GSK3β/β-catenin signaling is correlated with the differentiation of glioma cells induced by Wogonin

Toxicology Letters

Volumn 222, Issue 2, 2013, Pages 212-223

  Wang, Yajing ^a   Zhang, Yi ^a   Qian, Chen ^a   Cai, Min ^a   Li, Yan ^b   Li, Zhiyu ^a   You, Qidong ^a   Wang, Qing ^c   Hu, Rong ^a   Guo, Qinglong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b JIANGSU PROVINCIAL CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^c WUXI NO 2 PEOPLE S HOSPITAL   (China)

Author keywords

Cell cycle; Differentiation; Glioblastoma cells; GSK 3 catenin pathway; Wogonin

Indexed keywords

BETA CATENIN; CISPLATIN; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1B; DICKKOPF 1 PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCOGEN SYNTHASE KINASE 3; LITHIUM CHLORIDE; PROTEIN KINASE B; WOGONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CELL LINEAGE; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG MEGADOSE; ENZYME ACTIVATION; ENZYME INHIBITION; G1 PHASE CELL CYCLE CHECKPOINT; GENE OVEREXPRESSION; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SCUTELLARIA BAICALENSIS; SIGNAL TRANSDUCTION; TUMOR DIFFERENTIATION; TUMOR VOLUME; WESTERN BLOTTING;

CELL CYCLE; DIFFERENTIATION; GLIOBLASTOMA CELLS; GSK-3Β/Β-CATENIN PATHWAY; WOGONIN;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BETA CATENIN; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DRUGS, CHINESE HERBAL; FLAVANONES; G0 PHASE; GLIOMA; GLYCOGEN SYNTHASE KINASE 3; HUMANS; NEOPLASM TRANSPLANTATION; NERVE TISSUE PROTEINS; NEURONS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84883529991     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.07.013     Document Type: Article

References (43)

