Detection of antibodies to dsDNA: An overview of laboratory assays

Lupus

Volumn 15, Issue 7, 2006, Pages 403-407

  Rouquette, Anne Marie ^a   Desgruelles, C ^a  

^a HÔPITAL TENON   (France)

Author keywords

dsDNA antibodies; Methods of detection; Systemic lupus erythematosus (SLE)

Indexed keywords

DOUBLE STRANDED DNA ANTIBODY; IMMUNOGLOBULIN G; MACROGOL;

ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; CRITHIDIA; DISEASE COURSE; DISEASE EXACERBATION; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOASSAY; IMMUNOFLUORESCENCE TEST; LABORATORY TEST; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN MICROARRAY; RADIOIMMUNOASSAY; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANTIBODIES, ANTINUCLEAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICROARRAY ANALYSIS; RADIOIMMUNOASSAY;

EID: 33746582779     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1191/0961203306lu2324oa     Document Type: Article

References (43)

1. Tan EM. Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv Immunol 1989; 44: 93-151.
2. Tan EM, Cohen AS, Fries JF et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 1271-1277.
3. Egner W. The use of laboratory tests in the diagnosis of SLE. J Clin Pathol 2000; 53: 424-432.
4. Solomon DH, Kavanaugh AJ, Schur PH; American College of Rheumatology Ad Hoc Committee on Immunologic Testing Guidelines. Evidence-based guidelines for the use of immunologic tests: antinuclear antibody testing. Arthritis Rheum 2002; 47: 434-444.
5. Hahn BH. Mechanisms of disease: antibodies to DNA, N Engl J Med 1998; 338: 1359-1368.
6. Kavanaugh AF, Solomon DH; American College of Rheumatology Ad Hoc Committee on Immunologic Testing Guidelines. Guidelines for immunologic laboratory testing in the rheumatic diseases: anti-DNA antibody tests. Arthritis Rheum 2002; 47: 546-555.
7. Aarden LA, de Groot ER, Feltkamp TE. Immunology of DNA. III. Crithidia luciliae, a simple substrate for the determination of anti-dsDNA with the immunofluorescence technique. Ann N Y Acad Sci 1975; 254: 505-515.
8. Aarden LA, Smeenk R. Measurements of antibodies specific for DNA. In Lefkovits I, Pernis B ed. Immunological methods, Vol. II. Academic Press; 1981: 75-82.
9. Smeenk RJ, Berden JO, Swaak AG. ds-DNA autoantibodies. In Peter JB, Shoenfeld Y eds. Autoantibodies. Elsevier, 1996: 227-236.
10. Aarden LA, Lakmaker F, Feltkamp TE. Immunology of DNA. I. The influence of reaction conditions on the Farr assay as used for the detection of anti-dsDNA. J Immunol Methods 1976; 10: 27-37.
11. Pisetsky DS, Reich CF. The influence of DNA size on the binding of anti-DNA antibodies in the solid and fluid phase. Clin Immunol Immunopathol 1994; 72: 350-356.
12. Feltkamp TE, Kirkwood TB, Maini RN, Aarden LA. The first international standard for antibodies to double stranded DNA. Ann Rheum Dis 1988; 47: 740-746.
13. Servais G, Daens S, Guillaume MP, Cumps J, Duchateau J, Peretz A. Diagnostic specificities and sensitivities of anti dsDNA, anti membrane DNA and anti nucleosomes autoantibodies. Scand J Clin Lab Invest 2001; 235(Suppl): 61-67.
14. Amoura Z, Koutouzov S, Piette JC. The role of nucleosomes in lupus. Curr Opin Rheumatol 2000; 12: 369-373.
15. Forger F, Matthias T, Oppermann M, Becker H, Helmke K. Clinical significance of anti-dsDNA antibody isotypes: IgG/IgM ratio of anti-dsDNA antibodies as a prognostic marker for lupus nephritis. Lupus 2004; 13: 36-44.
16. Werwitzke S, Trick D, Kamino K et al. Inhibition of lupus disease by anti-double-stranded DNA antibodies of the IgM isotype in the (NZB × NZW)F1 mouse. Arthritis Rheum 2005; 52: 3629-3638.
17. Shoenfeld Y, Toubi E. Protective autoantibodies: role in homeostasis, clinical importance, and therapeutic potential. Arthritis Rheum 2005; 52: 2599-2606.
18. Hylkema MN, van Bruggen MC, ten Hove T et al. Histone-containing immune complexes are to a large extent responsible for anti-dsDNA reactivity in the Farr assay of active SLE patients. J Autoimmun 2000; 14(2): 159-168.
19. Brinkman K, Termaat R, Van den Brink H, Berden J, Smeenk R. The specificity of the anti-dsDNA ELISA. A closer look. J Immunol Methods 1991; 139: 91-100.
20. Werle E, Blazek M, Fiehn W. The clinical significance of measuring different anti-dsDNA antibodies by using the Farr assay, an enzyme immunoassay and a Crithidia luciliae immunofluorescence test. Lupus 1992; 1: 369-377.
21. Tan EM, Smolen JS, McDougal JS et al. A critical evaluation of enzyme immunoassays for detection of antinuclear autoantibodies of denned specificities. I. Precision, sensitivity, and specificity. Arthritis Rheum 1999; 42: 455-464.
