Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells

Toxicology

Volumn 312, Issue 1, 2013, Pages 36-47

  He, Licheng ^a   Lu, Na ^a   Dai, Qinsheng ^a   Zhao, Yue ^a   Zhao, Li ^a   Wang, Hu ^a   Li, Zhiyu ^a   You, Qidong ^a   Guo, Qinglong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

catenin; CDK8; Colorectal cancer; G1 arrest; Wogonin

Indexed keywords

BETA CATENIN; CYCLIN A; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 8; CYCLIN E; WNT PROTEIN; WOGONIN;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; CANCER CELL CULTURE; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME INACTIVATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

Β-CATENIN; ADENOMATOUS POLYSIS COIL; APC; AXIN; AXIS INHIBITION PROTEIN; CDK; CDK8; COLORECTAL CANCER; CYCLIN-DEPENDENT KINASES; DISHEVELED; DVL; G1 ARREST; GLYCOGEN SYNTHASE KINASE 3Β; GSK3Β; LEF; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN; LRP; LYMPHOID ENHANCER FACTOR; MED12; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 12 HOMOLOG; RB; RETINOBLASTOMA PROTEIN; T-CELL FACTOR; TCF; WOGONIN;

CELL SURVIVAL; COLORECTAL NEOPLASMS; CYCLIN-DEPENDENT KINASE 8; DRUGS, CHINESE HERBAL; FLAVANONES; G1 PHASE CELL CYCLE CHECKPOINTS; HCT116 CELLS; HUMANS; LYMPHOID ENHANCER-BINDING FACTOR 1; WNT SIGNALING PATHWAY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84882744881     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2013.07.013     Document Type: Review

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