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Volumn 309, Issue , 2015, Pages 125-139

Models and mechanisms for hippocampal dysfunction in obesity and diabetes

Author keywords

Diabetes; Hippocampus; Insulin resistance; Long term potentiation; Obesity; Synapse

Indexed keywords

INSULIN; STREPTOZOCIN;

EID: 84945478080     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2015.04.045     Document Type: Review
Times cited : (86)

References (149)
  • 1
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • Abbott N.J., Rönnbäck L., Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 2006, 7:41-53.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 41-53
    • Abbott, N.J.1    Rönnbäck, L.2    Hansson, E.3
  • 2
    • 0034960515 scopus 로고    scopus 로고
    • Corticosterone exerts site-specific and state-dependent effects in prefrontal cortex and amygdala on regulation of adrenocorticotropic hormone, insulin and fat depots
    • Akana S.F., Chu A., Soriano L., Dallman M.F. Corticosterone exerts site-specific and state-dependent effects in prefrontal cortex and amygdala on regulation of adrenocorticotropic hormone, insulin and fat depots. J Neuroendocrinol 2001, 13:625-637.
    • (2001) J Neuroendocrinol , vol.13 , pp. 625-637
    • Akana, S.F.1    Chu, A.2    Soriano, L.3    Dallman, M.F.4
  • 3
    • 0037121623 scopus 로고    scopus 로고
    • Corticosterone and stress reduce synaptic potentiation in mouse hippocampal slices with mild stimulation
    • Alfarez D.N., Wiegert O., Joëls M., Krugers H.J. Corticosterone and stress reduce synaptic potentiation in mouse hippocampal slices with mild stimulation. Neuroscience 2002, 115:1119-1126.
    • (2002) Neuroscience , vol.115 , pp. 1119-1126
    • Alfarez, D.N.1    Wiegert, O.2    Joëls, M.3    Krugers, H.J.4
  • 4
    • 84892659350 scopus 로고    scopus 로고
    • Diagnosis and classification of diabetes mellitus
    • American Diabetes Association Diagnosis and classification of diabetes mellitus. Diabetes Care 2014, 37:S81-S90.
    • (2014) Diabetes Care , vol.37 , pp. S81-S90
    • American Diabetes, Association1
  • 5
    • 84924047127 scopus 로고    scopus 로고
    • Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: Focus on brain indoleamine 2,3-dioxygenase activation
    • André C., Dinel A.L., Ferreira G., Layé S., Castanon N. Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: Focus on brain indoleamine 2,3-dioxygenase activation. Brain Behav Immun 2014, 41:10-21.
    • (2014) Brain Behav Immun , vol.41 , pp. 10-21
    • André, C.1    Dinel, A.L.2    Ferreira, G.3    Layé, S.4    Castanon, N.5
  • 6
    • 55249088143 scopus 로고    scopus 로고
    • Rod-Shaped monocytes patrol the brain vasculature and give rise to perivascular macrophages under the influence of proinflammatory cytokines and angiopoietin-2
    • Audoy-Rémus J., Richard J.F., Soulet D., Zhou H., Kubes P., Vallières L. Rod-Shaped monocytes patrol the brain vasculature and give rise to perivascular macrophages under the influence of proinflammatory cytokines and angiopoietin-2. J Neurosci 2008, 28:10187-10199.
    • (2008) J Neurosci , vol.28 , pp. 10187-10199
    • Audoy-Rémus, J.1    Richard, J.F.2    Soulet, D.3    Zhou, H.4    Kubes, P.5    Vallières, L.6
  • 8
    • 34249048643 scopus 로고    scopus 로고
    • Intrahippocampal insulin improves memory in a passive-avoidance task in male Wistar rats
    • Babri S., Badie H.G., Khamenei S., Seyedlar M.O. Intrahippocampal insulin improves memory in a passive-avoidance task in male Wistar rats. Brain Cogn 2007, 64:86-91.
    • (2007) Brain Cogn , vol.64 , pp. 86-91
    • Babri, S.1    Badie, H.G.2    Khamenei, S.3    Seyedlar, M.O.4
  • 9
    • 0030664286 scopus 로고
    • Transport of insulin across the blood-brain barrier: saturability at euglycemic doses of insulin
    • Banks W.A., Jaspan J.B., Huang W., Kastin A.J. Transport of insulin across the blood-brain barrier: saturability at euglycemic doses of insulin. Peptides 1987, 18:1423-1429.
    • (1987) Peptides , vol.18 , pp. 1423-1429
    • Banks, W.A.1    Jaspan, J.B.2    Huang, W.3    Kastin, A.J.4
  • 11
    • 84865451370 scopus 로고    scopus 로고
    • Fasting hyperglycemia in the Goto-Kakizaki rat is dependent on corticosterone: a confounding variable in rodent models of type 2 diabetes
    • Beddow S.A., Samuel V.T. Fasting hyperglycemia in the Goto-Kakizaki rat is dependent on corticosterone: a confounding variable in rodent models of type 2 diabetes. Dis Model Mech 2012, 5:681-685.
    • (2012) Dis Model Mech , vol.5 , pp. 681-685
    • Beddow, S.A.1    Samuel, V.T.2
  • 12
    • 0018579341 scopus 로고
    • Maximum oxygen consumption of rats and its changes with various experimental procedures
    • Bedford T.G., Tipton C.M., Wilson N.C., Oppliger R.A., Gisolfi C.V. Maximum oxygen consumption of rats and its changes with various experimental procedures. J Appl Physiol 1979, 47:1278-1283.
    • (1979) J Appl Physiol , vol.47 , pp. 1278-1283
    • Bedford, T.G.1    Tipton, C.M.2    Wilson, N.C.3    Oppliger, R.A.4    Gisolfi, C.V.5
  • 13
    • 84896733596 scopus 로고    scopus 로고
    • Short exposure to a diet rich in both fat and sugar or sugar alone impairs place, but not object recognition memory in rats
    • Beilharz J.E., Maniam J., Morris M.J. Short exposure to a diet rich in both fat and sugar or sugar alone impairs place, but not object recognition memory in rats. Brain Behav Immun 2014, 37:134-141.
    • (2014) Brain Behav Immun , vol.37 , pp. 134-141
    • Beilharz, J.E.1    Maniam, J.2    Morris, M.J.3
  • 14
    • 9744256993 scopus 로고    scopus 로고
    • Preserved LTP and water maze learning in hyperglycaemic-hyperinsulinemic ZDF rats
    • Belanger A., Lavoie N., Trudeau F., Massicotte G., Gagnon S. Preserved LTP and water maze learning in hyperglycaemic-hyperinsulinemic ZDF rats. Physiol Behav 2004, 83:483-494.
    • (2004) Physiol Behav , vol.83 , pp. 483-494
    • Belanger, A.1    Lavoie, N.2    Trudeau, F.3    Massicotte, G.4    Gagnon, S.5
  • 15
    • 0032572613 scopus 로고    scopus 로고
    • Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment
    • Biessels G.J., Kamal A., Urban I.J., Spruijt B.M., Erkelens D.W., Gispen W.H. Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment. Brain Res 1998, 800:125-135.
