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Volumn 2, Issue 12, 2014, Pages

Endurance exercise induces REDD1 expression and transiently decreases mTORC1 signaling in rat skeletal muscle

Author keywords

4E BP1; MTORC1; Protein synthesis; REDD1; S6K1

Indexed keywords

ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN KINASE; ADENOSINE TRIPHOSPHATE; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; PEPTIDES AND PROTEINS; PROTEIN KINASE; REGULATED IN DEVELOPMENT AND DNA DAMAGE RESPONSE 1; S6 KINASE; SERINE; THREONINE; UNCLASSIFIED DRUG;

EID: 85003502867     PISSN: None     EISSN: 2051817X     Source Type: Journal    
DOI: 10.14814/phy2.12254     Document Type: Article
Times cited : (31)

References (50)
  • 1
    • 18144386162 scopus 로고    scopus 로고
    • Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation
    • Atherton, P. J., J. Babraj, K. Smith, J. Singh, M. J. Rennie, and H. Wackerhage. 2005. Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation. FASEB J. 19:786-788
    • (2005) FASEB J , vol.19 , pp. 786-788
    • Atherton, P.J.1    Babraj, J.2    Smith, K.3    Singh, J.4    Rennie, M.J.5    Wackerhage, H.6
  • 2
    • 0032948278 scopus 로고    scopus 로고
    • Phosphorylation of p70S6k correlates with increased skeletal muscle mass following resistance exercise
    • Baar, K., and K. Esser. 1999. Phosphorylation of p70S6k correlates with increased skeletal muscle mass following resistance exercise. Am. J. Physiol. 276:C120-C127.
    • (1999) Am. J. Physiol , vol.276 , pp. C120-C127
    • Baar, K.1    Esser, K.2
  • 3
    • 0028914883 scopus 로고
    • Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans
    • Biolo, G., S. P. Maggi, B. D. Williams, K. D. Tipton, and R. R. Wolfe. 1995. Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans. Am. J. Physiol. 268:E514-E520.
    • (1995) Am. J. Physiol , vol.268 , pp. E514-E520
    • Biolo, G.1    Maggi, S.P.2    Williams, B.D.3    Tipton, K.D.4    Wolfe, R.R.5
  • 4
    • 0142062041 scopus 로고    scopus 로고
    • Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: A dose-response study
    • Boh_e, J., A. Low, R. R. Wolfe, and M. J. Rennie. 2003. Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose-response study. J. Physiol. 552:315-324
    • (2003) J. Physiol , vol.552 , pp. 315-324
    • Boh_E, J.1    Low, A.2    Wolfe, R.R.3    Rennie, M.J.4
  • 5
    • 10044276783 scopus 로고    scopus 로고
    • Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
    • Brugarolas, J., K. Lei, R. L. Hurley, B. D. Manning, J. H. Reiling, E. Hafen, et al. 2004. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev. 18:2893-2904
    • (2004) Genes Dev , vol.18 , pp. 2893-2904
    • Brugarolas, J.1    Lei, K.2    Hurley, R.L.3    Manning, B.D.4    Reiling, J.H.5    Hafen, E.6
  • 6
    • 0028802746 scopus 로고
    • A hierarchy of ATP-consuming processes in mammalian cells
    • Buttgereit, F., and M. D. Brand. 1995. A hierarchy of ATP-consuming processes in mammalian cells. Biochem. J. 312:163-167
    • (1995) Biochem. J , vol.312 , pp. 163-167
    • Buttgereit, F.1    Brand, M.D.2
  • 8
    • 77957348890 scopus 로고    scopus 로고
    • Early time course of Akt phosphorylation after endurance and resistance exercise
    • Camera, D. M., J. Edge, M. J. Short, J. A. Hawley, and V. G. Coffey. 2010. Early time course of Akt phosphorylation after endurance and resistance exercise. Med. Sci. Sports Exerc. 42:1843-1852
    • (2010) Med. Sci. Sports Exerc , vol.42 , pp. 1843-1852
    • Camera, D.M.1    Edge, J.2    Short, M.J.3    Hawley, J.A.4    Coffey, V.G.5
  • 9
    • 0025165834 scopus 로고
    • Effect of exercise and recovery on muscle protein synthesis in human subjects
    • Carraro, F., C. A. Stuart, W. H. Hartl, J. Rosenblatt, and R. R. Wolfe. 1990. Effect of exercise and recovery on muscle protein synthesis in human subjects. Am. J. Physiol. 259: E470-E476.
