Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 14, 2012, Pages 4194-4200

  Li, Huan Qiu ^a   Yang, Jing ^a   Ma, Shuhua ^b   Qiao, Chunhua ^a  

^a SOOCHOW UNIVERSITY   (China)

^b TOWSON UNIVERSITY   (United States)

Author keywords

Acylsulfonamide; Antagonist; Apoptosis; Bcl 2; Structure based design

Indexed keywords

2 (5 BENZYLIDENE 4 OXO 4,5 DIHYDROTHIAZOL 2 YLAMINO) 3 METHYL N TOSYLBUTANAMIDE; 2 (5 BENZYLIDENE 4 OXO 4,5 DIHYDROTHIAZOL 2 YLAMINO) 4 METHYL N TOSYLPENTANAMIDE; 2 [5 (2 CHLOROBENZYLIDENE) 4 OXO 4,5 DIHYDROTHIAZOL 2 YLAMINO] 3 METHYL N TOSYLBUTANAMIDE; 2 [5 (2 CHLOROBENZYLIDENE) 4 OXO 4,5 DIHYDROTHIAZOL 2 YLAMINO] 3 PHENYL N TOSYLPROPANAMIDE; 2 [5 (2 CHLOROBENZYLIDENE) 4 OXO 4,5 DIHYDROTHIAZOL 2 YLAMINO] 4 METHYL N TOSYLPENTANAMIDE; 2 [5 (2 FLUOROBENZYLIDENE) 4 OXO 4,5 DIHYDROTHIAZOL 2 YLAMINO] 3 PHENYL N TOSYLPROPANAMIDE; 2 [5 (2 FLUOROBENZYLIDENE) 4 OXO 4,5 DIHYDROTHIAZOL 2 YLAMINO] 4 METHYL N TOSYLPENTANAMIDE; 2 [5 (3 CHLOROBENZYLIDENE) 4 OXO 4,5 DIHYDROTHIAZOL 2 YLAMINO] 4 METHYL N TOSYLPENTANAMIDE; 2 [5 (4 METHOXYBENZYLIDENE) 4 OXO 4,5 DIHYDROTHIAZOL 2 YLAMINO] 3 METHYL N TOSYLBUTANAMIDE; 2 [5 (BIPHENYL 4 YLMETHYLENE) 4 OXO 4,5 DIHYDROTHIAZOL 2 YLAMINO] 3 PHENYL N TOSYLPROPANAMIDE; ACYLSULFONAMIDE DERIVATIVE; ANTINEOPLASTIC AGENT; GOSSYPOL; PROTEIN BCL 2; PROTEIN INHIBITOR; RHODANINE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DOCKING; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTER SIMULATION; DRUG DESIGN; HEP G2 CELLS; HUMANS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2; RHODANINE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84863216964     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.05.079     Document Type: Article

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