Enzymatic Hydrolysis Does Not Reduce the Biological Reactivity of Soybean Proteins for All Allergic Subjects

Journal of Agricultural and Food Chemistry

Volumn 63, Issue 43, 2015, Pages 9629-9639

  Panda, Rakhi ^a,c   Tetteh, Afua O ^a,d   Pramod, Siddanakoppalu N ^b   Goodman, Richard E ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^b KUVEMPU UNIVERSITY   (India)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

enzymatic hydrolysis; functional assay; IgE binding; soybean

Indexed keywords

ALLERGENS; BINS; BROMELAIN; CELL CULTURE; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; POLYACRYLONITRILES; PROTEINS;

ALLERGIC PATIENTS; FUNCTIONAL ASSAYS; IGE BINDINGS; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (LC MS/MS); SOYBEAN; SOYBEAN PRODUCTS; SOYBEAN PROTEIN ISOLATES (SPI); TWO DIMENSIONAL (2 D);

ENZYMATIC HYDROLYSIS;

CHYMOTRYPSIN; IMMUNOGLOBULIN E; SOYBEAN PROTEIN; SUBTILISIN; TRYPSIN;

CHEMISTRY; FOOD ALLERGY; HUMAN; HYDROLYSIS; IMMUNOLOGY; SOYBEAN;

CHYMOTRYPSIN; FOOD HYPERSENSITIVITY; HUMANS; HYDROLYSIS; IMMUNOGLOBULIN E; SOYBEAN PROTEINS; SOYBEANS; SUBTILISINS; TRYPSIN;

EID: 84946430190     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/acs.jafc.5b02927     Document Type: Article

References (41)

