Autoantibodies, lupus and the science of sabotage

Rheumatology

Volumn 43, Issue 11, 2004, Pages 1326-1336

  Rahman, Anisur ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; AUTOANTIBODY; CARDIOLIPIN; DNA ANTIBODY; DOUBLE STRANDED DNA; HISTONE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY; PHOSPHOLIPID ANTIBODY; SERINE;

ANTIPHOSPHOLIPID SYNDROME; BINDING ASSAY; BINDING SITE; COMBINED IMMUNODEFICIENCY; COMPLEMENTARITY DETERMINING REGION; COMPUTER MODEL; CORRELATION ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOPATHOGENESIS; IN VITRO STUDY; MOLECULAR CLONING; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; REVIEW; SEQUENCE ANALYSIS; SOMATIC MUTATION; STATISTICAL ANALYSIS; STRUCTURE ANALYSIS; SYSTEMIC LUPUS ERYTHEMATOSUS; TISSUE INJURY;

ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIPHOSPHOLIPID SYNDROME; AUTOANTIBODIES; BINDING SITES, ANTIBODY; COMPUTER SIMULATION; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MODELS, IMMUNOLOGICAL;

EID: 8344288224     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/keh354     Document Type: Review

References (66)

1. Tan EM, Cohen AS, Fries JF et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-7.
2. Cervera R, Khamashta MA, Font J et al. Systemic lupus erythematosus - clinical and immunologic patterns of disease expression in a cohort of 1000 patients. Medicine (Baltimore) 1993;72:113-21.
3. Isenberg DA, Ravirajan CT, Rahman A, Kalsi JK. The role of antibodies to DNA in systemic lupus erythematosus. Lupus 1997;6:290-304.
4. Isenberg DA, Shoenfeld Y, Walport M et al. Detection of cross-reactive anti-DNA idiotypes in the serum of systemic lupus erythematosus patients and of their relatives. Arthritis Rheum 1985;28:999-1007.
5. Swaak AJG, Aarden LA, Statius van Eps LW, Feltkamp TEW. Anti-ds DNA and complement profiles as prognostic guides in systemic lupus erythematosus. Arthritis Rheum 1979;22:226-35.
6. Ter Borg EJ, Horst G, Hummel EJ, Limburg PL, Kallenberg CGM. Measurement of increases in anti-double-stranded DNA antibody levels as a predictor of disease exacerbation in systemic lupus erythematosus. Arthritis Rheum 1990;33:634-43.
7. Koffler D, Schur PH, Kunkel HG. Immunological studies concerning the nephritis of systemic lupus erythematosus. J Exp Med 1967;126:607-24.
8. Winfield JB, Faiferman I, Koffler D. Avidity of anti-DNA antibodies in serum and IgG glomerular eluates from patients with systemic lupus erythematosus. Association of high avidity anti-native DNA antibody with glomerulonephritis. J Clin Invest 1977;59:90-6.
9. Madaio MP, Carlson J, Cataldo J, Ucci A, Mighorini P, Pankewycz, O. Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits. J Immunol 1987; 138:2883-9.
10. Mostoslavsky G, Fischel R, Yachimovich N et al. Lupus anti-DNA antibodies cross-react with a glomerular structural protein: a case for tissue injury by molecular mimicry. Eur J Immunol 2001;31:1221-7.
11. Ehrenstein MR, Katz DR, Griffiths MH et al. Human IgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice. Kidney Int 1995;48:705-11.
12. Ravirajan CT, Rahman MAA, Papadaki L et al. Genetic, structural and functional properties of a human IgG anti-DNA autoantibody. Eur J Immunol 1998;28:339-50.
13. Arbuckle MR, McClain MT, Rubertone MD et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med 2003;349:1526-33.
14. Okamura M, Kanayama Y, Amastu K et al. Significance of enzyme linked immunosorbent assay (ELISA) for antibodies to double stranded and single stranded DNA in patients with lupus nephritis: correlation with severity of renal histology. Ann Rheum Dis 1993;52:14-20.
15. Deocharan B, Qing X, Lichaucu J, Putterman C. α-Actinin is a cross-reactive renal target for pathogenic anti-DNA antibodies. J Immunol 2002;168:3072-8.
16. Michaud J-L, Lemieux LT, Dube M, Vanderheyden BC, Robertson SJ, Kennedy CRJ. Focal and segmental glomerulosclerosis in mice with podocyte-specific expression of mutant α-actinin-4. J Am Soc Nephrol 2003;14:1200-11.
17. Mason LJ, Ravirajan CT, Rahman A, Putterman C, Isenberg DA. Is α-actinin a target for pathogenic anti-DNA antibodies in lupus nephritis. Arthritis Rheum 2004;50:866-70.
