메뉴 건너뛰기




Volumn 6, Issue SEP, 2015, Pages

Mechanisms of kidney injury in lupus nephritis - the role of anti-dsDNA antibodies

Author keywords

Anti dsDNA antibodies; Cyclophosphamide; Fibrosis; Inflammation; Lupus nephritis; Mesangial cells; Mycophenolic acid; Proximal renal tubular epithelial cells

Indexed keywords

ALPHA ACTININ; CALRETICULIN; CORTICOSTEROID; CXCL1 CHEMOKINE; CYCLOPHOSPHAMIDE; DEOXYRIBONUCLEASE I; DOUBLE STRANDED DNA ANTIBODY; FIBRONECTIN; INTERLEUKIN 6; LIPOCORTIN 2; MYCOPHENOLIC ACID; MYOSIN I; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA;

EID: 84946564455     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00475     Document Type: Review
Times cited : (116)

References (135)
  • 1
    • 0142009533 scopus 로고    scopus 로고
    • Development of autoantibodies before the clinical onset of systemic lupus erythematosus
    • Arbuckle MR, McClain MT, Rubertone MV, Scofield RH, Dennis GJ, James JA, et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med (2003) 349:1526-33. doi: 10.1056/NEJMoa021933.
    • (2003) N Engl J Med , vol.349 , pp. 1526-1533
    • Arbuckle, M.R.1    McClain, M.T.2    Rubertone, M.V.3    Scofield, R.H.4    Dennis, G.J.5    James, J.A.6
  • 2
    • 34447320202 scopus 로고    scopus 로고
    • Fifty years of anti-ds DNA antibodies: are we approaching journey's end?
    • Isenberg DA, Manson JJ, Ehrenstein MR, Rahman A. Fifty years of anti-ds DNA antibodies: are we approaching journey's end? Rheumatology (Oxford) (2007) 46:1052-6. doi:10.1093/rheumatology/kem112.
    • (2007) Rheumatology (Oxford) , vol.46 , pp. 1052-1056
    • Isenberg, D.A.1    Manson, J.J.2    Ehrenstein, M.R.3    Rahman, A.4
  • 3
    • 0036232276 scopus 로고    scopus 로고
    • Mesangial cell-binding anti-DNA antibodies in patients with systemic lupus erythematosus
    • Chan TM, Leung JK, Ho SK, Yung S. Mesangial cell-binding anti-DNA antibodies in patients with systemic lupus erythematosus. J Am Soc Nephrol (2002) 13:1219-29. doi:10.1097/01.ASN.0000014223.71109.13.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1219-1229
    • Chan, T.M.1    Leung, J.K.2    Ho, S.K.3    Yung, S.4
  • 4
    • 40049093765 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • Rahman A, Isenberg DA. Systemic lupus erythematosus. N Engl J Med (2008) 358:929-39. doi:10.1056/NEJMra071297.
    • (2008) N Engl J Med , vol.358 , pp. 929-939
    • Rahman, A.1    Isenberg, D.A.2
  • 5
    • 0032493059 scopus 로고    scopus 로고
    • Antibodies to DNA
    • Hahn BH. Antibodies to DNA. N Engl J Med (1998) 338:1359-68. doi:10.1056/NEJM199805073381906.
    • (1998) N Engl J Med , vol.338 , pp. 1359-1368
    • Hahn, B.H.1
  • 7
    • 0026753816 scopus 로고
    • Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites
    • Vlahakos DV, Foster MH, Adams S, Katz M, Ucci AA, Barrett KJ, et al. Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites. Kidney Int (1992) 41:1690-700. doi:10.1038/ki.1992.242.
    • (1992) Kidney Int , vol.41 , pp. 1690-1700
    • Vlahakos, D.V.1    Foster, M.H.2    Adams, S.3    Katz, M.4    Ucci, A.A.5    Barrett, K.J.6
  • 8
    • 77949535653 scopus 로고    scopus 로고
    • Anti-dsDNA antibodies promote initiation, and acquired loss of renal Dnase1 promotes progression of lupus nephritis in autoimmune (NZBxNZW)F1 mice
    • Fenton K, Fismen S, Hedberg A, Seredkina N, Fenton C, Mortensen ES, et al. Anti-dsDNA antibodies promote initiation, and acquired loss of renal Dnase1 promotes progression of lupus nephritis in autoimmune (NZBxNZW)F1 mice. PLoS One (2009) 4:e8474. doi:10.1371/journal.pone.0008474.
    • (2009) PLoS One , vol.4
    • Fenton, K.1    Fismen, S.2    Hedberg, A.3    Seredkina, N.4    Fenton, C.5    Mortensen, E.S.6
  • 9
    • 13444291211 scopus 로고    scopus 로고
    • Pathogenic autoantibodies in lupus nephritis
    • Waldman M, Madaio MP. Pathogenic autoantibodies in lupus nephritis. Lupus (2005) 14:19-24. doi:10.1191/0961203305lu2054oa.
    • (2005) Lupus , vol.14 , pp. 19-24
    • Waldman, M.1    Madaio, M.P.2
  • 10
    • 33745915839 scopus 로고    scopus 로고
    • Nephritogenic anti-DNA antibodies regulate gene expression in MRL/lpr mouse glomerular mesangial cells
    • Qing X, Zavadil J, Crosby MB, Hogarth MP, Hahn BH, Mohan C, et al. Nephritogenic anti-DNA antibodies regulate gene expression in MRL/lpr mouse glomerular mesangial cells. Arthritis Rheum (2006) 54:2198-210. doi:10.1002/art.21934.
    • (2006) Arthritis Rheum , vol.54 , pp. 2198-2210
    • Qing, X.1    Zavadil, J.2    Crosby, M.B.3    Hogarth, M.P.4    Hahn, B.H.5    Mohan, C.6
  • 11
    • 84863664311 scopus 로고    scopus 로고
    • Autoantibodies and resident renal cells in the pathogenesis of lupus nephritis: getting to know the unknown
    • Yung S, Chan TM. Autoantibodies and resident renal cells in the pathogenesis of lupus nephritis: getting to know the unknown. Clin Dev Immunol (2012) 2012:139365. doi:10.1155/2012/139365.
    • (2012) Clin Dev Immunol , vol.2012
    • Yung, S.1    Chan, T.M.2
  • 12
    • 33744756400 scopus 로고    scopus 로고
    • Nephritogenic lupus antibodies recognize glomerular basement membrane-associated chromatin fragments released from apoptotic intraglomerular cells
    • Kalaaji M, Mortensen E, Jorgensen L, Olsen R, Rekvig OP. Nephritogenic lupus antibodies recognize glomerular basement membrane-associated chromatin fragments released from apoptotic intraglomerular cells. Am J Pathol (2006) 168:1779-92. doi:10.2353/ajpath.2006.051329.
    • (2006) Am J Pathol , vol.168 , pp. 1779-1792
    • Kalaaji, M.1    Mortensen, E.2    Jorgensen, L.3    Olsen, R.4    Rekvig, O.P.5
  • 13
    • 65249171440 scopus 로고    scopus 로고
    • Nephritogenic potential of anti-DNA antibodies against necrotic nucleosomes
    • Mortensen ES, Rekvig OP. Nephritogenic potential of anti-DNA antibodies against necrotic nucleosomes. J Am Soc Nephrol (2009) 20:696-704. doi:10.1681/asn.2008010112.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 696-704
    • Mortensen, E.S.1    Rekvig, O.P.2
  • 14
    • 1442323830 scopus 로고    scopus 로고
    • New approaches to the renal pathogenicity of anti-DNA antibodies in systemic lupus erythematosus
    • Putterman C. New approaches to the renal pathogenicity of anti-DNA antibodies in systemic lupus erythematosus. Autoimmun Rev (2004) 3:7-11. doi:10.1016/S1568-9972(03)00082-X.
    • (2004) Autoimmun Rev , vol.3 , pp. 7-11
    • Putterman, C.1
  • 15
    • 33746582779 scopus 로고    scopus 로고
    • Detection of antibodies to dsDNA: an overview of laboratory assays
    • Rouquette AM, Desgruelles C. Detection of antibodies to dsDNA: an overview of laboratory assays. Lupus (2006) 15:403-7. doi:10.1191/0961203306lu2324oa.
    • (2006) Lupus , vol.15 , pp. 403-407
    • Rouquette, A.M.1    Desgruelles, C.2
  • 16
    • 17144392936 scopus 로고    scopus 로고
    • Anti-DNA antibodies: a diagnostic and prognostic tool for systemic lupus erythematosus?
    • Riboldi P, Gerosa M, Moroni G, Radice A, Allegri F, Sinico A, et al. Anti-DNA antibodies: a diagnostic and prognostic tool for systemic lupus erythematosus? Autoimmunity (2005) 38:39-45. doi:10.1080/08916930400022616.
    • (2005) Autoimmunity , vol.38 , pp. 39-45
    • Riboldi, P.1    Gerosa, M.2    Moroni, G.3    Radice, A.4    Allegri, F.5    Sinico, A.6
  • 17
    • 0036559118 scopus 로고    scopus 로고
    • Methodological update detection of antibodies to dsDNA: current insights into its relevance
    • Smeenk RJ. Methodological update detection of antibodies to dsDNA: current insights into its relevance. Clin Exp Rheumatol (2002) 20:294-300.