    • (1990) Am. J. Physiol , vol.259 , pp. E470-E476
    • Carraro, F.1    Stuart, C.A.2    Hartl, W.H.3    Rosenblatt, J.4    Wolfe, R.R.5
  • 11
    • 38949116663 scopus 로고    scopus 로고
    • Effects of resistance exercise with and without creatine supplementation on gene expression and cell signaling in human skeletal muscle
    • Deldicque, L., P. Atherton, R. Pate, D. Theisen, H. Nielens, M. J. Rennie, et al. 2008b. Effects of resistance exercise with and without creatine supplementation on gene expression and cell signaling in human skeletal muscle. J. Appl. Physiol. (1985) 104:371-378
    • (2008) J. Appl. Physiol. (1985) , vol.104 , pp. 371-378
    • Deldicque, L.1    Atherton, P.2    Pate, R.3    Theisen, D.4    Nielens, H.5    Rennie, M.J.6
  • 12
    • 33749351995 scopus 로고    scopus 로고
    • Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle
    • Dreyer, H. C., S. Fujita, J. G. Cadenas, D. L. Chinkes, E. Volpi, and B. B. Rasmussen. 2006. Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. J. Physiol. 576:613-624
    • (2006) J. Physiol , vol.576 , pp. 613-624
    • Dreyer, H.C.1    Fujita, S.2    Cadenas, J.G.3    Chinkes, D.L.4    Volpi, E.5    Rasmussen, B.B.6
  • 13
    • 38949126221 scopus 로고    scopus 로고
    • Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle
    • Dreyer, H. C., M. J. Drummond, B. Pennings, S. Fujita, E. L. Glynn, D. L. Chinkes, et al. 2008. Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle. Am. J. Physiol. 294:E392-E400.
    • (2008) Am. J. Physiol , vol.294 , pp. E392-E400
    • Dreyer, H.C.1    Drummond, M.J.2    Pennings, B.3    Fujita, S.4    Glynn, E.L.5    Chinkes, D.L.6
  • 15
    • 66149097065 scopus 로고
    • Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling
    • 2009
    • Drummond, M. J., H. C. Dreyer, C. S. Fry, E. L. Glynn, and B. B. Rasmussen. 2009. Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling. J. Appl. Physiol. (1985) 106:1374-1384
    • (1985) J. Appl. Physiol , vol.106 , pp. 1374-1384
    • Drummond, M.J.1    Dreyer, H.C.2    Fry, C.S.3    Glynn, E.L.4    Rasmussen, B.B.5
  • 16
    • 0036298152 scopus 로고    scopus 로고
    • Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles
    • Durante, P. E., K. J. Mustard, S. H. Park, W. W. Winder, and D. G. Hardie. 2002. Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles. Am. J. Physiol. 283:E178-E186.
    • (2002) Am. J. Physiol , vol.283 , pp. E178-E186
    • Durante, P.E.1    Mustard, K.J.2    Park, S.H.3    Winder, W.W.4    Hardie, D.G.5
  • 17
    • 84880318105 scopus 로고    scopus 로고
    • Mammalian target of rapamycin pathway is up-regulated by both acute endurance exercise and chronic muscle contraction in rat skeletal muscle
    • Edgett, B. A., M. L. Fortner, A. Bonen, and B. J. Gurd. 2013. Mammalian target of rapamycin pathway is up-regulated by both acute endurance exercise and chronic muscle contraction in rat skeletal muscle. Appl. Physiol. Nutr. Metab. 38:862-869
    • (2013) Appl. Physiol. Nutr. Metab , vol.38 , pp. 862-869
    • Edgett, B.A.1    Fortner, M.L.2    Bonen, A.3    Gurd, B.J.4
  • 19
    • 0031935851 scopus 로고    scopus 로고
    • Availability of eIF4E regulates skeletal muscle protein synthesis during recovery from exercise
    • Gautsch, T. A., J. C. Anthony, S. R. Kimball, G. L. Paul, D. K. Layman, and L. S. Jefferson. 1998. Availability of eIF4E regulates skeletal muscle protein synthesis during recovery from exercise. Am. J. Physiol. 274:C406-C414.
