-
1
-
-
67651091732
-
Patterns of pathogenesis: Discrimination of pathogenic and nonpathogenic microbes by the innate immune system
-
Vance RE, Isberg RR, Portnoy DA: Patterns of pathogenesis: Discrimination of pathogenic and nonpathogenic microbes by the innate immune system. Cell Host and Microbe 2009; 6: 10-21
-
(2009)
Cell Host and Microbe
, vol.6
, pp. 10-21
-
-
Vance, R.E.1
Isberg, R.R.2
Portnoy, D.A.3
-
2
-
-
33646183566
-
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large
-
Beutler B, Jiang Z, Georgel P, Crozat K, Croker B, Rutschmann S, Du X, Hoebe K: Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu Rev Immunol 2006; 24: 353-389
-
(2006)
Annu Rev Immunol
, vol.24
, pp. 353-389
-
-
Beutler, B.1
Jiang, Z.2
Georgel, P.3
Crozat, K.4
Croker, B.5
Rutschmann, S.6
Du, X.7
Hoebe, K.8
-
3
-
-
56549116047
-
Toll-like receptor and RIGI-like receptor signaling
-
Kawai T, Akira S: Toll-like receptor and RIGI-like receptor signaling. Ann NY Acad Sci 2008; 1143: 1-20
-
(2008)
Ann NY Acad Sci
, vol.1143
, pp. 1-20
-
-
Kawai, T.1
Akira, S.2
-
4
-
-
35349016235
-
Recognition of microorganisms and activation of the immune response
-
Medzhitov R: Recognition of microorganisms and activation of the immune response. Nature 2007; 449: 819-826
-
(2007)
Nature
, vol.449
, pp. 819-826
-
-
Medzhitov, R.1
-
5
-
-
79951578449
-
Inflammasomes: Current understanding and open questions
-
Bauernfeind F, Ablasser A, Bartok E, Kim S, Schmid-Burgk J, Cavlar T, Hornung V: Inflammasomes: Current understanding and open questions. Cell Mol Life Sci 2011; 68: 765-783
-
(2011)
Cell Mol Life Sci
, Issue.68
, pp. 765-783
-
-
Bauernfeind, F.1
Ablasser, A.2
Bartok, E.3
Kim, S.4
Schmid-Burgk, J.5
Cavlar, T.6
Hornung, V.7
-
6
-
-
0035953543
-
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
-
Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A: The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 2001; 410: 1099-1103
-
(2001)
Nature
, vol.410
, pp. 1099-1103
-
-
Hayashi, F.1
Smith, K.D.2
Ozinsky, A.3
Hawn, T.R.4
Yi, E.C.5
Goodlett, D.R.6
Eng, J.K.7
Akira, S.8
Underhill, D.M.9
Aderem, A.10
-
7
-
-
80053349020
-
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
-
Zhao Y, Yang J, Shi J, Gong Y-N, Lu Q, Xu H, Liu L, Shao F: The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature 2011; 477: 596-600
-
(2011)
Nature
, Issue.477
, pp. 596-600
-
-
Zhao, Y.1
Yang, J.2
Shi, J.3
Gong, Y.-N.4
Lu, Q.5
Xu, H.6
Liu, L.7
Shao, F.8
-
8
-
-
80053379974
-
Innate immune recognition of bacterial ligands by naips determines inflammasome specificity
-
Kofoed EM, Vance RE: Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 2011; 477: 592-595
-
(2011)
Nature
, Issue.477
, pp. 592-595
-
-
Kofoed, E.M.1
Vance, R.E.2
-
9
-
-
52549099416
-
Critical function for Naip5 in inflammasome activation by a conserved carboxy-Terminal domain of flagellin
-
Lightfield KL, Persson J, Brubaker SW, Witte CE, von Moltke J, Dunipace EA, Henry T, Sun YH, Cado D, Dietrich WF, Monack DM, Tsolis RM, Vance RE: Critical function for Naip5 in inflammasome activation by a conserved carboxy-Terminal domain of flagellin. Nat Immunol 2008; 9: 1171-1178
-
(2008)
Nat Immunol
, vol.9
, pp. 1171-1178
-
-
Lightfield, K.L.1
Persson, J.2
Brubaker, S.W.3
Witte, C.E.4
