Metabolic syndrome and obesity among users of second generation antipsychotics: A global challenge for modern psychopharmacology

Pharmacological Research

Volumn 101, Issue , 2015, Pages 74-85

  Rojo, Leonel E ^a   Gaspar, Pablo A ^b,c   Silva, H ^c   Risco, L ^c   Arena, Pamela ^a   Cubillos Robles, Karen ^a   Jara, Belen ^a  

^a UNIVERSIDAD ARTURO PRAT   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

^c HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE   (Chile)

Author keywords

Diabetes; Insulin resistance; Metabolic syndrome; Obesity; Schizophrenia; Second generation antipsychotics

Indexed keywords

ADIPONECTIN; AMANTADINE; ANTIDIABETIC AGENT; ANTIDIABETIC POLYPHENOL; ANTIOBESITY AGENT; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; BERBERINE; BETAHISTINE; CINNAMON EXTRACT; CLOZAPINE; DELPHINIDIN; FAMOTIDINE; LEPTIN; METFORMIN; NEUROLEPTIC AGENT; NIZATIDINE; OLANZAPINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; POLYPHENOL DERIVATIVE; RANITIDINE; REBOXETINE; RESVERATROL; ROSIGLITAZONE; SECOND GENERATION ANTIPSYCHOTIC AGENT; SIBUTRAMINE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TETRAHYDROLIPSTATIN; TOPIRAMATE; UNCLASSIFIED DRUG; POLYPHENOL;

CHEMOPROPHYLAXIS; DIABETES MELLITUS; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG USE; HUMAN; INSULIN RESISTANCE; LIPID ANALYSIS; LIPID STORAGE; METABOLIC SYNDROME X; MOLECULAR DYNAMICS; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; POMEGRANATE JUICE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSYCHOPHARMACOLOGY; REVIEW; SCHIZOPHRENIA; TEA; WEIGHT GAIN; ADOLESCENT; ADULT; ANIMAL; BIOLOGICAL MODEL; CHEMICALLY INDUCED; CHILD; DRUG EFFECTS; LIPID METABOLISM; METABOLISM;

ADOLESCENT; ADULT; ANIMALS; ANTIPSYCHOTIC AGENTS; CHILD; HUMANS; HYPOGLYCEMIC AGENTS; LIPID METABOLISM; METABOLIC SYNDROME X; MODELS, BIOLOGICAL; OBESITY; POLYPHENOLS; PSYCHOPHARMACOLOGY; WEIGHT GAIN;

EID: 84945481150     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2015.07.022     Document Type: Review

References (140)

1. V.L. Albaugh, C.R. Henry, N.T. Bello, A. Hajnal, S.L. Lynch, B. Halle, and C.J. Lynch Hormonal and metabolic effects of olanzapine and clozapine related to body weight in rodents Obesity (Silver Spring) 14 2006 36 51
2. A.T. Ali, W.E. Hochfeld, R. Myburgh, and M.S. Pepper Adipocyte and adipogenesis Eur. J. Cell Biol. 92 2013 229 236
3. J. Ananth, R. Venkatesh, K. Burgoyne, R. Gadasalli, R. Binford, and S. Gunatilake Atypical antipsychotic induced weight gain: pathophysiology and management Ann. Clin. Psychiatry 16 2004 75 85
4. J. Anath, R. Venkatesh, K. Burgoyne, D. Augustines, V. Corpuz, and S. Gunatilake Weight gain associated with atypical antipsychotic drugs: mechanisms and management Expert Rev. Neurother. 3 2003 59 68
5. R.A. Anderson, Z. Zhan, R. Luo, X. Guo, Q. Guo, J. Zhou, J. Kong, P.A. Davis, and B.J. Stoecker Cinnamon extract lowers glucose, insulin and cholesterol in people with elevated serum glucose J. Tradit. Complement. Med. 2015
6. M. Atmaca, M. Kuloglu, E. Tezcan, and B. Ustundag Nizatidine treatment and its relationship with leptin levels in patients with olanzapine-induced weight gain Hum. Psychopharmacol.: Clin. Exp. 18 2003 457 461
7. M. Atmaca, M. Kuloglu, E. Tezcan, B. Ustundag, and N. Kilic Nizatidine for the treatment of patients with quetiapine-induced weight gain Hum. Psychopharmacol.: Clin. Exp. 19 2004 37 40
8. P. Auvichayapat, M. Prapochanung, O. Tunkamnerdthai, B.-O. Sripanidkulchai, N. Auvichayapat, B. Thinkhamrop, S. Kunhasura, S. Wongpratoom, S. Sinawat, and P. Hongprapas Effectiveness of green tea on weight reduction in obese Thais: a randomized, controlled trial Physiol. Behav. 93 2008 486 491
9. M.P. Ball, K.R. Warren, S. Feldman, R.P. Mcmahon, D.L. Kelly, and R.W. Buchanan Placebo-controlled trial of atomoxetine for weight reduction in people with schizophrenia treated with clozapine or olanzapine Clin. Schizophr. Relat. Psychoses 5 2011 17 25
10. S.A. Banihani, S.M. Makahleh, Z. El-Akawi, R.A. Al-Fashtaki, O.F. Khabour, M.Y. Gharibeh, N.A. Saadah, F.H. Al-Hashimi, and N.J. Al-Khasieb Fresh pomegranate juice ameliorates insulin resistance, enhances β-cell function, and decreases fasting serum glucose in type 2 diabetic patients Nutr. Res. 34 2014 862 867
