Over-activation of TLR5 signaling by high-dose flagellin induces liver injury in mice

Cellular and Molecular Immunology

Volumn 12, Issue 6, 2015, Pages 729-742

  Xiao, Yang ^a   Liu, Fang ^a   Yang, Jingyi ^a   Zhong, Maohua ^a   Zhang, Ejuan ^a   Li, Yaoming ^a   Zhou, Dihan ^a   Cao, Yuan ^a   Li, Wei ^a   Yu, Jie ^a   Yang, Yi ^a   Yan, Huimin ^a  

^a WUHAN INSTITUTE OF VIROLOGY   (China)

Author keywords

flagellin; liver injury; pathological effect; TLR5

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; FLAGELLIN; GLUTATHIONE; INFLAMMASOME; INTERLEUKIN 8; MALONALDEHYDE; MONOCYTE CHEMOTACTIC PROTEIN 1; TOLL LIKE RECEPTOR 5; RECOMBINANT PROTEIN;

ADAPTIVE IMMUNITY; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GENE; BACTERIAL INFECTION; BLOOD SAMPLING; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FLIC GENE; FLUORESCENCE ACTIVATED CELL SORTING; GENE CONSTRUCT; GENE EXPRESSION; GENE SEQUENCE; HISTOPATHOLOGY; IMMUNOCOMPETENT CELL; INFLAMMATION; INNATE IMMUNITY; LIPID PEROXIDATION; LIVER FUNCTION; LIVER INJURY; LIVER NECROSIS; MACROPHAGE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SALMONELLA ENTERICA SEROVAR TYPHI; SIGNAL TRANSDUCTION; SPLEEN CELL; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CHEMISTRY; DEFICIENCY; DRUG EFFECTS; ESCHERICHIA COLI; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LIVER; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; PATHOGENICITY; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; SALMONELLA ENTERICA; TOXIC HEPATITIS;

AMINO ACID SEQUENCE; ANIMALS; CHEMICAL AND DRUG INDUCED LIVER INJURY; CLONING, MOLECULAR; ESCHERICHIA COLI; FEMALE; FLAGELLIN; GENE EXPRESSION REGULATION; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; NEUTROPHIL INFILTRATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SALMONELLA ENTERICA; SEQUENCE DELETION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 5;

EID: 84946050712     PISSN: 16727681     EISSN: 20420226     Source Type: Journal    
DOI: 10.1038/cmi.2014.110     Document Type: Article

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