Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes

Chemistry and Biology

Volumn 17, Issue 9, 2010, Pages 937-948

  MacAuley, Matthew S ^a   He, Yuan ^b   Gloster, Tracey M ^a   Stubbs, Keith A ^a   Davies, Gideon J ^b   Vocadlo, David J ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

^b UNIVERSITY OF YORK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

6 ACETAMIDO 6 DEOXYCASTANOSPERMINE; 6-ACETAMIDO-6-DEOXYCASTANOSPERMINE; BETA N ACETYLHEXOSAMINIDASE; CARBAMIC ACID DERIVATIVE; DEOXYGLUCOSE; DRUG DERIVATIVE; ENZYME INHIBITOR; HEXOSAMINIDASE C; INDOLIZINE DERIVATIVE; INSULIN; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, MOUSE; N ACETYLGLUCOSAMINE; N ACETYLGLUCOSAMINONO 1,5 LACTONE O (PHENYLCARBAMOYL)OXIME; N-ACETYLGLUCOSAMINONO-1,5-LACTONE O-(PHENYLCARBAMOYL)OXIME; OXIME; PROTEIN KINASE B;

ADIPOCYTE; ANIMAL; ARTICLE; BINDING SITE; CELL STRAIN 3T3; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVE SITE; ENZYMOLOGY; HUMAN; INSULIN RESISTANCE; METABOLISM; MOUSE; PHOSPHORYLATION; X RAY CRYSTALLOGRAPHY;

3T3-L1 CELLS; ACETYLGLUCOSAMINE; ADIPOCYTES; ANIMALS; BETA-N-ACETYLHEXOSAMINIDASES; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DEOXYGLUCOSE; ENZYME INHIBITORS; HUMANS; INDOLIZINES; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; MICE; OXIMES; PHENYLCARBAMATES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 77956963665     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2010.07.006     Document Type: Article

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