A reciprocal allosteric mechanism for efficient transfer of labile intermediates between active sites in CAD, the mammalian pyrimidine-biosynthetic multienzyme polypeptide

European Journal of Biochemistry

Volumn 247, Issue 3, 1997, Pages 1063-1073

  Irvine, Heather S ^a   Shaw, Seán M ^a   Paton, Ann ^a   Carrey, Elizabeth A ^a,b  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Allostery; Aspartate transcarbamoylase; Carbamoyl phosphate; Channeling; Conformational change

Indexed keywords

CARBAMOYL PHOSPHATE SYNTHASE;

ALLOSTERISM; ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PYRIMIDINE SYNTHESIS;

MAMMALIA;

EID: 0030751062     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1997.01063.x     Document Type: Article

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