11. T. Baptista, A. Mata, L. Teneud, M. De Quijada, H.W. Han, and L. Hernandez Effects of long-term administration of clozapine on body weight and food intake in rats Pharmacol. Biochem. Behav. 45 1993 51 54
12. T. Baptista, N. Rangel, Y. El Fakih, E. Uzcátegui, T. Galeazzi, S. Beaulieu, and E. Araujo De Baptista Rosiglitazone in the assistance of metabolic control during olanzapine administration in schizophrenia: a pilot double-blind, placebo-controlled, 12-week trial Pharmacopsychiatry 42 2009 14 19
13. T. Baptista, N. Rangel, V. Fernández, E. Carrizo, Y. El Fakih, E. Uzcátegui, T. Galeazzi, M.A. Gutiérrez, M. Servigna, A. Dávila, M. Uzcátegui, A. Serrano, L. Connell, S. Beaulieu, and E.A. De Baptista Metformin as an adjunctive treatment to control body weight and metabolic dysfunction during olanzapine administration: a multicentric double-blind placebo-controlled trial Schizophr. Res. 93 2007 99 108
14. A. Basu, M. Du, K. Sanchez, M.J. Leyva, N.M. Betts, S. Blevins, M. Wu, C.E. Aston, and T.J. Lyons Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome Nutrition 27 2011 206 213
15. E. Blessing, L. Kader, R. Arpandy, Y. Ootsuka, W.W. Blessing, and C. Pantelis Atypical antipsychotics cause an acute increase in cutaneous hand blood flow in patients with schizophrenia and schizoaffective disorder Aust. N. Z. J. Psychiatry 45 2011 646 653
16. W.W. Blessing, A. Zilm, and Y. Ootsuka Clozapine reverses increased brown adipose tissue thermogenesis induced by 3,4-methylenedioxymethamphetamine and by cold exposure in conscious rats Neuroscience 141 2006 2067 2073
17. T. Bromel, W.F. Blum, A. Ziegler, E. Schulz, M. Bender, C. Fleischhaker, H. Remschmidt, J.C. Krieg, and J. Hebebrand Serum leptin levels increase rapidly after initiation of clozapine therapy Mol. Psychiatry 3 1998 76 80
18. K.K. Buhman, H.C. Chen, and R.V. Farese The enzymes of neutral lipid synthesis J. Biol. Chem. 276 2001 40369 40372
19. P. Cavazzoni, Y. Tanaka, S.M. Roychowdhury, A. Breier, and D.B. Allison Nizatidine for prevention of weight gain with olanzapine: a double-blind placebo-controlled trial Eur. Neuropsychopharmacol. 13 2003 81 85
20. W.T. Cefalu, J. Ye, A. Zuberi, D.M. Ribnicky, I. Raskin, Z. Liu, Z.Q. Wang, P.J. Brantley, L. Howard, and M. Lefevre Botanicals and the metabolic syndrome Am. J. Clin. Nutr. 87 2008 481S 487S
21. R. Coccurello, and A. Moles Potential mechanisms of atypical antipsychotic-induced metabolic derangement: clues for understanding obesity and novel drug design Pharmacol. Ther. 127 2010 210 251
22. F.C. Cohen Entry order as a consideration for innovation strategies Nat. Rev. Durg Discovery 2006
23. S. Cohen, J. Chiles, and A. Macnaughton Weight gain associated with clozapine Am. J. Psychiatry 147 1990 503 504
24. M.P. Czech Obesity notches up fatty liver Nat. Med. 19 2013 969 971
25. C.H. Chen, M.C. Huang, C.F. Kao, S.K. Lin, P.H. Kuo, C.C. Chiu, and M.L. Lu Effects of adjunctive metformin on metabolic traits in nondiabetic clozapine-treated patients with schizophrenia and the effect of metformin discontinuation on body weight a 24-week, randomized, double-blind, placebo-controlled study J. Clin. Psychiatry 74 2013 e424 e430
26. S. Chen, X. Zhao, L. Ran, J. Wan, X. Wang, Y. Qin, F. Shu, Y. Gao, L. Yuan, Q. Zhang, and M. Mi Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: a randomized controlled trial Dig. Liver Dis. 47 2015 226 232
27. D.M. Cheng, P. Kuhn, A. Poulev, L.E. Rojo, M.A. Lila, and I. Raskin In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix Food Chem. 135 2012 2994 3002
28. G. Chiva-Blanch, M. Urpi-Sarda, E. Ros, P. Valderas-Martinez, R. Casas, S. Arranz, M. Guillen, R.M. Lamuela-Raventos, R. Llorach, C. Andres-Lacueva, and R. Estruch Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: a randomized clinical trial Clin. Nutr. 32 2013 200 206
29. G. Chiva-Blanch, M. Urpi-Sarda, E. Ros, P. Valderas-Martinez, R. Casas, S. Arranz, M. Guillén, R.M. Lamuela-Raventós, R. Llorach, C. Andres-Lacueva, and R. Estruch Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: a randomized clinical trial Clin. Nutr. 32 2013 200 206