1. Goodman, R. E.; Hefle, S. L.; Taylor, S. L.; van Ree, R. Assessing genetically modified crops to minimize the risk of increased food allergy: a review Int. Arch. Allergy Immunol. 2005, 137, 153-166 10.1159/000086314
2. Savage, J. H.; Kaeding, A. J.; Matsui, E. C.; Wood, R. A. The natural history of soy allergy J. Allergy Clin. Immunol. 2010, 125, 683-686 10.1016/j.jaci.2009.12.994
3. Sicherer, S. H.; Sampson, H. A.; Burks, A. W. Peanut and soy allergy: a clinical and therapeutic dilemma Allergy 2000, 55, 515-521 10.1034/j.1398-9995.2000.00119.x
4. Ladics, G. S.; Budzizewski, G. J.; Herman, R. A.; Herouet-Guicheney, C.; Joshi, S.; Lipscomb, E. A.; McClain, S.; Ward, J. J. Measurement of endogenous allergens in genetically modified soybeans-short communication Regul. Toxicol. Pharmacol. 2014, 70, 75-79 10.1016/j.yrtph.2014.06.006
5. Holzhauser, T.; Wackermann, O.; Ballmer-Weber, B. K.; Bindslev-Jensen, C.; Scibilia, J.; Perono-Garoffo, L.; Utsumi, S.; Poulsen, L. K.; Vieths, S. Soybean (Glycine max) allergy in Europe: Gly m 5 (β-conglycinin) and Gly m 6 (glycinin) are potential diagnostic markers for severe allergic reactions to soy J. Allergy Clin. Immunol. 2009, 123, 452-458 10.1016/j.jaci.2008.09.034
6. Singh, P.; Kumar, R.; Sabapathy, S. N.; Bawa, A. S. Functional and edible uses of soy protein products Compr. Rev. Food Sci. Food Saf. 2008, 7, 14-28 10.1111/j.1541-4337.2007.00025.x
7. Jiang, J.; Xiong, Y. L.; Chen, J. Role of β-conglycinin and glycinin subunits in the pH shifting-induced structural and physicochemical changes of soy protein isolate J. Food Sci. 2011, 76, C293-C302 10.1111/j.1750-3841.2010.02035.x
8. Keerati-U-Rai, M.; Corredig, M. Heat-induced changes occurring in oil/water emulsions stabilized by soy glycinin and β-conglycinin J. Agric. Food Chem. 2010, 58, 9171-9180 10.1021/jf101425j
9. Kosma, P.; Sjolander, S.; Landgren, E.; Borres, M. P.; Hedlin, G. Severe reactions after the intake of soy drink in birch pollen-allergic children sensitized to Gly m 4 Acta Paediatr. 2011, 100, 305-306 10.1111/j.1651-2227.2010.02049.x
10. Host, A.; Halken, S. Hypoallergenic formulas-when, to whom and how long: after more than 15 years we know the right indication! Allergy 2004, 59 (Suppl. 78) 45-52 10.1111/j.1398-9995.2004.00574.x
11. L'Hocine, L.; Boye, J. I. Allergenicity of soybean: new developments in identification of allergenic proteins, cross-reactivities and hypoallergenization technologies Crit. Rev. Food Sci. Nutr. 2007, 47, 127-143 10.1080/10408390600626487
12. Molina Ortiz, S.; Wagner, J. R. Hydrolysates of native and modified soy protein isolates: structural characteristics, solubility and foaming properties Food Res. Int. 2002, 35, 511-518 10.1016/S0963-9969(01)00149-1
13. Adler-Nissen, J. Enzymatic hydrolysis of proteins for increased solubility J. Agric. Food Chem. 1976, 24, 1090-1093 10.1021/jf60208a021
14. Calderon de la Barca, A. M.; Ruiz-Salazar, R. A.; Jara-Marini, M. E. Enzymatic hydrolysis and synthesis of soy proteins to improve its amino acid composition and functional properties J. Food Sci. 2000, 65, 246-253 10.1111/j.1365-2621.2000.tb15988.x
15. Kim, S. Y.; Park, P. S. W.; Rhee, K. C. Functional properties of proteolytic enzyme modified soy protein isolate J. Agric. Food Chem. 1990, 38, 651-656 10.1021/jf00093a014
16. Molina Ortiz, S.; Anon, M. C. Analysis of products, mechanisms of reaction and some functional properties of soy protein hydrolysates J. Am. Oil Chem. Soc. 2000, 77, 1293-1301 10.1007/s11746-000-0204-4
17. Sun, X. D. Enzymatic hydrolysis of soy proteins and the hydrolysates utilization Int. J. Food Sci. Technol. 2011, 46, 2447-2459 10.1111/j.1365-2621.2011.02785.x
18. Tsumura, K.; Kugimiya, W.; Bando, N.; Hiemori, M.; Ogawa, T. Preparation of hypoallergenic soybean protein with processing functionality by selective enzyme hydrolysis Food Sci. Technol. Res. 1999, 5, 171-175 10.3136/fstr.5.171
19. Lee, H. W.; Keum, E. H.; Lee, S. J.; Sung, D. E.; Chung, D. H.; Lee, S. I.; Oh, S. Allergenicity of proteolytic hydrolysates of the soybean 11S globulin J. Food Sci. 2007, 72, C168-C172 10.1111/j.1750-3841.2007.00307.x
20. Wang, Z.; Li, L.; Yuan, D.; Zhao, X.; Cui, S.; Hu, J.; Wang, J. Reduction of the allergenic protein in soybean meal by enzymatic hydrolysis Food Agric. Immunol. 2014, 25 (3) 301-310 10.1080/09540105.2013.782268
21. Sung, D.; Ahn, K. M.; Lim, S.; Oh, S. Allergenicity of an enzymatic hydrolysate of soybean 2S protein J. Sci. Food Agric. 2014, 94, 2482-2487 10.1002/jsfa.6583
