Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat

Psychopharmacology

Volumn 219, Issue 3, 2012, Pages 783-794

  Jassim, Goran ^a,b   Skrede, Silje ^a,b   Vázquez, María Jesús ^c,d   Wergedal, Hege ^a   Vik Mo, Audun O ^a,b   Lunder, Niclas ^e   Diéguez, Carlos ^c,d   Vidal Puig, Antonio ^f   Berge, Rolf K ^a   López, Miguel ^c,d   Steen, Vidar M ^a,b   Fernø, Johan ^a,b  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^d Instituto de Salud Carlos III   (Spain)

^e DIAKONHJEMMET HOSPITAL   (Norway)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Animal model; Antipsychotic; Clozapine; Diabetes; Energy; Fatty acid; Gene expression; Glucose; Lipid; Metabolism; Obesity

Indexed keywords

CLOZAPINE; FATTY ACID; GLUCOSE; OLANZAPINE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; DISORDERS OF CARBOHYDRATE METABOLISM; DRUG BLOOD LEVEL; DRUG EFFECT; DYSLIPIDEMIA; FEMALE; GENE EXPRESSION PROFILING; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; LIPID METABOLISM; LIPID STORAGE; NONHUMAN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; TISSUE PRESERVATION; WEIGHT GAIN;

ANIMALS; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; BLOOD GLUCOSE; CARBOHYDRATE METABOLISM; CLOZAPINE; FATTY ACIDS, NONESTERIFIED; FEMALE; LIPID METABOLISM; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; WEIGHT GAIN;

EID: 84856650002     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2397-y     Document Type: Article

References (49)