30. D.J. Klein M.D., PH.D, E.M. Cottingham, M. Sorter M.D., B.A. Barton M.D., and J.A. Morrison P.D. A randomized, double-blind, placebo-controlled trial of metformin treatment of weight gain associated with initiation of atypical antipsychotic therapy in children and adolescents Am. J. Psychiatry 163 2006 2072 2079
31. M. De Hert, J. Detraux, R. Van Winkel, W. Yu, and C.U. Correll Metabolic and cardiovascular adverse effects associated with antipsychotic drugs Nat. Rev. Endocrinol. 8 2012 114 126
32. W. Deberdt, A. Winokur, P.A. Cavazzoni, Q.N. Trzaskoma, C.D. Carlson, F.P. Bymaster, K. Wiener, M. Floris, and A. Breier Amantadine for weight gain associated with olanzapine treatment Eur. Neuropsychopharmacol. 15 2005 13 21
33. K.K. Devulapalli, and H.A. Nasrallah An analysis of the high psychotropic off-label use in psychiatric disorders. The majority of psychiatric diagnoses haveapproved drug Asian J. Psychiatry 2 2009 29 36
34. R. Domitrovic The molecular basis for the pharmacological activity of anthocyans Curr. Med. Chem. 18 2011 4454 4469
35. S. Dzitoyeva, H. Chen, and H. Manev 5-Lipoxygenase-activating protein as a modulator of olanzapine-induced lipid accumulation in adipocyte J. Lipids 2013 864593
36. D. Esposito, A. Chen, M.H. Grace, S. Komarnytsky, and M.A. Lila Inhibitory effects of wild blueberry anthocyanins and other flavonoids on biomarkers of acute and chronic inflammation in vitro J. Agric. Food Chem. 2014
37. L. Fajas, K. Schoonjans, L. Gelman, J.B. Kim, J. Najib, G. Martin, J.C. Fruchart, M. Briggs, B.M. Spiegelman, and J. Auwerx Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism Mol. Cell. Biol. 19 1999 5495 5503
38. J. Fernø, A.O. Vik-Mo, G. Jassim, B. Håvik, K. Berge, S. Skrede, O.A. Gudbrandsen, J. Waage, N. Lunder, S. Mørk, R.K. Berge, H.A. Jørgensen, and V.M. Steen Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver Psychopharmacology (Berl) 2009 73 84
39. P.A. Gaspar, C. Bosman, S. Ruiz, F. Aboitiz, 2009. The aberrant connectivity hypothesis in schizophrenia.
40. P.A. Gaspar, M.L. Bustamante, L.E. Rojo, and A. Martinez From glutamatergic dysfunction to cognitive impairment: boundaries in the therapeutic of the schizophrenia Curr. Pharm. Biotechnol. 13 2012 1543 1548
41. K.A. Graham, H. Gu, J.A. Lieberman, J.B. Harp, and D.O. Perkins Double-blind, placebo-controlled investigation of amantadine for weight loss in subjects who gained weight with olanzapine Am. J. Psychiatry 162 2005 1744 1746
42. K.A. Grove, and J.D. Lambert Laboratory, epidemiological, and human intervention studies show that tea (Camellia sinensis) may be useful in the prevention of obesity J. Nutr. 140 2015 446 453
43. J.N. Harrison, F. Cluxton-Keller, and D. Gross Antipsychotic medication prescribing trends in children and adolescents J. Pediatr. Health Care 26 2012 139 145
44. A. Hasan, P. Falkai, T. Wobrock, J. Lieberman, B. Glenthoj, W.F. Gattaz, F. Thibaut, H.J. Moller, and Schizophrenia, W. T. F. O. T. G. F World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: update 2012 on the long-term treatment of schizophrenia and management of antipsychotic-induced side effects World J. Biol. Psychiatry 14 2013 2 44
45. H. Hauner, K. Rohrig, J. Hebebrand, and T. Skurk No evidence for a direct effect of clozapine on fat-cell formation and production of leptin and other fat-cell-derived factors Mol. Psychiatry 8 2003 258 259
46. M. He, C. Deng, and X.F. Huang The role of hypothalamic H1 receptor antagonism in antipsychotic-induced weight gain CNS Drugs 27 2013 423 434
47. C. Hegedus, D. Kovacs, L. Drimba, R. Sari, A. Varga, J. Nemeth, Z. Szilvassy, and B. Peitl Investigation of the metabolic effects of chronic clozapine treatment on CCK-1 receptor deficient Otsuka Long Evans Tokushima Fatty (OLETF) rats Eur. J. Pharmacol. 718 2013 188 196
48. D.C. Henderson, P.M. Copeland, T.B. Daley, C.P. Borba, C. Cather, D.D. Nguyen, P.M. Louie, A.E. Evins, O. Freudenreich, D. Hayden, and D.C. Goff A double-blind, placebo-controlled trial of sibutramine for olanzapine-associated weight gain Am. J. Psychiatry 162 2005 954 962