1. Benitez J.A., Arregui L., Cabrera G., Segovia J. Valproic acid induces polarization, neuronal-like differentiation of a subpopulation of C6 glioma cells and selectively regulates transgene expression. Neuroscience 2008, 156:911-920.
2. Bianchi M.G., Gazzola G.C., Tognazzi L., Bussolati O. C6 glioma cells differentiated by retinoic acid overexpress the glutamate transporter excitatory amino acid carrier 1 (EAAC1). Neuroscience 2008, 151:1042-1052.
3. Chang C.Y., Ma K.H., Wang J.K., Tung Y.L., Chueh S.H. Inhibition of protein kinase C promotes differentiation of neuroblastoma×glioma NG108-15 hybrid cells. European Journal of Neuroscience 2011, 34:1074-1084.
4. Chen Y.C., Shen S.C., Lee W.R., Lin H.Y., Ko C.H., Shih C.M., Yang L.L. Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1. Archives of Toxicology 2002, 76:351-359.
5. Cohen P., Frame S. The renaissance of GSK3. Nature Reviews in Molecular Cell Biology 2001, 2:769-776.
6. Cuevas P., Diaz-Gonzalez D., Dujovny M. Differentiation-inducing activity of neomycin in cultured rat glioma cells. Neurological Research 2004, 26:401-403.
7. Gao J., Morgan W.A., Sanchez-Medina A., Corcoran O. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Toxicology and Applied Pharmacology 2011, 254:221-228.
8. Georgopoulou N., Hurel C., Politis P.K., Gaitanou M., Matsas R., Thomaidou D. BM88 is a dual function molecule inducing cell cycle exit and neuronal differentiation of neuroblastoma cells via cyclin D1 down-regulation and retinoblastoma protein hypophosphorylation. Journal of Biological Chemistry 2006, 281:33606-33620.
9. Gil Y.G., Kang M.K. Capsaicin induces apoptosis and terminal differentiation in human glioma A172 cells. Life Science 2008, 82:997-1003.
10. Hai J., Lin Q., Zhang H., Lu Y., Yi J. Cyclic AMP-dependent regulation of differentiation of rat C6 glioma cells by panaxydol. Neurological Research 2009, 31:274-279.
11. He S., Zhu W., Zhou Y., Huang Y., Ou Y., Li Y., Yan G. Transcriptional and post-transcriptional down-regulation of cyclin D1 contributes to C6 glioma cell differentiation induced by forskolin. Journal of Cellular Biochemistry 2011, 112:2241-2249.
12. Huang K.F., Zhang G.D., Huang Y.Q., Diao Y. Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway. International Immunopharmacology 2011, 12:334-341.
13. Hui K.M., Huen M.S., Wang H.Y., Zheng H., Sigel E., Baur R., Ren H., Li Z.W., Wong J.T., Xue H. Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi. Biochemical Pharmacology 2002, 64:1415-1424.
14. Kawamata H., Tachibana M., Fujimori T., Imai Y. Differentiation-inducing therapy for solid tumors. Current Pharmaceutical Design 2006, 12:379-385.
15. Kiningham K.K., Cardozo Z.A., Cook C., Cole M.P., Stewart J.C., Tassone M., Coleman M.C., Spitz D.R. All-trans-retinoic acid induces manganese superoxide dismutase in human neuroblastoma through NF-kappaB. Free Radical Biology and Medicine 2008, 44:1610-1616.
16. Korur S., Huber R.M., Sivasankaran B., Petrich M., Morin P., Hemmings B.A., Merlo A., Lino M.M. GSK3beta regulates differentiation and growth arrest in glioblastoma. PLoS ONE 2009, 4:e7443.
17. Lee D.H., Lee T.H., Jung C.H., Kim Y.H. Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells. Cellular Signalling 2012, 24:2216-2225.
18. Leszczyniecka M., Roberts T., Dent P., Grant S., Fisher P.B. Differentiation therapy of human cancer: basic science and clinical applications. Pharmacology and Therapeutics 2001, 90:105-156.
19. Li-Weber M. New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treatment Reviews 2009, 35:57-68.
20. Li Y., Lu H., Huang Y., Xiao R., Cai X., He S., Yan G. Glycogen synthase kinases-3beta controls differentiation of malignant glioma cells. International Journal of Cancer 2010, 127:1271-1282.
21. Li Y., Lu H.M., Li G., Yan G.M. Glycogen synthase kinase-3beta regulates astrocytic differentiation of U87-MG human glioblastoma cells. Acta Pharmacologica Sinica 2010, 31:355-360.
22. Lim J.S., Yoo M., Kwon H.J., Kim H., Kwon Y.K. Wogonin induces differentiation and neurite outgrowth of neural precursor cells. Biochemical and Biophysical Research Communications 2010, 402:42-47.
23. Louis D.N., Ohgaki H., Wiestler O.D., Cavenee W.K., Burger P.C., Jouvet A., Scheithauer B.W., Kleihues P. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathologica 2007, 114:97-109.
