Anti-obesity and anti-diabetic effects of CL316,243, a highly specific β3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats: Induction of uncoupling protein and activation of glucose transporter 4 in white fat

European Journal of Endocrinology

Volumn 136, Issue 4, 1997, Pages 429-437

  Umekawa, Tsunekazu ^a   Yoshida, Toshihide ^a   Sakane, Naoki ^a   Saito, Masayuki ^b   Kumamoto, Kenzo ^c   Kondo, Motoharu ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c MEIJI UNIVERSITY OF INTEGRATIVE MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; GLUCOSE TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; THERMOGENESIS;

EID: 0030976887     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1360429     Document Type: Article

References (46)

1. 3-adrenergic receptor mRNA in man. Journal of Clinical Investigation 1993 91 344-349.
2. 3-adrenoceptor mRNA in human tissues. European Journal of Pharmacology 1995 289 223-228.
3. 3-adrenoceptors in obesity. Journal of Clinical Investigation 1995 95 1109-1116.
4. 3-adrenoceptor in man. Journal of Clinical Investigation 1995 95 2239-2245.
5. 3-adrenergic-receptor gene. New England Journal of Medicine 1995 333 343-347.
6. 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns. New England Journal of Medicine 1995 333 348-351.
7. 3-adrenergic-receptor and an increased capacity to gain weight in patients with morbid obesity. New England Journal of Medicine 1995 333 352-354.
8. 3-adrenergic-receptor gene and response to treatment of obesity. Lancet 1995 346 1433-1434.
9. Arch JRS, Ainsworth AT, Cawthorne MA, Piercy V, Sennitt MV, Thordy VE et al. Atypical β-adrenoceptor on brown adipocytes as target for anti obesity drugs. Nature 1984 309 163-165.
10. 3-adrenoceptor agonists in the treatment of obesity and diabetes. International Journal of Obesity 1996 20 191-199.
11. Yen TT. β-agonists as antiobesity, antidiabetic and nutrient partitioning agents. Obesity Research 1995 3 531S-536S.
12. 3 receptors. A promising antidiabetic and antiobesity agent. Journal of Medicinal Chemistry 1992 35 3081-3084.
13. 3-adrenergic agonist, in mice with monosodium-L-glutamate-induced obesity. European Journal of Endocrinology 1994 131 97-102.
14. 3-agonist, on energy balance and brown and white adipose tissue in rats. American Journal of Physiology 1994 266 R1371-R1382.
15. Kawano K, Hirashima T, Mori S, Kurosumi M & Saitoh Y. A new rat strain with non-insulin dependent diabetes mellitus, 'OLETF'. Rat News Letter 1991 25 24-26.
16. Kawano K, Hirashima T, Mori S, Saitoh Y, Kurosumi M & Natori T. Spontaneous long-term hyperglycemic rat with diabetic complications. Diabetes 1992 41 1422-1428.
17. Nicholls DG. Hamster brown adipose tissue mitochondria, purine nucleotide control of ion conductance of the inner membrane and the nature of the nucleotide binding site. European Journal of Biochemistry 1976 63 223-228.
18. Yoshida T, Umekawa T, Wakabayashi Y, Yoshimoto K, Sakane N & Kondo M. Anti-obesity and anti-diabetic effects of mazindol in yellow KK mice: Its activating effect on brown adipose tissue thermogenesis. Clinical and Experimental Pharmacology and Physiology 1996 23 476-482.
19. Birnbaum MJ. Identification of a novel gene encoding an insulin-responsive glucose transporter. Cell 1989 57 305-315.
20. Siritz WI, deSautel SL, Kayano T, Bell GI & Pessin JE. Regulation of glucose transporter messenger RNA in insulin-deficient states. Nature 1989 340 72-74.
21. Le Marchand-Brustel Y, Olichon-Berthe C, Grémeaux T, Tanti JF, Rochet N & Van Obberghen E. Glucose transporter in insulin sensitive tissue of lean and obese mice. Effect of the thermogenetic agent BRL26830A. Endocrinology 1990 127 2687-2695.
22. Himms-Hagen J. Brown adipose tissue thermogenesis and obesity. Progress in Lipid Research 1989 28 67-115.