    • (1998) Brain Res , vol.800 , pp. 125-135
    • Biessels, G.J.1    Kamal, A.2    Urban, I.J.3    Spruijt, B.M.4    Erkelens, D.W.5    Gispen, W.H.6
  • 16
    • 0033807601 scopus 로고    scopus 로고
    • Improvement of insulin sensitivity after adrenalectomy in patients with pheochromocytoma
    • Blüher M., Windgassen M., Paschke R. Improvement of insulin sensitivity after adrenalectomy in patients with pheochromocytoma. Diabetes Care 2000, 23:1591-1592.
    • (2000) Diabetes Care , vol.23 , pp. 1591-1592
    • Blüher, M.1    Windgassen, M.2    Paschke, R.3
  • 17
    • 84863051235 scopus 로고    scopus 로고
    • Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits
    • Bouret S.G., Bates S.H., Chen S., Myers M.G., Simerly R.B. Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits. J Neurosci 2012, 32:1244-1252.
    • (2012) J Neurosci , vol.32 , pp. 1244-1252
    • Bouret, S.G.1    Bates, S.H.2    Chen, S.3    Myers, M.G.4    Simerly, R.B.5
  • 20
    • 15944416743 scopus 로고    scopus 로고
    • Recombinant methionyl human leptin administration to achieve high physiologic or pharmacologic leptin levels does not alter circulating inflammatory marker levels in humans with leptin sufficiency or excess
    • Chan J.L., Bullen J., Stoyneva V., Depaoli A.M., Addy C., Mantzoros C.S. Recombinant methionyl human leptin administration to achieve high physiologic or pharmacologic leptin levels does not alter circulating inflammatory marker levels in humans with leptin sufficiency or excess. J Clin Endocrinol Metab 2005, 90:1618-1624.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1618-1624
    • Chan, J.L.1    Bullen, J.2    Stoyneva, V.3    Depaoli, A.M.4    Addy, C.5    Mantzoros, C.S.6
  • 23
    • 28844493414 scopus 로고    scopus 로고
    • Physiological and pathological changes in glucose regulate brain Akt and glycogen synthase kinase-3
    • Clodfelder-Miller B., De Sarno P., Zmijewska A.A., Song L., Jope R.S. Physiological and pathological changes in glucose regulate brain Akt and glycogen synthase kinase-3. J Biol Chem 2005, 280:39723-39731.
    • (2005) J Biol Chem , vol.280 , pp. 39723-39731
    • Clodfelder-Miller, B.1    De Sarno, P.2    Zmijewska, A.A.3    Song, L.4    Jope, R.S.5
  • 25
    • 34548499151 scopus 로고    scopus 로고
    • Exercise builds brain health: key roles of growth factor cascades and inflammation
    • Cotman C.W., Berchtold N.C., Christie L.A. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci 2007, 30:464-472.
    • (2007) Trends Neurosci , vol.30 , pp. 464-472
    • Cotman, C.W.1    Berchtold, N.C.2    Christie, L.A.3
  • 26
    • 33845886915 scopus 로고    scopus 로고
    • Abdominal obesity and metabolic syndrome
    • Després J.P., Lemieux I. Abdominal obesity and metabolic syndrome. Nature 2006, 444:881-887.
    • (2006) Nature , vol.444 , pp. 881-887
    • Després, J.P.1    Lemieux, I.2
  • 27
    • 84896395852 scopus 로고    scopus 로고
    • Glucocorticoid sensitization of microglia in a genetic mouse model of obesity and diabetes
    • Dey A., Hao S., Erion J.R., Wosiski-Kuhn M., Stranahan A.M. Glucocorticoid sensitization of microglia in a genetic mouse model of obesity and diabetes. J Neuroimmunol 2014, 269:20-27.
    • (2014) J Neuroimmunol , vol.269 , pp. 20-27
    • Dey, A.1    Hao, S.2    Erion, J.R.3    Wosiski-Kuhn, M.4    Stranahan, A.M.5
  • 29
    • 80052838069 scopus 로고    scopus 로고
    • Cognitive and emotional alterations are related to hippocampal inflammation in a mouse model of metabolic syndrome
    • Dinel A.L., André C., Aubert A., Ferreira G., Layé S., Castanon N. Cognitive and emotional alterations are related to hippocampal inflammation in a mouse model of metabolic syndrome. PLoS One 2011, 6:e24325.
    • (2011) PLoS One , vol.6 , pp. e24325
    • Dinel, A.L.1    André, C.2    Aubert, A.3    Ferreira, G.4    Layé, S.5    Castanon, N.6
  • 30
    • 0026090520 scopus 로고
    • Adaptation to low calorie intake in obese mice: contribution of a metabolic component to diminished energy expenditures during and after weight loss
    • Dulloo A.G., Calokatisa R. Adaptation to low calorie intake in obese mice: contribution of a metabolic component to diminished energy expenditures during and after weight loss. Int J Obes 1991, 15(1):7-16.
    • (1991) Int J Obes , vol.15 , Issue.1 , pp. 7-16
    • Dulloo, A.G.1    Calokatisa, R.2
  • 31
    • 0041672217 scopus 로고    scopus 로고
    • Regional effects of wheel running and environmental enrichment on cell genesis and microglia proliferation in the adult murine neocortex
    • Ehninger D., Kempermann G. Regional effects of wheel running and environmental enrichment on cell genesis and microglia proliferation in the adult murine neocortex. Cereb Cortex 2003, 13:845-851.
    • (2003) Cereb Cortex , vol.13 , pp. 845-851
    • Ehninger, D.1    Kempermann, G.2
  • 33
    • 79951540531 scopus 로고    scopus 로고
    • Activity-dependent regulation of surface glucose transporter-3
    • Ferreira J.M., Burnett A.L., Rameau G.A. Activity-dependent regulation of surface glucose transporter-3. J Neurosci 2011, 31:1991-1999.
    • (2011) J Neurosci , vol.31 , pp. 1991-1999
    • Ferreira, J.M.1    Burnett, A.L.2    Rameau, G.A.3
  • 34
    • 33745800033 scopus 로고    scopus 로고
    • Alpha-Tocopherol affects neuronal plasticity in adult rat dentate gyrus: the possible role of PKCdelta
    • Ferri P., Cecchini T., Ambrogini P., Betti M., Cuppini R., Del Grande P., Ciaroni S. Alpha-Tocopherol affects neuronal plasticity in adult rat dentate gyrus: the possible role of PKCdelta. J Neurobiol 2006, 66:793-810.