    • (2002) Clin Exp Rheumatol , vol.20 , pp. 294-300
    • Smeenk, R.J.1
  • 18
    • 0016492569 scopus 로고
    • Influence of molecular weight of DNA on the determination of anti-DNA antibodies in systemic lupus erythematosus (SLE) sera by radioimmunoassay
    • Geisert M, Heicke B, Metzmann E, Zahn RK. Influence of molecular weight of DNA on the determination of anti-DNA antibodies in systemic lupus erythematosus (SLE) sera by radioimmunoassay. Nucleic Acids Res (1975) 2:521-35. doi:10.1093/nar/2.4.521.
    • (1975) Nucleic Acids Res , vol.2 , pp. 521-535
    • Geisert, M.1    Heicke, B.2    Metzmann, E.3    Zahn, R.K.4
  • 19
    • 0016587129 scopus 로고
    • Immunology of DNA. III. Crithidia luciliae, a simple substrate for the determination of anti-dsDNA with the immunofluorescence technique
    • Aarden LA, de Groot ER, Feltkamp TE. Immunology of DNA. III. Crithidia luciliae, a simple substrate for the determination of anti-dsDNA with the immunofluorescence technique. Ann N Y Acad Sci (1975) 254:505-15. doi:10.1111/j.1749-6632.1975.tb29197.x.
    • (1975) Ann N Y Acad Sci , vol.254 , pp. 505-515
    • Aarden, L.A.1    de Groot, E.R.2    Feltkamp, T.E.3
  • 20
    • 84873709220 scopus 로고    scopus 로고
    • Comparison of three anti-dsDNA assays: performance and correlation with systemic lupus erythematosus disease activity
    • Venner AA, Ibanez D, Gladman DD, Urowitz MB, MacKinnon A, Blasutig IM, et al. Comparison of three anti-dsDNA assays: performance and correlation with systemic lupus erythematosus disease activity. Clin Biochem (2013) 46:317-20. doi:10.1016/j.clinbiochem.2012.12.004.
    • (2013) Clin Biochem , vol.46 , pp. 317-320
    • Venner, A.A.1    Ibanez, D.2    Gladman, D.D.3    Urowitz, M.B.4    MacKinnon, A.5    Blasutig, I.M.6
  • 21
    • 34249826624 scopus 로고    scopus 로고
    • Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice
    • Jiang C, Foley J, Clayton N, Kissling G, Jokinen M, Herbert R, et al. Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice. J Immunol (2007) 178:7422-31. doi:10.4049/jimmunol.178.11.7422.
    • (2007) J Immunol , vol.178 , pp. 7422-7431
    • Jiang, C.1    Foley, J.2    Clayton, N.3    Kissling, G.4    Jokinen, M.5    Herbert, R.6
  • 22
    • 79953692402 scopus 로고    scopus 로고
    • Activation-induced deaminase-deficient MRL/lpr mice secrete high levels of protective antibodies against lupus nephritis
    • Jiang C, Zhao ML, Scearce RM, Diaz M. Activation-induced deaminase-deficient MRL/lpr mice secrete high levels of protective antibodies against lupus nephritis. Arthritis Rheum (2011) 63:1086-96. doi:10.1002/art.30230.
    • (2011) Arthritis Rheum , vol.63 , pp. 1086-1096
    • Jiang, C.1    Zhao, M.L.2    Scearce, R.M.3    Diaz, M.4
  • 23
    • 8344288224 scopus 로고    scopus 로고
    • Autoantibodies, lupus and the science of sabotage
    • Rahman A. Autoantibodies, lupus and the science of sabotage. Rheumatology (Oxford) (2004) 43:1326-36. doi:10.1093/rheumatology/keh354.
    • (2004) Rheumatology (Oxford) , vol.43 , pp. 1326-1336
    • Rahman, A.1
  • 24
    • 0036954862 scopus 로고    scopus 로고
    • Systematic analysis of sequences of anti-DNA antibodies-relevance to theories of origin and pathogenicity
    • Rahman A, Giles I, Haley J, Isenberg D. Systematic analysis of sequences of anti-DNA antibodies-relevance to theories of origin and pathogenicity. Lupus (2002) 11:807-23. doi:10.1191/0961203302lu302rr.
    • (2002) Lupus , vol.11 , pp. 807-823
    • Rahman, A.1    Giles, I.2    Haley, J.3    Isenberg, D.4
  • 25
    • 0035896020 scopus 로고    scopus 로고
    • The importance of somatic mutations in the V(lambda) gene 2a2 in human monoclonal anti-DNA antibodies
    • Rahman A, Haley J, Radway-Bright E, Nagl S, Low DG, Latchman DS, et al. The importance of somatic mutations in the V(lambda) gene 2a2 in human monoclonal anti-DNA antibodies. J Mol Biol (2001) 307:149-60. doi:10.1006/jmbi.2000.4491.
    • (2001) J Mol Biol , vol.307 , pp. 149-160
    • Rahman, A.1    Haley, J.2    Radway-Bright, E.3    Nagl, S.4    Low, D.G.5    Latchman, D.S.6
  • 26
    • 84896518122 scopus 로고    scopus 로고
    • Autoreactive IgE is prevalent in systemic lupus erythematosus and is associated with increased disease activity and nephritis
    • Dema B, Pellefigues C, Hasni S, Gault N, Jiang C, Ricks TK, et al. Autoreactive IgE is prevalent in systemic lupus erythematosus and is associated with increased disease activity and nephritis. PLoS One (2014) 9:e90424. doi:10.1371/journal.pone.0090424.
    • (2014) PLoS One , vol.9
    • Dema, B.1    Pellefigues, C.2    Hasni, S.3    Gault, N.4    Jiang, C.5    Ricks, T.K.6
  • 27
  • 28
    • 0035060979 scopus 로고    scopus 로고
    • Lupus anti-DNA autoantibodies cross-react with a glomerular structural protein: a case for tissue injury by molecular mimicry
    • Mostoslavsky G, Fischel R, Yachimovich N, Yarkoni Y, Rosenmann E, Monestier M, et al. Lupus anti-DNA autoantibodies cross-react with a glomerular structural protein: a case for tissue injury by molecular mimicry. Eur J Immunol (2001) 31:1221-7. doi:10.1002/1521-4141(200104)31:4<1221::AID-IMMU1221>3.0.CO;2-P.
    • (2001) Eur J Immunol , vol.31 , pp. 1221-1227
    • Mostoslavsky, G.1    Fischel, R.2    Yachimovich, N.3    Yarkoni, Y.4    Rosenmann, E.5    Monestier, M.6
  • 29
    • 77955326124 scopus 로고    scopus 로고
    • Are anti-C1q antibodies different from other SLE autoantibodies?
    • Pickering MC, Botto M. Are anti-C1q antibodies different from other SLE autoantibodies? Nat Rev Rheumatol (2010) 6:490-3. doi:10.1038/nrrheum.2010.56.
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 490-493
    • Pickering, M.C.1    Botto, M.2
  • 30
    • 84905191911 scopus 로고    scopus 로고
    • The complement system in systemic lupus erythematosus: an update
    • Leffler J, Bengtsson AA, Blom AM. The complement system in systemic lupus erythematosus: an update. Ann Rheum Dis (2014) 73:1601-6. doi:10.1136/annrheumdis-2014-205287.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1601-1606
    • Leffler, J.1    Bengtsson, A.A.2    Blom, A.M.3
  • 32
    • 0027135420 scopus 로고
    • Nephritogenic autoantibodies in systemic lupus erythematosus: immunochemical properties, mechanisms of immune deposition, and genetic origins
    • Foster MH, Cizman B, Madaio MP. Nephritogenic autoantibodies in systemic lupus erythematosus: immunochemical properties, mechanisms of immune deposition, and genetic origins. Lab Invest (1993) 69:494-507.
    • (1993) Lab Invest , vol.69 , pp. 494-507
    • Foster, M.H.1    Cizman, B.2    Madaio, M.P.3
  • 33
    • 39549111438 scopus 로고    scopus 로고
    • Anti-DNA antibodies in the pathogenesis of lupus nephritis-the emerging mechanisms
    • Yung S, Chan TM. Anti-DNA antibodies in the pathogenesis of lupus nephritis-the emerging mechanisms. Autoimmun Rev (2008) 7:317-21. doi:10.1016/j.autrev.2007.12.001.
    • (2008) Autoimmun Rev , vol.7 , pp. 317-321
    • Yung, S.1    Chan, T.M.2
  • 34
    • 0028292951 scopus 로고
    • Genetic and structural evidence for antigen selection of anti-DNA antibodies
    • Radic MZ, Weigert M. Genetic and structural evidence for antigen selection of anti-DNA antibodies. Annu Rev Immunol (1994) 12:487-520. doi:10.1146/annurev.iy.12.040194.002415.
    • (1994) Annu Rev Immunol , vol.12 , pp. 487-520
    • Radic, M.Z.1    Weigert, M.2
  • 35
    • 0028074657 scopus 로고
    • Mutational analysis of an autoantibody: differential binding and pathogenicity
    • Katz JB, Limpanasithikul W, Diamond B. Mutational analysis of an autoantibody: differential binding and pathogenicity. J Exp Med (1994) 180:925-32. doi:10.1084/jem.180.3.925.
    • (1994) J Exp Med , vol.180 , pp. 925-932
    • Katz, J.B.1    Limpanasithikul, W.2    Diamond, B.3
  • 36
    • 33746990232 scopus 로고    scopus 로고
    • Association of alpha-actinin-binding anti-double-stranded DNA antibodies with lupus nephritis
    • Renaudineau Y, Croquefer S, Jousse S, Renaudineau E, Devauchelle V, Gueguen P, et al. Association of alpha-actinin-binding anti-double-stranded DNA antibodies with lupus nephritis. Arthritis Rheum (2006) 54:2523-32. doi:10.1002/art.22015.
