 125-129
-
(1997)
Mol Cell Biochem
, vol.174
, pp. 125-129
-
-
Löffler, M.1
Jöckel, J.2
Schuster, G.3
Becker, C.4
-
70
-
-
10344247697
-
Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells
-
Löffler M, Klein A, Hayek-Ouassini M, Knecht W, Konrad L (2004) Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells. Nucleosides Nucleotides Nucleic Acids 23: 1281-1285
-
(2004)
Nucleosides Nucleotides Nucleic Acids
, vol.23
, pp. 1281-1285
-
-
Löffler, M.1
Klein, A.2
Hayek-Ouassini, M.3
Knecht, W.4
Konrad, L.5
-
71
-
-
85000861246
-
Pyrimidine biosynthesis and degradation (catabolism)
-
Lennarz WJ, Lane MD (eds) Academic Press, Waltham
-
Löffler M, Zameitat E (2013) Pyrimidine biosynthesis and degradation (catabolism). In: Lennarz WJ, Lane MD (eds) The encyclopedia of biological chemistry vol 3. Academic Press, Waltham, pp 712-718
-
(2013)
The encyclopedia of biological chemistry
, vol.3
, pp. 712-718
-
-
Löffler, M.1
Zameitat, E.2
-
72
-
-
84879009206
-
Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction
-
Malik A, Czajka A (2013) Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction? Mitochondrion 12: 481-492
-
(2013)
Mitochondrion
, vol.12
, pp. 481-492
-
-
Malik, A.1
Czajka, A.2
-
73
-
-
0030683603
-
The role of phosphometabolites in cell proliferation, energy metabolism, and tumor therapy
-
Mazurek S, Boschek CB, Eigenbrodt E (1997) The role of phosphometabolites in cell proliferation, energy metabolism, and tumor therapy. J Bioenerg Biomembr 29: 315-330
-
(1997)
J Bioenerg Biomembr
, vol.29
, pp. 315-330
-
-
Mazurek, S.1
Boschek, C.B.2
Eigenbrodt, E.3
-
74
-
-
84862219795
-
Metabolism of deoxypyrimidines and deoxypyrimidine antiviral analogs in isolated brain mitochondria
-
McCann KA, Williams DW, McKee EE (2012) Metabolism of deoxypyrimidines and deoxypyrimidine antiviral analogs in isolated brain mitochondria. J Neurochem 122: 126-137
-
(2012)
J Neurochem
, vol.122
, pp. 126-137
-
-
McCann, K.A.1
Williams, D.W.2
McKee, E.E.3
-
75
-
-
34547767666
-
Maintaining precursor pools for mitochondrial DNA replication
-
Mathews CK, Song S (2007) Maintaining precursor pools for mitochondrial DNA replication. FASEB J 21: 2294-2303
-
(2007)
FASEB J
, vol.21
, pp. 2294-2303
-
-
Mathews, C.K.1
Song, S.2
-
76
-
-
84894262557
-
RAD-6: Pyrimidine synthesis and radiation sensitivity in Caenorhabditis elegans
-
Merry A, Qiao M, Hasler M, Kuwabara PE (2013) RAD-6: Pyrimidine synthesis and radiation sensitivity in Caenorhabditis elegans Biochem J 458: 343-353
-
(2013)
Biochem J
, vol.458
, pp. 343-353
-
-
Merry, A.1
Qiao, M.2
Hasler, M.3
Kuwabara, P.E.4
-
77
-
-
0014333306
-
Mammalian dihydroorotate: Ubiquinone-reductase complex
-
Miller RW, Kerr CT, Curry JR (1968) Mammalian dihydroorotate: ubiquinone-reductase complex. Can J Biochem 49: 1099-1106
-
(1968)
Can J Biochem
, vol.49
, pp. 1099-1106
-
-
Miller, R.W.1
Kerr, C.T.2
Curry, J.R.3
-
78
-
-
84855364968
-