22. Ladics, G. S.; van Bilsen, J. H.; Brouwer, H. M.; Vogel, L.; Vieths, S.; Knippels, L. M. Assessment of three human Fc epsilon RI-transfected RBL cell-lines for identifying IgE induced degranulation utilizing peanut-allergic patient sera and peanut protein extract Regul. Toxicol. Pharmacol. 2008, 51, 288-294 10.1016/j.yrtph.2008.04.012
23. Sorgentini, D. A.; Wagner, J. R.; Anon, M. C. Effects of thermal treatment of soy protein isolates on the characteristics and structure- function relationship of soluble and insoluble fractions J. Agric. Food Chem. 1995, 43, 2471-2479 10.1021/jf00057a029
24. Cabanillas, B.; Pedrosa, M. M.; Rodriguez, J.; Gonzalez, A.; Muzquiz, M.; Cuadrado, C.; Crespo, J. F.; Burbano, C. Effects of enzymatic hydrolysis on lentil allergenicity Mol. Nutr. Food Res. 2010, 54, 1266-1272 10.1002/mnfr.200900249
25. Hasim, S.; Tati, S.; Madayiputhiya, N.; Nandakumar, R.; Nickerson, K. W. Histone biotinylation in Candida albicans FEMS Yeast Res. 2013, 13, 529-539 10.1111/1567-1364.12056
26. Vogel, L.; Luttkopf, D.; Hatahet, L.; Haustein, D.; Vieths, S. Development of a functional in vitro assay as a novel tool for the standardization of allergen extracts in the human system Allergy 2005, 60, 1021-1028 10.1111/j.1398-9995.2005.00803.x
27. Clemente, A.; Vioque, J.; Sanchez-Vioque, R.; Pedroche, J.; Millan, F. Production of extensive chickpea (Cicer arietinum L.) protein hydrolysates with reduced antigenic activity J. Agric. Food Chem. 1999, 47, 3776-3781 10.1021/jf981315p
28. Szymkiewicz, A.; Jedrychowski, L. Reduction of immunoreactive properties of pean globulins as the result of enzymatic modification Acta Aliment. 2005, 34, 295-306 10.1556/AAlim.34.2005.3.12
29. Wigotzki, M.; Schubert, S.; Steinhart, H.; Paschke, H. Effects of in vitro digestion on the IgE-binding activity of proteins from hazelnuts (Corylus avellana). Internet Symposium on Food Allergens 2 (1); 2000; http://www.food-allergens.de/.
30. Kasera, R.; Singh, A. B.; Lavasa, S.; Prasad, K. N.; Arora, N. Enzymatic hydrolysis: a method in alleviating legume allergenicity Food Chem. Toxicol. 2015, 76, 54-60 10.1016/j.fct.2014.11.023
31. Cabanillas, B.; Pedrosa, M. M.; Rodriguez, J.; Muzquiz, M.; Maleki, S. J.; Cuadrado, C.; Burbano, C.; Crespo, J. F. Influence of enzymatic hydrolysis on the allergenicity of roasted peanut protein extract Int. Arch. Allergy Immunol. 2012, 157, 41-50 10.1159/000324681
32. Shi, X.; Guo, R.; White, B. L.; Yancey, A.; Sanders, T. H.; Davis, J. P.; Burks, A. W.; Kulis, M. Allergenic properties of enzymatically hydrolyzed peanut flour extracts Int. Arch. Allergy Immunol. 2013, 162, 123-130 10.1159/000351920
33. Panda, R.; Ariyarathna, H.; Tetteh, A.; Pramod, S. N.; Taylor, S. L.; Ballmer-Weber, B. K.; Goodman, R. E. Challenges in testing genetically modified crops for potential increases in endogenous allergen expression for safety Allergy 2013, 68, 142-151 10.1111/all.12076
34. Hamilton, R. G.; Franklin Adkinson, N., Jr. In vitro assays for the diagnosis of IgE-mediated disorders J. Allergy Clin. Immunol. 2004, 114, 213-225 10.1016/j.jaci.2004.06.046
35. Kleine Budde, I.; de Heer, P. G.; van der Zee, J. S.; Aalberse, R. C. The stripped basophil histamine release bioassay as a tool for the detection of allergen-specific IgE in serum Int. Arch. Allergy Immunol. 2001, 126, 277-285 10.1159/000049524
36. Dibbern, D. A., Jr.; Palmer, G. W.; Williams, P. B.; Bock, S. A.; Dreskin, S. C. RBL cells expressing human FcεRI are a sensitive tool for exploring functional IgE-allergen interactions: studies with sera from peanut-sensitive patients J. Immunol. Methods 2003, 274, 37-45 10.1016/S0022-1759(02)00369-1
37. Zhou, Y.-H.; Chen, Z.; Purcell, R. H.; Emerson, S. U. Positive reactions on western blots do not necessarily indicate the epitopes on antigens are continuous Immunol. Cell Biol. 2007, 85, 73-78 10.1038/sj.icb.7100004
38. Huang, L.; Mills, E. N. C.; Carter, J. M.; Morgan, M. R. A. Analysis of thermal stability of soya globulins using monoclonal antibodies Biochim. Biophys. Acta, Protein Struct. Mol. Enzymol. 1998, 1388, 215-226 10.1016/S0167-4838(98)00190-3
39. L'Hocine, L.; Boye, J.; Jouve, S. Ionic strength and pH-induced changes in the immunoreactivity of purified soybean glycinin and its relation to protein molecular structure J. Agric. Food Chem. 2007, 55, 5819-5826 10.1021/jf070281v
40. Adachi, M.; Kanamori, J.; Masuda, T.; Yagasaki, K.; Kitamura, K.; Mikami, B.; Utsumi, S. Ctrystal structure of soybean 11s globulin: glycinin A3B4 homohexamer Proc. Natl. Acad. Sci. U. S. A. 2003, 100, 7395-7400 10.1073/pnas.0832158100
41. Jin, T.; Guo, F.; Chen, Y.-W.; Howard, A.; Zhang, Y.-Z. Crystal structure of Ara h 3, a major allergen in peanut Mol. Immunol. 2009, 46, 1796-1804 10.1016/j.molimm.2009.01.023