    • (2006) Arthritis Rheum , vol.54 , pp. 2523-2532
    • Renaudineau, Y.1    Croquefer, S.2    Jousse, S.3    Renaudineau, E.4    Devauchelle, V.5    Gueguen, P.6
  • 37
    • 78149305875 scopus 로고    scopus 로고
    • Anti-dsDNA antibodies bind to mesangial annexin II in lupus nephritis
    • Yung S, Cheung KF, Zhang Q, Chan TM. Anti-dsDNA antibodies bind to mesangial annexin II in lupus nephritis. J Am Soc Nephrol (2010) 21:1912-27. doi:10.1681/ASN.2009080805.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1912-1927
    • Yung, S.1    Cheung, K.F.2    Zhang, Q.3    Chan, T.M.4
  • 38
    • 0037829136 scopus 로고    scopus 로고
    • Multiple autoantibodies form the glomerular immune deposits in patients with systemic lupus erythematosus
    • Mannik M, Merrill CE, Stamps LD, Wener MH. Multiple autoantibodies form the glomerular immune deposits in patients with systemic lupus erythematosus. J Rheumatol (2003) 30:1495-504.
    • (2003) J Rheumatol , vol.30 , pp. 1495-1504
    • Mannik, M.1    Merrill, C.E.2    Stamps, L.D.3    Wener, M.H.4
  • 39
    • 0024506642 scopus 로고
    • Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney
    • Raz E, Brezis M, Rosenmann E, Eilat D. Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney. J Immunol (1989) 142:3076-82.
    • (1989) J Immunol , vol.142 , pp. 3076-3082
    • Raz, E.1    Brezis, M.2    Rosenmann, E.3    Eilat, D.4
  • 40
    • 0026597719 scopus 로고
    • Different mechanisms by which anti-DNA MoAbs bind to human endothelial cells and glomerular mesangial cells
    • Chan TM, Frampton G, Staines NA, Hobby P, Perry GJ, Cameron JS. Different mechanisms by which anti-DNA MoAbs bind to human endothelial cells and glomerular mesangial cells. Clin Exp Immunol (1992) 88:68-74. doi:10.1111/j.1365-2249.1992.tb03041.x.
    • (1992) Clin Exp Immunol , vol.88 , pp. 68-74
    • Chan, T.M.1    Frampton, G.2    Staines, N.A.3    Hobby, P.4    Perry, G.J.5    Cameron, J.S.6
  • 41
    • 0030880077 scopus 로고    scopus 로고
    • Identification of endothelial cell membrane proteins that bind anti-DNA antibodies from patients with systemic lupus erythematosus by direct or indirect mechanisms
    • Chan TM, Cheng IK. Identification of endothelial cell membrane proteins that bind anti-DNA antibodies from patients with systemic lupus erythematosus by direct or indirect mechanisms. J Autoimmun (1997) 10:433-9. doi:10.1006/jaut.1997.9998.
    • (1997) J Autoimmun , vol.10 , pp. 433-439
    • Chan, T.M.1    Cheng, I.K.2
  • 42
    • 0029921228 scopus 로고    scopus 로고
    • A prospective study on anti-endothelial cell antibodies in patients with systemic lupus erythematosus
    • Chan TM, Cheng IK. A prospective study on anti-endothelial cell antibodies in patients with systemic lupus erythematosus. Clin Immunol Immunopathol (1996) 78:41-6. doi:10.1006/clin.1996.0006.
    • (1996) Clin Immunol Immunopathol , vol.78 , pp. 41-46
    • Chan, T.M.1    Cheng, I.K.2
  • 43
    • 0029912208 scopus 로고    scopus 로고
    • Anti-DNA autoantibodies stimulate the release of interleukin-1 and interleukin-6 from endothelial cells
    • Lai KN, Leung JC, Bik Lai K, Li PK, Lai CK. Anti-DNA autoantibodies stimulate the release of interleukin-1 and interleukin-6 from endothelial cells. J Pathol (1996) 178:451-7. doi:10.1002/(SICI)1096-9896(199604)178:4<451::AID-PATH499>3.3.CO;2-G.
    • (1996) J Pathol , vol.178 , pp. 451-457
    • Lai, K.N.1    Leung, J.C.2    Bik Lai, K.3    Li, P.K.4    Lai, C.K.5
  • 44
    • 0037087262 scopus 로고    scopus 로고
    • Alpha-actinin is a cross-reactive renal target for pathogenic anti-DNA antibodies
    • Deocharan B, Qing X, Lichauco J, Putterman C. Alpha-actinin is a cross-reactive renal target for pathogenic anti-DNA antibodies. J Immunol (2002) 168:3072-8. doi:10.4049/jimmunol.168.6.3072.
    • (2002) J Immunol , vol.168 , pp. 3072-3078
    • Deocharan, B.1    Qing, X.2    Lichauco, J.3    Putterman, C.4
  • 45
    • 0029032263 scopus 로고
    • Anti-dsDNA antibodies cross-react with ribosomal P proteins expressed on the surface of glomerular mesangial cells to exert a cytostatic effect
    • Sun KH, Liu WT, Tsai CY, Tang SJ, Han SH, Yu CL. Anti-dsDNA antibodies cross-react with ribosomal P proteins expressed on the surface of glomerular mesangial cells to exert a cytostatic effect. Immunology (1995) 85:262-9.
    • (1995) Immunology , vol.85 , pp. 262-269
    • Sun, K.H.1    Liu, W.T.2    Tsai, C.Y.3    Tang, S.J.4    Han, S.H.5    Yu, C.L.6
  • 46
    • 0030858769 scopus 로고    scopus 로고
    • Receptor-mediated cellular entry of nuclear localizing anti-DNA antibodies via myosin 1
    • Yanase K, Smith RM, Puccetti A, Jarett L, Madaio MP. Receptor-mediated cellular entry of nuclear localizing anti-DNA antibodies via myosin 1. J Clin Invest (1997) 100:25-31. doi:10.1172/JCI119517.
    • (1997) J Clin Invest , vol.100 , pp. 25-31
    • Yanase, K.1    Smith, R.M.2    Puccetti, A.3    Jarett, L.4    Madaio, M.P.5
  • 47
    • 0035873090 scopus 로고    scopus 로고
    • Calreticulin, a potential cell surface receptor involved in cell penetration of anti-DNA antibodies
    • Seddiki N, Nato F, Lafaye P, Amoura Z, Piette JC, Mazie JC. Calreticulin, a potential cell surface receptor involved in cell penetration of anti-DNA antibodies. J Immunol (2001) 166:6423-9. doi:10.4049/jimmunol.166.10.6423.
    • (2001) J Immunol , vol.166 , pp. 6423-6429
    • Seddiki, N.1    Nato, F.2    Lafaye, P.3    Amoura, Z.4    Piette, J.C.5    Mazie, J.C.6
  • 48
    • 70449509134 scopus 로고    scopus 로고
    • Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo
    • Romay-Penabad Z, Montiel-Manzano MG, Shilagard T, Papalardo E, Vargas G, Deora AB, et al. Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo. Blood (2009) 114:3074-83. doi:10.1182/blood-2008-11-188698.
    • (2009) Blood , vol.114 , pp. 3074-3083
    • Romay-Penabad, Z.1    Montiel-Manzano, M.G.2    Shilagard, T.3    Papalardo, E.4    Vargas, G.5    Deora, A.B.6
  • 49
    • 0034685886 scopus 로고    scopus 로고
    • High affinity binding of beta 2-glycoprotein I to human endothelial cells is mediated by annexin II
    • Ma K, Simantov R, Zhang JC, Silverstein R, Hajjar KA, McCrae KR. High affinity binding of beta 2-glycoprotein I to human endothelial cells is mediated by annexin II. J Biol Chem (2000) 275:15541-8. doi:10.1074/jbc.275.20.15541.
    • (2000) J Biol Chem , vol.275 , pp. 15541-15548
    • Ma, K.1    Simantov, R.2    Zhang, J.C.3    Silverstein, R.4    Hajjar, K.A.5    McCrae, K.R.6
  • 50
    • 84921598818 scopus 로고    scopus 로고
    • Annexin A2 autoantibodies in thrombosis and autoimmune diseases
    • Canas F, Simonin L, Couturaud F, Renaudineau Y. Annexin A2 autoantibodies in thrombosis and autoimmune diseases. Thromb Res (2015) 135:226-30. doi:10.1016/j.thromres.2014.11.034.
    • (2015) Thromb Res , vol.135 , pp. 226-230
    • Canas, F.1    Simonin, L.2    Couturaud, F.3    Renaudineau, Y.4
  • 51
    • 78650831137 scopus 로고    scopus 로고
    • Toll-like receptor (TLR)-4 mediates anti-beta2GPI/beta2GPI-induced tissue factor expression in THP-1 cells
    • Zhou H, Yan Y, Xu G, Zhou B, Wen H, Guo D, et al. Toll-like receptor (TLR)-4 mediates anti-beta2GPI/beta2GPI-induced tissue factor expression in THP-1 cells. Clin Exp Immunol (2011) 163:189-98. doi:10.1111/j.1365-2249.2010.04291.x.
