Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis

Free Radical Biology and Medicine

Volumn 49, Issue 1, 2010, Pages 109-116

  Hail, Numsen ^a   Chen, Ping ^a   Kepa, Jadwiga J ^a   Bushman, Lane R ^a   Shearn, Colin ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Apoptosis; Dihydroorotate dehydrogenase; Fenretinide; Free radicals; Mitochondria; N (4 hydroxyphenyl)retinamide; Reactive oxygen species; Teriflunomide

Indexed keywords

DIHYDROOROTATE DEHYDROGENASE; FENRETINIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TERIFLUNOMIDE; CROTONIC ACID DERIVATIVE; OXIDOREDUCTASE; SMALL INTERFERING RNA; TOLUIDINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL CYCLE ARREST; CELL MEMBRANE; CELL PROLIFERATION; CELL TRANSFORMATION; COLON CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DNA SYNTHESIS; ELECTRON TRANSPORT; EPITHELIUM CELL; HUMAN; HUMAN CELL; KERATINOCYTE; MITOCHONDRION; PRIORITY JOURNAL; PROSTATE EPITHELIUM; PROTEIN EXPRESSION; PYRIMIDINE SYNTHESIS; RNA INTERFERENCE; CARCINOMA; COLON TUMOR; COMPARATIVE STUDY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PROSTATE TUMOR; SKIN; TRANSFORMED CELL LINE; TUMOR CELL LINE;

APOPTOSIS; CARCINOMA; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; COLONIC NEOPLASMS; CROTONIC ACIDS; EPITHELIAL CELLS; FENRETINIDE; HUMANS; MALE; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PROSTATIC NEOPLASMS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SKIN; TOLUIDINES; CROTONATES;

EID: 77953555526     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.04.006     Document Type: Article

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