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Volumn 58, Issue 12, 2015, Pages 2867-2876

Obesity resistance and increased energy expenditure by white adipose tissue browning in Oga +/- mice

Author keywords

Adipose tissue browning; Beige adipocyte; O GlcNAcase; O GlcNAcylation; Obesity; Thermogenesis

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUCOSE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; N ACETYLGLUCOSAMINE; O ACETYLGLUCOSAMINE; UNCLASSIFIED DRUG; BETA N ACETYLHEXOSAMINIDASE; GLUCOSE BLOOD LEVEL; HEXOSAMINIDASE C;

EID: 84946500719     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3736-z     Document Type: Article
Times cited : (30)

References (39)
  • 1
    • 79959381299 scopus 로고    scopus 로고
    • Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease
    • Hart GW, Slawson C, Ramirez-Correa G, Lagerlof O (2011) Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease. Annu Rev Biochem 80:825–858
    • (2011) Annu Rev Biochem , vol.80 , pp. 825-858
    • Hart, G.W.1    Slawson, C.2    Ramirez-Correa, G.3    Lagerlof, O.4
  • 2
    • 39749104251 scopus 로고    scopus 로고
    • Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance
    • Yang X, Ongusaha PP, Miles PD et al (2008) Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature 451:964–969
    • (2008) Nature , vol.451 , pp. 964-969
    • Yang, X.1    Ongusaha, P.P.2    Miles, P.D.3
  • 3
    • 77949332132 scopus 로고    scopus 로고
    • Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes
    • Whelan SA, Dias WB, Thiruneelakantapillai L, Lane MD, Hart GW (2010) Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes. J Biol Chem 285:5204–5211
    • (2010) J Biol Chem , vol.285 , pp. 5204-5211
    • Whelan, S.A.1    Dias, W.B.2    Thiruneelakantapillai, L.3    Lane, M.D.4    Hart, G.W.5
  • 4
    • 40449128605 scopus 로고    scopus 로고
    • Hepatic glucose sensing via the CREB coactivator CRTC2
    • Dentin R, Hedrick S, Xie J, Yates J III, Montminy M (2008) Hepatic glucose sensing via the CREB coactivator CRTC2. Science 319:1402–1405
    • (2008) Science , vol.319 , pp. 1402-1405
    • Dentin, R.1    Hedrick, S.2    Xie, J.3    Yates, J.4    Montminy, M.5
  • 5
    • 47749149232 scopus 로고    scopus 로고
    • O-GlcNAc regulates FoxO activation in response to glucose
    • Housley MP, Rodgers JT, Udeshi ND et al (2008) O-GlcNAc regulates FoxO activation in response to glucose. J Biol Chem 283:16283–16292
    • (2008) J Biol Chem , vol.283 , pp. 16283-16292
    • Housley, M.P.1    Rodgers, J.T.2    Udeshi, N.D.3
  • 6
    • 79959473762 scopus 로고    scopus 로고
    • O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver
    • Guinez C, Filhoulaud G, Rayah-Benhamed F et al (2011) O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver. Diabetes 60:1399–1413
    • (2011) Diabetes , vol.60 , pp. 1399-1413
    • Guinez, C.1    Filhoulaud, G.2    Rayah-Benhamed, F.3
  • 8
    • 20144389168 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in MGEA5 encoding O-GlcNAc-selective N-acetyl-beta-D glucosaminidase is associated with type 2 diabetes in Mexican Americans
    • Lehman DM, Fu DJ, Freeman AB et al (2005) A single nucleotide polymorphism in MGEA5 encoding O-GlcNAc-selective N-acetyl-beta-D glucosaminidase is associated with type 2 diabetes in Mexican Americans. Diabetes 54:1214–1221
    • (2005) Diabetes , vol.54 , pp. 1214-1221
    • Lehman, D.M.1    Fu, D.J.2    Freeman, A.B.3
  • 9
    • 0036396628 scopus 로고    scopus 로고
    • Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians
    • Farook VS, Bogardus C, Prochazka M (2002) Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians. Mol Genet Metab 77:189–193
    • (2002) Mol Genet Metab , vol.77 , pp. 189-193
    • Farook, V.S.1    Bogardus, C.2    Prochazka, M.3
  • 10
    • 84864287504 scopus 로고    scopus 로고
    • Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