23. Trayhurn P. Brown adipose tissue and energy balance. In Brown Adipose Tissue, pp 299-338. Eds P Trayhurn & DG Nicholls. London: Arnold, 1986.
24. Cannon B & Lindberg O. Mitochondria from brown adipose tissue: isolation and properties. Methods in Enzymology 1979 55 76-78.
25. Lowry OH, Rosebrough NJ, Farr AL & Randall RJ. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951 193 265-275.
26. Yonetani T & Ray GS. A study on cytochrome oxidase: kinetics of the aerobic oxidation of ferrocytochrome c by cytochrome oxidase. Journal of Biological Chemistry 1965 240 3392-3398.
27. Nicholls DG. Hamster brown adipose tissue mitochondria, purine nucleotide control of ion conductance of the inner membrane and the nature of the nucleotide binding site. European Journal of Biochemistry 1976 63 223-228.
28. Ricquier D, Raimbault S, Champigny O, Miroux B & Bouillaud F. The uncoupling protein is not expressed in rat liver. FEBS Letters 1992 303 103-106.
29. Tsukazaki K, Nikami H, Shimizu Y, Kawada T, Yoshida T & Saito M. Chronic administration of β-adrenergic agonists can mimic the stimulative effect of cold exposure on protein synthesis in rat brown adipose tissue. Journal of Biochemistry 1995 117 96-100.
30. Lin CS & Klingenberg M. Isolation of the uncoupling protein from brown adipose tissue mitochondria. FEBS Letters 1980 133 299-303.
31. Shimizu Y, Nikami H, Tsukazaki K, Machado UF, Yano H, Seino Y et al. Increased expression of glucose transporter GLUT-4 in brown adipose tissue of fasted rats after cold exposure. American Journal of Physiology 1993 264 E890-E895.
32. 3-adrenergic agonist. Journal of Clinical Investigation 1996 97 2898-2904.
33. 3-adrenergic agonist, in yellow KK mice. Life Sciences 1994 54 491-498.
34. Rothwell NJ & Stock MJ. A role for brown adipose tissue in diet-induced thermogenesis. Nature 1979 281 31-35.
35. Fisler JS, Yoshida T & Bray GA. Catecholamine turnover in S5B/P1 and Osborne-Mendel rats: Response to a high fat diet. American Journal of Physiology 1984 247 R290-R295.
36. Yoshida T, Nishioka H, Yoshioka K & Kondo M. Reduced norepinephrine turnover in interscapular brown adipose tissue of obese rats after ovariectomy. Metabolism 1987 36 1-6.
37. Foster DO. Quantitative role of brown adipose tissue in themogenesis. In Brown Adipose Tissue, pp 31-51. Eds P Trayhurn & DG Nicholls. London: Arnold, 1986.
38. 3-adrenergic receptor stimulation restores message and expression of brown fat mitochondrial uncoupling protein in adult dogs. Proceedings of the National Academy of Sciences of the USA 1991 88 10774-10777.
39. Ricquier D, Raimbault S, Champigny O, Miroux B & Bouillaud F. The uncoupling protein is not expressed in rat liver. FEBS Letters 1992 303 103-106.
40. Saito M, Minokoshi Y & Shimazu T. Brown adipose tissue after ventromedial hypothalamic lesions in rats. American Journal of Physiology 1985 248 E20-E25.
41. Vander Turg JG, Ohshima K, Yoshida T, Romsos DR & Bray GA. Adrenalectomy increases norepinephrine turnover in brown adipose tissue of obese (ob/ob) mice. Life Sciences 1984 34 1423-1432.
42. 3-adrenoceptor agonist, BRL268 30A works by release of endogenous insulin. American Journal of Clinical Nutrition 1992 55 237S-241S.
43. 3-adrenoceptor agonist, BRL26830A, on insulin and glucagon release in mice. Endocrinologica Japonica 1991 38 641-646.
44. 3-adrenoceptor agonist, on insulin secretion in the perfused mouse pancreas. Endocrine Journal 1994 41 671-675.
45. Nikami H, Shimizu Y, Endoh D, Yano H & Saito M. Cold exposure increases glucose utilization and glucose transporter expression in brown adipose tissue. Biochemical and Biophysical Research Communications 1992 185 1078-1082.
46. 3-adrenergic agonist, BRL35135A, on glucose uptake in rat skeletal muscle in vivo and in vitro. Journal of Endocrinology 1993 139 479-486.