Metabolically active human brown adipose tissue derived stem cells

Stem Cells

Volumn 32, Issue 2, 2014, Pages 572-581

  Silva, Francisco J ^a   Holt, Dolly J ^a   Vargas, Vanessa ^a   Yockman, James ^a   Boudina, Sihem ^a   Atkinson, Donald ^a   Grainger, David W ^b   Revelo, Monica P ^a   Sherman, Warren ^c   Bull, David A ^a   Patel, Amit N ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c NewYork Presbyterian Hospital   (United States)

Author keywords

Adipose; Brown adipose tissue; Diabetes; Obesity; Scaffolds; Stem cells

Indexed keywords

ADIPOSE; BROWN ADIPOSE TISSUE; DIABETES; OBESITY; SCAFFOLDS; STEM CELLS;

ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ANIMALS; BIOLOGICAL EVOLUTION; CELL DIFFERENTIATION; ENERGY METABOLISM; HUMANS; MICE; MUSCLE, SKELETAL; OBESITY; PLURIPOTENT STEM CELLS; THERMOGENESIS;

EID: 84894558872     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1595     Document Type: Article

References (34)

1. Ogden C, Kit B, Flegal K. Prevalence of obesity in the Unites States. NCHS Data Brief 2012;82: 1-8.
2. Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature 2006; 444: 881-887.
3. Prevention CfDCa. US National diabetes fact sheet: National estimates, general information on diabetes, prediabetes in the Unites States. Atlanta: US Department of Health, Human Services CfDCaP, 2011.
4. Virtanen KA, Lidell ME, Orava J et al. Functional brown adipose tissue in healthy adults. N Engl J Med 2009;360: 1518-1525.
5. Cypess AM, Lehman S, Williams G et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009;360: 1509-1517.
6. Cypess AM, White AP, Vernochet C et al. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med 2013; 19: 635-639.
7. Nicholls DG, Locke RM. Thermogenic mechanisms in brown fat. Physiol Rev 1984; 64: 1-64.
8. Ouellet V, Labbe SM, Blondin DP et al. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest 2012;122: 545-552.
9. Lidell ME, Enerback S. Brown adipose tissue-A new role in humans? Nat Rev Endocrinol 2010;6: 319-325.
10. Castillo-Quan JI. From white to brown fat through the PGC-1a-dependent myokine irisin: Implications for diabetes and obesity. Dis Model Mech 2012;5: 293-295.
11. Baglioni S, Francalanci M, Squecco R et al. Characterization of human adult stemcell populations isolated from visceral and subcutaneous adipose tissue. Faseb J 2009; 23: 3494-3505.
12. Mizuno H. Adipose-derived stem and stromal cells for cell-based therapy: Current status of preclinical studies and clinical trials. Curr Opin Mol Ther 2010;12: 442-449.
13. Fuller SA, Takahashi M, Hurrell JG. Cloning of hybridoma cell lines by limiting dilution. Curr Protoc Mol Biol 2001;Chapter 11: Unit11 18.
14. Cristofalo VJ, Allen RG, Pignolo RJ et al. Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation. Proc Natl Acad Sci USA 1998; 95: 10614-10619.
15. Bostrom P, Wu J, Jedrychowski MP et al. A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012;481: 463-468.
16. Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 2007;293: E444-E452.
17. Heaton JM. The distribution of brown adipose tissue in the human. J Anat 1972; 112: 35-39.
18. Wu J, Bostrom P, Sparks LM et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012;150: 366-376.
19. Israels SJ, McMillan-Ward EM. Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin alphaIIbbeta3 in activated platelets. Thromb Res 2010;125: 152-158.
20. Kim YJ, Yu JM, Joo HJ et al. Role of CD9 in proliferation and proangiogenic action of human adipose-derived mesenchymal stem cells. Pflugers Arch 2007;455: 283-296.
21. Liu TM, Martina M, Hutmacher DW et al. Identification of common pathways mediating differentiation of bone marrowand adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages. Stem Cells 2007;25: 750-760.
22. Muraglia A, Corsi A, Riminucci M et al. Formation of a chondro-osseous rudiment in micromass cultures of human bone-marrow stromal cells. J Cell Sci 2003;116: 2949-2955.
23. Patel AN, Yockman J, Vargas V et al. Putative population of adipose-derived stem cells isolated from mediastinal tissue during cardiac surgery. Cell Transplant 2013;22: 507-511.
24. Lee P, Greenfield JR, Ho KK et al. A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 2010;299: E601-E606.
25. Gunawardana SC. Therapeutic value of brown adipose tissue: Correcting metabolic disease through generating healthy fat. Adipocyte 2012;1: 250-255.
26. Stanford KI, Middelbeek RJ, Townsend KL et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest 2013;123: 215-223.
27. Lidell ME, Betz MJ, Dahlqvist Leinhard O et al. Evidence for two types of brown adipose tissue in humans. Nat Med 2013;19: 631-634.
28. Moitra J, Mason MM, Olive M et al. Life without white fat: A transgenic mouse. Genes Dev 1998;12: 3168-3181.
29. Ho AD, Wagner W, Franke W. Heterogeneity of mesenchymal stromal cell preparations. Cytotherapy 2008;10: 320-330.
30. Kern S, Eichler H, Stoeve J et al. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 2006;24: 1294-1301.
31. Covas DT, Panepucci RA, Fontes AM et al. Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD1461 perivascular cells and fibroblasts. Exp Hematol 2008;36: 642-654.
32. Gunawardana SC, Piston DW. Reversal of type 1 diabetes in mice by brown adipose tissue transplant. Diabetes 2012;61: 674-682.
33. Christian M, Parker MG. The engineering of brown fat. J Mol Cell Biol 2010;2: 23-25.
34. Nechad M, Kuusela P, Carneheim C et al. Development of brown fat cells in monolayer culture. I. Morphological and biochemical distinction from white fat cells in culture. Exp Cell Res 1983;149: 105-118.