    • (1998) Am. J. Physiol , vol.274 , pp. C406-C414
    • Gautsch, T.A.1    Anthony, J.C.2    Kimball, S.R.3    Paul, G.L.4    Layman, D.K.5    Jefferson, L.S.6
  • 20
    • 79954618679 scopus 로고    scopus 로고
    • Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique
    • Goodman, C. A., D. M. Mabrey, J. W. Frey, M. H. Miu, E. K. Schmidt, P. Pierre, et al. 2011. Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique. FASEB J. 25:1028-1039.
    • (2011) FASEB J , vol.25 , pp. 1028-1039
    • Goodman, C.A.1    Mabrey, D.M.2    Frey, J.W.3    Miu, M.H.4    Schmidt, E.K.5    Pierre, P.6
  • 21
    • 84908052263 scopus 로고    scopus 로고
    • Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction
    • Gordon, B. S., J. L. Steiner, C. H. Lang, L. S. Jefferson, and S. R. Kimball. 2014. Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction. Am. J. Physiol. 307:E703-E711.
    • (2014) Am. J. Physiol , vol.307 , pp. E703-E711
    • Gordon, B.S.1    Steiner, J.L.2    Lang, C.H.3    Jefferson, L.S.4    Kimball, S.R.5
  • 22
    • 84880709668 scopus 로고    scopus 로고
    • MTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin
    • Kang, S. A., M. E. Pacold, C. L. Cervantes, D. Lim, H. J. Lou, K. Ottina, et al. 2013. mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science 341:1236566.
    • (2013) Science , vol.341
    • Kang, S.A.1    Pacold, M.E.2    Cervantes, C.L.3    Lim, D.4    Lou, H.J.5    Ottina, K.6
  • 23
    • 84872369332 scopus 로고    scopus 로고
    • The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb
    • Kelleher, A. R., S. R. Kimball, M. D. Dennis, R. J. Schilde, and L. S. Jefferson. 2013. The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb. Am. J. Physiol. 304:E229-E236.
    • (2013) Am. J. Physiol , vol.304 , pp. E229-E236
    • Kelleher, A.R.1    Kimball, S.R.2    Dennis, M.D.3    Schilde, R.J.4    Jefferson, L.S.5
  • 24
    • 84929458808 scopus 로고    scopus 로고
    • Changes in REDD1, REDD2, and atrogene mRNA expression are prevented in skeletal muscle fixed in a stretched position during hindlimb immobilization
    • Kelleher, A. R., B. S. Gordon, S. R. Kimball, and L. S. Jefferson. 2014. Changes in REDD1, REDD2, and atrogene mRNA expression are prevented in skeletal muscle fixed in a stretched position during hindlimb immobilization. Physiol. Rep. 2:e00246.
    • (2014) Physiol. Rep , vol.2
    • Kelleher, A.R.1    Gordon, B.S.2    Kimball, S.R.3    Jefferson, L.S.4
  • 25
    • 77956556496 scopus 로고    scopus 로고
    • Control of translation initiation through integration of signals generated by hormones, nutrients, and exercise
    • Kimball, S. R., and L. S. Jefferson. 2010. Control of translation initiation through integration of signals generated by hormones, nutrients, and exercise. J. Biol. Chem. 285:29027-29032
    • (2010) J. Biol. Chem , vol.285 , pp. 29027-29032
    • Kimball, S.R.1    Jefferson, L.S.2
  • 26
    • 41249094257 scopus 로고    scopus 로고
    • Rapid turnover of the mTOR complex 1 (MTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis
    • Kimball, S. R., A. N. Do, L. Kutzler, D. R. Cavener, and L. S. Jefferson. 2008. Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis. J. Biol. Chem. 283:3465-3475
    • (2008) J. Biol. Chem , vol.283 , pp. 3465-3475
    • Kimball, S.R.1    Do, A.N.2    Kutzler, L.3    Cavener, D.R.4    Jefferson, L.S.5
  • 28
    • 80053911646 scopus 로고    scopus 로고
    • Post-exercise protein synthesis rates are only marginally higher in type I compared with type II muscle fibres following resistance-type exercise
    • Koopman, R., B. G. Gleeson, A. P. Gijsen, B. Groen, J. M. Senden, M. J. Rennie, et al. 2011. Post-exercise protein synthesis rates are only marginally higher in type I compared with type II muscle fibres following resistance-type exercise. Eur. J. Appl. Physiol. 111:1871-1878.