49. D.C. Henderson, X. Fan, B. Sharma, P.M. Copeland, C.P. Borba, R. Boxill, O. Freudenreich, C. Cather, A. Eden Evins, and D.C. Goff A double-blind, placebo-controlled trial of rosiglitazone for clozapine-induced glucose metabolism impairment in patients with schizophrenia Acta Psychiatr. Scand. 119 2009 457 465
50. J.D. Hoehns, M.M. Fouts, M.W. Kelly, and K.B. Tu Sudden cardiac death with clozapine and sertraline combination Ann. Pharmacother. 35 2001 862 866
51. C.-H. Hsu, T.-H. Tsai, Y.-H. Kao, K.-C. Hwang, T.-Y. Tseng, and P. Chou Effect of green tea extract on obese women: a randomized, double-blind, placebo-controlled clinical trial Clin. Nutr. 27 2008 363 370
52. Y. Hu, E. Kutscher, and G.E. Davies Berberine inhibits SREBP-1-related clozapine and risperidone induced adipogenesis in 3T3-L1 cells Phytother. Res. 24 2010 1831 1838
53. Y. Hu, E. Kutscher, and G.E. Davies Berberine inhibits SREBP-1-related clozapine and risperidone induced adipogenesis in 3T3-L1 cells Phytother. Res. 24 2010 1831 1838
54. Y. Hu, A.J. Young, E.A. Ehli, D. Nowotny, P.S. Davies, E.A. Droke, T.J. Soundy, and G.E. Davies Metformin and berberine prevent olanzapine-induced weight gain in rats PLoS One 9 2014 e93310
55. G. Jassim, S. Skrede, M.J. Vazquez, H. Wergedal, A.O. Vik-Mo, N. Lunder, C. Dieguez, A. Vidal-Puig, R.K. Berge, M. Lopez, V.M. Steen, and J. Ferno Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat Psychopharmacology (Berl) 219 2012 783 794
56. G. Joffe, P. Takala, E. Tchoukhine, H. Hakko, M. Raidma, H. Putkonen, M. Eronen, and P. Rasanen Orlistat in clozapine- or olanzapine-treated patients with overweight or obesity: a 16-week randomized, double-blind, placebo-controlled trial J. Clin. Psychiatry 69 2008 706 711
57. M.H. Johnson, E.G. De Mejia, J. Fan, M.A. Lila, and G.G. Yousef Anthocyanins and proanthocyanidins from blueberry-blackberry fermented beverages inhibit markers of inflammation in macrophages and carbohydrate-utilizing enzymes in vitro Mol. Nutr. Food Res. 57 2013 1182 1197
58. P.T. Kanellos, A.C. Kaliora, N.K. Tentolouris, V. Argiana, D. Perrea, N. Kalogeropoulos, A.M. Kountouri, and V.T. Karathanos A pilot, randomized controlled trial to examine the health outcomes of raisin consumption in patients with diabetes Nutrition 30 2014 358 364
59. M.A. Katzman, L. Jacobs, M. Marcus, M. Vermani, and A.C. Logan Weight gain and psychiatric treatment: is there as role for green tea and conjugated linoleic acid Lipids Health Dis. 6 2007 14
60. G. Kaur, and S.K. Kulkarni Studies on modulation of feeding behavior by atypical antipsychotics in female mice Prog. Neuropsychopharmacol. Biol. Psychiatry 26 2002 277 285
61. D.L. Kelly, R.P. Mcmahon, F. Liu, R.C. Love, H. Wehring, J.C. Shim, K.R. Warren, and R.R. Conley Cardiovascular disease mortality in chronic schizophrenia patients treated with clozapine J. Clin. Psychiatry 71 2010 304
62. Y.H. Ko, S.H. Joe, I.K. Jung, and S.H. Kim Topiramate as an adjuvant treatment with atypical antipsychotics in schizophrenic patients experiencing weight gain Clin. Neuropharmacol. 28 2005 169 175
63. T. Kraus, M. Haack, A. Schuld, D. Hinze-Selch, M. Kuhn, M. Uhr, and T. Pollmacher Body weight and leptin plasma levels during treatment with antipsychotic drugs Am. J. Psych. 156 1999 312 314
64. Y. Kurimoto, Y. Shibayama, S. Inoue, M. Soga, M. Takikawa, C. Ito, F. Nanba, T. Yoshida, Y. Yamashita, H. Ashida, and T. Tsuda Black soybean seed coat extract ameliorates hyperglycemia and insulin sensitivity via the activation of AMP-activated protein kinase in diabetic mice J. Agric. Food Chem. 61 2013 5558 5564
65. C. Kursungoz, M. Ak, and T. Yanik Effects of risperidone treatment on the expression of hypothalamic neuropeptide in appetite regulation in Wistar rats Brain Res. 1596 2015 146 155
66. J.S. Lamberti, G.O. Costea, D. Olson, J.F. Crilly, K. Maharaj, X. Tu, A. Groman, M.B. Dietz, M.P. Bushey, T. Olivares, and K. Wiener Diabetes mellitus among outpatients receiving clozapine: prevalence and clinical-demographic correlates J. Clin. Psychiatry 66 2005 900 906
67. M. Leonhauser, 2012. Antisychotics: multiple indications help drive growth. Pm360 marjet watch: the essential source for pharma marketers, 1, 22-24.