    • (2011) Clin Exp Immunol , vol.163 , pp. 189-198
    • Zhou, H.1    Yan, Y.2    Xu, G.3    Zhou, B.4    Wen, H.5    Guo, D.6
  • 52
    • 84866914816 scopus 로고    scopus 로고
    • Annexin A2 and A5 serve as new ligands for C1q on apoptotic cells
    • Martin M, Leffler J, Blom AM. Annexin A2 and A5 serve as new ligands for C1q on apoptotic cells. J Biol Chem (2012) 287:33733-44. doi:10.1074/jbc. M112.341339.
    • (2012) J Biol Chem , vol.287 , pp. 33733-33744
    • Martin, M.1    Leffler, J.2    Blom, A.M.3
  • 54
    • 46749138272 scopus 로고    scopus 로고
    • Anti-annexin II antibodies in systemic autoimmune diseases and antiphospholipid syndrome
    • Salle V, Maziere JC, Smail A, Cevallos R, Maziere C, Fuentes V, et al. Anti-annexin II antibodies in systemic autoimmune diseases and antiphospholipid syndrome. J Clin Immunol (2008) 28:291-7. doi:10.1007/s10875-008-9188-1.
    • (2008) J Clin Immunol , vol.28 , pp. 291-297
    • Salle, V.1    Maziere, J.C.2    Smail, A.3    Cevallos, R.4    Maziere, C.5    Fuentes, V.6
  • 55
    • 33644661974 scopus 로고    scopus 로고
    • Increased mesangial cell hyaluronan expression in lupus nephritis is mediated by anti-DNA antibody-induced IL-1beta
    • Yung S, Tsang RC, Leung JK, Chan TM. Increased mesangial cell hyaluronan expression in lupus nephritis is mediated by anti-DNA antibody-induced IL-1beta. Kidney Int (2006) 69:272-80. doi:10.1038/sj.ki.5000042.
    • (2006) Kidney Int , vol.69 , pp. 272-280
    • Yung, S.1    Tsang, R.C.2    Leung, J.K.3    Chan, T.M.4
  • 56
    • 67650065024 scopus 로고    scopus 로고
    • Anti-DNA antibody induction of protein kinase C phosphorylation and fibronectin synthesis in human and murine lupus and the effect of mycophenolic acid
    • Yung S, Zhang Q, Zhang CZ, Chan KW, Lui SL, Chan TM. Anti-DNA antibody induction of protein kinase C phosphorylation and fibronectin synthesis in human and murine lupus and the effect of mycophenolic acid. Arthritis Rheum (2009) 60:2071-82. doi:10.1002/art.24573.
    • (2009) Arthritis Rheum , vol.60 , pp. 2071-2082
    • Yung, S.1    Zhang, Q.2    Zhang, C.Z.3    Chan, K.W.4    Lui, S.L.5    Chan, T.M.6
  • 57
    • 0020585222 scopus 로고
    • Antibody penetration into living cells. IV. Different effects of anti-native DNA and anti-ribonucleoprotein IgG on the cell cycle of activated T gamma cells
    • Alarcon-Segovia D, Llorente L. Antibody penetration into living cells. IV. Different effects of anti-native DNA and anti-ribonucleoprotein IgG on the cell cycle of activated T gamma cells. Clin Exp Immunol (1983) 52:365-71.
    • (1983) Clin Exp Immunol , vol.52 , pp. 365-371
    • Alarcon-Segovia, D.1    Llorente, L.2
  • 58
    • 0034994099 scopus 로고    scopus 로고
    • Antinuclear antibodies: to penetrate or not to penetrate, that was the question
    • Alarcon-Segovia D. Antinuclear antibodies: to penetrate or not to penetrate, that was the question. Lupus (2001) 10:315-8. doi:10.1191/096120301669579565.
    • (2001) Lupus , vol.10 , pp. 315-318
    • Alarcon-Segovia, D.1
  • 59
    • 0032192564 scopus 로고    scopus 로고
    • Cellular penetration and nuclear localization of anti-DNA antibodies: mechanisms, consequences, implications and applications
    • Madaio MP, Yanase K. Cellular penetration and nuclear localization of anti-DNA antibodies: mechanisms, consequences, implications and applications. J Autoimmun (1998) 11:535-8. doi:10.1006/jaut.1998.0217.
    • (1998) J Autoimmun , vol.11 , pp. 535-538
    • Madaio, M.P.1    Yanase, K.2
  • 60
    • 0017913233 scopus 로고
    • Antibody to nuclear ribonucleoprotein penetrates live human mononuclear cells through Fc receptors
    • Alarcon-Segovia D, Ruiz-Arguelles A, Fishbein E. Antibody to nuclear ribonucleoprotein penetrates live human mononuclear cells through Fc receptors. Nature (1978) 271:67-9. doi:10.1038/271067a0.
    • (1978) Nature , vol.271 , pp. 67-69
    • Alarcon-Segovia, D.1    Ruiz-Arguelles, A.2    Fishbein, E.3
  • 61
    • 34548588356 scopus 로고    scopus 로고
    • Fcgamma receptors mediate internalization of anti-Ro and anti-La autoantibodies from Sjogren's syndrome and apoptosis in human salivary gland cell line A-253
    • Lisi S, Sisto M, Soleti R, Saponaro C, Scagliusi P, D'Amore M, et al. Fcgamma receptors mediate internalization of anti-Ro and anti-La autoantibodies from Sjogren's syndrome and apoptosis in human salivary gland cell line A-253. J Oral Pathol Med (2007) 36:511-23. doi:10.1111/j.1600-0714.2007.00563.x.
    • (2007) J Oral Pathol Med , vol.36 , pp. 511-523
    • Lisi, S.1    Sisto, M.2    Soleti, R.3    Saponaro, C.4    Scagliusi, P.5    D'Amore, M.6
  • 62
    • 0031571270 scopus 로고    scopus 로고
    • Autoantibodies to ribosomal P proteins penetrate into live hepatocytes and cause cellular dysfunction in culture
    • Koscec M, Koren E, Wolfson-Reichlin M, Fugate RD, Trieu E, TargoffIN, et al. Autoantibodies to ribosomal P proteins penetrate into live hepatocytes and cause cellular dysfunction in culture. J Immunol (1997) 159:2033-41.
    • (1997) J Immunol , vol.159 , pp. 2033-2041
    • Koscec, M.1    Koren, E.2    Wolfson-Reichlin, M.3    Fugate, R.D.4    Trieu, E.5    Targoff, I.N.6
  • 63
    • 84937514514 scopus 로고    scopus 로고
    • Anti-alpha-actinin antibodies are part of the anti-cell membrane antibody spectrum that characterize patients with lupus nephritis
    • Seret G, Canas F, Pougnet-Di Costanzo L, Hanrotel-Saliou C, Jousse-Joulin S, Le Meur Y, et al. Anti-alpha-actinin antibodies are part of the anti-cell membrane antibody spectrum that characterize patients with lupus nephritis. J Autoimmun (2015) 61:54-61. doi:10.1016/j.jaut.2015.05.009.
    • (2015) J Autoimmun , vol.61 , pp. 54-61
    • Seret, G.1    Canas, F.2    Pougnet-Di Costanzo, L.3    Hanrotel-Saliou, C.4    Jousse-Joulin, S.5    Le Meur, Y.6
  • 64
    • 0028023538 scopus 로고
    • An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II
    • Hajjar KA, Jacovina AT, Chacko J. An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II. J Biol Chem (1994) 269:21191-7.
    • (1994) J Biol Chem , vol.269 , pp. 21191-21197
    • Hajjar, K.A.1    Jacovina, A.T.2    Chacko, J.3
  • 65
    • 2442481067 scopus 로고    scopus 로고
    • Alpha-actinin revisited: a fresh look at an old player
    • Otey CA, Carpen O. Alpha-actinin revisited: a fresh look at an old player. Cell Motil Cytoskeleton (2004) 58:104-11. doi:10.1002/cm.20007.
    • (2004) Cell Motil Cytoskeleton , vol.58 , pp. 104-111
    • Otey, C.A.1    Carpen, O.2
  • 66
    • 33744924742 scopus 로고    scopus 로고
    • Differential binding of cross-reactive anti-DNA antibodies to mesangial cells: the role of alpha-actinin
    • Zhao Z, Deocharan B, Scherer PE, Ozelius LJ, Putterman C. Differential binding of cross-reactive anti-DNA antibodies to mesangial cells: the role of alpha-actinin. J Immunol (2006) 176:7704-14. doi:10.4049/jimmunol.176.12.7704.
    • (2006) J Immunol , vol.176 , pp. 7704-7714
    • Zhao, Z.1    Deocharan, B.2    Scherer, P.E.3    Ozelius, L.J.4    Putterman, C.5
  • 67
    • 34548769408 scopus 로고    scopus 로고
    • Alpha-actinin immunization elicits anti-chromatin autoimmunity in nonautoimmune mice
    • Deocharan B, Zhou Z, Antar K, Siconolfi-Baez L, Angeletti RH, Hardin J, et al. Alpha-actinin immunization elicits anti-chromatin autoimmunity in nonautoimmune mice. J Immunol (2007) 179:1313-21. doi:10.4049/jimmunol.179.2.1313.
    • (2007) J Immunol , vol.179 , pp. 1313-1321
    • Deocharan, B.1    Zhou, Z.2    Antar, K.3    Siconolfi-Baez, L.4    Angeletti, R.H.5    Hardin, J.6
  • 68
    • 1542283744 scopus 로고    scopus 로고
    • Is alpha-actinin a target for pathogenic anti-DNA antibodies in lupus nephritis?
    • Mason LJ, Ravirajan CT, Rahman A, Putterman C, Isenberg DA. Is alpha-actinin a target for pathogenic anti-DNA antibodies in lupus nephritis? Arthritis Rheum (2004) 50:866-70. doi:10.1002/art.20103.