    • (2011) Eur. J. Appl. Physiol , vol.111 , pp. 1871-1878
    • Koopman, R.1    Gleeson, B.G.2    Gijsen, A.P.3    Groen, B.4    Senden, J.M.5    Rennie, M.J.6
  • 29
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • Laplante, M., and D. M. Sabatini. 2012. mTOR signaling in growth control and disease. Cell 149:274-293
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 30
    • 78549235463 scopus 로고    scopus 로고
    • Skeletal muscle gene expression in response to resistance exercise: Sex specific regulation
    • Liu, D., M. A. Sartor, G. A. Nader, L. Gutmann, M. K. Treutelaar, E. E. Pistilli, et al. 2010. Skeletal muscle gene expression in response to resistance exercise: sex specific regulation. BMC Genom. 11:659.
    • (2010) BMC Genom , vol.11 , pp. 659
    • Liu, D.1    Sartor, M.A.2    Nader, G.A.3    Gutmann, L.4    Treutelaar, M.K.5    Pistilli, E.E.6
  • 31
    • 84879250657 scopus 로고    scopus 로고
    • Mammalian target of rapamycin-independent S6K1 and 4E-BP1 phosphorylation during contraction in rat skeletal muscle
    • Liu, Y., D. Vertommen, M. H. Rider, and Y. C. Lai. 2013. Mammalian target of rapamycin-independent S6K1 and 4E-BP1 phosphorylation during contraction in rat skeletal muscle. Cell. Signal. 25:1877-1886
    • (2013) Cell. Signal , vol.25 , pp. 1877-1886
    • Liu, Y.1    Vertommen, D.2    Rider, M.H.3    Lai, Y.C.4
  • 32
    • 34547683916 scopus 로고    scopus 로고
    • Changes in signalling pathways regulating protein synthesis in human muscle in the recovery period after endurance exercise
    • Mascher, H., H. Andersson, P. A. Nilsson, B. Ekblom, and E. Blomstrand. 2007. Changes in signalling pathways regulating protein synthesis in human muscle in the recovery period after endurance exercise. Acta Physiol. (Oxf) 191:67-75
    • (2007) Acta Physiol. (Oxf) , vol.191 , pp. 67-75
    • Mascher, H.1    Andersson, H.2    Nilsson, P.A.3    Ekblom, B.4    Blomstrand, E.5
  • 33
    • 79955663097 scopus 로고    scopus 로고
    • Enhanced rates of muscle protein synthesis and elevated mTOR signalling following endurance exercise in human subjects
    • Mascher, H., B. Ekblom, O. Rooyacker, and E. Blomstrand. 2011. Enhanced rates of muscle protein synthesis and elevated mTOR signalling following endurance exercise in human subjects. Acta Physiol. (Oxf) 202:175-184
    • (2011) Acta Physiol. (Oxf) , vol.202 , pp. 175-184
    • Mascher, H.1    Ekblom, B.2    Rooyacker, O.3    Blomstrand, E.4
  • 34
    • 65349086122 scopus 로고    scopus 로고
    • Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD
    • McGhee, N. K., L. S. Jefferson, and S. R. Kimbal. 2009. Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD. J. Nutr. 139:828-834
    • (2009) J. Nutr , vol.139 , pp. 828-834
    • McGhee, N.K.1    Jefferson, L.S.2    Kimbal, S.R.3
  • 35
    • 66149100909 scopus 로고
    • Cellular mechanisms regulating protein synthesis and skeletal muscle hypertrophy in animals
    • 2009
    • Miyazaki, M., and K. A. Esser. 2009. Cellular mechanisms regulating protein synthesis and skeletal muscle hypertrophy in animals. J. Appl. Physiol. (1985) 106:1367-1373.