24. Lu N., Gao Y., Ling Y., Chen Y., Yang Y., Gu H.Y., Qi Q., Liu W., Wang X.T., You Q.D., Guo Q.L. Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2. Life Science 2008, 82:956-963.
25. Massague J. G1 cell-cycle control and cancer. Nature 2004, 432:298-306.
26. Nurse P. A long twentieth century of the cell cycle and beyond. Cell 2000, 100:71-78.
27. Parajuli P., Joshee N., Chinni S.R., Rimando A.M., Mittal S., Sethi S., Yadav A.K. Delayed growth of glioma by Scutellaria flavonoids involve inhibition of Akt, GSK-3 and NF-kappa B signaling. Journal of Neuro-Oncology 2011, 101:15-24.
28. Parajuli P., Joshee N., Rimando A.M., Mittall S., Yadav A.K. In vitro antitumor mechanisms of various Scutellaria extracts and constituent flavonoids. Planta Medica 2009, 75:41-48.
29. Qi Q., Peng J., Liu W., You Q., Yang Y., Lu N., Wang G., Guo Q. Toxicological studies of wogonin in experimental animals. Phytotherapy Research 2009, 23:417-422.
30. Redova M., Chlapek P., Loja T., Zitterbart K., Hermanova M., Sterba J., Veselska R. Influence of LOX/COX inhibitors on cell differentiation induced by all-trans retinoic acid in neuroblastoma cell lines. International Journal of Molecular Medicine 2010, 25:271-280.
31. Shirsat N.V., Kayal J.J., Shaikh S., Mehta A. Growth inhibition and differentiation of C6 glioma cells on treatment with HMBA. Cell Biology International 2001, 25:621-627.
32. Siddikuzzaman Guruvayoorappan C., Berlin Grace V.M. All trans retinoic acid and cancer. Immunopharmacology and Immunotoxicology 2011, 33:241-249.
33. Takahashi-Yanaga F., Sasaguri T. GSK-3beta regulates cyclin D1 expression: a new target for chemotherapy. Cellular Signalling 2008, 20:581-589.
34. Tsai C.F., Yeh W.L., Huang S.M., Tan T.W., Lu D.Y. Wogonin induces reactive oxygen species production and cell apoptosis in human glioma cancer cells. International Journal of Molecular Sciences 2012, 13:9877-9892.
35. Tsai Y.J., Chen I.L., Horng L.Y., Wu R.T. Induction of differentiation in rat C6 glioma cells with Saikosaponins. Phytotherapy Research 2002, 16:117-121.
36. Wang C., Pattabiraman N., Zhou J.N., Fu M., Sakamaki T., Albanese C., Li Z., Wu K., Hulit J., Neumeister P., Novikoff P.M., Brownlee M., Scherer P.E., Jones J.G., Whitney K.D., Donehower L.A., Harris E.L., Rohan T., Johns D.C., Pestell R.G. Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation. Molecular and Cellular Biology 2003, 23:6159-6173.
37. Xu D., Huang Y.J., Li Y., Yin W., Yan G.M. Orphan nuclear receptor Nur77 is required for the differentiation of C6 glioma cells induced by cholera toxin. Acta Pharmacologica Sinica 2009, 30:1543-1549.
38. Xu M., Lu N., Zhang H., Dai Q., Wei L., Li Z., You Q., Guo Q. Wogonin induced cytotoxicity in human hepatocellular carcinoma cells by activation of unfolded protein response and inactivation of AKT. Hepatology Research 2012.
39. Yang L., Wang Q., Li D., Zhou Y., Zheng X., Sun H., Yan J., Zhang L., Lin Y., Wang X. Wogonin enhances antitumor activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo through ROS-mediated downregulation of cFLIPL and IAP proteins. Apoptosis 2013, 18:618-626.
40. Yang L., Zhang H.W., Hu R., Yang Y., Qi Q., Lu N., Liu W., Chu Y.Y., You Q.D., Guo Q.L. Wogonin induces G(1) phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21(Cip1) in human cervical carcinoma HeLa cells. Biochemistry and Cell Biology 2009, 87:933-942.
41. Zhang H.W., Yang Y., Zhang K., Qiang L., Yang L., Hu Y., Wang X.T., You Q.D., Guo Q.L. Wogonin induced differentiation and G1 phase arrest of human U-937 leukemia cells via PKCdelta phosphorylation. European Journal of Pharmacology 2008, 591:7-12.
42. Zhang K., Guo Q.L., You Q.D., Yang Y., Zhang H.W., Yang L., Gu H.Y., Qi Q., Tan Z., Wang X. Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression. Cancer Science 2008, 99:689-695.
43. Zhang R., Banik N.L., Ray S.K. Combination of all-trans retinoic acid and interferon-gamma upregulated p27(kip1) and down regulated CDK2 to cause cell cycle arrest leading to differentiation and apoptosis in human glioblastoma LN18 (PTEN-proficient) and U87MG (PTEN-deficient) cells. Cancer Chemotherapy and Pharmacology 2008, 62:407-416.