Running induces widespread structural alterations in the hippocampus and entorhinal cortex

Hippocampus

Volumn 17, Issue 11, 2007, Pages 1017-1022

  Stranahan, Alexis M ^a   Khalil, David ^a   Gould, Elizabeth ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

CA1 pyramidal cell; Dendritic spine; Dentate gyrus; Physical exercise; Plasticity

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CELL STRUCTURE; CONTROLLED STUDY; DENDRITIC SPINE; DENTATE GYRUS; ENTORHINAL CORTEX; GRANULE CELL; HIPPOCAMPUS; MALE; NERVE CELL PLASTICITY; NONHUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; RUNNING;

ANIMALS; CARBOCYANINES; DENDRITIC SPINES; ENTORHINAL CORTEX; HIPPOCAMPUS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; NEURONAL PLASTICITY; NEURONS, AFFERENT; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; RUNNING;

EID: 36349012003     PISSN: 10509631     EISSN: 10981063     Source Type: Journal    
DOI: 10.1002/hipo.20348     Document Type: Article

References (30)

1. Anderson BJ, Rapp DN, Baek DH, McCloskey DP, Coburn-Litvak PS, Robinson JK. 2000. Exercise Influences spatial learning in the radial arm maze. Physiol Behav 70:425-429.
2. Baruch DE, Swain RA, Helmstetter FJ. 2004. Effects of exercise on Pavlovian fear conditioning. Behav Neurosci 118:1123-1127.
3. Baylor AM, Spirduso WW. 1988. Systematic aerobic exercise and components of reaction time in older women. J Gerontol 43:121-126.
4. Briones TL, Suh E, Jozsa L, Rogozinska M, Woods J, Wadowska M. 2005. Changes in number of synapses and mitochondria in presynaptic terminals in the dentate gyrus following cerebral ischemia and rehabilitation training. Brain Res 1033:51-57.
5. Buitrago MM, Schulz JB, Dichgans J, Luft AR. 2004. Short and long-term motor skill learning in an accelerated rotarod training paradigm. Neurobiol Learning Mem 81:211-216.
6. Burghardt PR, Pasumarthi RK, Wilson MA, Fadel J. 2006. Alterations in fear conditioning and amygdalar activation following chronic wheel running in rats. Pharmacol Biochem Behav 84:306-312.
7. Colcombe SJ, Kramer AF, Erickson KI, Scalf P, McAuley E, Cohen NJ, Webb A, Jerome GJ, Marquez DX, Elavsky S. 2004. Cardiovascular fitness, cortical plasticity, and aging. Proc Natl Acad Sci USA 101:3316-3321.
8. Eadie BD, Redila VA, Christie BR. 2005. Voluntary exercise alters the cytoarchitecture of the adult dentate gyrus by increasing cellular proliferation, dendritic complexity, and spine density. J Comp Neurol 486:39-47.
9. Eisenstein SA, Holmes PV. 2007. Chronic and voluntary exercise enhances learning of conditioned place preference to morphine in rats. Pharmacol Biochem Behav 86:607-615.
10. Faherty CJ, Kerley D, Smeyne RJ. 2003. A Golgi-Cox morphological analysis of neuronal changes induced by environmental enrichment. Brain Res Dev Brain Res 141:55-61.
11. Holmes MM, Galea LA, Mistlberger RE, Kempermann G. 2004. Adult hippocampal neurogenesis and voluntary running activity: Circadian and dose-dependent effects. J Neurosci Res 76:216-222.
12. Knafo S, Ariav G, Barkai E, Libersat F. 2004. Olfactory learning-induced increase in spine density along the apical dendrites of CA1 hippocampal neurons. Hippocampus 14:819-825.
13. Kozorovitskiy Y, Gross CG, Kopil C, Battaglia L, McBreen M, Stranahan AM, Gould E. 2005. Experience induces structural and biochemical changes in the adult primate brain. Proc Natl Acad Sci USA 102:17478-17482.
14. Lautenschlager NT, Almeida OP. 2006. Physical activity and cognition in old age. Curr Opin Psychiatry 19:190-193.
15. Leuner B, Falduto J, Shors TJ. 2003. Associative memory formation increases the observation of dendritic spines in the hippocampus. J Neurosci 23:659-665.
16. Leuner B, Gould E, Shors TJ. 2006. Is there a link between adult neurogenesis and learning? Hippocampus 16:216-224.
17. Neeper SA, Gomez-Pinilla F, Choi J, Cotman CW. 1996. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res 726:49-56.
18. Oladehin A, Waters RS. 2001. Location and distribution of Fos protein expression in rat hippocampus following acute moderate aerobic exercise. Exp Brain Res 137:26-35.
19. Paxinos G, Watson C. 1998. The Rat Brain in Stereotaxic Coordinates. California: Academic Press.
20. Pereira AC, Huddleston DE, Brickman AM, Sosunov AA, Hen R, McKhann GM, Sloan R, Gage FH, Brown TR, Small SA. 2007. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci USA 104:5638-5643.
21. Redila VA, Christie BR. 2006. Exercise-induced changes in dendritic structure and complexity in the adult hippocampal dentate gyrus. Neuroscience 137:1299-1307.
22. Rex CS, Lin CY, Kramar EA, Chen LY, Gall CM, Lynch G. 2007. Brain-derived neurotrophic factor promotes long-term potentiation-related cytoskeletal changes in adult hippocampus. J Neurosci 27:3017-3029.
23. Rhodes JS, Garland T Jr, Gammie SC. 2003. Patterns of brain activity associated with variation in voluntary wheel-running behavior. Behav Neurosci 117:1243-1256.
24. Stranahan AM, Khalil D, Gould E. 2006. Social isolation delays the positive effects of running on adult neurogenesis. Nat Neurosci 9:526-533.
25. Trejo JL, Carro E, Torres-Aleman I. 2001. Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus. J Neurosci 21:1628-1634.
26. van Hoomissen JD, Holmes PV, Zellner AS, Poudevigne A, Dishman RK. 2004. Effects of β-adrenoreceptor blockade during chronic exercise on contextual fear conditioning and mRNA for galanin and brain-derived neurotrophic factor. Behav Neurosci 118:1378-1390.
27. van Praag H, Christie BR, Sejnowski TJ, Gage FH. 1999. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci USA 96:13427-13431.
28. Vaynman S, Ying Z, Gomez-Pinilla F. 2004. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci 20:2580-2590.
29. Witter M, Moser E. 2006. Spatial representation and the architecture of the entorhinal cortex. Trends Neurosci 29:671-678.
30. Zhao C, Teng EM, Summers RG Jr, Ming GL, Gage FH. 2006. Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus. J Neurosci 26:3-11.