22. Blatt NB, Glick GD. Anti-DNA autoantibodies and systemic lupus erythematosus. Pharmacol Ther 1999; 83: 125-139.
23. Takeuchi Y, Ishikawa O, Miyachi Y. The comparative study of anti-double stranded DNA antibody levels measured by radioimmunoassay and enzyme-linked immunosorbent assay in systemic lupus erythematosus. J Dermatol 1997; 24: 297-300.
24. Isenberg DA, Dudeney C, Williams W et al. Measurement of anti-DNA antibodies: a reappraisal using five different methods. Ann Rheum Dis 1987; 46: 448-456.
25. Smeenk R, Brinkman K, van den Brink H, Swaak T. A comparison of assays used for the detection of antibodies to DNA. Clin Rheumatol 1990; 9(Suppl 1): 63-72.
26. Esdaile JM, Abrahamowicz M, Joseph L, MacKenzie T, Li Y, Danoff D. Laboratory tests as predictors of disease exacerbations in systemic lupus erythematosus. Why some tests fail. Arthritis Rheum 1996; 39: 370-378.
27. Tan EM, Smolen JS, McDougal JS et al. A critical evaluation of enzyme immunoassay kits for detection of antinuclear autoantibodies of defined specificities. II. Potential for quantitation of antibody content. J Rheumatol 2002; 29: 68-74.
28. Wong KH, Lawton JW, Cheng SK, Lee SS, Lau CS. Measurement of anti-dsDNA: a comparative study of two ELISA and the Crithidia assay. Pathology 1998; 30: 57-61.
29. Derksen RH, Bast EJ, Strooisma T, Jacobs JW. A comparison between the Farr radioimmunoassay and a new automated fluorescence immunoassay for the detection of antibodies against double stranded DNA in serum. Ann Rheum Dis 2002; 61: 1099-1102.
30. Villalta D, Bizzaro N, Corazza D, Tozzoli R, Tonutti E. Evaluation of a new automated enzyme fluoroimmunoassay using recombinant plasmid dsDNA for the detection of anti-dsDNA antibodies in SLE. J Clin Lab Anal 2002; 16: 227-232.
31. Smeenk RJ, van den Brink HG, Brinkman K, Termaat RM, Berden JH, Swaak AJ. Anti-dsDNA: choice of assay in relation to clinical value. Rheumatol Int 1991; 11: 101-107.
32. Smeenk RJ. Methodological update detection of antibodies to dsDNA: current insights into its relevance. Clin Exp Rheumatol 2002; 20: 294-300.
33. ter Borg EJ, Horst G, Hummel EJ, Limburg PC, Kallenberg CG. Measurement of increases of anti double stranded DNA antibody levels as a predictor of disease exacerbation in systemic lupus erythematosus: a long-term, prospective study. Arthritis Rheum 1990; 33: 634-643.
34. Brinkman K, Termaat R, Berden JH, Smeenk RJ. Anti-DNA antibodies and lupus nephritis: the complexity of crossreactivity. Immunol Today 1990; 11: 232-234.
35. Ho A, Magder LS, Barr SG, Petri M. Decreases in anti-double-stranded DNA levels are associated with concurrent flares in patients with systemic lupus erythematosus. Arthritis Rheum 2001; 44: 2342-2349.
36. Linnik MD, Hu JZ, Heilbrunn KR et al. Relationship between anti-double-stranded DNA antibodies and exacerbation of renal disease in patients with systemic lupus erythematosus. Arthritis Rheum 2005; 52: 1129-1137.
37. Swaak AJ, Aarden LA, Statius van Eps LW, Feltkamp TE. Anti-dsDNA and complement profiles as prognostic guides in systemic lupus erythematosus. Arthritis Rheum 1979; 22: 226-235.
38. Fritzler MJ. New technologies in the detection of autoantibodies: evaluation of addressable laserbeads immunoassays. In Conrad K, Bachmann MP, Chan EKL, Friztler MJ, Humbel RL, Sack U, Shoenfeld Y eds. From animal models to human genetics: research on the induction and pathogenicity of autoantibodies. Lengerich Pabst Science Publishers; 2004: 449-459.
39. Fulton RJ, McDade RL, Smith PL, Kienker LJ, Kettman JR Jr. Advanced multiplexed analysis with the FlowMetrix system. Clin Chem 1997; 43: 1749-1756.
40. Rouquette AM, Desgruelles C, Laroche P. Evaluation of the new multiplexed immunoassay, FIDIS, for simultaneous quantitative determination of antinuclear antibodies and comparison with conventional methods. Am J Clin Pathol 2003; 120: 676-681.
41. Abreu I, Bostos A, Cardoso C et al. Multicentre evaluation of the new multiplex assay FIDIS connective. Comparison rush conventional methods. In Conrad K, Bachmann MP, Chan EKL, Friztler MJ, Humbel RL, Sack U, Shoenfeld Y eds. From animal models to human genetics: research on the induction and pathogenicity of autoantibodies. Lengerich Pabst Science Publishers, 2004:467-468.
42. Robinson WH, Steinman L, Utz PJ. Protein arrays for autoantibody profiling and fine-specificity mapping. Proteomics 2003; 3: 2077-2084.
43. Moser KL, Gaffney PM, Grandits ME et al. The use of microarrays to study autoimmunity. J Investig Dermatol Symp Proc 2004; 9: 18-22.