Identification of CAD as an androgen receptor interactant and an early marker of prostate tumor recurrence
-
Morin A, Fritsch L, Mathieu JRR, Gilbert C, Guarmit B, Firlej V, Gallou-Kabani C, Viellefond A, Delongchamps NB, Cabon F (2012) Identification of CAD as an androgen receptor interactant and an early marker of prostate tumor recurrence. FASEB J 26: 460-467
-
(2012)
FASEB J
, vol.26
, pp. 460-467
-
-
Morin, A.1
Fritsch, L.2
Mathieu, J.R.R.3
Gilbert, C.4
Guarmit, B.5
Firlej, V.6
Gallou-Kabani, C.7
Viellefond, A.8
Delongchamps, N.B.9
Cabon, F.10
-
79
-
-
0022400840
-
Enzymes of uracil catabolism in normal and neoplastic human tissues
-
Naguib FNM, Kouni MH, Cha S (1985) Enzymes of uracil catabolism in normal and neoplastic human tissues. Cancer Res 45: 5405-5412
-
(1985)
Cancer Res
, vol.45
, pp. 5405-5412
-
-
Naguib, F.N.M.1
Kouni, M.H.2
Cha, S.3
-
80
-
-
0034434583
-
Mitochondrial DNA disorders
-
Naviaux RK (2000) Mitochondrial DNA disorders. Eur J Pediatr 159: S219-226
-
(2000)
Eur J Pediatr
, vol.159
, pp. S219-S226
-
-
Naviaux, R.K.1
-
81
-
-
73349110071
-
Exome sequencing identifies a mendelian disorder
-
Ng SB, Buckingham KJ, Lee C, Bigham AW, Tabor HK, Dent KM, Huff CD, Shannon PT, Jabs EW, Nickerson DA, Shendure J, Bamshad MJ (2010) Exome sequencing identifies a mendelian disorder. Nat Genet 42: 30-35
-
(2010)
Nat Genet
, vol.42
, pp. 30-35
-
-
Ng, S.B.1
Buckingham, K.J.2
Lee, C.3
Bigham, A.W.4
Tabor, H.K.5
Dent, K.M.6
Huff, C.D.7
Shannon, P.T.8
Jabs, E.W.9
Nickerson, D.A.10
Shendure, J.11
Bamshad, M.J.12
-
82
-
-
85047694201
-
Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiency
-
Nishigaki Y, Marti R, Copeland WC, Hirano M (2013) Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiency. J Clin Invest 111: 1913-1921
-
(2013)
J Clin Invest
, vol.111
, pp. 1913-1921
-
-
Nishigaki, Y.1
Marti, R.2
Copeland, W.C.3
Hirano, M.4
-
83
-
-
67650685040
-
Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer
-
Parker WB (2009) Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer. Chem Rev 109: 2880-2893
-
(2009)
Chem Rev
, vol.109
, pp. 2880-2893
-
-
Parker, W.B.1
-
84
-
-
0025189946
-
Retention of in vivo antipyrimidine effects of brequinar sodium (DUP-785; NSC 368390) in murine liver, bone marrow and colon cancer
-
Peters GJ, Nadal JC, Laurensse EJ, de Kant E, Pinedo HM (1990) Retention of in vivo antipyrimidine effects of brequinar sodium (DUP-785; NSC 368390) in murine liver, bone marrow and colon cancer. Biochem Pharmacol 39: 135-144
-
(1990)
Biochem Pharmacol
, vol.39
, pp. 135-144
-
-
Peters, G.J.1
Nadal, J.C.2
Laurensse, E.J.3
de Kant, E.4
Pinedo, H.M.5
-
85
-
-
34249671789
-
Mitochondrial dysfunction and molecular pathways of disease
-
Pieczenik SR, Neustadt J (2007) Mitochondrial dysfunction and molecular pathways of disease. Exp Mol Pathol 83: 84-92
-
(2007)
Exp Mol Pathol
, vol.83
, pp. 84-92
-
-
Pieczenik, S.R.1
Neustadt, J.2
-
86
-
-
0023938135
-
Oxygen dependent regulation of DNA synthesis and growth of Ehrlich ascites tumor cells in vitro and in vivo