    • (1985) J. Appl. Physiol , vol.106 , pp. 1367-1373
    • Miyazaki, M.1    Esser, K.A.2
  • 36
    • 41949089334 scopus 로고
    • Adding protein to a carbohydrate supplement provided after endurance exercise enhances 4E-BP1 and RPS6 signaling in skeletal muscle
    • 2008
    • Morrison, P. J., D. Hara, Z. Ding, and J. L. Ivy. 2008. Adding protein to a carbohydrate supplement provided after endurance exercise enhances 4E-BP1 and RPS6 signaling in skeletal muscle. J. Appl. Physiol. (1985) 104:1029-1036
    • (1985) J. Appl. Physiol , vol.104 , pp. 1029-1036
    • Morrison, P.J.1    Hara, D.2    Ding, Z.3    Ivy, J.L.4
  • 37
    • 79951958957 scopus 로고    scopus 로고
    • Rapid induction of REDD1 expression by endurance exercise in rat skeletal muscle
    • Murakami, T., K. Hasegawa, and M. Yoshinaga. 2011. Rapid induction of REDD1 expression by endurance exercise in rat skeletal muscle. Biochem. Biophys. Res. Commun. 405:615-619.
    • (2011) Biochem. Biophys. Res. Commun , vol.405 , pp. 615-619
    • Murakami, T.1    Hasegawa, K.2    Yoshinaga, M.3
  • 38
    • 28244435131 scopus 로고    scopus 로고
    • Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men
    • Rose, A. J., C. Broholm, K. Kiillerich, S. G. Finn, C. G. Proud, M. H. Rider, et al. 2005. Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men. J. Physiol. 569:223-228
    • (2005) J. Physiol , vol.569 , pp. 223-228
    • Rose, A.J.1    Broholm, C.2    Kiillerich, K.3    Finn, S.G.4    Proud, C.G.5    Rider, M.H.6
  • 39
    • 63849188637 scopus 로고    scopus 로고
    • A Ca2+-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions
    • Rose, A. J., T. J. Alsted, T. K. Jensen, J. B. Kobbero, S. J. Maarbjerg, J. Jensen, et al. 2009. A Ca2+-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions. J. Physiol. 587:1547-1563.
    • (2009) J. Physiol , vol.587 , pp. 1547-1563
    • Rose, A.J.1    Alsted, T.J.2    Jensen, T.K.3    Kobbero, J.B.4    Maarbjerg, S.J.5    Jensen, J.6
  • 40
    • 63949084607 scopus 로고    scopus 로고
    • SUnSET, a nonradioactive method to monitor protein synthesis
    • Schmidt, E. K., G. Clavarino, M. Ceppi, and P. Pierre. 2009. SUnSET, a nonradioactive method to monitor protein synthesis. Nat. Methods 6:275-277
    • (2009) Nat. Methods , vol.6 , pp. 275-277
    • Schmidt, E.K.1    Clavarino, G.2    Ceppi, M.3    Pierre, P.4
  • 41
    • 4143101270 scopus 로고    scopus 로고
    • Postexercise protein metabolism in older and younger men following moderate-intensity aerobic exercise
    • Sheffield-Moore, M., C. W. Yeckel, E. Volpi, S. E. Wolf, B. Morio, D. L. Chinkes, et al. 2004. Postexercise protein metabolism in older and younger men following moderate-intensity aerobic exercise. Am. J. Physiol. 287: E513-E522.