    • (2006) J Neurobiol , vol.66 , pp. 793-810
    • Ferri, P.1    Cecchini, T.2    Ambrogini, P.3    Betti, M.4    Cuppini, R.5    Del Grande, P.6    Ciaroni, S.7
  • 36
    • 66449136112 scopus 로고    scopus 로고
    • Palatable foods, stress, and energy stores sculpt corticotropin-releasing factor, adrenocorticotropin, and corticosterone concentrations after restraint
    • Foster M.T., Warne J.P., Ginsberg A.B., Horneman H.F., Pecoraro N.C., Akana S.F., Dallman M.F. Palatable foods, stress, and energy stores sculpt corticotropin-releasing factor, adrenocorticotropin, and corticosterone concentrations after restraint. Endocrinology 2009, 150:2325-2333.
    • (2009) Endocrinology , vol.150 , pp. 2325-2333
    • Foster, M.T.1    Warne, J.P.2    Ginsberg, A.B.3    Horneman, H.F.4    Pecoraro, N.C.5    Akana, S.F.6    Dallman, M.F.7
  • 37
    • 75049084559 scopus 로고    scopus 로고
    • Changing perspectives regarding late-life dementia
    • Fotuhi M., Hachinski V., Whitehouse P.J. Changing perspectives regarding late-life dementia. Nat Rev Neurol 2009, 5:649-658.
    • (2009) Nat Rev Neurol , vol.5 , pp. 649-658
    • Fotuhi, M.1    Hachinski, V.2    Whitehouse, P.J.3
  • 38
    • 33644511746 scopus 로고    scopus 로고
    • Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics
    • Frank M.G., Wieseler-Frank J.L., Watkins L.R., Maier S.F. Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics. J Neurosci Methods 2006, 151:121-130.
    • (2006) J Neurosci Methods , vol.151 , pp. 121-130
    • Frank, M.G.1    Wieseler-Frank, J.L.2    Watkins, L.R.3    Maier, S.F.4
  • 39
    • 84855985525 scopus 로고    scopus 로고
    • Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses
    • Frank M.G., Thompson B.M., Watkins L.R., Maier S.F. Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses. Brain Behav Immun 2012, 26:337-345.
    • (2012) Brain Behav Immun , vol.26 , pp. 337-345
    • Frank, M.G.1    Thompson, B.M.2    Watkins, L.R.3    Maier, S.F.4
  • 41
    • 14144255054 scopus 로고    scopus 로고
    • Where is the blood-brain barrier. . .really?
    • Ge S., Song L., Pachter J.S. Where is the blood-brain barrier. . .really?. J Neurosci Res 2005, 79:421-427.
    • (2005) J Neurosci Res , vol.79 , pp. 421-427
    • Ge, S.1    Song, L.2    Pachter, J.S.3
  • 42
    • 84881609950 scopus 로고    scopus 로고
    • Fatty acids differentially regulate insulin resistance through endoplasm reticulum stress-mediated induction of tribbles homologue 3: a potential link between dietary fat composition and the pathophysiological outcomes of obesity
    • Geng T., Hu W., Broadwater M.H., Snider J.M., Bielawski J., Russo S.B., Schwacke J.H., Ross J., Cowart L.A. Fatty acids differentially regulate insulin resistance through endoplasm reticulum stress-mediated induction of tribbles homologue 3: a potential link between dietary fat composition and the pathophysiological outcomes of obesity. Diabetologia 2013, 56:2078-2087.
    • (2013) Diabetologia , vol.56 , pp. 2078-2087
    • Geng, T.1    Hu, W.2    Broadwater, M.H.3    Snider, J.M.4    Bielawski, J.5    Russo, S.B.6    Schwacke, J.H.7    Ross, J.8    Cowart, L.A.9
  • 43
    • 0017066391 scopus 로고
    • Production of spontaneous diabetic rats by repetition of selective breeding
    • Goto Y., Kakizaki M., Masaki N. Production of spontaneous diabetic rats by repetition of selective breeding. Tohoku J Exp Med 1976, 119:85-90.
    • (1976) Tohoku J Exp Med , vol.119 , pp. 85-90
    • Goto, Y.1    Kakizaki, M.2    Masaki, N.3
  • 44
    • 79251575885 scopus 로고    scopus 로고
    • The effects of two forms of physical activity on eyeblink classical conditioning
    • Green J.T., Chess A.C., Burns M., Schachinger K.M., Thanellou A. The effects of two forms of physical activity on eyeblink classical conditioning. Behav Brain Res 2011, 219(1):165-174.
    • (2011) Behav Brain Res , vol.219 , Issue.1 , pp. 165-174
    • Green, J.T.1    Chess, A.C.2    Burns, M.3    Schachinger, K.M.4    Thanellou, A.5
  • 45
    • 0025357162 scopus 로고
    • Learning and memory impairment in rats fed a high saturated fat diet
    • Greenwood C.E., Winocur G. Learning and memory impairment in rats fed a high saturated fat diet. Behav Neural Biol 1990, 53:74-87.
    • (1990) Behav Neural Biol , vol.53 , pp. 74-87
    • Greenwood, C.E.1    Winocur, G.2
  • 47
    • 70349285955 scopus 로고    scopus 로고
    • Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent
    • Grillo C.A., Piroli G.G., Hendry R.M., Reagan L.P. Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent. Brain Res 2009, 1296:35-45.
    • (2009) Brain Res , vol.1296 , pp. 35-45
    • Grillo, C.A.1    Piroli, G.G.2    Hendry, R.M.3    Reagan, L.P.4
  • 48
    • 80053435488 scopus 로고    scopus 로고
    • Obesity/hyperleptinemic phenotype impairs structural and functional plasticity in the rat hippocampus
    • Grillo C.A., Piroli G.G., Junor L., Wilson S.P., Mott D.D., Wilson M.A., Reagan L.P. Obesity/hyperleptinemic phenotype impairs structural and functional plasticity in the rat hippocampus. Physiol Behav 2011, 105:138-144.
    • (2011) Physiol Behav , vol.105 , pp. 138-144
    • Grillo, C.A.1    Piroli, G.G.2    Junor, L.3    Wilson, S.P.4    Mott, D.D.5    Wilson, M.A.6    Reagan, L.P.7
  • 50
    • 79955013424 scopus 로고    scopus 로고
    • Downregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats
    • Grillo C.A., Piroli G.G., Kaigler K.F., Wilson S.P., Wilson M.A., Reagan L.P. Downregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats. Behav Brain Res 2011, 222:230-235.
    • (2011) Behav Brain Res , vol.222 , pp. 230-235
    • Grillo, C.A.1    Piroli, G.G.2    Kaigler, K.F.3    Wilson, S.P.4    Wilson, M.A.5    Reagan, L.P.6
  • 51
    • 1542373666 scopus 로고    scopus 로고
    • Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification
    • Guillemin G.J., Brew B.J. Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification. J Leukoc Biol 2004, 75:388-397.
