Human endothelial cells generate Th17 and regulatory T cells under inflammatory conditions

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 7, 2011, Pages 2891-2896

  Taflin, Cécile ^a,c   Favier, Benoit ^b,c   Baudhuin, Jeremy ^b,c   Savenay, Alain ^a   Hemon, Patrice ^a,c   Bensussan, Armand ^a,c   Charron, Dominique ^a,c   Glotz, Denis ^a,c   Mooney, Nuala ^a,c  

^a SAINT LOUIS HOSPITAL   (France)

^b Inst Univ d'Hématologie   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Immune regulation; MHC class II

Indexed keywords

HLA DR ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; STAT3 PROTEIN; TRANSCRIPTION FACTOR FOXP3;

ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL EXPANSION; CELL INTERACTION; CELL POPULATION; CELL PROLIFERATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; MEMORY T LYMPHOCYTE; MICROENVIRONMENT; MICROVASCULAR ENDOTHELIAL CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; TH17 CELL;

CELL PROLIFERATION; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HLA-DR ANTIGENS; HUMANS; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-6; OLIGONUCLEOTIDES; POLYMERASE CHAIN REACTION; STAT3 TRANSCRIPTION FACTOR; STATISTICS, NONPARAMETRIC; T-LYMPHOCYTES, REGULATORY; TH17 CELLS;

EID: 79952602026     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1011811108     Document Type: Article

References (36)

1. Waaga AM, et al. (2001) Regulatory functions of self-restricted MHC class II allopeptide-specific Th2 clones in vivo. J Clin Invest 107:909-916. (Pubitemid 32274044)
2. Zhou L, Chong MM, Littman DR (2009) Plasticity of CD4+ T cell lineage differentiation. Immunity 30:646-655.
3. Konieczny BT, et al. (1998) IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways. J Immunol 160:2059-2064. (Pubitemid 28119882)
4. Zhou P, et al. (2000) Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance. J Immunol 165:5580-5587.
5. Nickerson P, et al. (1996) Prolonged islet allograft acceptance in the absence of interleukin 4 expression. Transpl Immunol 4:81-85. (Pubitemid 26167069)
6. Yuan X, et al. (2008) A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med 205:3133-3144.
7. Burlingham WJ, et al. (2007) IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants. J Clin Invest 117: 3498-3506. (Pubitemid 350097005)
8. Lochner M, et al. (2008) In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J Exp Med 205:1381-1393.
9. Zhou L, et al. (2008) TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 453:236-240. (Pubitemid 351667978)
10. Yang XO, et al. (2008) Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29:44-56.
11. Beriou G, et al. (2009) IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood 113:4240-4249.
12. Ayyoub M, et al. (2009) Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t. Proc Natl Acad Sci USA 106:8635-8640.
13. Voo KS, et al. (2009) Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci USA 106:4793-4798.
14. Al-Lamki RS, Bradley JR, Pober JS (2008) Endothelial cells in allograft rejection. Transplantation 86:1340-1348.
15. Shiao SL, et al. (2007) Human effector memory CD4+ T cells directly recognize allogeneic endothelial cells in vitro and in vivo. J Immunol 179:4397-4404.
16. Marelli-Berg FM, et al. (1996) Major histocompatibility complex class II-expressing endothelial cells induce allospecific nonresponsiveness in naive T cells. J Exp Med 183: 1603-1612.
17. Pober JS, et al. (1984) Interactions of T lymphocytes with human vascular endothelial cells: Role of endothelial cells surface antigens. Immunobiology 168:483-494. (Pubitemid 15153381)
18. Krupnick AS, et al. (2005) Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells. J Immunol 175: 6265-6270. (Pubitemid 41598864)
19. LaGier AJ, Pober JS (2006) Immune accessory functions of human endothelial cells are modulated by overexpression of B7-H1 (PDL1). Hum Immunol 67:568-578. (Pubitemid 44205322)
20. Ades EW, et al. (1992) HMEC-1: Establishment of an immortalized human microvascular endothelial cell line. J Invest Dermatol 99:683-690. (Pubitemid 23002027)
21. Miyara M, et al. (2009) Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 30:899-911.
22. Hughes CC, Savage CO, Pober JS (1990) Endothelial cells augment T cell interleukin 2 production by a contact-dependent mechanism involving CD2/LFA-3 interaction. J Exp Med 171:1453-1467. (Pubitemid 20167543)
23. Shi X, Franko B, Frantz C, Amin HM, Lai R (2006) JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells. Br J Haematol 135:26-32. (Pubitemid 44337660)
24. Baecher-Allan C, Wolf E, Hafler DA (2006) MHC class II expression identifies functionally distinct human regulatory T cells. J Immunol 176:4622-4631.
25. Kreisel D, et al. (2004) Vascular endothelium does not activate CD4+ direct allorecognition in graft rejection. J Immunol 173:3027-3034. (Pubitemid 39142008)
26. Coombes JL, et al. (2007) A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 204:1757-1764. (Pubitemid 47236314)
27. Bachmann MF, et al. (1997) Distinct roles for LFA-1 and CD28 during activation of naive T cells: Adhesion versus costimulation. Immunity 7:549-557. (Pubitemid 27508706)
28. Kandula S, Abraham C (2004) LFA-1 on CD4+ T cells is required for optimal antigen-dependent activation in vivo. J Immunol 173:4443-4451. (Pubitemid 39280674)
29. Ghannam S, Pène J, Torcy-Moquet G, Jorgensen C, Yssel H (2010) Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype. J Immunol 185:302-312.
30. Bedke T, Pretsch L, Karakhanova S, Enk AH, Mahnke K (2010) Endothelial cells augment the suppressive function of CD4+ CD25+ Foxp3+ regulatory T cells: Involvement of programmed death-1 and IL-10. J Immunol 184:5562-5570.
31. Durant L, et al. (2010) Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity 32:605-615.
32. Nadazdin O, et al. (2010) Phenotype, distribution and alloreactive properties of memory T cells from cynomolgus monkeys. Am J Transplant 10:1375-1384.
33. Leveque L, et al. (2009) Interleukin 2-mediated conversion of ovarian cancer-associated CD4+ regulatory T cells into proinflammatory interleukin 17-producing helper T cells. J Immunother 32:101-108.
34. Eissner G, et al. (2002) Fludarabine induces apoptosis, activation, and allogenicity in human endothelial and epithelial cells: Protective effect of defibrotide. Blood 100: 334-340. (Pubitemid 35177465)
35. Shiao SL, McNiff JM, Pober JS (2005) Memory T cells and their costimulators in human allograft injury. J Immunol 175:4886-4896. (Pubitemid 41456370)
36. Lu SX, et al. (2008) STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease. Blood 112:5254-5258.