    • (2004) Am. J. Physiol , vol.287 , pp. E513-E522
    • Sheffield-Moore, M.1    Yeckel, C.W.2    Volpi, E.3    Wolf, S.E.4    Morio, B.5    Chinkes, D.L.6
  • 42
    • 84894523716 scopus 로고    scopus 로고
    • Making new contacts: The mTOR network in metabolism and signalling crosstalk
    • Shimobayashi, M., and M. N. Hall. 2014. Making new contacts: the mTOR network in metabolism and signalling crosstalk. Nat. Rev. Mol. Cell Biol. 15:155-162
    • (2014) Nat. Rev. Mol. Cell Biol , vol.15 , pp. 155-162
    • Shimobayashi, M.1    Hall, M.N.2
  • 43
    • 0036118562 scopus 로고    scopus 로고
    • Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis
    • Shoshani, T., A. Faerman, I. Mett, E. Zelin, T. Tenne, S. Gorodin, et al. 2002. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol. Cell. Biol. 22:2283-2293
    • (2002) Mol. Cell. Biol , vol.22 , pp. 2283-2293
    • Shoshani, T.1    Faerman, A.2    Mett, I.3    Zelin, E.4    Tenne, T.5    Gorodin, S.6
  • 44
    • 21744459535 scopus 로고    scopus 로고
    • Regulation of mTOR and cell growth in response to energy stress by REDD1
    • Sofer, A., K. Lei, C. M. Johannessen, and L. W. Ellisen. 2005. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol. Cell. Biol. 25:5834-5845
    • (2005) Mol. Cell. Biol , vol.25 , pp. 5834-5845
    • Sofer, A.1    Lei, K.2    Johannessen, C.M.3    Ellisen, L.W.4
  • 45
    • 0029806713 scopus 로고
    • Muscle protein metabolism in female swimmers after a combination of resistance and endurance exercise
    • 1996
    • Tipton, K. D., A. A. Ferrando, B. D. Williams, and R. R. Wolfe. 1996. Muscle protein metabolism in female swimmers after a combination of resistance and endurance exercise. J. Appl. Physiol. (1985) 81:2034-2038
    • (1985) J. Appl. Physiol , vol.81 , pp. 2034-2038
    • Tipton, K.D.1    Ferrando, A.A.2    Williams, B.D.3    Wolfe, R.R.4
  • 46
    • 15044340650 scopus 로고    scopus 로고
    • Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins
    • Wang, X., A. Beugnet, M. Murakami, S. Yamanaka, and C. G. Proud. 2005. Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins. Mol. Cell. Biol. 25:2558-2572
    • (2005) Mol. Cell. Biol , vol.25 , pp. 2558-2572
    • Wang, X.1    Beugnet, A.2    Murakami, M.3    Yamanaka, S.4    Proud, C.G.5
  • 47
    • 81355132716 scopus 로고    scopus 로고
    • Resistance exercise enhances the molecular signaling of mitochondrial biogenesis induced by endurance exercise in human skeletal muscle
    • Wang, L., H. Mascher, N. Psilander, E. Blomstrand, and K. Sahlin. 2011. Resistance exercise enhances the molecular signaling of mitochondrial biogenesis induced by endurance exercise in human skeletal muscle. J. Appl. Physiol. (1985) 111:1335-1344
    • (2011) J. Appl. Physiol. (1985) , vol.111 , pp. 1335-1344
    • Wang, L.1    Mascher, H.2    Psilander, N.3    Blomstrand, E.4    Sahlin, K.5
  • 48
    • 0014172598 scopus 로고
    • The measurement of total lysine turnover in the rat by intravenous infusion of L-[U-14C] lysine
    • Waterlow, J. C., and J. M. Stephen. 1967. The measurement of total lysine turnover in the rat by intravenous infusion of L-[U-14C] lysine. Clin. Sci. 33:489-506
    • (1967) Clin. Sci , vol.33 , pp. 489-506
    • Waterlow, J.C.1    Stephen, J.M.2
  • 49
    • 48549107440 scopus 로고    scopus 로고
    • Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle
    • Wilkinson, S. B., S. M. Phillips, P. J. Atherton, R. Patel, K. E. Yarasheski, M. A. Tarnopolsky, et al. 2008. Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle. J. Physiol. 586:3701-3717
    • (2008) J. Physiol , vol.586 , pp. 3701-3717
    • Wilkinson, S.B.1    Phillips, S.M.2    Atherton, P.J.3    Patel, R.4    Yarasheski, K.E.5    Tarnopolsky, M.A.6
  • 50
    • 33745024082 scopus 로고    scopus 로고
    • Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (MTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle
    • Williamson, D. L., N. Kubica, S. R. Kimball, and L. S. Jefferson. 2006. Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle. J. Physiol. 573:497-510
    • (2006) J. Physiol , vol.573 , pp. 497-510
    • Williamson, D.L.1    Kubica, N.2    Kimball, S.R.3    Jefferson, L.S.4


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