    • (2004) Arthritis Rheum , vol.50 , pp. 866-870
    • Mason, L.J.1    Ravirajan, C.T.2    Rahman, A.3    Putterman, C.4    Isenberg, D.A.5
  • 69
    • 13444270344 scopus 로고    scopus 로고
    • Cross-reactivity of human lupus anti-DNA antibodies with alpha-actinin and nephritogenic potential
    • Zhao Z, Weinstein E, Tuzova M, Davidson A, Mundel P, Marambio P, et al. Cross-reactivity of human lupus anti-DNA antibodies with alpha-actinin and nephritogenic potential. Arthritis Rheum (2005) 52:522-30. doi:10.1002/art.20862.
    • (2005) Arthritis Rheum , vol.52 , pp. 522-530
    • Zhao, Z.1    Weinstein, E.2    Tuzova, M.3    Davidson, A.4    Mundel, P.5    Marambio, P.6
  • 70
    • 75649096046 scopus 로고    scopus 로고
    • Relationship between anti-dsDNA, anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study
    • Manson JJ, Ma A, Rogers P, Mason LJ, Berden JH, van der Vlag J, et al. Relationship between anti-dsDNA, anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study. Arthritis Res Ther (2009) 11:R154. doi:10.1186/ar2831.
    • (2009) Arthritis Res Ther , vol.11 , pp. R154
    • Manson, J.J.1    Ma, A.2    Rogers, P.3    Mason, L.J.4    Berden, J.H.5    van der Vlag, J.6
  • 71
    • 79960143926 scopus 로고    scopus 로고
    • Nephritogenic antibodies bind in glomeruli through interaction with exposed chromatin fragments and not with renal cross-reactive antigens
    • Mjelle JE, Rekvig OP, Van Der Vlag J, Fenton KA. Nephritogenic antibodies bind in glomeruli through interaction with exposed chromatin fragments and not with renal cross-reactive antigens. Autoimmunity (2011) 44:373-83. doi:10.3109/08916934.2010.541170.
    • (2011) Autoimmunity , vol.44 , pp. 373-383
    • Mjelle, J.E.1    Rekvig, O.P.2    Van Der Vlag, J.3    Fenton, K.A.4
  • 72
    • 33644925272 scopus 로고    scopus 로고
    • Critical comparative analyses of anti-alpha-actinin and glomerulus-bound antibodies in human and murine lupus nephritis
    • Kalaaji M, Sturfelt G, Mjelle JE, Nossent H, Rekvig OP. Critical comparative analyses of anti-alpha-actinin and glomerulus-bound antibodies in human and murine lupus nephritis. Arthritis Rheum (2006) 54:914-26. doi:10.1002/art.21622.
    • (2006) Arthritis Rheum , vol.54 , pp. 914-926
    • Kalaaji, M.1    Sturfelt, G.2    Mjelle, J.E.3    Nossent, H.4    Rekvig, O.P.5
  • 73
    • 0032813046 scopus 로고    scopus 로고
    • Role of nucleosomes for induction and glomerular binding of autoantibodies in lupus nephritis
    • Berden JH, Licht R, van Bruggen MC, Tax WJ. Role of nucleosomes for induction and glomerular binding of autoantibodies in lupus nephritis. Curr Opin Nephrol Hypertens (1999) 8:299-306. doi:10.1097/00041552-199905000-00005.
    • (1999) Curr Opin Nephrol Hypertens , vol.8 , pp. 299-306
    • Berden, J.H.1    Licht, R.2    van Bruggen, M.C.3    Tax, W.J.4
  • 74
    • 47249092794 scopus 로고    scopus 로고
    • Glomerular targets of nephritogenic autoantibodies in systemic lupus erythematosus
    • van Bavel CC, Fenton KA, Rekvig OP, van der Vlag J, Berden JH. Glomerular targets of nephritogenic autoantibodies in systemic lupus erythematosus. Arthritis Rheum (2008) 58:1892-9. doi:10.1002/art.23626.
    • (2008) Arthritis Rheum , vol.58 , pp. 1892-1899
    • van Bavel, C.C.1    Fenton, K.A.2    Rekvig, O.P.3    van der Vlag, J.4    Berden, J.H.5
  • 75
    • 0029893337 scopus 로고    scopus 로고
    • Lupus autoantibodies interact directly with distinct glomerular and vascular cell surface antigens
    • D'Andrea DM, Coupaye-Gerard B, Kleyman TR, Foster MH, Madaio MP. Lupus autoantibodies interact directly with distinct glomerular and vascular cell surface antigens. Kidney Int (1996) 49:1214-21. doi:10.1038/ki.1996.175.
    • (1996) Kidney Int , vol.49 , pp. 1214-1221
    • D'Andrea, D.M.1    Coupaye-Gerard, B.2    Kleyman, T.R.3    Foster, M.H.4    Madaio, M.P.5
  • 76
    • 0033180545 scopus 로고    scopus 로고
    • Anti-DNA autoantibodies and systemic lupus erythematosus
    • Blatt NB, Glick GD. Anti-DNA autoantibodies and systemic lupus erythematosus. Pharmacol Ther (1999) 83:125-39. doi:10.1016/S0163-7258(99)00022-4.
    • (1999) Pharmacol Ther , vol.83 , pp. 125-139
    • Blatt, N.B.1    Glick, G.D.2
  • 77
    • 84863334924 scopus 로고    scopus 로고
    • Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice
    • Krishnan MR, Wang C, Marion TN. Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice. Kidney Int (2012) 82:184-92. doi:10.1038/ki.2011.484.
    • (2012) Kidney Int , vol.82 , pp. 184-192
    • Krishnan, M.R.1    Wang, C.2    Marion, T.N.3
  • 78
    • 0035138056 scopus 로고    scopus 로고
    • Anti-dsDNA antibody up-regulates interleukin 6, but not cyclo-oxygenase, gene expression in glomerular mesangial cells: a marker of immune-mediated renal damage?
    • Yu CL, Sun KH, Tsai CY, Hsieh SC, Yu HS. Anti-dsDNA antibody up-regulates interleukin 6, but not cyclo-oxygenase, gene expression in glomerular mesangial cells: a marker of immune-mediated renal damage? Inflamm Res (2001) 50:12-8. doi:10.1007/s000110050718.
    • (2001) Inflamm Res , vol.50 , pp. 12-18
    • Yu, C.L.1    Sun, K.H.2    Tsai, C.Y.3    Hsieh, S.C.4    Yu, H.S.5
  • 79
    • 0031929999 scopus 로고    scopus 로고
    • The effect of human polyclonal anti-dsDNA autoantibodies on apoptotic gene expression in cultured rat glomerular mesangial cells
    • Yu CL, Huang MH, Tsai CY, Tsai YY, Tsai ST, Sun KH, et al. The effect of human polyclonal anti-dsDNA autoantibodies on apoptotic gene expression in cultured rat glomerular mesangial cells. Scand J Rheumatol (1998) 27:54-60. doi:10.1080/030097498441182.
    • (1998) Scand J Rheumatol , vol.27 , pp. 54-60
    • Yu, C.L.1    Huang, M.H.2    Tsai, C.Y.3    Tsai, Y.Y.4    Tsai, S.T.5    Sun, K.H.6
  • 80
    • 84878261201 scopus 로고    scopus 로고
    • The lupus-derived anti-double-stranded DNA IgG contributes to myofibroblast-like phenotype in mesangial cells
    • Zhang Y, Yang J, Jiang S, Fang C, Xiong L, Cheng H, et al. The lupus-derived anti-double-stranded DNA IgG contributes to myofibroblast-like phenotype in mesangial cells. J Clin Immunol (2012) 32:1270-8. doi:10.1007/s10875-012-9724-x.
    • (2012) J Clin Immunol , vol.32 , pp. 1270-1278
    • Zhang, Y.1    Yang, J.2    Jiang, S.3    Fang, C.4    Xiong, L.5    Cheng, H.6
  • 81
    • 77951971046 scopus 로고    scopus 로고
    • The role of defective clearance of apoptotic cells in systemic autoimmunity
    • Munoz LE, Lauber K, Schiller M, Manfredi AA, Herrmann M. The role of defective clearance of apoptotic cells in systemic autoimmunity. Nat Rev Rheumatol (2010) 6:280-9. doi:10.1038/nrrheum.2010.46.
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 280-289
    • Munoz, L.E.1    Lauber, K.2    Schiller, M.3    Manfredi, A.A.4    Herrmann, M.5
  • 82
    • 79961086472 scopus 로고    scopus 로고
    • Disturbances of apoptotic cell clearance in systemic lupus erythematosus
    • Shao WH, Cohen PL. Disturbances of apoptotic cell clearance in systemic lupus erythematosus. Arthritis Res Ther (2011) 13:202. doi:10.1186/ar3206.
    • (2011) Arthritis Res Ther , vol.13 , pp. 202
    • Shao, W.H.1    Cohen, P.L.2
  • 83
    • 0029822118 scopus 로고    scopus 로고
    • Spontaneously produced anti-DNA/DNase I autoantibodies modulate nuclear apoptosis in living cells
    • Madaio MP, Fabbi M, Tiso M, Daga A, Puccetti A. Spontaneously produced anti-DNA/DNase I autoantibodies modulate nuclear apoptosis in living cells. Eur J Immunol (1996) 26:3035-41. doi:10.1002/eji.1830261232.