    • (2004) J Leukoc Biol , vol.75 , pp. 388-397
    • Guillemin, G.J.1    Brew, B.J.2
  • 54
    • 0037559727 scopus 로고    scopus 로고
    • C-fos reduces corticosterone-mediated effects on neurotrophic factor expression in the rat hippocampal CA1 region
    • Hansson A.C., Sommer W., Rimondini R., Andbjer B., Strömberg I., Fuxe K. C-fos reduces corticosterone-mediated effects on neurotrophic factor expression in the rat hippocampal CA1 region. J Neurosci 2003, 23:6013-6022.
    • (2003) J Neurosci , vol.23 , pp. 6013-6022
    • Hansson, A.C.1    Sommer, W.2    Rimondini, R.3    Andbjer, B.4    Strömberg, I.5    Fuxe, K.6
  • 56
    • 84924150591 scopus 로고    scopus 로고
    • Indomethacin reverses decreased hippocampal cell proliferation in streptozotocin-induced diabetic mice
    • Ho N., Brookshire B.R., Clark J.E., Lucki I. Indomethacin reverses decreased hippocampal cell proliferation in streptozotocin-induced diabetic mice. Metab Brain Dis 2015, 30:555-562.
    • (2015) Metab Brain Dis , vol.30 , pp. 555-562
    • Ho, N.1    Brookshire, B.R.2    Clark, J.E.3    Lucki, I.4
  • 57
    • 17844391500 scopus 로고    scopus 로고
    • The hardship of obesity: a soft-wired hypothalamus
    • Horvath T.L. The hardship of obesity: a soft-wired hypothalamus. Nat Neurosci 2005, 8:561-565.
    • (2005) Nat Neurosci , vol.8 , pp. 561-565
    • Horvath, T.L.1
  • 58
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • Hotamisligil G.S., Shargill N.S., Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259:87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 59
    • 67349151166 scopus 로고    scopus 로고
    • The neuro-symphony of stress
    • Joëls M., Baram T.Z. The neuro-symphony of stress. Nat Rev Neurosci 2009, 10:459-466.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 459-466
    • Joëls, M.1    Baram, T.Z.2
  • 61
    • 2342536173 scopus 로고    scopus 로고
    • Learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: interaction of diabetes and ageing
    • Kamal A., Biessels G.J., Duis S.E., Gispen W.H. Learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: interaction of diabetes and ageing. Diabetologia 2000, 43:500-506.
    • (2000) Diabetologia , vol.43 , pp. 500-506
    • Kamal, A.1    Biessels, G.J.2    Duis, S.E.3    Gispen, W.H.4
  • 62
    • 84864118287 scopus 로고    scopus 로고
    • Immunological complications of obesity
    • Kanneganti T.D., Dixit V.D. Immunological complications of obesity. Nat Immunol 2012, 13:707-712.
    • (2012) Nat Immunol , vol.13 , pp. 707-712
    • Kanneganti, T.D.1    Dixit, V.D.2
  • 63
    • 77954981010 scopus 로고    scopus 로고
    • The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat
    • Kanoski S.E., Zhang Y., Zheng W., Davidson T.L. The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat. J Alzheimers Dis 2010, 21:207-219.
    • (2010) J Alzheimers Dis , vol.21 , pp. 207-219
    • Kanoski, S.E.1    Zhang, Y.2    Zheng, W.3    Davidson, T.L.4
  • 66
    • 71949112504 scopus 로고    scopus 로고
    • Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes
    • Kim B., Backus C., Oh S., Hayes J.M., Feldman E.L. Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes. Endocrinology 2009, 150:5294-5301.
    • (2009) Endocrinology , vol.150 , pp. 5294-5301
    • Kim, B.1    Backus, C.2    Oh, S.3    Hayes, J.M.4    Feldman, E.L.5
  • 68
    • 34248358339 scopus 로고    scopus 로고
    • Feast or famine: the sympathetic nervous system response to nutrient intake
    • Landsberg L. Feast or famine: the sympathetic nervous system response to nutrient intake. Cell Mol Neurobiol 2006, 26:497-508.
    • (2006) Cell Mol Neurobiol , vol.26 , pp. 497-508
    • Landsberg, L.1
  • 69
    • 64849111978 scopus 로고    scopus 로고
    • Impaired neurogenesis in adult type-2 diabetic rats
    • Lang B.T., Yan Y., Dempsey R.J., Vemuganti R. Impaired neurogenesis in adult type-2 diabetic rats. Brain Res 2009, 1258:25-33.
    • (2009) Brain Res , vol.1258 , pp. 25-33
    • Lang, B.T.1    Yan, Y.2    Dempsey, R.J.3    Vemuganti, R.4
  • 70
    • 0031797937 scopus 로고    scopus 로고
    • Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats
    • Lannert H., Hoyer S. Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats. Behav Neurosci 1998, 112:1199-1208.
    • (1998) Behav Neurosci , vol.112 , pp. 1199-1208
    • Lannert, H.1    Hoyer, S.2
  • 71
    • 79960016949 scopus 로고    scopus 로고
    • Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways
    • Lee C.C., Huang C.C., Hsu K.S. Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways. Neuropharmacology 2011, 61:867-879.
    • (2011) Neuropharmacology , vol.61 , pp. 867-879
    • Lee, C.C.1    Huang, C.C.2    Hsu, K.S.3
  • 72
    • 33846252240 scopus 로고    scopus 로고
    • Genome-wide atlas of gene expression in the adult mouse brain
    • Lein E.S., Hawrylycz M.J., Ao N., Ayres M., Bensinger A., et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 2007, 445:168-176.
    • (2007) Nature , vol.445 , pp. 168-176
    • Lein, E.S.1    Hawrylycz, M.J.2    Ao, N.3    Ayres, M.4    Bensinger, A.5
  • 73
    • 37549029242 scopus 로고    scopus 로고
    • The mechanisms of alloxan- and streptozotocin-induced diabetes
    • Lenzen S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 2008, 51:216-226.
    • (2008) Diabetologia , vol.51 , pp. 216-226
    • Lenzen, S.1
  • 74
    • 0037008873 scopus 로고    scopus 로고
    • Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents
    • Li X.L., Aou S., Oomura Y., Hori N., Fukunaga K., Hori T. Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents. Neuroscience 2002, 113:607-615.
    • (2002) Neuroscience , vol.113 , pp. 607-615
    • Li, X.L.1    Aou, S.2    Oomura, Y.3    Hori, N.4    Fukunaga, K.5    Hori, T.6
  • 75
    • 84876397853 scopus 로고    scopus 로고
    • Pentamethylquercetin protects against diabetes-related cognitive deficits in diabetic Goto-Kakizaki rats
    • Li X.H., Xin X., Wang Y., Wu J.Z., Jin Z.D., Ma L.N., Nie C.J., Xiao X., Hu Y., Jin M.W. Pentamethylquercetin protects against diabetes-related cognitive deficits in diabetic Goto-Kakizaki rats. J Alzheimers Dis 2013, 34:755-767.