68. T.A. Lett, T.J. Wallace, N.I. Chowdhury, A.K. Tiwari, J.L. Kennedy, and D.J. Muller Pharmacogenetics of antipsychotic-induced weight gain: review and clinical implications Mol. Psychiatry 17 2012 242 266
69. D. Li, Y. Zhan, Y. Liu, R. Sun, and M. Xia Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients J. Nutr. 145 2015 742 748
70. M.A. Lila Anthocyanins and human health: an in vitro investigative approach J. Biomed. Biotechnol. 2004 2004 306 313
71. M.A. Lila, D.M. Ribnicky, L.E. Rojo, P. Rojas-Silva, A. Oren, R. Havenaar, E.M. Janle, I. Raskin, G.G. Yousef, and M.H. Grace Complementary approaches to gauge the bioavailability and distribution of ingested berry polyphenolics J. Agric. Food Chem. 60 2012 5763 5771
72. P. Manu, L. Dima, M. Shulman, D. Vancampfort, M. De Hert, and C.U. Correll Weight gain and obesity in schizophrenia: epidemiology, pathobiology, and management Acta Psychiatr. Scand. 2015
73. C.M. Matthaiou, N. Goutzourelas, D. Stagos, E. Sarafoglou, A. Jamurtas, S.D. Koulocheri, S.A. Haroutounian, A.M. Tsatsakis, and D. Kouretas Pomegranate juice consumption increases GSH levels and reduces lipid and protein oxidation in human blood Food. Chem Toxicol. 73 2014 1 6
74. A. Mckean, and E. Monasterio Off-label use of atypical antipsychotics: cause for concern? CNS Drugs 26 2012 383 390
75. A. Mckean, and E. Monasterio Indications of atypical antipsychotics in the elderly Expert Rev. Clin. Pharmacol. 8 2015 5 7
76. D.D. Mellor, T. Sathyapalan, E.S. Kilpatrick, S. Beckett, and S.L. Atkin High-cocoa polyphenol-rich chocolate improves HDL cholesterol in Type 2 diabetes patients Diabet. Med. 27 2015 1318 1321
77. A.J. Mitchell, D. Vancampfort, K. Sweers, R. Van Winkel, W. Yu, and M. De Hert Prevalence of metabolic syndrome and metabolic abnormalities in schizophrenia and related disorders - a systematic review and meta-analysis Schizophr. Bull. 39 2013 306 318
78. D.L. Morris, and L. Rui Recent advances in understanding leptin signaling and leptin resistance Am. J. Physiol. - Endocrinol. Metab. 297 2009 E1247 E1259
79. R.F. Morrison, and S.R. Farmer Hormonal signaling and transcriptional control of adipocyte differentiation J. Nutr. 130 2000 3116 3121
80. D. Muller-Wieland, B. Knebel, J. Haas, and J. Kotzka Srebp-1 and fatty liver. Clinical relevance for diabetes obesity dyslipidemia and atherosclerosis Herz 37 2012 273 278
81. M.G. Myers, R.L. Leibel, R.J. Seeley, and M.W. Schwartz Obesity and leptin resistance: distinguishing cause from effect Trends Endocrinol. Metab.: TEM 21 2010 643 651
82. M. Myslobodsky Ingenuity pathway analysis of clozapine-induced obesity Obes. Facts 1 2008 93 102
83. H.A. Nasrallah, P.D. Harvey, D. Casey, C.T. Csoboth, J.I. Hudson, L. Julian, E. Lentz, K.H. Nuechterlein, D.O. Perkins, N. Kotowsky, T.G. Skale, L.R. Snowden, R. Tandon, C. Tek, D. Velligan, S. Vinogradov, and C. O'gorman The management of schizophrenia in clinical practice (MOSAIC) registry: a focus on patients, caregivers, illness severity, functional status, disease burden and healthcare utilization Schizophr. Res. 2015
84. J.E. Oh, Y.M. Cho, S.N. Kwak, J.H. Kim, K.W. Lee, H. Jung, S.W. Jeong, and O.J. Kwon Inhibition of mouse brown adipocyte differentiation by second-generation antipsychotics Exp. Mol. Med. 44 2012 545 553
85. K.J. Oh, J. Park, S.Y. Lee, I. Hwang, K. J.B, and T.S. Park Atypical antipsychotic drugs perturb AMPK-dependent regulation of hepatic lipid metabolism J. Physiol. Endocrinol. Metab 300 2011 624 632
86. Y. Okumura, J. Fujita, and T. Matsumoto Trends of psychotropic medication use among children and adolescents in Japan data from the national insurance claims database between 2002 and 2010 Seishin Shinkeigaku Zasshi 116 2014 921 935