-
Probst H, Schiffer H, Gekeler V, Scheffler K (1988) Oxygen dependent regulation of DNA synthesis and growth of Ehrlich ascites tumor cells in vitro and in vivo. Cancer Res 48: 2053-2060
-
(1988)
Cancer Res
, vol.48
, pp. 2053-2060
-
-
Probst, H.1
Schiffer, H.2
Gekeler, V.3
Scheffler, K.4
-
87
-
-
36849015267
-
Mitochondrial thymidine kinase and the enzymatic network regulating thymidine triphosphate pools in cultured human cells
-
Rampazzo C, Fabris S, Franzolin E, Crovatto K, Frangini M, Bianchi V (2007) Mitochondrial thymidine kinase and the enzymatic network regulating thymidine triphosphate pools in cultured human cells. J Biol Chem 282: 3478-34769
-
(2007)
J Biol Chem
, vol.282
, pp. 3478-34769
-
-
Rampazzo, C.1
Fabris, S.2
Franzolin, E.3
Crovatto, K.4
Frangini, M.5
Bianchi, V.6
-
89
-
-
0034070355
-
Requirements for the mitochondrial import and localization of dihydroorotate dehydrogenase
-
Rawls J, Knecht W, Diekert K, Lill R, Löffler M (2000) Requirements for the mitochondrial import and localization of dihydroorotate dehydrogenase. Eur J Biochem 267: 2079-2087
-
(2000)
Eur J Biochem
, vol.267
, pp. 2079-2087
-
-
Rawls, J.1
Knecht, W.2
Diekert, K.3
Lill, R.4
Löffler, M.5
-
90
-
-
0023925454
-
From deoxynucleotides to DNA synthesis
-
Reichard P (1988) From deoxynucleotides to DNA synthesis. Annu Rev Biochem 57: 349-374
-
(1988)
Annu Rev Biochem
, vol.57
, pp. 349-374
-
-
Reichard, P.1
-
91
-
-
0023644515
-
Further characterization of the Krebs tricarboxylic acid cycle metabolon
-
Robinson JB Jr, Inman L, Sumegi B, Srere PA (1987) Further characterization of the Krebs tricarboxylic acid cycle metabolon. J Biol Chem 262: 1786-90
-
(1987)
J Biol Chem
, vol.262
, pp. 1786-1790
-
-
Robinson, J.B.1
Inman, L.2
Sumegi, B.3
Srere, P.A.4
-
92
-
-
84874961313
-
Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis
-
Robitaille AM, Christen S, Shimobayashi M, Cornu M, Fava LL, Moes S, Prescianotto-Baschong- C, Sauer U, Jenoe P, Hall MN (2013) Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 339: 1320-1323
-
(2013)
Science
, vol.339
, pp. 1320-1323
-
-
Robitaille, A.M.1
Christen, S.2
Shimobayashi, M.3
Cornu, M.4
Fava, L.L.5
Moes, S.6
Prescianotto-Baschong, C.7
Sauer, U.8
Jenoe, P.9
Hall, M.N.10
-
93
-
-
0032555586
-
Leflunomide inhibits pyrimidine de novo synthesis in mitogenstimulated T-lymphocytes from healthy humans
-
Rückemann K, Fairbanks LD, Carrey EA, Hawrylowicz CM, Richards DF, Kirschbaum B, Simmonds HA (1995) Leflunomide inhibits pyrimidine de novo synthesis in mitogenstimulated T-lymphocytes from healthy humans. J Biol Chem 273: 21682-21691
-
(1995)
J Biol Chem
, vol.273
, pp. 21682-21691
-
-
Rückemann, K.1
Fairbanks, L.D.2
Carrey, E.A.3
Hawrylowicz, C.M.4
Richards, D.F.5
Kirschbaum, B.6
Simmonds, H.A.7
-
94
-
-
10344250455
-
Deoxyribonucleoside kinases in mitochondrial DNA depletion
-
