Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway

Journal of Neuroinflammation

Volumn 12, Issue 1, 2015, Pages

  Chuang, Dennis Y ^a,b   Simonyi, Agnes ^a,b   Kotzbauer, Paul T ^c   Gu, Zezong ^a,b   Sun, Grace Y ^a,b  

^a UNIVERSITY OF MISSOURI   (United States)

^b University of Missouri   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Arachidonic acid; CPLA2; Lipoxygenase; Microglia; NO; ROS

Indexed keywords

ARACHIDONYL TRIFLUOROMETHYL KETONE; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; CYTOSOLIC PHOSPHOLIPASE A2; F ACTIN; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; LIPOXYGENASE; LIPOXYGENASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; PHALLOIDIN; PHOSPHOLIPASE A2; PHOSPHOLIPASE INHIBITOR; PROSTAGLANDIN E2; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; ACTIN; PROSTAGLANDIN SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BV 2 CELL; CELL IMMORTALIZATION; CELL ISOLATION; CELL LINE; CELL STRESS; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; IMMUNOCYTOCHEMISTRY; MICROGLIA; MOUSE; NERVE CELL STIMULATION; NERVOUS SYSTEM INFLAMMATION; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PROSTAGLANDIN RELEASE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CYTOSOL; DRUG EFFECTS; ENZYMOLOGY; FEMALE; GENETICS; INFLAMMATION; KNOCKOUT MOUSE; MACROPHAGE ACTIVATION; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; PRIMARY CELL CULTURE;

ACTINS; ANIMALS; CELL LINE; CYTOSOL; FEMALE; INFLAMMATION; LIPOXYGENASE; MACROPHAGE ACTIVATION; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROGLIA; NITRIC OXIDE; PHOSPHOLIPASES A2; PRIMARY CELL CULTURE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84946488668     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-015-0419-0     Document Type: Article

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