    • (1996) Eur J Immunol , vol.26 , pp. 3035-3041
    • Madaio, M.P.1    Fabbi, M.2    Tiso, M.3    Daga, A.4    Puccetti, A.5
  • 84
    • 84874538904 scopus 로고    scopus 로고
    • Impact of the tumor necrosis factor receptor-associated protein 1 (Trap1) on renal DNaseI shutdown and on progression of murine and human lupus nephritis
    • Fismen S, Thiyagarajan D, Seredkina N, Nielsen H, Jacobsen S, Elung-Jensen T, et al. Impact of the tumor necrosis factor receptor-associated protein 1 (Trap1) on renal DNaseI shutdown and on progression of murine and human lupus nephritis. Am J Pathol (2013) 182:688-700. doi:10.1016/j.ajpath.2012.11.013.
    • (2013) Am J Pathol , vol.182 , pp. 688-700
    • Fismen, S.1    Thiyagarajan, D.2    Seredkina, N.3    Nielsen, H.4    Jacobsen, S.5    Elung-Jensen, T.6
  • 85
    • 84859118446 scopus 로고    scopus 로고
    • Silencing of renal DNaseI in murine lupus nephritis imposes exposure of large chromatin fragments and activation of toll like receptors and the Clec4e
    • Thiyagarajan D, Fismen S, Seredkina N, Jacobsen S, Elung-Jensen T, Kamper AL, et al. Silencing of renal DNaseI in murine lupus nephritis imposes exposure of large chromatin fragments and activation of toll like receptors and the Clec4e. PLoS One (2012) 7:e34080. doi:10.1371/journal.pone.0034080.
    • (2012) PLoS One , vol.7
    • Thiyagarajan, D.1    Fismen, S.2    Seredkina, N.3    Jacobsen, S.4    Elung-Jensen, T.5    Kamper, A.L.6
  • 86
    • 77957797842 scopus 로고    scopus 로고
    • Renal Dnase1 enzyme activity and protein expression is selectively shut down in murine and human membranoproliferative lupus nephritis
    • Zykova SN, Tveita AA, Rekvig OP. Renal Dnase1 enzyme activity and protein expression is selectively shut down in murine and human membranoproliferative lupus nephritis. PLoS One (2010) 5:e12096. doi:10.1371/journal.pone.0012096.
    • (2010) PLoS One , vol.5
    • Zykova, S.N.1    Tveita, A.A.2    Rekvig, O.P.3
  • 88
    • 0019797317 scopus 로고
    • Serum deoxyribonuclease I and clinical activity in systemic lupus erythematosus
    • Chitrabamrung S, Rubin RL, Tan EM. Serum deoxyribonuclease I and clinical activity in systemic lupus erythematosus. Rheumatol Int (1981) 1:55-60. doi:10.1007/BF00541153.
    • (1981) Rheumatol Int , vol.1 , pp. 55-60
    • Chitrabamrung, S.1    Rubin, R.L.2    Tan, E.M.3
  • 89
    • 0034917006 scopus 로고    scopus 로고
    • Chemokine expression precedes inflammatory cell infiltration and chemokine receptor and cytokine expression during the initiation of murine lupus nephritis
    • Perez de Lema G, Maier H, Nieto E, Vielhauer V, Luckow B, Mampaso F, et al. Chemokine expression precedes inflammatory cell infiltration and chemokine receptor and cytokine expression during the initiation of murine lupus nephritis. J Am Soc Nephrol (2001) 12:1369-82.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 1369-1382
    • Perez de Lema, G.1    Maier, H.2    Nieto, E.3    Vielhauer, V.4    Luckow, B.5    Mampaso, F.6
  • 90
    • 0029918714 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 levels in patients with glomerular disease
    • Rovin BH, Doe N, Tan LC. Monocyte chemoattractant protein-1 levels in patients with glomerular disease. Am J Kidney Dis (1996) 27:640-6. doi:10.1016/S0272-6386(96)90097-9.
    • (1996) Am J Kidney Dis , vol.27 , pp. 640-646
    • Rovin, B.H.1    Doe, N.2    Tan, L.C.3
  • 91
    • 0033402848 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein 1-dependent leukocytic infiltrates are responsible for autoimmune disease in MRL-Fas(lpr) mice
    • Tesch GH, Maifert S, Schwarting A, Rollins BJ, Kelley VR. Monocyte chemoattractant protein 1-dependent leukocytic infiltrates are responsible for autoimmune disease in MRL-Fas(lpr) mice. J Exp Med (1999) 190:1813-24. doi:10.1084/jem.190.12.1813.
    • (1999) J Exp Med , vol.190 , pp. 1813-1824
    • Tesch, G.H.1    Maifert, S.2    Schwarting, A.3    Rollins, B.J.4    Kelley, V.R.5
  • 92
    • 84930667149 scopus 로고    scopus 로고
    • Anti-dsDNA antibodies induce inflammation via endoplasmic reticulum stress in human mesangial cells
    • Zhang H, Zhao C, Wang S, Huang Y, Wang H, Zhao J, et al. Anti-dsDNA antibodies induce inflammation via endoplasmic reticulum stress in human mesangial cells. J Transl Med (2015) 13:178. doi:10.1186/s12967-015-0536-7.
    • (2015) J Transl Med , vol.13 , pp. 178
    • Zhang, H.1    Zhao, C.2    Wang, S.3    Huang, Y.4    Wang, H.5    Zhao, J.6
  • 93
    • 0027949106 scopus 로고
    • Role of protein kinase pathways in IL-1-induced chemoattractant expression by human mesangial cells
    • Rovin BH, Tan LC. Role of protein kinase pathways in IL-1-induced chemoattractant expression by human mesangial cells. Kidney Int (1994) 46:1059-68. doi:10.1038/ki.1994.367.
    • (1994) Kidney Int , vol.46 , pp. 1059-1068
    • Rovin, B.H.1    Tan, L.C.2
  • 94
    • 84876803671 scopus 로고    scopus 로고
    • Nucleosomes contribute to increase mesangial cell chemokine expression during the development of lupus nephritis
    • Kanapathippillai P, Hedberg A, Fenton CG, Fenton KA. Nucleosomes contribute to increase mesangial cell chemokine expression during the development of lupus nephritis. Cytokine (2013) 62:244-52. doi:10.1016/j.cyto.2013.03.016.
    • (2013) Cytokine , vol.62 , pp. 244-252
    • Kanapathippillai, P.1    Hedberg, A.2    Fenton, C.G.3    Fenton, K.A.4
  • 95
    • 3042844142 scopus 로고    scopus 로고
    • Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli
    • Peterson KS, Huang JF, Zhu J, D'Agati V, Liu X, Miller N, et al. Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli. J Clin Invest (2004) 113:1722-33. doi:10.1172/JCI200419139.
    • (2004) J Clin Invest , vol.113 , pp. 1722-1733
    • Peterson, K.S.1    Huang, J.F.2    Zhu, J.3    D'Agati, V.4    Liu, X.5    Miller, N.6
  • 96
    • 0033214841 scopus 로고    scopus 로고
    • TNF-alpha and IL-1 sequentially induce endothelial ICAM-1 and VCAM-1 expression in MRL/lpr lupus-prone mice
    • McHale JF, Harari OA, Marshall D, Haskard DO. TNF-alpha and IL-1 sequentially induce endothelial ICAM-1 and VCAM-1 expression in MRL/lpr lupus-prone mice. J Immunol (1999) 163:3993-4000.
    • (1999) J Immunol , vol.163 , pp. 3993-4000
    • McHale, J.F.1    Harari, O.A.2    Marshall, D.3    Haskard, D.O.4
  • 97
    • 0023732974 scopus 로고
    • Increased tumor necrosis factor and IL-1 beta gene expression in the kidneys of mice with lupus nephritis
    • Boswell JM, Yui MA, Burt DW, Kelley VE. Increased tumor necrosis factor and IL-1 beta gene expression in the kidneys of mice with lupus nephritis. J Immunol (1988) 141:3050-4.
    • (1988) J Immunol , vol.141 , pp. 3050-3054
    • Boswell, J.M.1    Yui, M.A.2    Burt, D.W.3    Kelley, V.E.4
  • 98
    • 0024330731 scopus 로고
    • Tumor necrosis factor and IL-1 in New Zealand Black/White mice. Enhanced gene expression and acceleration of renal injury
    • Brennan DC, Yui MA, Wuthrich RP, Kelley VE. Tumor necrosis factor and IL-1 in New Zealand Black/White mice. Enhanced gene expression and acceleration of renal injury. J Immunol (1989) 143:3470-5.
    • (1989) J Immunol , vol.143 , pp. 3470-3475
    • Brennan, D.C.1    Yui, M.A.2    Wuthrich, R.P.3    Kelley, V.E.4
  • 100
    • 84906841910 scopus 로고    scopus 로고
    • The association of cytokines with disease activity and damage scores in systemic lupus erythematosus patients
    • McCarthy EM, Smith S, Lee RZ, Cunnane G, Doran MF, Donnelly S, et al. The association of cytokines with disease activity and damage scores in systemic lupus erythematosus patients. Rheumatology (Oxford) (2014) 53:1586-94. doi:10.1093/rheumatology/ket428.
    • (2014) Rheumatology (Oxford) , vol.53 , pp. 1586-1594
    • McCarthy, E.M.1    Smith, S.2    Lee, R.Z.3    Cunnane, G.4    Doran, M.F.5    Donnelly, S.6
  • 101
    • 84862991350 scopus 로고    scopus 로고
    • Early interleukin 6 production by leukocytes during ischemic acute kidney injury is regulated by TLR4
    • Chen J, Hartono JR, John R, Bennett M, Zhou XJ, Wang Y, et al. Early interleukin 6 production by leukocytes during ischemic acute kidney injury is regulated by TLR4. Kidney Int (2011) 80:504-15. doi:10.1038/ki.2011.140.