Von Moltke, J.5
Dunipace, E.A.6
Henry, T.7
Sun, Y.H.8
Cado, D.9
Dietrich, W.F.10
Monack, D.M.11
Tsolis, R.M.12
Vance, R.E.13
-
10
-
-
5644244144
-
Bacterial flagellins: Mediators of pathogenicity and host immune responses in mucosa
-
Ramos HC, Rumbo M, Sirard JC: Bacterial flagellins: Mediators of pathogenicity and host immune responses in mucosa. Trends Microbiol 2004; 12: 509-517
-
(2004)
Trends Microbiol
, vol.12
, pp. 509-517
-
-
Ramos, H.C.1
Rumbo, M.2
Sirard, J.C.3
-
11
-
-
0036800129
-
Role of EHEC O157:H7 virulence factors in the activation of intestinal epithelial cell Nf-κB and MAP kinase pathways and the upregulated expression of interleukin 8
-
Berin MC, Darfeuille-Michaud A, Egan LJ, Miyamoto Y, Kagnoff MF: Role of EHEC O157:H7 virulence factors in the activation of intestinal epithelial cell Nf-κB and MAP kinase pathways and the upregulated expression of interleukin 8. Cell Microbiol 2002; 4: 635-648
-
(2002)
Cell Microbiol
, vol.4
, pp. 635-648
-
-
Berin, M.C.1
Darfeuille-Michaud, A.2
Egan, L.J.3
Miyamoto, Y.4
Kagnoff, M.F.5
-
12
-
-
42049095095
-
An agonist of Tolllike receptor 5 has radioprotective activity in mouse and primate models
-
Burdelya LG, Krivokrysenko VI, Tallant TC, Strom E, Gleiberman AS, Gupta D, Kurnasov OV, Fort FL, Osterman AL, Didonato JA, Feinstein E, Gudkov AV: An agonist of Tolllike receptor 5 has radioprotective activity in mouse and primate models. Science 2008; 320: 226-230
-
(2008)
Science
, vol.320
, pp. 226-230
-
-
Burdelya, L.G.1
Krivokrysenko, V.I.2
Tallant, T.C.3
Strom, E.4
Gleiberman, A.S.5
Gupta, D.6
Kurnasov, O.V.7
Fort, F.L.8
Osterman, A.L.9
Didonato, J.A.10
Feinstein, E.11
Gudkov, A.V.12
-
13
-
-
0036671894
-
The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proil-β
-
Martinon F, Burns K, Tschopp J: The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol Cell 2002; 10: 417-426
-
(2002)
Mol Cell
, vol.10
, pp. 417-426
-
-
Martinon, F.1
Burns, K.2
Tschopp, J.3
-
15
-
-
0347776208
-
Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility
-
Smith KD, Andersen-Nissen E, Hayashi F, Strobe K, Bergman MA, Barrett SL, Cookson BT, Aderem A: Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility. Nat Immunol 2003; 4: 1247-1253
-
(2003)
Nat Immunol
, vol.4
, pp. 1247-1253
-
-
Smith, K.D.1
Andersen-Nissen, E.2
Hayashi, F.3
Strobe, K.4
Bergman, M.A.5
Barrett, S.L.6
Cookson, B.T.7
Aderem, A.8
-
16
-
-
0035892911
-
Salmonella flagellin-dependent proinflammatory responses are localized to the conserved amino and carboxyl regions of the protein
-
Eaves-Pyles TD, Wong HR, Odoms K, Pyles RB: Salmonella flagellin-dependent proinflammatory responses are localized to the conserved amino and carboxyl regions of the protein. J Immunol 2001; 167: 7009-7016
-
(2001)
J Immunol
, vol.167
, pp. 7009-7016
-
-
Eaves-Pyles, T.D.1
Wong, H.R.2
Odoms, K.3
Pyles, R.B.4
-
17
-
-
76749122801
-
Recombinant flagellins with partial deletions of the hypervariable domain lose antigenicity but not mucosal adjuvancy
-
Liu F, Yang J, Zhang Y, Zhou D, Chen Y, Gai W, Shi W, Li Q, Tien P, Yan H: Recombinant flagellins with partial deletions of the hypervariable domain lose antigenicity but not mucosal adjuvancy. Biochem Biophys Res Commun 2010; 392: 582-587
-
(2010)
Biochem Biophys Res Commun
