Genetics of common forms of heart failure: Challenges and potential solutions

Current Opinion in Cardiology

Volumn 30, Issue 3, 2015, Pages 222-227

  Rau, Christoph D ^a   Lusis, Aldons J ^b   Wang, Yibin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

animal model; genome wide association studies; heart failure; intermediate phenotype

Indexed keywords

BLOOD PRESSURE; BLOOD VESSEL WALL; CHROMOSOME 1; CHROMOSOME 10; CHROMOSOME 12; CHROMOSOME 15; CHROMOSOME 17; CHROMOSOME 3; CHROMOSOME 5; CHROMOSOME 6; CLINICAL FEATURE; CONGESTIVE CARDIOMYOPATHY; DIET; ENVIRONMENTAL FACTOR; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC STRAIN; GENETIC VARIABILITY; HEART EJECTION FRACTION; HEART FAILURE; HEREDITY; HUMAN; LINKAGE ANALYSIS; LIPID BLOOD LEVEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SEDENTARY LIFESTYLE; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY;

GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HEART FAILURE; HUMANS; PHENOTYPE;

EID: 84928557361     PISSN: 02684705     EISSN: 15317080     Source Type: Journal    
DOI: 10.1097/HCO.0000000000000160     Document Type: Review

References (38)

1. Go AS, Mozaffarian D, Roger VL, et al. Heart disease and stroke statistics: 2013 update-a report from the American Heart Association. Circulation 2013; 127:e6-e245.
2. Ford ES, Capewell S. Proportion of the decline in cardiovascular mortality disease due to prevention versus treatment: public health versus clinical care. Annu Rev Public Health 2011; 32:5-22.
3. Hall MJ, Levant S, DeFrances CJ. Hospitalization for congestive heart failure: United States, 2000-2010. NCHS Data Brief 2012:1-8.
4. KrumholzHM, Chen YT,Wang Y, et al. Predictors of readmission among elderly survivors of admission with heart failure. Am Heart J 2000; 139:72-77.
5. Parsa A, Chang Y-PC, Kelly RJ, et al. Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality. Clin Transl Sci 2011; 4:17-23.
6. Villard E, Perret C, Gary F, et al. A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy. Eur Heart J 2011; 32:1065-1076.
7. Morrison AC, Felix JF, Cupples LA, et al. Genomic variation associated with mortality among adults of European and African ancestry with heart failure: The cohorts for heart and aging research in genomic epidemiology consortium. Circ Cardiovasc Genet 2010; 3:248-255.
8. Larson MG, Atwood LD, Benjamin EJ, et al. Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes. BMC Med Genet 2007; 8 (Suppl 1):S5.
9. Stranger BE, Stahl EA, Raj T. Progress and promise of genome-wide association studies for human complex trait genetics. Genetics 2011; 187:367-383.
10. Teslovich TM, Musunuru K, Smith AV, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010; 466:707-713.
11. Vasan RS, Glazer NL, Felix JF, et al. Genetic variants associated with cardiac structure and function: A meta-analysis and replication of genome-wide association data. JAMA 2009; 302:168-178.
12. Fox ER, Musani SK, Barbalic M, et al. Genome-wide association study of cardiac structure and systolic function in African Americans: The Candidate Gene Association Resource (CARe) study. Circ Cardiovasc Genet 2013; 6:37-46.
13. Post WS, Larson MG, Myers RH, et al. Heritability of left ventricular mass: The Framingham Heart Study. Hypertension 1997; 30:1025-1028.
14. Swan L, Birnie DH, Padmanabhan S, et al. The genetic determination of left ventricular mass in healthy adults. Eur Heart J 2003; 24:577-582.
15. Smith NL, Felix JF, Morrison AC, et al. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: A prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. Circ Cardiovasc Genet 2010; 3:256-266.