Saada-Reisch A (2004) Deoxyribonucleoside kinases in mitochondrial DNA depletion. Nucleosides Nucleotides Nucleic Acids 23: 1205-1215
-
(2004)
Nucleosides Nucleotides Nucleic Acids
, vol.23
, pp. 1205-1215
-
-
Saada-Reisch, A.1
-
95
-
-
0029047348
-
Hepatic purine and pyrimidine metabolism: Implications for antiviral chemotherapy of viral hepatitis
-
Shaw T, Locarini SA (1995) Hepatic purine and pyrimidine metabolism: implications for antiviral chemotherapy of viral hepatitis. Liver 15: 169-184
-
(1995)
Liver
, vol.15
, pp. 169-184
-
-
Shaw, T.1
Locarini, S.A.2
-
96
-
-
79957952535
-
Hypoxia-inducible factor 1: Regulation of mitochondrial metabolism and mediator of ischemic preconditioning
-
Semenza GL (2011) Hypoxia-inducible factor 1: regulation of mitochondrial metabolism and mediator of ischemic preconditioning. Biochim Biophys Acta 1813: 1263-1268
-
(2011)
Biochim Biophys Acta
, vol.1813
, pp. 1263-1268
-
-
Semenza, G.L.1
-
97
-
-
0037013259
-
Growth dependent regulation of mammalian pyrimidine biosynthesis by the protein kinase A and MAPK signaling cascades
-
Sigoillot FD, Evans DR, Guy HI (2002) Growth dependent regulation of mammalian pyrimidine biosynthesis by the protein kinase A and MAPK signaling cascades. J Biol Chem 277: 15745-15751
-
(2002)
J Biol Chem
, vol.277
, pp. 15745-15751
-
-
Sigoillot, F.D.1
Evans, D.R.2
Guy, H.I.3
-
98
-
-
21844445823
-
Nuclear localisation and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD
-
Sigoillot FD, Kotsis DH, Serre V, Sigoillot SM, Evans DR, Guy HI (2005) Nuclear localisation and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD. J Biol Chem 280: 25611-25620
-
(2005)
J Biol Chem
, vol.280
, pp. 25611-25620
-
-
Sigoillot, F.D.1
Kotsis, D.H.2
Serre, V.3
Sigoillot, S.M.4
Evans, D.R.5
Guy, H.I.6
-
99
-
-
23644434087
-
Intergenomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis
-
Singh KK, Kulawiec M, Still I, Desouki MM, Geradts J, Matsui SI (2005) Intergenomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis. Gene 354: 140-146
-
(2005)
Gene
, vol.354
, pp. 140-146
-
-
Singh, K.K.1
Kulawiec, M.2
Still, I.3
Desouki, M.M.4
Geradts, J.5
Matsui, S.I.6
-
100
-
-
49749121841
-
A novel role for mitochondria in regulating epigenetic modification in the nucleus
-
Smiraglia DJ, Kulawiec M, Bistulfi GL, Gupta G, Singh KK (2008) A novel role for mitochondria in regulating epigenetic modification in the nucleus. Cancer Biol Ther 7: 1182-1190
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 1182-1190
-
-
Smiraglia, D.J.1
Kulawiec, M.2
Bistulfi, G.L.3
Gupta, G.4
Singh, K.K.5
-
101
-
-
0023676214
-
Consequences of the depletion of cellular deoxynucleotides triphosphate pools on the excision repair process in cultured human fibroblasts
-
Snyder RD (1988) Consequences of the depletion of cellular deoxynucleotides triphosphate pools on the excision repair process in cultured human fibroblasts. Mutat Res 200: 193-199
-
(1988)
Mutat Res
, vol.200
, pp. 193-199
-
-
Snyder, R.D.1
-
102
-
-
33644992894
-