1. VL Albaugh JG Judson P She CH Lang KP Maresca JL Joyal CJ Lynch 2011 Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis Mol Psychiatry 16 569 581 20308992 10.1038/mp.2010.33 1:CAS:528:DC%2BC3MXltVGlu78%3D
2. DB Allison JL Mentore M Heo LP Chandler JC Cappelleri MC Infante PJ Weiden 1999 Antipsychotic-induced weight gain: a comprehensive research synthesis Am J Psychiat 156 1686 1696 10553730 1:STN:280: DC%2BD3c%2FhvFWmug%3D%3D (Pubitemid 29517559)
3. MB Assie E Carilla-Durand L Bardin M Maraval M Aliaga N Malfetes M Barbara A Newman-Tancredi 2008 The antipsychotics clozapine and olanzapine increase plasma glucose and corticosterone levels in rats: comparison with aripiprazole, ziprasidone, bifeprunox and F15063 Eur J Pharmacol 592 160 166 18640111 10.1016/j.ejphar.2008.06.105 1:CAS:528:DC%2BD1cXhtVegu7bL
4. TJ Bartness CK Song 2007 Brain-adipose tissue neural crosstalk Physiol Behav 91 343 351 17521684 10.1016/j.physbeh.2007.04.002 1:CAS:528: DC%2BD2sXnsFKrsrg%3D (Pubitemid 47016533)
5. AB Birkenaes KI Birkeland JA Engh A Faerden H Jonsdottir PA Ringen S Friis S Opjordsmoen OA Andreassen 2008 Dyslipidemia independent of body mass in antipsychotic-treated patients under real-life conditions J Clin Psychopharmacol 28 132 137 18344722 10.1097/JCP.0b013e318166c4f7 1:CAS:528:DC%2BD1cXjt1Gjt74%3D (Pubitemid 351417117)
6. EG Bligh WJ Dyer 1959 A rapid method of total lipid extraction and purification Can J Biochem Physiol 37 911 917 13671378 10.1139/o59-099 1:CAS:528:DyaG1MXhtVSgt70%3D
7. HN Boyda L Tse RM Procyshyn D Wong TK Wu CC Pang AM Barr 2010 A parametric study of the acute effects of antipsychotic drugs on glucose sensitivity in an animal model Prog Neuropsychopharmacol Biol Psychiatry 34 945 954 20452386 10.1016/j.pnpbp.2010.04.024 1:CAS:528:DC%2BC3cXpt1Krtrg%3D
8. JE Caminos R Nogueiras R Gallego S Bravo S Tovar T Garcia-Caballero FF Casanueva C Dieguez 2005 Expression and regulation of adiponectin and receptor in human and rat placenta J Clin Endocrinol Metab 90 4276 4286 15855268 10.1210/jc.2004-0930 1:CAS:528:DC%2BD2MXmtlCiu7Y%3D (Pubitemid 41058209)
9. AF Chintoh SW Mann L Lam A Giacca P Fletcher J Nobrega G Remington 2009 Insulin resistance and secretion in vivo: effects of different antipsychotics in an animal model Schizophr Res 108 127 133 19157785 10.1016/j.schres.2008.12.012
10. X Deng C Yellaturu L Cagen HG Wilcox EA Park R Raghow MB Elam 2007 Expression of the rat sterol regulatory element-binding protein-1c gene in response to insulin is mediated by increased transactivating capacity of specificity protein 1 (Sp1) J Biol Chem 282 17517 17529 17449871 10.1074/jbc.M702228200 1:CAS:528:DC%2BD2sXmt1ektLo%3D (Pubitemid 47100272)
11. M Duclos M Bouchet A Vettier D Richard 2005 Genetic differences in hypothalamic-pituitary-adrenal axis activity and food restriction-induced hyperactivity in three inbred strains of rats J Neuroendocrinol 17 740 752 16219003 10.1111/j.1365-2826.2005.01367.x 1:CAS:528:DC%2BD2MXhtF2it73E (Pubitemid 41555752)
12. J Ferno MB Raeder AO Vik-Mo S Skrede M Glambek KJ Tronstad H Breilid R Lovlie RK Berge C Stansberg VM Steen 2005 Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action? Pharmacogenomics J 5 298 304 16027736 10.1038/sj.tpj.6500323 1:CAS:528:DC%2BD2MXhtVehsL7E (Pubitemid 41486229)
13. J Ferno S Skrede AO Vik-Mo B Havik VM Steen 2006 Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs BMC Neurosci 7 69 17052361 10.1186/1471-2202-7-69 (Pubitemid 44741152)
14. J Ferno S Varela S Skrede MJ Vázquez R Nogueiras C Diéguez A Vidal-Puig VM Steen M López 2011 Olanzapine-induced hyperphagia and weight gain associate with orexigenic hypothalamic neuropeptide signaling without concomitant AMPK phosphorylation PLoS ONE 6 e20571 21695181 10.1371/journal.pone.0020571
15. J Ferno AO Vik-Mo G Jassim B Havik K Berge S Skrede OA Gudbrandsen J Waage N Lunder S Mork RK Berge HA Jorgensen VM Steen 2009 Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver Psychopharmacology (Berl) 203 73 84 10.1007/s00213-008-1370-x