87. M. Poyurovsky, C. Fuchs, A. Pashinian, A. Levi, S. Faragian, R. Maayan, and I. Gil-Ad Attenuating effect of reboxetine on appetite and weight gain in olanzapine-treated schizophrenia patients: a double-blind placebo-controlled study Psychopharmacology (Berl) 192 2007 441 448
88. M. Poyurovsky, I. Isaacs, C. Fuchs, M. Schneidman, S. Faragian, R. Weizman, and A. Weizman Attenuation of olanzapine-induced weight gain with reboxetine in patients with schizophrenia: a double-blind, placebo-controlled study Am. J. Psychiatry 160 2003 297 302
89. M. Poyurovsky, A. Pashinian, I. Gil-Ad, R. Maayan, M. Schneidman, C. Fuchs, and A. Weizman Olanzapine-induced weight gain in patients with first-episode schizophrenia: a double-blind, placebo-controlled study of fluoxetine addition Am. J. Psychiatry 159 2002 1058 1060
90. M. Poyurovsky, V. Tal, R. Maayan, I. Gil-Ad, C. Fuchs, and A. Weizman The effect of famotidine addition on olanzapine-induced weight gain in first-episode schizophrenia patients: a double-blind placebo-controlled pilot study Eur. Neuropsychopharmacol. 14 2004 332 336
91. N.R. Qi, J. Wang, V. Zidek, and Kurtz Tw A new transgenic rat model of hepatic steatosis and the metabolic syndrome Hypertension 2005 1004 1011
92. F. Ranjbar, A. Ghanepour, H. Sadeghi-Bazargani, M. Asadlo, and A. Alizadeh The effect of ranitidine on olanzapine-induced weight gain BioMed Res. Int. 2013 5
93. M.D. Ren-Rong Wu, M.D. Jing-Ping Zhao, M.D. Xiao-Feng Guo, M.D. Yi-Qun He, M.D. Mao-Sheng Fang, M.D. Wen-Bin Guo, M.D. Jin-Dong Chen, and M.D. Le-Hua Li Metformin addition attenuates olanzapine-induced weight gain in drug-naive first-episode schizophrenia patients: a double-blind, placebo-controlled study Am. J. Psychiatry 165 2008 352 358
94. G.P. Reynolds, and S.L. Kirk Metabolic side effects of antipsychotic drug treatment - pharmacological mechanisms Pharmacol. Ther. 125 2010 169 179
95. D.M. Ribnicky, D.E. Roopchand, A. Oren, M. Grace, A. Poulev, M.A. Lila, R. Havenaar, and I. Raskin Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1) Food Chem. 142 2014 349 357
96. R. Ricci, and F. Bevilacqua The potential role of leptin and adiponectin in obesity: a comparative review Vet. J. 191 2012 292 298
97. M. Richards, S. Chiba, M. Ninomiya, C. Wakabayasi, and H. Kunugi Inhibition of olanzapine-induced weight gain by the retinoid analog Am-80 Pharmacopsychiatry 46 2013 267 273
98. L.E. Rojo, D. Ribnicky, S. Logendra, A. Poulev, P. Rojas-Silva, P. Kuhn, R. Dorn, M.H. Grace, M.A. Lila, and I. Raskin In vitro and in vivo anti-diabetic effects of anthocyanins from Maqui Berry (Aristotelia chilensis) Food Chem. 131 2012 387 396
99. D.E. Roopchand, C.G. Krueger, K. Moskal, B. Fridlender, M.A. Lila, and I. Raskin Food-compatible method for the efficient extraction and stabilization of cranberry pomace polyphenols Food Chem. 141 2013 3664 3669
100. D.E. Roopchand, P. Kuhn, L.E. Rojo, M.A. Lila, and I. Raskin Blueberry polyphenol-enriched soybean flour reduces hyperglycemia, body weight gain and serum cholesterol in mice Pharmacol. Res. 68 2013 59 67
101. M. Rosenblat, T. Hayek, and M. Aviram Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages Atherosclerosis 187 2006 363 371
102. M. Rosenblat, T. Hayek, and M. Aviram Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages Atherosclerosis 187 2006 363 371
103. R. Rosenheck Second generation antipsychotics: evolution of scientic knowledge or uncovering fraud Epidemiol. Psychiatr. Sci. 2013 22
104. S.M. More, R.S. Kharwade, A.O. Turaskar, P.P. Wankhade, and R.A. Sheikh The effect of resveratrol on weight gain associated with olanzapine treatment Int. Res. J. Pharm. 3 6 2012