Mitochondrial DNA maintenance and bioenergetics
-
Stuart JA, Brown MF (2006) Mitochondrial DNA maintenance and bioenergetics. Biochim Biophys Acta 1757: 79-89
-
(2006)
Biochim Biophys Acta
, vol.1757
, pp. 79-89
-
-
Stuart, J.A.1
Brown, M.F.2
-
103
-
-
0015440251
-
Two carbamyl phosphate synthetases of mammals: Specific roles in control of pyrimidine and urea biosynthesis
-
Tatibana M, Shigesada K (1972) Two carbamyl phosphate synthetases of mammals: specific roles in control of pyrimidine and urea biosynthesis. Adv Enzyme Regul 10: 249-271
-
(1972)
Adv Enzyme Regul
, vol.10
, pp. 249-271
-
-
Tatibana, M.1
Shigesada, K.2
-
104
-
-
0028143584
-
Physiological concentrations of purines and pyrimidines
-
Traut TW (1994) Physiological concentrations of purines and pyrimidines. Mol Cell Biochem 140: 1-22
-
(1994)
Mol Cell Biochem
, vol.140
, pp. 1-22
-
-
Traut, T.W.1
-
105
-
-
0029685786
-
Uracil metabolism - UMP synthesis from orotic acid or uridine and conversion to ß-alanine: Enzymes and cDNA
-
Traut TW, Jones ME (1996) Uracil metabolism - UMP synthesis from orotic acid or uridine and conversion to ß-alanine: enzymes and cDNA. Prog Nucleic Acid Res Mol Biol 53: 1-78
-
(1996)
Prog Nucleic Acid Res Mol Biol
, vol.53
, pp. 1-78
-
-
Traut, T.W.1
Jones, M.E.2
-
106
-
-
84874638661
-
Mitochondria and cancer: Past, present, and future
-
Verschoor ML, Ungard R, Harbottle A, Jakupciak JP, Parr RL, Singh G (2013) Mitochondria and cancer: past, present, and future. BioMed Res Intern. doi: 10.1155/2013/612369
-
(2013)
BioMed Res Intern
-
-
Verschoor, M.L.1
Ungard, R.2
Harbottle, A.3
Jakupciak, J.P.4
Parr, R.L.5
Singh, G.6
-
108
-
-
79956300922
-
The kinetic effects on thymidine kinase 2 by enzyme-bound dTTP may explain the mitochondrial side effects of antiviral thymidine analogs
-
Wang L, Sun R, Eriksson S (2011) The kinetic effects on thymidine kinase 2 by enzyme-bound dTTP may explain the mitochondrial side effects of antiviral thymidine analogs. Antimicrob Agents Chemother 55: 2552-2558
-
(2011)
Antimicrob Agents Chemother
, vol.55
, pp. 2552-2558
-
-
Wang, L.1
Sun, R.2
Eriksson, S.3
-
109
-
-
0029035986
-
Purification, cloning and expression of murine uridine phosphorylase
-
Watanabe SI, Hino A, Wada K, Eliason JF, Uchida T (1995) Purification, cloning and expression of murine uridine phosphorylase. J Biol Chem 270: 12191-12196
-
(1995)
J Biol Chem
, vol.270
, pp. 12191-12196
-
-
Watanabe, S.I.1
Hino, A.2
Wada, K.3
Eliason, J.F.4
Uchida, T.5
-
110
-
-
84866665390
-
Mitochondria and cancer
-
Wallace DC (2012) Mitochondria and cancer. Nature Rev 12: 685-698
-
(2012)
Nature Rev
, vol.12
, pp. 685-698
-
-
Wallace, D.C.1
-
111
-
-
0020955571
-
Biochemical strategy of cancer cells and the design of chemotherapy: GHA Clowes Memorial Lecture
-
Weber G (1983) Biochemical strategy of cancer cells and the design of chemotherapy: GHA Clowes Memorial Lecture. Cancer Res 43: 3466-3492
-
(1983)
Cancer Res
, vol.43
, pp. 3466-3492