    • Wu J, Bostrom P, Sparks LM et al (2012) Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150:366–376
    • (2012) Cell , vol.150 , pp. 366-376
    • Wu, J.1    Bostrom, P.2    Sparks, L.M.3
  • 11
    • 84860872762 scopus 로고    scopus 로고
    • O-GlcNAcase is essential for embryonic development and maintenance of genomic stability
    • Yang YR, Song M, Lee H et al (2012) O-GlcNAcase is essential for embryonic development and maintenance of genomic stability. Aging Cell 11:439–448
    • (2012) Aging Cell , vol.11 , pp. 439-448
    • Yang, Y.R.1    Song, M.2    Lee, H.3
  • 12
    • 84862777029 scopus 로고    scopus 로고
    • O-GlcNAc modification of PPAR gamma reduces its transcriptional activity
    • Ji S, Park SY, Roth J, Kim HS, Cho JW (2012) O-GlcNAc modification of PPAR gamma reduces its transcriptional activity. Biochem Biophys Res Commun 417:1158–1163
    • (2012) Biochem Biophys Res Commun , vol.417 , pp. 1158-1163
    • Ji, S.1    Park, S.Y.2    Roth, J.3    Kim, H.S.4    Cho, J.W.5
  • 13
    • 84898613353 scopus 로고    scopus 로고
    • Cross-talk between two essential nutrient-sensitive enzymes: O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK)
    • Bullen JW, Balsbaugh JL, Chanda D et al (2014) Cross-talk between two essential nutrient-sensitive enzymes: O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK). J Biol Chem 289:10592–10606
    • (2014) J Biol Chem , vol.289 , pp. 10592-10606
    • Bullen, J.W.1    Balsbaugh, J.L.2    Chanda, D.3
  • 14
    • 34147143863 scopus 로고    scopus 로고
    • Chronic hexosamine flux stimulates fatty acid oxidation by activating AMP-activated protein kinase in adipocytes
    • Luo B, Parker GJ, Cooksey RC et al (2007) Chronic hexosamine flux stimulates fatty acid oxidation by activating AMP-activated protein kinase in adipocytes. J Biol Chem 282:7172–7180
    • (2007) J Biol Chem , vol.282 , pp. 7172-7180
    • Luo, B.1    Parker, G.J.2    Cooksey, R.C.3
  • 15
    • 84887431711 scopus 로고    scopus 로고
    • Brown and beige fat: development, function and therapeutic potential
    • Harms M, Seale P (2013) Brown and beige fat: development, function and therapeutic potential. Nat Med 19:1252–1263
    • (2013) Nat Med , vol.19 , pp. 1252-1263
    • Harms, M.1    Seale, P.2
  • 16
    • 47649114560 scopus 로고    scopus 로고
    • A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
    • Yuzwa SA, Macauley MS, Heinonen JE et al (2008) A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol 4:483–490
    • (2008) Nat Chem Biol , vol.4 , pp. 483-490
    • Yuzwa, S.A.1    Macauley, M.S.2    Heinonen, J.E.3
  • 17
    • 84904810180 scopus 로고    scopus 로고
    • OGA heterozygosity suppresses intestinal tumorigenesis in Apcmin/+ mice
    • Yang YR, Jang HJ, Yoon S et al (2014) OGA heterozygosity suppresses intestinal tumorigenesis in Apcmin/+ mice. Oncogenesis 3:e109
    • (2014) Oncogenesis , vol.3
    • Yang, Y.R.1    Jang, H.J.2    Yoon, S.3
  • 18
    • 0035920122 scopus 로고    scopus 로고
    • beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase
    • Cao W, Medvedev AV, Daniel KW, Collins S (2001) beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase. J Biol Chem 276:27077–27082
    • (2001) J Biol Chem , vol.276 , pp. 27077-27082
    • Cao, W.1    Medvedev, A.V.2    Daniel, K.W.3    Collins, S.4
  • 19
    • 0037117511 scopus 로고    scopus 로고
    • Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes
    • Vosseller K, Wells L, Lane MD, Hart GW (2002) Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A 99:5313–5318
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 5313-5318
    • Vosseller, K.1    Wells, L.2    Lane, M.D.3    Hart, G.W.4
  • 20
    • 0036679303 scopus 로고    scopus 로고
    • Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia
    • McClain DA, Lubas WA, Cooksey RC et al (2002) Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia. Proc Natl Acad Sci U S A 99:10695–10699
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 10695-10699
    • McClain, D.A.1    Lubas, W.A.2    Cooksey, R.C.3
  • 21
    • 60149092312 scopus 로고    scopus 로고
    • A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells
    • Stubbs KA, Macauley MS, Vocadlo DJ (2009) A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells. Angew Chem 48:1300–1303
    • (2009) Angew Chem , vol.48 , pp. 1300-1303
    • Stubbs, K.A.1    Macauley, M.S.2    Vocadlo, D.J.3
  • 22
    • 77949305110 scopus 로고    scopus 로고
    • Increasing O-GlcNAc levels: an overview of small-molecule inhibitors of O-GlcNAcase
    • Macauley MS, Vocadlo DJ (2010) Increasing O-GlcNAc levels: an overview of small-molecule inhibitors of O-GlcNAcase. Biochim Biophys Acta 1800:107–121
    • (2010) Biochim Biophys Acta , vol.1800 , pp. 107-121
    • Macauley, M.S.1    Vocadlo, D.J.2
  • 23
    • 77956963665 scopus 로고    scopus 로고
    • Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes
    • Macauley MS, He YA, Gloster TM, Stubbs KA, Davies GJ, Vocadlo DJ (2010) Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes. Chem Biol 17:937–948
    • (2010) Chem Biol , vol.17 , pp. 937-948
    • Macauley, M.S.1    He, Y.A.2    Gloster, T.M.3    Stubbs, K.A.4    Davies, G.J.5    Vocadlo, D.J.6
  • 24
    • 58049197848 scopus 로고    scopus 로고
    • Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance
    • Macauley MS, Bubb AK, Martinez-Fleites C, Davies GJ, Vocadlo DJ (2008) Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance. J Biol Chem 283:34687–34695
    • (2008) J Biol Chem , vol.283 , pp. 34687-34695
    • Macauley, M.S.1    Bubb, A.K.2    Martinez-Fleites, C.3    Davies, G.J.4    Vocadlo, D.J.5
  • 25
    • 77956961240 scopus 로고    scopus 로고
    • Elevation of global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis
    • Macauley MS, Shan X, Yuzwa SA, Gloster TM, Vocadlo DJ (2010) Elevation of global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis. Chem Biol 17:949–958
    • (2010) Chem Biol , vol.17 , pp. 949-958
    • Macauley, M.S.1    Shan, X.2    Yuzwa, S.A.3    Gloster, T.M.4    Vocadlo, D.J.5
  • 26
    • 80052340258 scopus 로고    scopus 로고
    • O-GlcNAc modification of NFkappaB p65 inhibits TNF-alpha-induced inflammatory mediator expression in rat aortic smooth muscle cells
    • Xing D, Gong K, Feng W et al (2011) O-GlcNAc modification of NFkappaB p65 inhibits TNF-alpha-induced inflammatory mediator expression in rat aortic smooth muscle cells. PLoS One 6:e24021
    • (2011) PLoS One , vol.6
    • Xing, D.1    Gong, K.2    Feng, W.3
  • 27
    • 84930012265 scopus 로고    scopus 로고
    • Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-kappaB signaling
    • Yang YR, Kim DH, Seo YK et al (2015) Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-kappaB signaling. Oncotarget 20:12529–12542
    • (2015) Oncotarget , vol.20 , pp. 12529-12542
    • Yang, Y.R.1    Kim, D.H.2    Seo, Y.K.3
  • 28
    • 84871950193 scopus 로고    scopus 로고
    • Serum-stimulated cell cycle entry promotes ncOGT synthesis required for cyclin D expression
    • Olivier-Van Stichelen S, Drougat L, Dehennaut V et al (2012) Serum-stimulated cell cycle entry promotes ncOGT synthesis required for cyclin D expression. Oncogenesis 1:e36
    • (2012) Oncogenesis , vol.1
    • Olivier-Van Stichelen, S.1    Drougat, L.2    Dehennaut, V.3
  • 29
    • 83355163350 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha (PPARalpha) induces PPARgamma coactivator 1alpha (PGC-1alpha) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16
    • Hondares E, Rosell M, Diaz-Delfin J et al (2011) Peroxisome proliferator-activated receptor alpha (PPARalpha) induces PPARgamma coactivator 1alpha (PGC-1alpha) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16. J Biol Chem 286:43112–43122