18. Greaves M, Cohen H, Machin SJ, Mackie I. Guidelines on the investigation and management of the antiphospholipid antibody syndrome. Br J Haematol 2000;109:704-15.
19. Shah NM, Khamashta MA, Atsumi T, Hughes GR. Outcome of patients with anticardiolipin antibodies: a 10 year follow-up of 52 patients. Lupus 1998;7:3-6.
20. Cervera R, Piette J-C, Font J et al. Antiphospholipid syndrome. Clinical and immunologic manifestations and patterns of disease expression in a cohort of 1000 patients. Arthritis Rheum 2002; 46:1019-27.
21. Alarcon-Segovia D, Deleze M, Oria CV et al. Antiphospholipid antibodies and the antiphospholipid syndrome in systemic lupus erythematosus. Medicine (Baltimore) 1989;68:353-65.
22. Pierangeli SS, Harris EN. Antiphospholipid antibodies in an in vivo thrombosis model in mice. Lupus 1994;3:247-51.
23. Blank M, Cohen J, Toder V, Shoenfeld Y. Induction of antiphospholipid syndrome in naïve mice with mouse lupus monoclonal and human polyclonal anti-cardiolipin antibodies. Proc Natl Acad Sci USA 1991;88:3069-73.
24. Pierangeli SS, Liu X, Espinola R et al. Functional analyses of patient-derived IgG monoclonal anticardiolipin antibodies using in vivo thrombosis and in vivo microcirculation models. Thromb Haemost 2000;84:388-95.
25. Hunt JE, McNeil HP, Morgan GJ, Crameri RM, Krilis SA. A phospholipid-β2-glycoprotein I complex is an antigen for anti-cardiolipin antibodies occurring in autoimmune disease but not with infection. Lupus 1992;1:75-81.
26. Giles IP, Isenberg DA, Latchman DS, Rahman A. How do antiphospholipid antibodies bind β2-glycoprotein I? Arthritis Rheum 2003;48:2111-21.
27. Ordi J, Selva A, Monegal F, Porcel JM, Martinez-Costa V, Villardel M. Anticardiolipin antibodies and dependence on a serum cofactor. A mechanism of thrombosis. J Rheumatol 1993;20:1321-4.
28. Matsuura E, Igarashi Y, Yasuda T, Triplett DA, Koike T. Anticardiolipin antibodies recognize β2 glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. J Exp Med 1994;179:457-62.
29. H locus completed by analysis of the telomeric region of chromosome 14q. Nat Genet 1994;7:162-8.
30. H gene repertoire: differential effects of selection and somatic hypermutation in human peripheral CD5+/IgM+ and CD5-/IgM+ B cells. J Clin Invest 1997; 97: 2488-501.
31. de Wildt RMT, Tomlinson IM, van Venrooij WJ, Winter G, Hoet RMA. Comparable heavy and light chain pairings in normal and systemic lupus erythematosus IgG+ B cells. Eur J Immunol 2000;30:254-61.
32. Foster SJ, Brezinschek H-P, Brezinschek RI, Lipsky PE. Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells. J Clin Invest 1997;99:1614-27.
33. λ repertoire. J Immunol 1999; 162:2137-45.
34. Neuberger MS, Milstein C. Somatic hypermutation. Curr Opin Immunol 1995;7:248-54.
35. Shlomchik MJ, Marshak-Rothstein A, Wolfowicz CB, Rothstein TL, Weigert MG. The role of clonal selection and somatic mutation in autoimmunity. Nature 1987;328:805-11.
36. Blanco F, Longhurst C, Watts R et al. Identification and characterization of a new human DNA reactive monoclonal antibody and a common idiotype, WRI 176 Idβ. Lupus 1994;3:15-24.
37. Ehrenstein MR, Longhurst C, Isenberg DA. Production and analysis of IgG monoclonal anti-DNA antibodies from systemic lupus erythematosus (SLE) patients. Clin Exp Immunol 1993;92:39-45.
38. Ehrenstein MR, Longhurst CM, Latchman DS, Isenberg DA. Serological and genetic characterization of a human monoclonal immunoglobulin G anti-DNA idiotype. J Clin Invest 1994;93: 1787-97.
39. Menon S, Rahman MAA, Ravirajan CT et al. The production, binding characteristics and sequence analysis of four human IgG monoclonal antiphospholipid antibodies. J Autoimmun 1997;10: 43-57.
40. Amzel LM, Poljak RJ, Saul F, Varga JM, Richards FF. The three-dimensional structure of a combining region-ligand complex of immunoglobulin New at 3.4A resolution. Proc Natl Acad Sci USA 1974;71:1427-30.
41. Schable KF, Zachau HG. The variable genes of the human immunoglobulin κ locus. Biol Chem Hoppe-Seyler 1993;374: 1001-22.
42. λ repertoire. J Mol Biol 1996;264:220-32.
