Functional expression of human dihydroorotate dehydrogenase (DHODH) in pyr4 mutants of Ustilago maydis allows target validation of DHODH inhibitors in vivo

Applied and Environmental Microbiology

Volumn 73, Issue 10, 2007, Pages 3371-3379

  Zameitat, Elke ^a   Freymark, Gerald ^a,b   Dietz, Cornelia D ^a   Löffler, Monika ^a   Bölker, Michael ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b MAX PLANCK INSTITUTE FOR TERRESTRIAL MICROBIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSTATIC DRUGS; FUNCTIONAL EXPRESSION; PYRIMIDINE; TARGETING SIGNAL;

AMINES; BIOSYNTHESIS; CATALYSIS; CELL PROLIFERATION; GENE EXPRESSION; NUCLEOTIDES; OXIDATION;

ENZYME INHIBITION;

1,4 NAPHTHOQUINONE DERIVATIVE; 2 (3,3 DICHLOROALLYL) 3 HYDROXY 1,4 NAPHTHOQUINONE; 2 [4 (CHLOROPHENYL)CYCLOHEXYL] 3 HYDROXY 1,4 NAPHTHOQUINONE; [2,2' [3,3' DIMETHOXY (1,1' BIPHENYL) 4,4' DIYL]DIIMINO]BISBENZOIC ACID; ALPHA RESORCYLIC ACID; ANTHRANILIC ACID; ATOVAQUONE; BENZOIC ACID DERIVATIVE; BREQUINAR; CARBOXIN; COUMARIN; CYTOSTATIC AGENT; DIHYDROOROTATE DEHYDROGENASE; DIHYDROOROTATE DEHYDROGENASE INHIBITOR; DIHYDROOROTIC ACID DERIVATIVE; EFENAMIC ACID; FLUCYTOSINE; FLUOROOROTIC ACID; FLUOROURACIL; LAWSONE; MENADIONE; NSC 73735; OROTIC ACID; PROTOCATECHUIC ACID; PYRIMIDINE; QUINONE DERIVATIVE; SALICYLHYDROXAMIC ACID; TERIFLUNOMIDE; UNCLASSIFIED DRUG;

CATALYSIS; ENZYME ACTIVITY; FUNCTIONAL MORPHOLOGY; FUNGAL DISEASE; GENE EXPRESSION; HYDROGEN; MAIZE; MITOCHONDRION; PATHOGEN; PATHOGENICITY; PHENOTYPE; ULTRAVIOLET RADIATION;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CORN; ENZYME ANALYSIS; ESCHERICHIA COLI; FUNGAL GENE; FUNGAL STRAIN; FUNGAL VIRULENCE; FUNGUS MUTANT; GENE EXPRESSION; GENETIC COMPLEMENTATION; GENETIC ENGINEERING; IN VIVO STUDY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN EXPRESSION; PYR4 GENE; PYRIMIDINE SYNTHESIS; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; ULTRAVIOLET IRRADIATION; USTILAGO MAYDIS;

BIPHENYL COMPOUNDS; CLONING, MOLECULAR; DNA, FUNGAL; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GENE DELETION; GENE EXPRESSION; GENETIC COMPLEMENTATION TEST; HUMANS; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PROTEIN SORTING SIGNALS; PYRIMIDINES; RECOMBINANT PROTEINS; USTILAGO;

ESCHERICHIA COLI; USTILAGO MAYDIS; ZEA MAYS;

EID: 34249684322     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/AEM.02569-06     Document Type: Article

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