LW-213 induces G2/M cell cycle arrest through AKT/GSK3β/β-catenin signaling pathway in human breast cancer cells

Molecular Carcinogenesis

Volumn 55, Issue 5, 2016, Pages 778-792

  Zhao, Li ^a   Miao, Han Chi ^a   Li, Wen Jun ^a   Sun, Yang ^a   Huang, Shao Liang ^a   Li, Zhi Yu ^a   Guo, Qing Long ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Akt Gsk3 catenin signaling pathway; Breast cancer; G2 M arrest; LW 213; Wogonin derivative

Indexed keywords

ANTINEOPLASTIC AGENT; BETA CATENIN; CHECKPOINT KINASE 2; CYCLIN A; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; GLYCOGEN SYNTHASE KINASE 3BETA; LW 213; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WOGONIN; FLAVANONE DERIVATIVE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; LITHIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER TRANSPLANTATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MCF 7 CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; REGULATORY MECHANISM; UPREGULATION; XENOTRANSPLANTATION; ANIMAL; APOPTOSIS; BREAST NEOPLASMS; CELL PROLIFERATION; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; METABOLISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BETA CATENIN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; FLAVANONES; G2 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LITHIUM CHLORIDE; MCF-7 CELLS; MICE; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84946186463     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22321     Document Type: Article

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