    • (2013) J Alzheimers Dis , vol.34 , pp. 755-767
    • Li, X.H.1    Xin, X.2    Wang, Y.3    Wu, J.Z.4    Jin, Z.D.5    Ma, L.N.6    Nie, C.J.7    Xiao, X.8    Hu, Y.9    Jin, M.W.10
  • 76
    • 0034646330 scopus 로고    scopus 로고
    • Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death
    • Liu K., Paterson A.J., Chin E., Kudlow J.E. Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death. Proc Natl Acad Sci U S A 2000, 97:2820-2825.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 2820-2825
    • Liu, K.1    Paterson, A.J.2    Chin, E.3    Kudlow, J.E.4
  • 77
    • 33750158522 scopus 로고    scopus 로고
    • Hippocampal volume and cognitive performance in long-standing Type 1 diabetic patients without macrovascular complications
    • Lobnig B.M., Krömeke O., Optenhostert-Porst C., Wolf O.T. Hippocampal volume and cognitive performance in long-standing Type 1 diabetic patients without macrovascular complications. Diabet Med 2006, 23:32-39.
    • (2006) Diabet Med , vol.23 , pp. 32-39
    • Lobnig, B.M.1    Krömeke, O.2    Optenhostert-Porst, C.3    Wolf, O.T.4
  • 79
    • 0034718561 scopus 로고    scopus 로고
    • Experimental diabetes in rats causes hippocampal dendritic and synaptic reorganization and increased glucocorticoid reactivity to stress
    • Magariños A.M., McEwen B.S. Experimental diabetes in rats causes hippocampal dendritic and synaptic reorganization and increased glucocorticoid reactivity to stress. Proc Natl Acad Sci U S A 2000, 97:11056-11061.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 11056-11061
    • Magariños, A.M.1    McEwen, B.S.2
  • 80
    • 79959879208 scopus 로고    scopus 로고
    • Central insulin and leptin-mediated autonomic control of glucose homeostasis
    • Marino J.S., Xu Y., Hill J.W. Central insulin and leptin-mediated autonomic control of glucose homeostasis. Trends Endocrinol Metab 2011, 22:275-285.
    • (2011) Trends Endocrinol Metab , vol.22 , pp. 275-285
    • Marino, J.S.1    Xu, Y.2    Hill, J.W.3
  • 82
    • 0035136130 scopus 로고    scopus 로고
    • The regulation of total body fat: lessons learned from lipectomy studies
    • Mauer M.M., Harris R.B., Bartness T.J. The regulation of total body fat: lessons learned from lipectomy studies. Neurosci Biobehav Rev 2001, 25:15-28.
    • (2001) Neurosci Biobehav Rev , vol.25 , pp. 15-28
    • Mauer, M.M.1    Harris, R.B.2    Bartness, T.J.3
  • 83
    • 0032900831 scopus 로고    scopus 로고
    • Extracellular glucose concentrations in the rat hippocampus measured by zero-net-flux: effects of microdialysis flow rate, strain, and age
    • McNay E.C., Gold P.E. Extracellular glucose concentrations in the rat hippocampus measured by zero-net-flux: effects of microdialysis flow rate, strain, and age. J Neurochem 1999, 72:785-790.
    • (1999) J Neurochem , vol.72 , pp. 785-790
    • McNay, E.C.1    Gold, P.E.2
  • 85
    • 9444283277 scopus 로고    scopus 로고
    • Kinetics-effect relations of insulin-releasing drugs in patients with type 2 diabetes: brief overview
    • Melander A. Kinetics-effect relations of insulin-releasing drugs in patients with type 2 diabetes: brief overview. Diabetes 2004, 53:S151-S155.
    • (2004) Diabetes , vol.53 , pp. S151-S155
    • Melander, A.1
  • 86
    • 68949105560 scopus 로고    scopus 로고
    • Exercise-induced neuronal plasticity in central autonomic networks: role in cardiovascular control
    • Michelini L.C., Stern J.E. Exercise-induced neuronal plasticity in central autonomic networks: role in cardiovascular control. Exp Physiol 2009, 94:947-960.
    • (2009) Exp Physiol , vol.94 , pp. 947-960
    • Michelini, L.C.1    Stern, J.E.2
  • 87
    • 20744444237 scopus 로고    scopus 로고
    • A biochemical and functional characterization of diet-induced brain insulin resistance
    • Mielke J.G., Taghibiglou C., Liu L., Zhang Y., Jia Z., Adeli K., Wang Y.T. A biochemical and functional characterization of diet-induced brain insulin resistance. J Neurochem 2005, 93:1568-1578.
    • (2005) J Neurochem , vol.93 , pp. 1568-1578
    • Mielke, J.G.1    Taghibiglou, C.2    Liu, L.3    Zhang, Y.4    Jia, Z.5    Adeli, K.6    Wang, Y.T.7
  • 89
    • 0037135258 scopus 로고    scopus 로고
    • A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning
    • Molteni R., Barnard R.J., Ying Z., Roberts C.K., Gómez-Pinilla F. A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience 2002, 112:803-814.
    • (2002) Neuroscience , vol.112 , pp. 803-814
    • Molteni, R.1    Barnard, R.J.2    Ying, Z.3    Roberts, C.K.4    Gómez-Pinilla, F.5
  • 91
    • 33750939080 scopus 로고    scopus 로고
    • The effect of intrahippocampal insulin microinjection on spatial learning and memory
    • Moosavi M., Naghdi N., Maghsoudi N., Zahedi Asl S. The effect of intrahippocampal insulin microinjection on spatial learning and memory. Horm Behav 2006, 50:748-752.
    • (2006) Horm Behav , vol.50 , pp. 748-752
    • Moosavi, M.1    Naghdi, N.2    Maghsoudi, N.3    Zahedi Asl, S.4
  • 94
    • 84898027883 scopus 로고    scopus 로고
    • TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation
    • Norden D.M., Fenn A.M., Dugan A., Godbout J.P. TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation. Glia 2014, 62:881-895.
    • (2014) Glia , vol.62 , pp. 881-895
    • Norden, D.M.1    Fenn, A.M.2    Dugan, A.3    Godbout, J.P.4
  • 96
    • 84896690513 scopus 로고    scopus 로고
    • Prevalence of Childhood and Adult Obesity in the United States, 2011-2012
    • Ogden C.L., Carroll M.D., Kit B.K., Flegal K.M. Prevalence of Childhood and Adult Obesity in the United States, 2011-2012. JAMA 2014, 311:806-814.
    • (2014) JAMA , vol.311 , pp. 806-814
    • Ogden, C.L.1    Carroll, M.D.2    Kit, B.K.3    Flegal, K.M.4
  • 97
    • 84857985148 scopus 로고    scopus 로고
    • The cellular and signaling networks linking the immune system and metabolism in disease
    • Osborn O., Olefsky J.M. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med 2012, 18:363-374.