    • (2011) Kidney Int , vol.80 , pp. 504-515
    • Chen, J.1    Hartono, J.R.2    John, R.3    Bennett, M.4    Zhou, X.J.5    Wang, Y.6
  • 102
    • 0034094660 scopus 로고    scopus 로고
    • Monoclonal anti-double-stranded DNA autoantibody stimulates the expression and release of IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha from normal human mononuclear cells involving in the lupus pathogenesis
    • Sun KH, Yu CL, Tang SJ, Sun GH. Monoclonal anti-double-stranded DNA autoantibody stimulates the expression and release of IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha from normal human mononuclear cells involving in the lupus pathogenesis. Immunology (2000) 99:352-60. doi:10.1046/j.1365-2567.2000.00970.x.
    • (2000) Immunology , vol.99 , pp. 352-360
    • Sun, K.H.1    Yu, C.L.2    Tang, S.J.3    Sun, G.H.4
  • 103
    • 0347286849 scopus 로고    scopus 로고
    • Effects of mycophenolic acid on IL-6 expression of human renal proximal and distal tubular cells in vitro
    • Baer PC, Wegner B, Geiger H. Effects of mycophenolic acid on IL-6 expression of human renal proximal and distal tubular cells in vitro. Nephrol Dial Transplant (2004) 19:47-52. doi:10.1093/ndt/gfg429.
    • (2004) Nephrol Dial Transplant , vol.19 , pp. 47-52
    • Baer, P.C.1    Wegner, B.2    Geiger, H.3
  • 104
    • 33644878084 scopus 로고    scopus 로고
    • Effect of human anti-DNA antibodies on proximal renal tubular epithelial cell cytokine expression: implications on tubulointerstitial inflammation in lupus nephritis
    • Yung S, Tsang RC, Sun Y, Leung JK, Chan TM. Effect of human anti-DNA antibodies on proximal renal tubular epithelial cell cytokine expression: implications on tubulointerstitial inflammation in lupus nephritis. J Am Soc Nephrol (2005) 16:3281-94. doi:10.1681/ASN.2004110917.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3281-3294
    • Yung, S.1    Tsang, R.C.2    Sun, Y.3    Leung, J.K.4    Chan, T.M.5
  • 105
    • 79952602026 scopus 로고    scopus 로고
    • Human endothelial cells generate Th17 and regulatory T cells under inflammatory conditions
    • Taflin C, Favier B, Baudhuin J, Savenay A, Hemon P, Bensussan A, et al. Human endothelial cells generate Th17 and regulatory T cells under inflammatory conditions. Proc Natl Acad Sci U S A (2011) 108:2891-6. doi:10.1073/pnas.1011811108.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 2891-2896
    • Taflin, C.1    Favier, B.2    Baudhuin, J.3    Savenay, A.4    Hemon, P.5    Bensussan, A.6
  • 106
    • 70149085910 scopus 로고    scopus 로고
    • Peptidoglycan enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, focal adhesion kinase, Akt, and AP-1-dependent pathway
    • Chiu YC, Lin CY, Chen CP, Huang KC, Tong KM, Tzeng CY, et al. Peptidoglycan enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, focal adhesion kinase, Akt, and AP-1-dependent pathway. J Immunol (2009) 183:2785-92. doi:10.4049/jimmunol.0802826.
    • (2009) J Immunol , vol.183 , pp. 2785-2792
    • Chiu, Y.C.1    Lin, C.Y.2    Chen, C.P.3    Huang, K.C.4    Tong, K.M.5    Tzeng, C.Y.6
  • 107
    • 47049112010 scopus 로고    scopus 로고
    • The role of tumor necrosis factor-alpha in systemic lupus erythematosus
    • Aringer M, Smolen JS. The role of tumor necrosis factor-alpha in systemic lupus erythematosus. Arthritis Res Ther (2008) 10:202. doi:10.1186/ar2341.
    • (2008) Arthritis Res Ther , vol.10 , pp. 202
    • Aringer, M.1    Smolen, J.S.2
  • 108
    • 0032704934 scopus 로고    scopus 로고
    • The function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease
    • Kollias G, Douni E, Kassiotis G, Kontoyiannis D. The function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease. Ann Rheum Dis (1999) 58(Suppl 1):I32-9. doi:10.1136/ard.58.2008.i32.
    • (1999) Ann Rheum Dis , vol.58 , pp. I32-I39
    • Kollias, G.1    Douni, E.2    Kassiotis, G.3    Kontoyiannis, D.4
  • 109
    • 0028954960 scopus 로고
    • Biphasic increase in circulating and renal TNF-alpha in MRL-lpr mice with differing regulatory mechanisms
    • Yokoyama H, Kreft B, Kelley VR. Biphasic increase in circulating and renal TNF-alpha in MRL-lpr mice with differing regulatory mechanisms. Kidney Int (1995) 47:122-30. doi:10.1038/ki.1995.14.
    • (1995) Kidney Int , vol.47 , pp. 122-130
    • Yokoyama, H.1    Kreft, B.2    Kelley, V.R.3
  • 111
    • 0029020289 scopus 로고
    • Presence of tumor necrosis factor alpha and interleukin-6 in renal mesangial cells of lupus nephritis patients
    • Malide D, Russo P, Bendayan M. Presence of tumor necrosis factor alpha and interleukin-6 in renal mesangial cells of lupus nephritis patients. Hum Pathol (1995) 26:558-64. doi:10.1016/0046-8177(95)90253-8.
    • (1995) Hum Pathol , vol.26 , pp. 558-564
    • Malide, D.1    Russo, P.2    Bendayan, M.3
  • 112
    • 0023752553 scopus 로고
    • Fc-receptor cross-linking induces rapid secretion of tumor necrosis factor (cachectin) by human peripheral blood monocytes
    • Debets JM, Van der Linden CJ, Dieteren IE, Leeuwenberg JF, Buurman WA. Fc-receptor cross-linking induces rapid secretion of tumor necrosis factor (cachectin) by human peripheral blood monocytes. J Immunol (1988) 141:1197-201.
    • (1988) J Immunol , vol.141 , pp. 1197-1201
    • Debets, J.M.1    Van der Linden, C.J.2    Dieteren, I.E.3    Leeuwenberg, J.F.4    Buurman, W.A.5
  • 113
    • 0023874728 scopus 로고
    • Tumour necrosis factor-alpha in murine autoimmune 'lupus' nephritis
    • Jacob CO, McDevitt HO. Tumour necrosis factor-alpha in murine autoimmune 'lupus' nephritis. Nature (1988) 331:356-8. doi:10.1038/331356a0.
    • (1988) Nature , vol.331 , pp. 356-358
    • Jacob, C.O.1    McDevitt, H.O.2
  • 114
    • 0033947471 scopus 로고    scopus 로고
    • Accelerated autoimmunity and lupus nephritis in NZB mice with an engineered heterozygous deficiency in tumor necrosis factor
    • Kontoyiannis D, Kollias G. Accelerated autoimmunity and lupus nephritis in NZB mice with an engineered heterozygous deficiency in tumor necrosis factor. Eur J Immunol (2000) 30:2038-47. doi:10.1002/1521-4141(200007)30:7<2038::AID-IMMU2038>3.0.CO;2-K.
    • (2000) Eur J Immunol , vol.30 , pp. 2038-2047
    • Kontoyiannis, D.1    Kollias, G.2
  • 115
    • 84885648566 scopus 로고    scopus 로고
    • Mediators of inflammation and their effect on resident renal cells: implications in lupus nephritis
    • Yung S, Cheung KF, Zhang Q, Chan TM. Mediators of inflammation and their effect on resident renal cells: implications in lupus nephritis. Clin Dev Immunol (2013) 2013:317682. doi:10.1155/2013/317682.
    • (2013) Clin Dev Immunol , vol.2013
    • Yung, S.1    Cheung, K.F.2    Zhang, Q.3    Chan, T.M.4
  • 116
    • 54049128417 scopus 로고    scopus 로고
    • Pathogenic anti-DNA antibodies modulate gene expression in mesangial cells: involvement of HMGB1 in anti-DNA antibody-induced renal injury
    • Qing X, Pitashny M, Thomas DB, Barrat FJ, Hogarth MP, Putterman C. Pathogenic anti-DNA antibodies modulate gene expression in mesangial cells: involvement of HMGB1 in anti-DNA antibody-induced renal injury. Immunol Lett (2008) 121:61-73. doi:10.1016/j.imlet.2008.08.007.
    • (2008) Immunol Lett , vol.121 , pp. 61-73
    • Qing, X.1    Pitashny, M.2    Thomas, D.B.3    Barrat, F.J.4    Hogarth, M.P.5    Putterman, C.6
  • 117
    • 78649669329 scopus 로고    scopus 로고
    • Mechanistic connection between inflammation and fibrosis
    • Lee SB, Kalluri R. Mechanistic connection between inflammation and fibrosis. Kidney Int Suppl (2010) 78(Suppl 119):S22-6. doi:10.1038/ki.2010.418.
    • (2010) Kidney Int Suppl , vol.78 , pp. S22-S26
    • Lee, S.B.1    Kalluri, R.2
  • 118
    • 0026769228 scopus 로고
    • Tubulointerstitial changes as a major determinant in the progression of renal damage
    • Nath KA. Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis (1992) 20:1-17. doi:10.1016/S0272-6386(12)80312-X.