105. A.K. Sarvari, Z. Vereb, I.P. Uray, L. Fesus, and Z. Balajthy Atypical antipsychotics induce both proinflammatory and adipogenic gene expression in human adipocytes in vitro Biochem. Biophys. Res. Commun. 450 2014 1383 1389
106. A.K. Sárvári, Z. Veréb, I.P. Uray, L. Fésüs, and Z. Balajthy Atypical antipsychotics induce both proinflammatory and adipogenic gene expression in human adipocytes in vitro Biochem. Biophys. Res. Commun. 450 2014 1383 1389
107. R. Sasaki, N. Nishimura, H. Hoshino, Y. Isa, M. Kadowaki, T. Ichi, A. Tanaka, S. Nishiumi, I. Fukuda, H. Ashida, F. Horio, and T. Tsuda Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice Biochem. Pharmacol. 74 2007 1619 1627
108. M.E. Schreckinger, J. Wang, G. Yousef, M.A. Lila, and E. Gonzalez De Mejia Antioxidant capacity and in vitro inhibition of adipogenesis and inflammation by phenolic extracts of Vaccinium floribundum and Aristotelia chilensis J. Agric. Food Chem. 58 2010 8966 8976
109. S. Senniappan, C. Smith, 2010. Undefined diabetes unfolds.
110. A.L. Sertie, A.M. Suzuki, R.A. Sertie, S. Andreotti, F.B. Lima, M.R. Passos-Bueno, and W.F. Gattaz Effects of antipsychotics with different weight gain liabilities on human in vitro models of adipose tissue differentiation and metabolism Prog. Neuropsychopharmacol. Biol. Psychiatry 35 2011 1884 1890
111. H. Shimano, J.D. Horton, I. Shimomura, R.E. Hammer, M.S. Brown, and J.L. Goldstein Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells J. Clin. Invest. 1997 846 854
112. L. Sickert, D.J. Muller, A.K. Tiwari, S. Shaikh, C. Zai, R. De Souza, V. De Luca, H.Y. Meltzer, J.A. Lieberman, and J.L. Kennedy Association of the alpha 2A adrenergic receptor -1291C/G polymorphism and antipsychotic-induced weight gain in European-Americans Pharmacogenomics 10 2009 1169 1176
113. S. Skrede, J. Ferno, B. Bjorndal, W.R. Brede, P. Bohov, R.K. Berge, and V.M. Steen Lipid-lowering effects of tetradecylthioacetic acid in antipsychotic-exposed, female rats: challenges with long-term treatment PLoS One 7 2012 e50853
114. F.C. Starrenburg, and J.P. Bogers How can antipsychotics cause diabetes mellitus? Insights based on receptor-binding profiles, humoral factors and transporter proteins Eur. Psychiatry 24 2009 164 170
115. A.J. Stull, K.C. Cash, W.D. Johnson, C.M. Champagne, and W.T. Cefalu Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and women J. Nutr. 140 2010 1764 1768
116. J. Stull April, C. Cash Katherine, D. Johnson William, M. Champagne Catherine, and T. Cefalu William Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and women J. Nutr. 140 10 2010 1764 1768
117. M.E. Symonds Adipose Tissue Biology 2011 Springer New York
118. M. Takikawa, S. Inoue, F. Horio, and T. Tsuda Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice J. Nutr. 140 2010 527 533
119. K.L. Teff, and S.F. Kim Atypical antipsychotics and the neural regulation of food intake and peripheral metabolism Physiol. Behav. 104 2011 590 598
120. M. Trino Baptista Phd, Jessan Martínez Md, Anny Lacruz Msci, Nairy Rangel Md, Serge Beaulieu Md, Ana Serrano Md, Yinet Arapé Md, Maritza Martinez Md, Soaira De Mendoza Md, Luis Teneud Md, Phd, and Luis Hernández Md Metformin for prevention of weight gain and insulin resistance with olanzapine: a double-blind placebo-controlled trial Can. J. Psychiatry 2006 192 196
121. T. Tsuda, F. Horio, and T. Osawa Cyanidin 3-O-beta-d-glucoside suppresses nitric oxide production during a zymosan treatment in rats J. Nutr. Sci. Vitaminol. (Tokyo) 48 2002 305 310
122. T. Tsuda, Y. Ueno, H. Aoki, T. Koda, F. Horio, N. Takahashi, T. Kawada, and T. Osawa Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes Biochem. Biophys. Res. Commun. 316 2004 149 157