    • (2012) Nat Med , vol.18 , pp. 363-374
    • Osborn, O.1    Olefsky, J.M.2
  • 99
    • 0033304576 scopus 로고    scopus 로고
    • Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects
    • Ozata M., Ozdemir I.C., Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab 1999, 84:3686-3695.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3686-3695
    • Ozata, M.1    Ozdemir, I.C.2    Licinio, J.3
  • 101
  • 102
    • 33646358276 scopus 로고    scopus 로고
    • Alzheimer's disease could be "type 3 diabetes"
    • Pilcher H. Alzheimer's disease could be "type 3 diabetes". Lancet Neurol 2006, 5:388-389.
    • (2006) Lancet Neurol , vol.5 , pp. 388-389
    • Pilcher, H.1
  • 103
    • 0037078231 scopus 로고    scopus 로고
    • Peripheral glucose administration stimulates the translocation of GLUT8 glucose transporter to the endoplasmic reticulum in the rat hippocampus
    • Piroli G.G., Grillo C.A., Hoskin E.K., Znamensky V., Katz E.B., Milner T.A., McEwen B.S., Charron M.J., Reagan L.P. Peripheral glucose administration stimulates the translocation of GLUT8 glucose transporter to the endoplasmic reticulum in the rat hippocampus. J Comp Neurol 2002, 452:103-114.
    • (2002) J Comp Neurol , vol.452 , pp. 103-114
    • Piroli, G.G.1    Grillo, C.A.2    Hoskin, E.K.3    Znamensky, V.4    Katz, E.B.5    Milner, T.A.6    McEwen, B.S.7    Charron, M.J.8    Reagan, L.P.9
  • 104
    • 76849101075 scopus 로고    scopus 로고
    • Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders
    • Profenno L.A., Porsteinsson A.P., Faraone S.V. Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders. Biol Psychiatry 2010, 67:505-512.
    • (2010) Biol Psychiatry , vol.67 , pp. 505-512
    • Profenno, L.A.1    Porsteinsson, A.P.2    Faraone, S.V.3
  • 105
    • 0345044545 scopus 로고    scopus 로고
    • Regulation of GLUT-3 glucose transporter in the hippocampus of diabetic rats subjected to stress
    • Reagan L.P., Magariños A.M., Lucas L.R., van Bueren A., McCall A.L., McEwen B.S. Regulation of GLUT-3 glucose transporter in the hippocampus of diabetic rats subjected to stress. Am J Physiol 1999, 276:E879-E886.
    • (1999) Am J Physiol , vol.276 , pp. E879-E886
    • Reagan, L.P.1    Magariños, A.M.2    Lucas, L.R.3    van Bueren, A.4    McCall, A.L.5    McEwen, B.S.6
  • 107
    • 84919462598 scopus 로고    scopus 로고
    • Dietary-induced obesity disrupts trace fear conditioning and decreases hippocampal reelin expression
    • Reichelt A.C., Maniam J., Westbrook R.F., Morris M.J. Dietary-induced obesity disrupts trace fear conditioning and decreases hippocampal reelin expression. Brain Behav Immun 2015, 43:68-75.
    • (2015) Brain Behav Immun , vol.43 , pp. 68-75
    • Reichelt, A.C.1    Maniam, J.2    Westbrook, R.F.3    Morris, M.J.4
  • 108
    • 58149468794 scopus 로고    scopus 로고
    • Glucocorticoid receptor blockade normalizes hippocampal alterations and cognitive impairment in streptozotocin-induced type 1 diabetes mice
    • Revsin Y., Rekers N.V., Louwe M.C., Saravia F.E., De Nicola A.F., de Kloet E.R., Oitzl M.S. Glucocorticoid receptor blockade normalizes hippocampal alterations and cognitive impairment in streptozotocin-induced type 1 diabetes mice. Neuropsychopharmacology 2009, 34:747-758.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 747-758
    • Revsin, Y.1    Rekers, N.V.2    Louwe, M.C.3    Saravia, F.E.4    De Nicola, A.F.5    de Kloet, E.R.6    Oitzl, M.S.7
  • 109
    • 84892727198 scopus 로고    scopus 로고
    • What we talk about when we talk about fat
    • Rosen E.D., Spiegelman B.M. What we talk about when we talk about fat. Cell 2014, 156:20-44.
    • (2014) Cell , vol.156 , pp. 20-44
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 110
    • 84856770221 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease impairs hippocampal-dependent memory in male rats
    • Ross A.P., Bruggeman E.C., Kasumu A.W., Mielke J.G., Parent M.B. Non-alcoholic fatty liver disease impairs hippocampal-dependent memory in male rats. Physiol Behav 2012, 106(2):133-141.
    • (2012) Physiol Behav , vol.106 , Issue.2 , pp. 133-141
    • Ross, A.P.1    Bruggeman, E.C.2    Kasumu, A.W.3    Mielke, J.G.4    Parent, M.B.5
  • 111
    • 0028604486 scopus 로고
    • STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells
    • Schnedl W.J., Ferber S., Johnson J.H., Newgard C.B. STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. Diabetes 1994, 43:1326-1333.
    • (1994) Diabetes , vol.43 , pp. 1326-1333
    • Schnedl, W.J.1    Ferber, S.2    Johnson, J.H.3    Newgard, C.B.4
  • 114
    • 0001891313 scopus 로고    scopus 로고
    • Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity
    • Shanley L.J., Irving A.J., Harvey J. Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity. J Neurosci 2001, 21:1-6.
    • (2001) J Neurosci , vol.21 , pp. 1-6
    • Shanley, L.J.1    Irving, A.J.2    Harvey, J.3
  • 115
    • 0023202481 scopus 로고
    • Adrenalectomy and steroid treatment in obese (ob/ob) and diabetic (db/db) mice
    • Shimomura Y., Bray G.A., Lee M. Adrenalectomy and steroid treatment in obese (ob/ob) and diabetic (db/db) mice. Horm Metab Res 1987, 19:295-299.
    • (1987) Horm Metab Res , vol.19 , pp. 295-299
    • Shimomura, Y.1    Bray, G.A.2    Lee, M.3
  • 116
    • 0842277726 scopus 로고    scopus 로고
    • Intracerebroventricular injection of streptozotocin causes neurotoxicity to myelin that contributes to spatial memory deficits in rats
    • Shoham S., Bejar C., Kovalev E., Weinstock M. Intracerebroventricular injection of streptozotocin causes neurotoxicity to myelin that contributes to spatial memory deficits in rats. Exp Neurol 2003, 184:1043-1052.
    • (2003) Exp Neurol , vol.184 , pp. 1043-1052
    • Shoham, S.1    Bejar, C.2    Kovalev, E.3    Weinstock, M.4
  • 117
    • 77955173815 scopus 로고    scopus 로고
    • Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis
    • Sickmann H.M., Waagepetersen H.S., Schousboe A., Benie A.J., Bouman S.D. Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis. J Cereb Blood Flow Metab 2010, 30:1527-1537.