    • (1992) Am J Kidney Dis , vol.20 , pp. 1-17
    • Nath, K.A.1
  • 119
    • 0030997570 scopus 로고    scopus 로고
    • The glomerular deposition of PAS positive material correlates with renal function in human kidney diseases
    • Vleming LJ, Baelde JJ, Westendorp RG, Daha MR, van Es LA, Bruijn JA. The glomerular deposition of PAS positive material correlates with renal function in human kidney diseases. Clin Nephrol (1997) 47:158-67.
    • (1997) Clin Nephrol , vol.47 , pp. 158-167
    • Vleming, L.J.1    Baelde, J.J.2    Westendorp, R.G.3    Daha, M.R.4    van Es, L.A.5    Bruijn, J.A.6
  • 121
    • 84946562046 scopus 로고    scopus 로고
    • Distinct effects of mycophenolate mofetil and cyclophosphamide on renal fibrosis in NZBWF1/J mice
    • Yung S, Zhang Q, Chau MK, Chan TM. Distinct effects of mycophenolate mofetil and cyclophosphamide on renal fibrosis in NZBWF1/J mice. Autoimmunity (2015):1-17. doi:10.3109/08916934.2015.1054027.
    • (2015) Autoimmunity , pp. 1-17
    • Yung, S.1    Zhang, Q.2    Chau, M.K.3    Chan, T.M.4
  • 122
    • 0028109801 scopus 로고
    • Transforming growth factor beta in tissue fibrosis
    • Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis. N Engl J Med (1994) 331:1286-92. doi:10.1056/NEJM199411103311907.
    • (1994) N Engl J Med , vol.331 , pp. 1286-1292
    • Border, W.A.1    Noble, N.A.2
  • 123
    • 33644638349 scopus 로고    scopus 로고
    • Renal fibrosis: new insights into the pathogenesis and therapeutics
    • Liu Y. Renal fibrosis: new insights into the pathogenesis and therapeutics. Kidney Int (2006) 69:213-7. doi:10.1038/sj.ki.5000054.
    • (2006) Kidney Int , vol.69 , pp. 213-217
    • Liu, Y.1
  • 124
    • 84875728626 scopus 로고    scopus 로고
    • Protein kinase Cbeta is required for lupus development in Sle mice
    • Oleksyn D, Pulvino M, Zhao J, Misra R, Vosoughi A, Jenks S, et al. Protein kinase Cbeta is required for lupus development in Sle mice. Arthritis Rheum (2013) 65:1022-31. doi:10.1002/art.37825.
    • (2013) Arthritis Rheum , vol.65 , pp. 1022-1031
    • Oleksyn, D.1    Pulvino, M.2    Zhao, J.3    Misra, R.4    Vosoughi, A.5    Jenks, S.6
  • 125
    • 0036318317 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies
    • Rastaldi MP, Ferrario F, Giardino L, Dell'Antonio G, Grillo C, Grillo P, et al. Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies. Kidney Int (2002) 62:137-46. doi:10.1046/j.1523-1755.2002.00430.x.
    • (2002) Kidney Int , vol.62 , pp. 137-146
    • Rastaldi, M.P.1    Ferrario, F.2    Giardino, L.3    Dell'Antonio, G.4    Grillo, C.5    Grillo, P.6
  • 126
    • 37849189626 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for the development of renal tubulointerstitial fibrosis
    • Rastaldi MP. Epithelial-mesenchymal transition and its implications for the development of renal tubulointerstitial fibrosis. J Nephrol (2006) 19:407-12.
    • (2006) J Nephrol , vol.19 , pp. 407-412
    • Rastaldi, M.P.1
  • 127
    • 84930376257 scopus 로고    scopus 로고
    • Anti-dsDNA antibody induces soluble fibronectin secretion by proximal renal tubular epithelial cells and downstream increase of TGF-beta1 and collagen synthesis
    • Yung S, Ng CY, Ho SK, Cheung KF, Chan KW, Zhang Q, et al. Anti-dsDNA antibody induces soluble fibronectin secretion by proximal renal tubular epithelial cells and downstream increase of TGF-beta1 and collagen synthesis. J Autoimmun (2015) 58:111-22. doi:10.1016/j.jaut.2015.01.008.
    • (2015) J Autoimmun , vol.58 , pp. 111-122
    • Yung, S.1    Ng, C.Y.2    Ho, S.K.3    Cheung, K.F.4    Chan, K.W.5    Zhang, Q.6
  • 128
    • 20944448271 scopus 로고    scopus 로고
    • Early proinflammatory activation of renal tubular cells by normal and pathologic IgG
    • Ronda N, Cravedi P, Benozzi L, Lunghi P, Bonati A, Allegri L, et al. Early proinflammatory activation of renal tubular cells by normal and pathologic IgG. Nephron Exp Nephrol (2005) 100:e77-84. doi:10.1159/000084573.
    • (2005) Nephron Exp Nephrol , vol.100 , pp. e77-e84
    • Ronda, N.1    Cravedi, P.2    Benozzi, L.3    Lunghi, P.4    Bonati, A.5    Allegri, L.6
  • 129
    • 0029071793 scopus 로고
    • Murine and human antibodies to native DNA that cross-react with the A and D SnRNP polypeptides cause direct injury of cultured kidney cells
    • Koren E, Koscec M, Wolfson-Reichlin M, Ebling FM, Tsao B, Hahn BH, et al. Murine and human antibodies to native DNA that cross-react with the A and D SnRNP polypeptides cause direct injury of cultured kidney cells. J Immunol (1995) 154:4857-64.
    • (1995) J Immunol , vol.154 , pp. 4857-4864
    • Koren, E.1    Koscec, M.2    Wolfson-Reichlin, M.3    Ebling, F.M.4    Tsao, B.5    Hahn, B.H.6
  • 130
    • 84864574499 scopus 로고    scopus 로고
    • Survival analysis and causes of mortality in patients with lupus nephritis
    • Yap DY, Tang CS, Ma MK, Lam MF, Chan TM. Survival analysis and causes of mortality in patients with lupus nephritis. Nephrol Dial Transplant (2012) 27:3248-54. doi:10.1093/ndt/gfs073.
    • (2012) Nephrol Dial Transplant , vol.27 , pp. 3248-3254
    • Yap, D.Y.1    Tang, C.S.2    Ma, M.K.3    Lam, M.F.4    Chan, T.M.5
  • 131
    • 0034687429 scopus 로고    scopus 로고
    • Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis
    • Chan TM, Li FK, Tang CS, Wong RW, Fang GX, Ji YL, et al. Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis. Hong Kong-Guangzhou Nephrology Study Group. N Engl J Med (2000) 343:1156-62.
    • (2000) N Engl J Med , vol.343 , pp. 1156-1162
    • Chan, T.M.1    Li, F.K.2    Tang, C.S.3    Wong, R.W.4    Fang, G.X.5    Ji, Y.L.6
  • 132
    • 0034045586 scopus 로고    scopus 로고
    • Mycophenolate mofetil and its mechanisms of action
    • Allison AC, Eugui EM. Mycophenolate mofetil and its mechanisms of action. Immunopharmacology (2000) 47:85-118. doi:10.1016/S0162-3109(00)00188-0.
    • (2000) Immunopharmacology , vol.47 , pp. 85-118
    • Allison, A.C.1    Eugui, E.M.2
  • 133
    • 34147176657 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition of human proximal tubular epithelial cells: effects of rapamycin, mycophenolate, cyclosporin, azathioprine, and methylprednisolone
    • Copeland JW, Beaumont BW, Merrilees MJ, Pilmore HL. Epithelial-to-mesenchymal transition of human proximal tubular epithelial cells: effects of rapamycin, mycophenolate, cyclosporin, azathioprine, and methylprednisolone. Transplantation (2007) 83:809-14. doi:10.1097/01.tp.0000255680.71816.aa.
    • (2007) Transplantation , vol.83 , pp. 809-814
    • Copeland, J.W.1    Beaumont, B.W.2    Merrilees, M.J.3    Pilmore, H.L.4
  • 134
    • 0036424451 scopus 로고    scopus 로고
    • Mycophenolic acid antagonizes the activation of cultured human mesangial cells
    • Dubus I, Vendrely B, Christophe I, Labouyrie JP, Delmas Y, Bonnet J, et al. Mycophenolic acid antagonizes the activation of cultured human mesangial cells. Kidney Int (2002) 62:857-67. doi:10.1046/j.1523-1755.2002.00514.x.
    • (2002) Kidney Int , vol.62 , pp. 857-867
    • Dubus, I.1    Vendrely, B.2    Christophe, I.3    Labouyrie, J.P.4    Delmas, Y.5    Bonnet, J.6
  • 135
    • 49649106988 scopus 로고    scopus 로고
    • Effects of mycophenolic acid on human fibroblast proliferation, migration and adhesion in vitro and in vivo
    • Morath C, Reuter H, Simon V, Krautkramer E, Muranyi W, Schwenger V, et al. Effects of mycophenolic acid on human fibroblast proliferation, migration and adhesion in vitro and in vivo. Am J Transplant (2008) 8:1786-97. doi:10.1111/j.1600-6143.2008.02322.x.
    • (2008) Am J Transplant , vol.8 , pp. 1786-1797
    • Morath, C.1    Reuter, H.2    Simon, V.3    Krautkramer, E.4    Muranyi, W.5    Schwenger, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.