Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 9, 2015, Pages 1994-2003

  Wan, Yichao ^a   Wu, Shaolei ^a   Xiao, Guizhi ^a   Liu, Tingting ^a   Hou, Xuben ^a   Chen, Chen ^a   Guan, Peng ^a   Yang, Xinying ^a   Fang, Hao ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

2 Thioxo 4 thiazolidinone; Anti tumor; Bcl 2; Inhibitors

Indexed keywords

MCL1 PROTEIN, HUMAN; PROTEIN BCL 2; PROTEIN MCL 1; THIAZOLIDINE DERIVATIVE;

ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DESIGN; DRUG EFFECTS; HUMAN; K562 CELL LINE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; K562 CELLS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; PROTO-ONCOGENE PROTEINS C-BCL-2; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES;

EID: 84939998333     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.03.024     Document Type: Article

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