16. KN Frayn 2002 Adipose tissue as a buffer for daily lipid flux Diabetologia 45 1201 1210 12242452 10.1007/s00125-002-0873-y 1:CAS:528:DC%2BD38XntFegur0%3D
17. H Hauner EF Pfeiffer 1989 Regional differences in glucocorticoid action on rat adipose tissue metabolism Horm Metab Res 21 581 582 2680864 10.1055/s-2007-1009292 1:CAS:528:DyaK3cXjtVyjtg%3D%3D (Pubitemid 19255456)
18. JY Kim E van de Wall M Laplante A Azzara ME Trujillo SM Hofmann T Schraw JL Durand H Li G Li LA Jelicks MF Mehler DY Hui Y Deshaies GI Shulman GJ Schwartz PE Scherer 2007 Obesity-associated improvements in metabolic profile through expansion of adipose tissue J Clin Invest 117 2621 2637 17717599 10.1172/JCI31021 1:CAS:528:DC%2BD2sXhtVCms7nM (Pubitemid 47494363)
19. SF Kim AS Huang AM Snowman C Teuscher SH Snyder 2007 Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase PNAS 104 3456 3459 17360666 10.1073/pnas.0611417104 1:CAS:528:DC%2BD2sXjtVWltLY%3D (Pubitemid 46364180)
20. WK Kroeze SJ Hufeisen BA Popadak SM Renock S Steinberg P Ernsberger K Jayathilake HY Meltzer BL Roth 2003 H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs Neuropsychopharmacology 28 519 526 12629531 10.1038/sj.npp.1300027 1:CAS:528:DC%2BD3sXhslyjt7Y%3D
21. D Langin 2006 Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome Pharmacological research : the official journal of the Italian Pharmacological Society 53 482 491 10.1016/j.phrs.2006.03.009 1:CAS:528:DC%2BD28XltFCntLg%3D (Pubitemid 43767551)
22. MA Lazar 2005 How obesity causes diabetes: not a tall tale Science 307 373 375 15662001 10.1126/science.1104342 1:CAS:528:DC%2BD2MXksFyhsA%3D%3D (Pubitemid 40139971)
23. S Leucht C Corves D Arbter RR Engel C Li JM Davis 2009 Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis Lancet 373 31 41 19058842 10.1016/S0140-6736(08)61764-X 1:CAS:528: DC%2BD1MXht1Wqsw%3D%3D
24. JA Lieberman TS Stroup JP McEvoy MS Swartz RA Rosenheck DO Perkins RS Keefe SM Davis CE Davis BD Lebowitz J Severe JK Hsiao 2005 Effectiveness of antipsychotic drugs in patients with chronic schizophrenia N Engl J Med 353 1209 1223 16172203 10.1056/NEJMoa051688 1:CAS:528:DC%2BD2MXhtVeltL%2FN (Pubitemid 41345943)
25. PB Martinez de Morentin L Varela J Ferno R Nogueiras C Dieguez M Lopez 2010 Hypothalamic lipotoxicity and the metabolic syndrome Biochim Biophys Acta 1801 350 361 19796707 10.1016/j.bbalip.2009.09.016 1:CAS:528: DC%2BC3cXitVejtbo%3D
26. PJ Martins M Haas S Obici 2010 Central nervous system delivery of the antipsychotic olanzapine induces hepatic insulin resistance Diabetes 59 2418 2425 20682682 10.2337/db10-0449 1:CAS:528:DC%2BC3cXhsVGhs7nM
27. T Nagamine 2008 Olanzapine-induced elevation of serum triglyceride levels in a normal weight patient with schizophrenia Intern Med 47 181 182 18239330 10.2169/internalmedicine.47.0557 (Pubitemid 351372634)
28. HA Nasrallah 2008 Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles Mol Psychiatry 13 27 35 17848919 10.1038/sj.mp.4002066 1:CAS:528:DC%2BD2sXhsVegtLrI (Pubitemid 350275185)
29. JW Newcomer 2005 Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review CNS Drugs 19 Suppl 1 1 93 15998156 1:CAS:528:DC%2BD2MXltFCqu74%3D (Pubitemid 40677047)
30. M Ota K Mori A Nakashima YS Kaneko K Fujiwara M Itoh A Nagasaka A Ota 2002 Peripheral injection of risperidone, an atypical antipsychotic, alters the bodyweight gain of rats Clin Exp Pharmacol Physiol 29 980 989 12366389 10.1046/j.1440-1681.2002.t01-1-03755.x 1:CAS:528:DC%2BD38XnslSks7w%3D (Pubitemid 35177165)
31. RM Procyshyn KM Wasan AE Thornton AM Barr EY Chen E Pomarol-Clotet E Stip R Williams GW Macewan CL Birmingham WG Honer 2007 Changes in serum lipids, independent of weight, are associated with changes in symptoms during long-term clozapine treatment J Psychiatry Neurosci 32 331 338 17823649 (Pubitemid 47492758)
32. MB Raeder J Ferno AO Vik-Mo VM Steen 2006 SREBP activation by antipsychotic- and antidepressant-drugs in cultured human liver cells: relevance for metabolic side-effects? Mol Cell Biochem 289 167 173 16718372 10.1007/s11010-006-9160-4 1:CAS:528:DC%2BD28XptVajtbw%3D (Pubitemid 44322486)