, Issue.392
, pp. 582-587
-
-
Liu, F.1
Yang, J.2
Zhang, Y.3
Zhou, D.4
Chen, Y.5
Gai, W.6
Shi, W.7
Li, Q.8
Tien, P.9
Yan, H.10
-
18
-
-
49649129943
-
Deletion of flagellin's hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity
-
Nempont C, Cayet D, Rumbo M, Bompard C, Villeret V, Sirard JC: Deletion of flagellin's hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity. J Immunol 2008; 181: 2036-2043
-
(2008)
J Immunol
, vol.181
, pp. 2036-2043
-
-
Nempont, C.1
Cayet, D.2
Rumbo, M.3
Bompard, C.4
Villeret, V.5
Sirard, J.C.6
-
19
-
-
77957766952
-
A novel pathway for inducible nitric-oxide synthase activation through inflammasomes
-
Buzzo CL, Campopiano JC, Massis LM, Lage SL, Cassado AA, Leme-Souza R, Cunha LD, Russo M, Zamboni DS, Amarante-Mendes GP, Bortoluci KR: A novel pathway for inducible nitric-oxide synthase activation through inflammasomes. J Biol Chem 2010; 285: 32087-32095
-
(2010)
J Biol Chem
, Issue.285
, pp. 32087-32095
-
-
Buzzo, C.L.1
Campopiano, J.C.2
Massis, L.M.3
Lage, S.L.4
Cassado, A.A.5
Leme-Souza, R.6
Cunha, L.D.7
Russo, M.8
Zamboni, D.S.9
Amarante-Mendes, G.P.10
Bortoluci, K.R.11
-
20
-
-
84866501959
-
Flagellin-pac fusion protein is a highefficacy anti-caries mucosal vaccine
-
Sun Y, Shi W, Yang JY, Zhou DH, Chen Y, Zhang Y, Yang Y, He BX, Zhong MH, Li YM, Cao Y, Xiao Y, Li W, Yu J, Li YH, Fan MW, Yan H: Flagellin-PAc fusion protein is a highefficacy anti-caries mucosal vaccine. J Dent Res 2012; 91: 941-947
-
(2012)
J Dent Res
, Issue.91
, pp. 941-947
-
-
Sun, Y.1
Shi, W.2
Yang, J.Y.3
Zhou, D.H.4
Chen, Y.5
Zhang, Y.6
Yang, Y.7
He, B.X.8
Zhong, M.H.9
Li, Y.M.10
Cao, Y.11
Xiao, Y.12
Li, W.13
Yu, J.14
Li, Y.H.15
Fan, M.W.16
Yan, H.17
-
21
-
-
2342423630
-
Activation of raw264.7 macrophages by bacterial dna and lipopolysaccharide increases cell surface dna binding and internalization
-
McCoy SL, Kurtz SE, Hausman FA, Trune DR, Bennett RM, Hefeneider SH: Activation of RAW264.7 macrophages by bacterial DNA and lipopolysaccharide increases cell surface DNA binding and internalization. J Biol Chem 2004; 279: 17217-17223
-
(2004)
J Biol Chem
, vol.279
, pp. 17217-17223
-
-
McCoy, S.L.1
Kurtz, S.E.2
Hausman, F.A.3
Trune, D.R.4
Bennett, R.M.5
Hefeneider, S.H.6
-
22
-
-
15744389877
-
Gangliosides inhibit flagellin signaling in the absence of an effect on flagellin binding to Toll-like receptor 5
-
West AP, Dancho BA, Mizel SB: Gangliosides inhibit flagellin signaling in the absence of an effect on flagellin binding to Toll-like receptor 5. J Biol Chem 2005; 280: 9482-9488
-
(2005)
J Biol Chem
, vol.280
, pp. 9482-9488
-
-
West, A.P.1
Dancho, B.A.2
Mizel, S.B.3
-
23
-
-
33744493091
-
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf
-
Miao EA, Alpuche-Aranda CM, Dors M, Clark AE, Bader MW, Miller SI, Aderem A: Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf. Nat Immunol 2006; 7: 569-575
-
(2006)
Nat Immunol
, vol.7
, pp. 569-575
-
-
Miao, E.A.1
Alpuche-Aranda, C.M.2
Dors, M.3
Clark, A.E.4
Bader, M.W.5
Miller, S.I.6
Aderem, A.7
-
24
-
-
77649275262
-
Small interfering RNA (siRNA) delivery into murine bone marrow-derived macrophages by electroporation
-
Wiese M, Castiglione K, Hensel M, Schleicher U, Bogdan C, Jantsch J: Small interfering RNA (siRNA) delivery into murine bone marrow-derived macrophages by electroporation. J Immunol Methods 2010; 353: 102-110
