Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance

Journal of Biological Chemistry

Volumn 283, Issue 50, 2008, Pages 34687-34695

  Macauley, Matthew S ^a   Bubb, Abigail K ^b   Martinez Fleites, Carlos ^b   Davies, Gideon J ^b   Vocadlo, David J ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

^b UNIVERSITY OF YORK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; INSULIN; SUGAR (SUCROSE);

ACETAMIDO; ACTIVE SITES; ADIPOCYTES; BIOSYNTHETIC PATHWAYS; GLOBAL LEVELS; HEXOSAMINE; INSULIN RESISTANCES; MODIFIED PROTEINS; MOLECULAR BASES; NUTRIENT FLUXES; SELECTIVE INHIBITIONS; SELECTIVE INHIBITORS; TRANSLATIONAL MODIFICATIONS;

HORMONES;

1,2 DIDEOXY 2' PROPYL ALPHA GLUCOPYRANOSO [2,1 D] DELTA2' THIAZOLINE; ENZYME INHIBITOR; HEXOSAMINE; N ACETYL BETA GLUCOSAMINIDASE; N ACETYLGLUCOSAMINE; O (2 ACETAMIDO 2 DEOXY GLYCOPYRANOSYLIDENE) AMINO N PHENYLCARBAMATE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME STRUCTURE; INSULIN RESISTANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING;

3T3-L1 CELLS; ACETYLGLUCOSAMINE; ACETYLGLUCOSAMINIDASE; ADIPOCYTES; ANIMALS; CATALYTIC DOMAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; INSULIN RESISTANCE; KINETICS; MICE; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL;

BACTERIA (MICROORGANISMS);

EID: 58049197848     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M804525200     Document Type: Article

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