Design, synthesis and biological evaluation of 3-aryl-rhodanine benzoic acids as anti-apoptotic protein Bcl-2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 22, 2015, Pages 5265-5269

  Fu, Huansheng ^a   Hou, Xuben ^a   Wang, Lei ^a   Dun, Yanyan ^a   Yang, Xinying ^a   Fang, Hao ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Apoptosis; Bcl 2; Inhibitor; Rhodanine

Indexed keywords

3 ARYL RHODANINE BENZOIC ACID DERIVATIVE; APOPTOSIS INHIBITOR; BENZOIC ACID DERIVATIVE; PROTEIN BCL 2; PROTEIN BCL XL; RHODANINE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BCL2 PROTEIN, HUMAN; BCL2L1 PROTEIN, HUMAN; MCL1 PROTEIN, HUMAN; PROTEIN BCL X; PROTEIN MCL 1; SULFONAMIDE; THIAZOLE DERIVATIVE; WL 276;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; BREAST CANCER CELL LINE; CANCER INHIBITION; DRUG DESIGN; DRUG SYNTHESIS; FLUORESCENCE POLARIZATION IMMUNOASSAY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MYELOID LEUKEMIA CELL LINE; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; MOLECULAR DOCKING; SYNTHESIS; ULTRASTRUCTURE;

ANTINEOPLASTIC AGENTS; BCL-X PROTEIN; BENZOATES; CELL LINE, TUMOR; HUMANS; MOLECULAR DOCKING SIMULATION; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; PROTO-ONCOGENE PROTEINS C-BCL-2; RHODANINE; SULFONAMIDES; THIAZOLES;

EID: 84945944735     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.09.051     Document Type: Article

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