-
(2010)
J Immunol Methods
, Issue.353
, pp. 102-110
-
-
Wiese, M.1
Castiglione, K.2
Hensel, M.3
Schleicher, U.4
Bogdan, C.5
Jantsch, J.6
-
25
-
-
84876986561
-
Antigen replacement of domains D2 and D3 in flagellin promotes mucosal IgA production and attenuates flagellin-induced inflammatory response after intranasal immunization
-
Yang J, Zhong M, Zhang Y, Zhang E, Sun Y, Cao Y, Li Y, Zhou D, He B, Chen Y, Yang Y, Yu J, Yan H: Antigen replacement of domains D2 and D3 in flagellin promotes mucosal IgA production and attenuates flagellin-induced inflammatory response after intranasal immunization. Hum Vaccin Immunother 2013;9:1084-1092
-
(2013)
Hum Vaccin Immunother
, Issue.9
, pp. 1084-1092
-
-
Yang, J.1
Zhong, M.2
Zhang, Y.3
Zhang, E.4
Sun, Y.5
Cao, Y.6
Li, Y.7
Zhou, D.8
He, B.9
Chen, Y.10
Yang, Y.11
Yu, J.12
Yan, H.13
-
26
-
-
84861172621
-
Lselectin and P-selectin are novel biomarkers of cervicovaginal inflammation for preclinical mucosal safety assessment of anti-HIV-1 microbicide
-
Zhong M, He B, Yang J, Bao R, Zhang Y, Zhou D, Chen Y, Li L, Han C, Yang Y, Sun Y, Cao Y, Li Y, Shi W, Jiang S, Zhang X, Yan H: Lselectin and P-selectin are novel biomarkers of cervicovaginal inflammation for preclinical mucosal safety assessment of anti-HIV-1 microbicide. Antimicrob Agents Chemother 2012; 56: 3121-3132
-
(2012)
Antimicrob Agents Chemother
, Issue.56
, pp. 3121-3132
-
-
Zhong, M.1
He, B.2
Yang, J.3
Bao, R.4
Zhang, Y.5
Zhou, D.6
Chen, Y.7
Li, L.8
Han, C.9
Yang, Y.10
Sun, Y.11
Cao, Y.12
Li, Y.13
Shi, W.14
Jiang, S.15
Zhang, X.16
Yan, H.17
-
27
-
-
79953315378
-
Differential requirements for NAIP5 in activation of the NLRC4 inflammasome
-
Lightfield KL, Persson J, Trinidad NJ, Brubaker SW, Kofoed EM, Sauer JD, Dunipace EA, Warren SE, Miao EA, Vance RE: Differential requirements for NAIP5 in activation of the NLRC4 inflammasome. Infect Immun 2011; 79: 1606-1614
-
(2011)
Infect Immun
, Issue.79
, pp. 1606-1614
-
-
Lightfield, K.L.1
Persson, J.2
Trinidad, N.J.3
Brubaker, S.W.4
Kofoed, E.M.5
Sauer, J.D.6
Dunipace, E.A.7
Warren, S.E.8
Miao, E.A.9
Vance, R.E.10
-
28
-
-
60749119489
-
Induction of adaptive immunity by flagellin does not require robust activation of innate immunity
-
Sanders CJ, Franchi L, Yarovinsky F, Uematsu S, Akira S, Nunez G, Gewirtz AT: Induction of adaptive immunity by flagellin does not require robust activation of innate immunity. Eur J Immunol 2009; 39: 359-371
-
(2009)
Eur J Immunol
, vol.39
, pp. 359-371
-
-
Sanders, C.J.1
Franchi, L.2
Yarovinsky, F.3
Uematsu, S.4
Akira, S.5
Nunez, G.6
Gewirtz, A.T.7
-
29
-
-
0029979369
-
Biologic basis for interleukin-1 in disease
-
Dinarello CA: Biologic basis for interleukin-1 in disease. Blood 1996; 87: 2095-2147
-
(1996)
Blood
, vol.87
, pp. 2095-2147
-
-
Dinarello, C.A.1
-
30
-
-
78449269290
-
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
-
Miao EA, Leaf IA, Treuting PM, Mao DP, Dors M, Sarkar A, Warren SE, Wewers MD, Aderem A: Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol 2010; 11: 1136-1142
-
(2010)
Nat Immunol
, Issue.11
, pp. 1136-1142
-
-
Miao, E.A.1
Leaf, I.A.2
Treuting, P.M.3
Mao, D.P.4
Dors, M.5
Sarkar, A.6
Warren, S.E.7
Wewers, M.D.8