-
-
Weber, G.1
-
112
-
-
0002040183
-
Hereditary orotic aciduria and other disorders of pyrimidine metabolism
-
Scriver CR, Beaudet AL, Valle D, Sly WS (eds) 8th edn. McGraw-Hill, New York
-
Webster DR, Becroft DM, van Gennip AH, van Kuilenburg ABP (2001) Hereditary orotic aciduria and other disorders of pyrimidine metabolism. In: Scriver CR, Beaudet AL, Valle D, Sly WS (eds) The metabolic and molecular bases of inherited disease, vol 2, 8th edn. McGraw-Hill, New York, pp 2663-2702
-
(2001)
The metabolic and molecular bases of inherited disease
, vol.2
, pp. 2663-2702
-
-
Webster, D.R.1
Becroft, D.M.2
van Gennip, A.H.3
van Kuilenburg, A.B.P.4
-
113
-
-
79953064886
-
DHODH modulates transcriptional elongation in the neural crest and melanoma
-
White RM, Cech J, Ratanasirintrawoot S et al (2011) DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature 471: 518-522
-
(2011)
Nature
, vol.471
, pp. 518-522
-
-
White, R.M.1
Cech, J.2
Ratanasirintrawoot, S.3
-
114
-
-
25444508919
-
Analysis of the Zebrafish perplexed mutation reveals tissue-specific roles for de novo pyrimidine synthesis during development
-
Willer GB, Lee VM, Gregg RG, Link BA (2005) Analysis of the Zebrafish perplexed mutation reveals tissue-specific roles for de novo pyrimidine synthesis during development. Genetics 170: 1827-37
-
(2005)
Genetics
, vol.170
, pp. 1827-1837
-
-
Willer, G.B.1
Lee, V.M.2
Gregg, R.G.3
Link, B.A.4
-
115
-
-
38349141254
-
Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria
-
Xu Y, Johansson M, Karlsson A (2008) Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria. J Biol Chem 283: 1563-1571
-
(2008)
J Biol Chem
, vol.283
, pp. 1563-1571
-
-
Xu, Y.1
Johansson, M.2
Karlsson, A.3
-
116
-
-
34249684322
-
Functional expression of human dihydroorotate dehydrogenase in pyr4 mutants of Ustilago maydis allows target validation of DHODH inhibitors in vivo
-
Zameitat E, Freymark G, Dietz C, Löffler M, Bölker M (2007) Functional expression of human dihydroorotate dehydrogenase in pyr4 mutants of Ustilago maydis allows target validation of DHODH inhibitors in vivo. Appl Env Microbiol 73: 3371-3379
-
(2007)
Appl Env Microbiol
, vol.73
, pp. 3371-3379
-
-
Zameitat, E.1
Freymark, G.2
Dietz, C.3
Löffler, M.4
Bölker, M.5
-
117
-
-
57349119221
-
Structural biology of the purine biosynthetic pathway
-
Zhang Y, Morar M, Ealick SE (2008) Structural biology of the purine biosynthetic pathway. Cell Mol Life Sci 65: 3699-3724
-
(2008)
Cell Mol Life Sci
, vol.65
, pp. 3699-3724
-
-
Zhang, Y.1
Morar, M.2
Ealick, S.E.3
-
118
-
-
0030442457
-
Pyrimidine phosphorylase activity in differentiating HL-60 leukemia cells
-
Zhou Z, Sokolowski JA, Liu MP, Sartorelli AC, Handschuhmacher RE (1996) Pyrimidine phosphorylase activity in differentiating HL-60 leukemia cells. Mol Cell Differ 4: 263-274
-
(1996)
Mol Cell Differ
, vol.4
, pp. 263-274
-
-
Zhou, Z.1
Sokolowski, J.A.2
Liu, M.P.3
Sartorelli, A.C.4
Handschuhmacher, R.E.5
|