43. Lossos IS, Tibshirani R, Narasimhan B, Levy R. The inference of antigen selection on Ig genes. J Immunol 2000;165:5122-6.
44. Rahman A, Giles I, Haley J, Isenberg DA. Systematic analysis of sequences of anti-DNA antibodies - relevance to theories of origin and pathogenicity. Lupus 2002;12:807-23.
45. Giles I, Haley J, Nagl S, Isenberg DA, Latchman DS and Rahman A. A systematic analysis of sequences of human antiphospholipid and anti-β2 glycoprotein I antibodies reveals the importance of somatic mutations and certain sequence motifs. Semin Arthritis Rheum 2003;32:246-65.
46. Dorner T, Foster SJ, Farner NL, Lipsky PE. Immunoglobulin kappa chain editing in systemic lupus erythematosus. J Clin Invest 1998; 102:688-94.
47. Dorner T, Farner NL, Lipsky PE. Igλ and heavy chain usage in early untreated systemic lupus erythematosus suggests intensive B cell stimulation. J Immunol 1999;163:1027-36.
48. Radic MZ, Weigert M. Genetic and structural evidence for antigen selection of anti-DNA antibodies. Annu Rev Immunol 1994;12: 487-520.
49. Cocca BA, Seal SN, D'Agnillo P et al. Structural basis for autoantibody recognition of phosphatidylserine-β2GPI and apoptotic cells. Proc Natl Acad Sci USA 2001;98:13826-31.
50. MacCallum RM, Martin ACR, Thornton JM. Antibody-antigen interactions: contact analysis and binding site topography. J Mol Biol 1996;262:732-45.
51. Kalsi JK, Martin ACR, Hirabayashi Y et al. Functional and modelling studies of the binding of human monoclonal anti-DNA antibodies to DNA. Mol Immunol 1996;33:471-83.
52. Kettleborough CA, Ansell KH, Allen RW, Rosell-Vives E, Gussow DH, Bendig MM. Isolation of tumor specific single-chain Fv from immunized mice using phage-antibody libraries and the reconstruction of whole antibodies from these antibody fragments. Eur J Immunol 1994;24:952-8.
53. Rahman MAA, Kettleborough CA, Latchman DS, Isenberg DA. Properties of whole human IgG molecules produced by the expression of cloned anti-DNA antibody cDNA in mammalian cells. J Autoimmun 1998; 11:661-9.
54. Winkler TH, Fehr H, Kalden JR. Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas. Eur J Immunol 1992;22:1719-28.
55. λ gene 2a2 in human monoclonal anti-DNA antibodies. J Mol Biol 2001;307:149-60.
56. Katz JB, Limpanasithikul W, Diamond B. Mutational analysis of an autoantibody:differential binding and pathogenicity. J Exp Med 1994;180:925-32.
57. Van Bruggen MCJ, Walgreen B, Rijke TPM et al. Antigen specificity of anti-nuclear antibodies complexed to nucleosomes determines glomerular basement membrane binding in vivo. Eur J Immunol 1997;27:1564-9.
58. Kramers C, Hylkema MN, van Bruggen MCJ et al. Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo. J Clin Invest 1994;94:568-77.
59. Herrmann M, Voll RE, Zoller OM, Hagenhofer M, Ponner BB, Kalden JR. Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 1998;41:1241-50.
60. Haley J, Rahman A, Mason L, Giles I, Latchman DS, Isenberg DA. Somatic mutations to arginine residues affect the binding activity of a human monoclonal antibody to DNA, histones, SmD and Ro antigen. Mol Immunol 2004;40:745-58.
61. Mason LJ, Haley J, Rahman A, Latchman DS, Isenberg DA. Implantation of SCID mice with CHO cell lines which stably express human anti-DNA antibodies [abstract]. Clin Exp Rheumatol 2002; 20:269.
62. Zhu M, Olee T, Le DT et al. Characterization of IgG monoclonal anti-cardiolipin/antiβ2GPI antibodies from two patients with the antiphospholipid syndrome reveals three species of antibodies. Br J Haematol 1999;105:102-9.
63. Chukwuocha RU, Zhu M, Cho CS et al. Molecular and genetic characterizations of five pathogenic and two non-pathogenic monoclonal antiphospholipid antibodies. Mol Immunol 2002;39: 299-312.
64. Giles I, Haley J, Nagl S et al. Relative importance of different human aPL derived heavy and light chains in the binding of aPL to cardiolipin. Mol Immunol 2003;40:49-60.
65. Giles IP, Lambrianides N, Latchman DS et al. The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin [abstract]. Arthritis Rheum 2003;48(Suppl.):5164.
66. Cocca BA, Cline AM, Radic MZ. Blebs and apoptotic bodies are B cell autoantigens. J Immunol 2002;169:159-66.