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 1527-1537
    • Sickmann, H.M.1    Waagepetersen, H.S.2    Schousboe, A.3    Benie, A.J.4    Bouman, S.D.5
  • 119
    • 84908622865 scopus 로고    scopus 로고
    • High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1β, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism
    • Sobesky J.L., Barrientos R.M., De May H.S., Thompson B.M., Weber M.D., Watkins L.R., Maier S.F. High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1β, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism. Brain Behav Immun 2014, 42:22-32.
    • (2014) Brain Behav Immun , vol.42 , pp. 22-32
    • Sobesky, J.L.1    Barrientos, R.M.2    De May, H.S.3    Thompson, B.M.4    Weber, M.D.5    Watkins, L.R.6    Maier, S.F.7
  • 120
    • 84907762426 scopus 로고    scopus 로고
    • The effect of insulin and insulin-like growth factors on hippocampus- and amygdala-dependent long-term memory formation
    • Stern S.A., Chen D.Y., Alberini C.M. The effect of insulin and insulin-like growth factors on hippocampus- and amygdala-dependent long-term memory formation. Learn Mem 2014, 21:556-563.
    • (2014) Learn Mem , vol.21 , pp. 556-563
    • Stern, S.A.1    Chen, D.Y.2    Alberini, C.M.3
  • 121
    • 79960563163 scopus 로고    scopus 로고
    • Bidirectional metabolic regulation of neurocognitive function
    • Stranahan A.M., Mattson M.P. Bidirectional metabolic regulation of neurocognitive function. Neurobiol Learn Mem 2011, 96:507-516.
    • (2011) Neurobiol Learn Mem , vol.96 , pp. 507-516
    • Stranahan, A.M.1    Mattson, M.P.2
  • 122
    • 36349012003 scopus 로고    scopus 로고
    • Running induces widespread structural alterations in the hippocampus and entorhinal cortex
    • Stranahan A.M., Khalil D., Gould E. Running induces widespread structural alterations in the hippocampus and entorhinal cortex. Hippocampus 2007, 17:1017-1022.
    • (2007) Hippocampus , vol.17 , pp. 1017-1022
    • Stranahan, A.M.1    Khalil, D.2    Gould, E.3
  • 123
    • 39749137437 scopus 로고    scopus 로고
    • Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons
    • Stranahan A.M., Arumugam T.V., Cutler R.G., Lee K., Egan J.M., Mattson M.P. Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons. Nat Neurosci 2008, 11:309-317.
    • (2008) Nat Neurosci , vol.11 , pp. 309-317
    • Stranahan, A.M.1    Arumugam, T.V.2    Cutler, R.G.3    Lee, K.4    Egan, J.M.5    Mattson, M.P.6
  • 125
    • 55549139200 scopus 로고    scopus 로고
    • Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats
    • Stranahan A.M., Norman E.D., Lee K., Cutler R.G., Telljohann R.S., Egan J.M., Mattson M.P. Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus 2008, 18:1085-1088.
    • (2008) Hippocampus , vol.18 , pp. 1085-1088
    • Stranahan, A.M.1    Norman, E.D.2    Lee, K.3    Cutler, R.G.4    Telljohann, R.S.5    Egan, J.M.6    Mattson, M.P.7
  • 126
    • 70349262248 scopus 로고    scopus 로고
    • Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice
    • Stranahan A.M., Lee K., Martin B., Maudsley S., Golden E., Cutler R.G., Mattson M.P. Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice. Hippocampus 2009, 19:951-961.
    • (2009) Hippocampus , vol.19 , pp. 951-961
    • Stranahan, A.M.1    Lee, K.2    Martin, B.3    Maudsley, S.4    Golden, E.5    Cutler, R.G.6    Mattson, M.P.7
  • 127
    • 79951674291 scopus 로고    scopus 로고
    • Lowering corticosterone levels reinstates hippocampal brain-derived neurotropic factor and Trkb expression without influencing deficits in hypothalamic brain-derived neurotropic factor expression in leptin receptor-deficient mice
    • Stranahan A.M., Arumugam T.V., Mattson M.P. Lowering corticosterone levels reinstates hippocampal brain-derived neurotropic factor and Trkb expression without influencing deficits in hypothalamic brain-derived neurotropic factor expression in leptin receptor-deficient mice. Neuroendocrinology 2011, 93:58-64.
    • (2011) Neuroendocrinology , vol.93 , pp. 58-64
    • Stranahan, A.M.1    Arumugam, T.V.2    Mattson, M.P.3
  • 128
    • 84856521441 scopus 로고    scopus 로고
    • Anti-inflammatory effects of physical activity in relationship to improved cognitive status in humans and mouse models of Alzheimer's disease
    • Stranahan A.M., Martin B., Maudsley S. Anti-inflammatory effects of physical activity in relationship to improved cognitive status in humans and mouse models of Alzheimer's disease. Curr Alzheimer Res 2012, 9:86-92.
    • (2012) Curr Alzheimer Res , vol.9 , pp. 86-92
    • Stranahan, A.M.1    Martin, B.2    Maudsley, S.3
  • 130
    • 21544471809 scopus 로고    scopus 로고
    • Obesity, inactivity, and the prevalence of diabetes and diabetes-related cardiovascular comorbidities in the U.S., 2000-2002
    • Sullivan P.W., Morrato E.H., Ghushchyan V., Wyatt H.R., Hill J.O. Obesity, inactivity, and the prevalence of diabetes and diabetes-related cardiovascular comorbidities in the U.S., 2000-2002. Diabetes Care 2005, 28:1599-1603.
    • (2005) Diabetes Care , vol.28 , pp. 1599-1603
    • Sullivan, P.W.1    Morrato, E.H.2    Ghushchyan, V.3    Wyatt, H.R.4    Hill, J.O.5
  • 132
    • 72449128492 scopus 로고    scopus 로고
    • Hypothalamic inflammation and energy homeostasis: resolving the paradox
    • Thaler J.P., Choi S.J., Schwartz M.W., Wisse B.E. Hypothalamic inflammation and energy homeostasis: resolving the paradox. Front Neuroendocrinol 2010, 31:79-84.
    • (2010) Front Neuroendocrinol , vol.31 , pp. 79-84
    • Thaler, J.P.1    Choi, S.J.2    Schwartz, M.W.3    Wisse, B.E.4
  • 133
    • 13144276331 scopus 로고    scopus 로고
    • Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia
    • Tsuda M., Inoue K., Salter M.W. Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia. Trends Neurosci 2005, 28:101-107.
    • (2005) Trends Neurosci , vol.28 , pp. 101-107
    • Tsuda, M.1    Inoue, K.2    Salter, M.W.3
  • 134
    • 84908376800 scopus 로고    scopus 로고
    • Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease
    • Tucsek Z., Toth P., Sosnowska D., Gautam T., Mitschelen M., Koller A., Szalai G., Sonntag W.E., Ungvari Z., Csiszar A. Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease. J Gerontol A Biol Sci Med Sci 2014, 69:1212-1226.