123. T. Tsuda, Y. Ueno, H. Kojo, T. Yoshikawa, and T. Osawa Gene expression profile of isolated rat adipocytes treated with anthocyanins Biochim. Biophys. Acta 1733 2005 137 147
124. D. Vancampfort, K. Vansteelandt, C.U. Correll, A.J. Mitchell, A. De Herdt, P. Sienaert, M. Probst, and M. De Hert Metabolic syndrome and metabolic abnormalities in bipolar disorder: a meta-analysis of prevalence rates and moderators Am. J. Psychiatry 170 2013 265 274
125. G. Venkatasubramanian, S. Chittiprol, N. Neelakantachar, M. Naveen, J. Thirthall, B. Gangadhar, and K. Shetty Insulin and insulin-like growth factor-1 abnormalities in antipsychotic-naive schizophrenia Am. J. Psychiatry 164 2007 1557 1560
126. H. Verdoux, M. Tournier, and B. Bégaud Antipsychotic prescribing trends: a review of pharmaco-epidemiological studies Acta Psychiatr. Scand. 121 2010 4 10
127. E.V. Villalpando-Arteaga, E. Mendieta-Condado, H. Esquivel-Solis, A.A. Canales-Aguirre, F.J. Galvez-Gastelum, J.C. Mateos-Diaz, J.A. Rodriguez-Gonzalez, and A.L. Marquez-Aguirre Hibiscus sabdariffa L. aqueous extract attenuates hepatic steatosis through down-regulation of PPAR-gamma and SREBP-1c in diet-induced obese mice Food Funct. 4 2013 618 626
128. C. Wallis, and J. Willwerth Schizophrenia: a new drug brings patients back to life Times Mag. 140 1992 1
129. M. Wampers, L. Hanssens, R. Van Winkel, A. Heald, J. Collette, J. Peuskens, J.Y. Reginster, A. Scheen, and M. De Hert Differential effects of olanzapine and risperidone on plasma adiponectin levels over time: results from a 3-month prospective open-label study Eur. Neuropsychopharmacol. 22 2012 17 26
130. Z.Q. Wang, D. Ribnicky, X.H. Zhang, A. Zuberi, I. Raskin, Y. Yu, and W.T. Cefalu An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skeletal muscle in KK-A(y) mice J. Nutr. Biochem. 2015
131. R.A. Wani, M.A. Dar, M.A. Margoob, Y.H. Rather, I. Haq, and M.S. Shah Diabetes mellitus and impaired glucose tolerance in patients with schizophrenia, before and after antipsychotic treatment J. Neurosci. Rural Pract. 6 2015 17 22
132. R. Wu, J. Zhao, and H. Jin Lifestyle intervention and metformin for treatment of antipsychotic-induced weight gain: a randomized controlled trial JAMA 299 2008 185 193
133. L.-H. Yang, T.-M. Chen, S.-T. Yu, and Y.-H. Chen Olanzapine induces SREBP-1-related adipogenesis in 3T3-L1 cells Pharmacol. Res. 56 2007 202 208
134. L.H. Yang, T.M. Chen, S.T. Yu, and Y.H. Chen Olanzapine induces SREBP-1-related adipogenesis in 3T3-L1 cells Pharmacol. Res. 56 2007 202 208
135. Z. Yang, J.Y. Yin, Z.C. Gong, Q. Huang, H. Chen, W. Zhang, H.H. Zhou, and Z.Q. Liu Evidence for an effect of clozapine on the regulation of fat-cell derived factors Clin. Chem. Acta 2009 98 104
136. C.C. Zai, A.K. Tiwari, N.I. Chowdhury, E.J. Brandl, S.A. Shaikh, N. Freeman, J.A. Lieberman, H.Y. Meltzer, D.J. Muller, and J.L. Kennedy Association study of GABAA alpha2 receptor subunit gene variants in antipsychotic-associated weight gain J. Clin. Psychopharmacol. 35 2015 7 12
137. W.V. Zhang, I. Ramzan, and M. Murray Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis J. Pharmacol. Exp. Ther. 322 2007 770 777
138. Y. Zhou, and L. Rui Leptin signaling and leptin resistance Front. Med. 7 2013 207 222
139. Y. Zhu, W. Ling, H. Guo, F. Song, Q. Ye, T. Zou, D. Li, Y. Zhang, G. Li, Y. Xiao, F. Liu, Z. Li, Z. Shi, and Y. Yang Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: a randomized controlled trial Nutr Metab Cardiovasc Dis 23 2013 843 849
140. A. Zuddas, R. Zanni, and T. Usala Second generation antipsychotics (SGAS) for non-psychotic disorders in children and adolescents: a review of the randomized controlled studies Eur. Neuropsychopharmacol. 21 2011 600 620