33. G Ranganathan R Unal I Pokrovskaya A Yao-Borengasser B Phanavanh B Lecka-Czernik N Rasouli PA Kern 2006 The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment J Lipid Res 47 2444 2450 16894240 10.1194/jlr.M600248-JLR200 1:CAS:528: DC%2BD28XhtF2ku7fM (Pubitemid 44936106)
34. GP Reynolds SL Kirk 2010 Metabolic side effects of antipsychotic drug treatment-pharmacological mechanisms Pharmacol Ther 125 169 179 19931306 10.1016/j.pharmthera.2009.10.010 1:CAS:528:DC%2BD1MXhsFyiu77E
35. JA Romijn E Fliers 2005 Sympathetic and parasympathetic innervation of adipose tissue: metabolic implications Curr Opin Clin Nutr Metab Care 8 440 444 15930971 10.1097/01.mco.0000172586.09762.55 1:CAS:528:DC%2BD2MXotFSlsbo%3D (Pubitemid 40863060)
36. BL Roth DJ Sheffler WK Kroeze 2004 Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nature reviews Drug discovery 3 353 359 15060530 10.1038/nrd1346 1:CAS:528: DC%2BD2cXis1Gkt78%3D (Pubitemid 38499762)
37. C Rummel-Kluge K Komossa S Schwarz H Hunger F Schmid CA Lobos W Kissling JM Davis S Leucht 2010 Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis Schizophr Res 123 225 233 20692814 10.1016/j.schres.2010.07.012
38. J Sacher N Mossaheb C Spindelegger N Klein T Geiss-Granadia R Sauermann E Lackner C Joukhadar M Muller S Kasper 2008 Effects of olanzapine and ziprasidone on glucose tolerance in healthy volunteers Neuropsychopharmacology 33 1633 1641 17712347 10.1038/sj.npp.1301541 1:CAS:528:DC%2BD1cXlvVSrt70%3D (Pubitemid 351684708)
39. PR Shepherd BB Kahn 1999 Glucose transporters and insulin action-implications for insulin resistance and diabetes mellitus N Engl J Med 341 248 257 10413738 10.1056/NEJM199907223410406 1:CAS:528:DyaK1MXltVOju74%3D (Pubitemid 29334524)
40. H Shimano 2009 SREBPs: physiology and pathophysiology of the SREBP family FEBS J 276 616 621 19143830 10.1111/j.1742-4658.2008.06806.x 1:CAS:528:DC%2BD1MXhs1Kit7o%3D
41. I Shimomura M Matsuda RE Hammer Y Bashmakov MS Brown JL Goldstein 2000 Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice Mol Cell 6 77 86 10949029 1:CAS:528:DC%2BD3cXls1Kls7s%3D
42. GC Smith C Chaussade M Vickers J Jensen PR Shepherd 2008 Atypical antipsychotic drugs induce derangements in glucose homeostasis by acutely increasing glucagon secretion and hepatic glucose output in the rat Diabetologia 51 2309 2317 18843478 10.1007/s00125-008-1152-3 1:CAS:528:DC%2BD1cXhtlCjs77E
43. GC Smith MH Vickers E Cognard PR Shepherd 2009 Clozapine and quetiapine acutely reduce glucagon-like peptide-1 production and increase glucagon release in obese rats: implications for glucose metabolism and food choice behaviour Schizophr Res 115 30 40 19679451 10.1016/j.schres.2009.07.011
44. A Stefanidis AN Verty AM Allen NC Owens MA Cowley BJ Oldfield 2009 The role of thermogenesis in antipsychotic drug-induced weight gain Obesity 17 16 24 19107124 10.1038/oby.2008.468 1:CAS:528:DC%2BD1MXhtVGisg%3D%3D
45. G Tulipano C Rizzetti I Bianchi A Fanzani P Spano D Cocchi 2007 Clozapine-induced alteration of glucose homeostasis in the rat: the contribution of hypothalamic-pituitary-adrenal axis activation Neuroendocrinology 85 61 70 17374945 10.1159/000100981 1:CAS:528:DC%2BD2sXltVKjtLg%3D (Pubitemid 46725692)
46. S Virtue A Vidal-Puig 2008 It's not how fat you are, it's what you do with it that counts PLoS Biol 6 e237 18816166 10.1371/journal.pbio.0060237
47. S Virtue A Vidal-Puig 2010 Adipose tissue expandability, lipotoxicity and the metabolic syndrome-an allostatic perspective Biochim Biophys Acta 1801 338 349 20056169 10.1016/j.bbalip.2009.12.006 1:CAS:528:DC%2BC3cXitVejtb0%3D
48. J Winer CK Jung I Shackel PM Williams 1999 Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro Anal Biochem 270 41 49 10328763 10.1006/abio.1999.4085 1:CAS:528:DyaK1MXjtVersr0%3D (Pubitemid 29230718)
49. LH Yang TM Chen ST Yu YH Chen 2007 Olanzapine induces SREBP-1-related adipogenesis in 3T3-L1 cells Pharmacol Res 56 202 208 17651982 10.1016/j.phrs.2007.05.007 1:CAS:528:DC%2BD2sXpvF2qsLk%3D (Pubitemid 47321203)