Aderem, A.9
-
31
-
-
40649090426
-
Pseudomonas aeruginosa activates caspase 1 through Ipaf
-
Miao EA, Ernst RK, Dors M, Mao DP, Aderem A: Pseudomonas aeruginosa activates caspase 1 through Ipaf. Proc Natl Acad Sci USA 2008; 105: 2562-2567
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 2562-2567
-
-
Miao, E.A.1
Ernst, R.K.2
Dors, M.3
Mao, D.P.4
Aderem, A.5
-
32
-
-
33645843633
-
Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection
-
Molofsky AB, Byrne BG, Whitfield NN, Madigan CA, Fuse ET, Tateda K, Swanson MS: Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. J Exp Med 2006; 203: 1093-1104
-
(2006)
J Exp Med
, vol.203
, pp. 1093-1104
-
-
Molofsky, A.B.1
Byrne, B.G.2
Whitfield, N.N.3
Madigan, C.A.4
Fuse, E.T.5
Tateda, K.6
Swanson, M.S.7
-
33
-
-
33645791082
-
Flagellin-deficient Legionella mutants evade caspase-1-And Naip5-mediated macrophage immunity
-
Ren T, Zamboni DS, Roy CR, Dietrich WF, Vance RE: Flagellin-deficient Legionella mutants evade caspase-1-And Naip5-mediated macrophage immunity. PLoS Pathog 2006; 2:e18
-
(2006)
PLoS Pathog
, vol.2
-
-
Ren, T.1
Zamboni, D.S.2
Roy, C.R.3
Dietrich, W.F.4
Vance, R.E.5
-
34
-
-
33744464740
-
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages
-
Franchi L, Amer A, Body-Malapel M, Kanneganti TD, Ozoren N, Jagirdar R, Inohara N, Vandenabeele P, Bertin J, Coyle A, Grant EP, Nunez G: Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages. Nat Immunol 2006; 7: 576-582
-
(2006)
Nat Immunol
, vol.7
, pp. 576-582
-
-
Franchi, L.1
Amer, A.2
Body-Malapel, M.3
Kanneganti, T.D.4
Ozoren, N.5
Jagirdar, R.6
Inohara, N.7
Vandenabeele, P.8
Bertin, J.9
Coyle, A.10
Grant, E.P.11
Nunez, G.12
-
35
-
-
33845890803
-
Inflammasome adaptors and sensors: Intracellular regulators of infection and inflammation
-
Mariathasan S, Monack DM: Inflammasome adaptors and sensors: Intracellular regulators of infection and inflammation. Nat Rev Immunol 2007; 7: 31-40
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 31-40
-
-
Mariathasan, S.1
Monack, D.M.2
-
36
-
-
84859911615
-
NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense
-
Franchi L, Kamada N, Nakamura Y, Burberry A, Kuffa P, Suzuki S, Shaw MH, Kim YG, Nunez G: NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense. Nat Immunol 2012; 13: 449-456
-
(2012)
Nat Immunol
, Issue.13
, pp. 449-456
-
-
Franchi, L.1
Kamada, N.2
Nakamura, Y.3
Burberry, A.4
Kuffa, P.5
Suzuki, S.6
Shaw, M.H.7
Kim, Y.G.8
Nunez, G.9
-
37
-
-
21544448078
-
Evasion of Toll-like receptor 5 by flagellated bacteria
-
Andersen-Nissen E, Smith KD, Strobe KL, Barrett SL, Cookson BT, Logan SM, Aderem A: Evasion of Toll-like receptor 5 by flagellated bacteria. Proc Natl Acad Sci USA 2005; 102: 9247-9252
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 9247-9252
-
-
Andersen-Nissen, E.1
Smith, K.D.2
Strobe, K.L.3
Barrett, S.L.4
Cookson, B.T.5
Logan, S.M.6
Aderem, A.7
-
39
-
-
78649605448
-
TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin
-
Vijay-Kumar M, Carvalho FA, Aitken JD, Fifadara NH, Gewirtz AT: TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin. Eur J Immunol 2010; 40: 3528-3534
-
(2010)
Eur J Immunol
, Issue.40
, pp. 3528-3534
-
-
Vijay-Kumar, M.1
Carvalho, F.A.2
Aitken, J.D.3
Fifadara, N.H.4
Gewirtz, A.T.5
|