    • (2011) J Biol Chem , vol.286 , pp. 43112-43122
    • Hondares, E.1    Rosell, M.2    Diaz-Delfin, J.3
  • 30
    • 84858039282 scopus 로고    scopus 로고
    • PPAR gamma agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein
    • Ohno H, Shinoda K, Spiegelman BM, Kajimura S (2012) PPAR gamma agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab 15:395–404
    • (2012) Cell Metab , vol.15 , pp. 395-404
    • Ohno, H.1    Shinoda, K.2    Spiegelman, B.M.3    Kajimura, S.4
  • 31
    • 13444266177 scopus 로고    scopus 로고
    • Effects of Wnt signaling on brown adipocyte differentiation and metabolism mediated by PGC-1alpha
    • Kang S, Bajnok L, Longo KA et al (2005) Effects of Wnt signaling on brown adipocyte differentiation and metabolism mediated by PGC-1alpha. Mol Cell Biol 25:1272–1282
    • (2005) Mol Cell Biol , vol.25 , pp. 1272-1282
    • Kang, S.1    Bajnok, L.2    Longo, K.A.3
  • 32
    • 84864708480 scopus 로고    scopus 로고
    • O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1alpha stability
    • Ruan HB, Han X, Li MD et al (2012) O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1alpha stability. Cell Metab 16:226–237
    • (2012) Cell Metab , vol.16 , pp. 226-237
    • Ruan, H.B.1    Han, X.2    Li, M.D.3
  • 33
    • 84895061402 scopus 로고    scopus 로고
    • beta-Catenin is O-GlcNAc glycosylated at serine 23: implications for beta-catenin's subcellular localization and transactivator function
    • Ha JR, Hao L, Venkateswaran G, Huang YH, Garcia E, Persad S (2014) beta-Catenin is O-GlcNAc glycosylated at serine 23: implications for beta-catenin's subcellular localization and transactivator function. Exp Cell Res 321:153–166
    • (2014) Exp Cell Res , vol.321 , pp. 153-166
    • Ha, J.R.1    Hao, L.2    Venkateswaran, G.3    Huang, Y.H.4    Garcia, E.5    Persad, S.6
  • 34
    • 84924898037 scopus 로고    scopus 로고
    • Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis
    • Keembiyehetty C, Love DC, Harwood KR, Gavrilova O, Comly ME, Hanover JA (2015) Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis. J Biol Chem 290:7097–7113
    • (2015) J Biol Chem , vol.290 , pp. 7097-7113
    • Keembiyehetty, C.1    Love, D.C.2    Harwood, K.R.3    Gavrilova, O.4    Comly, M.E.5    Hanover, J.A.6
  • 36
    • 84916878247 scopus 로고    scopus 로고
    • O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat
    • Ruan HB, Dietrich MO, Liu ZW et al (2014) O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat. Cell 159:306–317
    • (2014) Cell , vol.159 , pp. 306-317
    • Ruan, H.B.1    Dietrich, M.O.2    Liu, Z.W.3
  • 37
    • 4444337997 scopus 로고    scopus 로고
    • Exploring the O-GlcNAc proteome: direct identification of O-GlcNAc-modified proteins from the brain
    • Khidekel N, Ficarro SB, Peters EC, Hsieh-Wilson LC (2004) Exploring the O-GlcNAc proteome: direct identification of O-GlcNAc-modified proteins from the brain. Proc Natl Acad Sci U S A 101:13132–13137
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 13132-13137
    • Khidekel, N.1    Ficarro, S.B.2    Peters, E.C.3    Hsieh-Wilson, L.C.4
  • 38
    • 84891381281 scopus 로고    scopus 로고
    • O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses
    • Taylor EW, Wang K, Nelson AR et al (2014) O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses. J Neurosci 34:10–21
    • (2014) J Neurosci , vol.34 , pp. 10-21
    • Taylor, E.W.1    Wang, K.2    Nelson, A.R.3
  • 39
    • 58649120835 scopus 로고    scopus 로고
    • In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation
    • Tallent MK, Varghis N, Skorobogatko Y et al (2009) In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation. J Biol Chem 284:174–181
    • (2009) J Biol Chem , vol.284 , pp. 174-181
    • Tallent, M.K.1    Varghis, N.2    Skorobogatko, Y.3


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