16. Meder B, Rü hle F, Weis T, et al. A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy. Eur Heart J 2014; 35:1069-1077.
17. Cappola TP, Li M, He J, et al. Common variants in HSPB7 and FRMD4B associated with advanced heart failure. Circ Cardiovasc Genet 2010; 3:147-154.
18. Yu B, Zheng Y, Alexander D, et al. Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. Genet Epidemiol 2013; 37:840-845.
19. De Jong S, Zwanenburg JJ, Visser F, et al. Direct detection of myocardial fibrosis by MRI. J Mol Cell Cardiol 2011; 51:974-979.
20. Creemers EE, Wilde AA, Pinto YM. Heart failure: Advances through genomics. Nat Rev Genet 2011; 12:357-362.
21. Breckenridge R. Heart failure and mouse models. Dis Model Mech 2010; 3:138-143.
22. Patten RD, Hall-Porter MR. Small animal models of heart failure: development of novel therapies, past and present. Circ Heart Fail 2009; 2:138-144.
23. Zaragoza C, Gomez-Guerrero C, Martin-Ventura JL, et al. Animal models of cardiovascular diseases. J Biomed Biotechnol 2011; 2011:497841.
24. Wheeler FC, Tang H, Marks OA, et al. Tnni3k modifies disease progression in murine models of cardiomyopathy. PLoS Genet 2009; 5:e1000647.
25. Le Corvoisier P, Park H-Y, Carlson KM, et al. Multiple quantitative trait loci modify the heart failure phenotype in murine cardiomyopathy. Hum Mol Genet 2003; 12:3097-3107.
26. Suzuki M. Genetic modifier loci affecting survival and cardiac function in murine dilated cardiomyopathy. Circulation 2002; 105:1824-1829.
27. Wheeler FC, Fernandez L, Carlson KM, et al. QTL mapping in a mouse model of cardiomyopathy reveals an ancestral modifier allele affecting heart function and survival. Mamm Genome 2005; 16:414-423.
28. McDermott-Roe C, Ye J, Ahmed R, et al. Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function. Nature 2011; 7367:114-118.
29. Philipp U, Broschk C, Vollmar A, DistlO. Evaluation of tafazzin as candidate for dilated cardiomyopathy in Irish wolfhounds. J Hered 2007; 98:506-509.
30. Meurs KM, Fox PR, Norgard M, et al. A prospective genetic evaluation of familial dilated cardiomyopathy in the Doberman pinscher. J Vet Intern Med 2007; 21:1016-1020.
31. Werner P, Raducha MG, Prociuk U, et al. A novel locus for dilated cardiomyopathy maps to canine chromosome 8. Genomics 2008; 91:517-521.
32. Okazaki Y, Okuizumi H, Ohsumi T, et al. A genetic linkage map of the Syrian hamster and localization of cardiomyopathy locus on chromosome 9qa2.1-b1 using RLGS spot-mapping. Nat Genet 1996; 13:87-90.
33. Kang HM, Zaitlen NA, Wade CM, et al. Efficient control of population structure in model organism association mapping. Genetics 2008; 178:1709-1723.
34. Lippert C, Listgarten J, Liu Y, et al. FaST linear mixed models for genome-wide association studies. Nat Methods 2011; 8:833-835.
35. Lanfear DE, Yang JJ, Mishra S, Sabbah HN. Genome-wide approach to identify novel candidate genes for beta blocker response in heart failure using an experimental model. Discov Med 2011; 11:359-366.
36. Meurs KM, Lahmers S, Keene BW, et al. A splice site mutation in a gene encoding for PDK4, a mitochondrial protein, is associated with the development of dilated cardiomyopathy in the Doberman pinscher. Hum Genet 2012; 131:1319-1325.
37. Rau CD, Wang J, Avetisyan R, et al. Mapping genetic contributions to cardiac pathology induced by beta-adrenergic stimulation in mice. Circ Cardiovasc Genet 2015; 8:40-49.
38. Hersch M, Peter B, Kang HM, et al. Mapping genetic variants associated with beta-adrenergic responses in inbred mice. PLoS One 2012; 7:e41032.