    • (2014) J Gerontol A Biol Sci Med Sci , vol.69 , pp. 1212-1226
    • Tucsek, Z.1    Toth, P.2    Sosnowska, D.3    Gautam, T.4    Mitschelen, M.5    Koller, A.6    Szalai, G.7    Sonntag, W.E.8    Ungvari, Z.9    Csiszar, A.10
  • 135
    • 0033360314 scopus 로고    scopus 로고
    • Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
    • van Praag H., Kempermann G., Gage F.H. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 1999, 2:266-270.
    • (1999) Nat Neurosci , vol.2 , pp. 266-270
    • van Praag, H.1    Kempermann, G.2    Gage, F.H.3
  • 136
    • 0031238676 scopus 로고    scopus 로고
    • Glucose transporter proteins in brain: delivery of glucose to neurons and glia
    • Vannucci S.J., Maher F., Simpson I.A. Glucose transporter proteins in brain: delivery of glucose to neurons and glia. Glia 1997, 21:2-21.
    • (1997) Glia , vol.21 , pp. 2-21
    • Vannucci, S.J.1    Maher, F.2    Simpson, I.A.3
  • 137
    • 67649793700 scopus 로고    scopus 로고
    • The genetic contribution to non-syndromic human obesity
    • Walley A.J., Asher J.E., Froguel P. The genetic contribution to non-syndromic human obesity. Nat Rev Genet 2009, 10:431-442.
    • (2009) Nat Rev Genet , vol.10 , pp. 431-442
    • Walley, A.J.1    Asher, J.E.2    Froguel, P.3
  • 139
    • 0042885568 scopus 로고    scopus 로고
    • Improvement of insulin sensitivity after adrenalectomy in patients with pheochromocytoma
    • Wiesner T.D., Blüher M., Windgassen M., Paschke R. Improvement of insulin sensitivity after adrenalectomy in patients with pheochromocytoma. J Clin Endocrinol Metab 2003, 88:3632-3636.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3632-3636
    • Wiesner, T.D.1    Blüher, M.2    Windgassen, M.3    Paschke, R.4
  • 140
    • 0035152834 scopus 로고    scopus 로고
    • Central nervous system perivascular cells are immunoregulatory cells that connect the CNS with the peripheral immune system
    • Williams K., Alvarez X., Lackner A.A. Central nervous system perivascular cells are immunoregulatory cells that connect the CNS with the peripheral immune system. Glia 2001, 36:156-164.
    • (2001) Glia , vol.36 , pp. 156-164
    • Williams, K.1    Alvarez, X.2    Lackner, A.A.3
  • 141
    • 0036627211 scopus 로고    scopus 로고
    • Tight junctions of the blood-brain barrier: development, composition and regulation
    • Wolburg H., Lippoldt A. Tight junctions of the blood-brain barrier: development, composition and regulation. Vascul Pharmacol 2002, 38:323-337.
    • (2002) Vascul Pharmacol , vol.38 , pp. 323-337
    • Wolburg, H.1    Lippoldt, A.2
  • 143
    • 63249111096 scopus 로고    scopus 로고
    • Mid- and late-life diabetes in relation to the risk of dementia: a population-based twin study
    • Xu W., Qiu C., Gatz M., Pedersen N.L., Johansson B., Fratiglioni L. Mid- and late-life diabetes in relation to the risk of dementia: a population-based twin study. Diabetes 2009, 58:71-77.
    • (2009) Diabetes , vol.58 , pp. 71-77
    • Xu, W.1    Qiu, C.2    Gatz, M.3    Pedersen, N.L.4    Johansson, B.5    Fratiglioni, L.6
  • 144
    • 79955600723 scopus 로고    scopus 로고
    • Midlife overweight and obesity increase late-life dementia risk: a population-based twin study
    • Xu W.L., Atti A.R., Gatz M., Pedersen N.L., Johansson B., Fratiglioni L. Midlife overweight and obesity increase late-life dementia risk: a population-based twin study. Neurology 2011, 76:1568-1574.
    • (2011) Neurology , vol.76 , pp. 1568-1574
    • Xu, W.L.1    Atti, A.R.2    Gatz, M.3    Pedersen, N.L.4    Johansson, B.5    Fratiglioni, L.6
  • 145
    • 84883733870 scopus 로고    scopus 로고
    • Molecular links between Alzheimer's disease and diabetes mellitus
    • Yang Y., Song W. Molecular links between Alzheimer's disease and diabetes mellitus. Neuroscience 2013, 250:140-150.
    • (2013) Neuroscience , vol.250 , pp. 140-150
    • Yang, Y.1    Song, W.2
  • 146
    • 38849186635 scopus 로고    scopus 로고
    • Impairment of hippocampal neurogenesis in streptozotocin-treated diabetic rats
    • Zhang W.J., Tan Y.F., Yue J.T., Vranic M., Wojtowicz J.M. Impairment of hippocampal neurogenesis in streptozotocin-treated diabetic rats. Acta Neurol Scand 2008, 117:205-210.
    • (2008) Acta Neurol Scand , vol.117 , pp. 205-210
    • Zhang, W.J.1    Tan, Y.F.2    Yue, J.T.3    Vranic, M.4    Wojtowicz, J.M.5
  • 147
    • 67349254152 scopus 로고    scopus 로고
    • Exacerbation of poststroke dementia by type 2 diabetes is associated with synergistic increases of beta-secretase activation and beta-amyloid generation in rat brains
    • Zhang T., Pan B.S., Zhao B., Zhang L.M., Huang Y.L., Sun F.Y. Exacerbation of poststroke dementia by type 2 diabetes is associated with synergistic increases of beta-secretase activation and beta-amyloid generation in rat brains. Neuroscience 2009, 161:1045-1056.
    • (2009) Neuroscience , vol.161 , pp. 1045-1056
    • Zhang, T.1    Pan, B.S.2    Zhao, B.3    Zhang, L.M.4    Huang, Y.L.5    Sun, F.Y.6
  • 148
    • 84889674445 scopus 로고    scopus 로고
    • Enhanced sympathetic activity in mice with brown adipose tissue transplantation (transBATation)
    • Zhu Z., Spicer E.G., Gavini C.K., Goudjo-Ako A.J., Novak C.M., Shi H. Enhanced sympathetic activity in mice with brown adipose tissue transplantation (transBATation). Physiol Behav 2014, 125:21-29.
    • (2014) Physiol Behav , vol.125 , pp. 21-29
    • Zhu, Z.1    Spicer, E.G.2    Gavini, C.K.3    Goudjo-Ako, A.J.4    Novak, C.M.5    Shi, H.6
  • 149
    • 13544268809 scopus 로고    scopus 로고
    • Neurovascular mechanisms of Alzheimer's neurodegeneration
    • Zlokovic B.V. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci 2005, 28:202-208.
    • (2005) Trends Neurosci , vol.28 , pp. 202-208
    • Zlokovic, B.V.1


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