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Volumn 34, Issue 43, 2015, Pages 5418-5426

Targeting the glucose-regulated protein-78 abrogates Pten-null driven AKT activation and endometrioid tumorigenesis

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; GLUCOSE REGULATED PROTEIN 78; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROGESTERONE RECEPTOR; PROTEIN KINASE B; CHAPERONE; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78; MONOCLONAL ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; PTEN PROTEIN, MOUSE;

EID: 84945455312     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2015.4     Document Type: Article
Times cited : (33)

References (44)
  • 5
    • 48649088412 scopus 로고    scopus 로고
    • Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice
    • Daikoku T, Hirota Y, Tranguch S, Joshi AR, DeMayo FJ, Lydon JP et al. Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Res 2008; 68: 5619-5627.
    • (2008) Cancer Res , vol.68 , pp. 5619-5627
    • Daikoku, T.1    Hirota, Y.2    Tranguch, S.3    Joshi, A.R.4    DeMayo, F.J.5    Lydon, J.P.6
  • 6
    • 58049209726 scopus 로고    scopus 로고
    • Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium
    • Fu Y, Wey S, Wang M, Ye R, Liao CP, Roy-Burman P et al. Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium. Proc Natl Acad Sci USA 2008; 105: 19444-19449.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19444-19449
    • Fu, Y.1    Wey, S.2    Wang, M.3    Ye, R.4    Liao, C.P.5    Roy-Burman, P.6
  • 7
    • 84862908844 scopus 로고    scopus 로고
    • Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling
    • Wey S, Luo B, Tseng CC, Ni M, Zhou H, Fu Y et al. Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling. Blood 2012; 119: 817-825.
    • (2012) Blood , vol.119 , pp. 817-825
    • Wey, S.1    Luo, B.2    Tseng, C.C.3    Ni, M.4    Zhou, H.5    Fu, Y.6
  • 8
    • 84880854554 scopus 로고    scopus 로고
    • PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling
    • Conley-LaComb MK, Saliganan A, Kandagatla P, Chen YQ, Cher ML, Chinni SR. PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling. Mol Cancer 2013; 12: 85.
    • (2013) Mol Cancer , vol.12 , pp. 85
    • Conley-LaComb, M.K.1    Saliganan, A.2    Kandagatla, P.3    Chen, Y.Q.4    Cher, M.L.5    Chinni, S.R.6
  • 9
    • 84890383811 scopus 로고    scopus 로고
    • Increased concentrations of fructose 2,6-bisphosphate contribute to the Warburg effect in phosphatase and tensin homolog (PTEN)-deficient cells
    • Cordero-Espinoza L, Hagen T. Increased concentrations of fructose 2,6-bisphosphate contribute to the Warburg effect in phosphatase and tensin homolog (PTEN)-deficient cells. J Biol Chem 2013; 288: 36020-36028.
    • (2013) J Biol Chem , vol.288 , pp. 36020-36028
    • Cordero-Espinoza, L.1    Hagen, T.2
  • 10
    • 0031870959 scopus 로고    scopus 로고
    • Pten is essential for embryonic development and tumour suppression
    • Di Cristofano A, Pesce B, Cordon-Cardo C, Pandolfi PP. Pten is essential for embryonic development and tumour suppression. Nat Genet 1998; 19: 348-355.
    • (1998) Nat Genet , vol.19 , pp. 348-355
    • Di Cristofano, A.1    Pesce, B.2    Cordon-Cardo, C.3    Pandolfi, P.P.4
  • 11
    • 77952043635 scopus 로고    scopus 로고
    • The critical role of AKT2 in hepatic steatosis induced by PTEN loss
    • He L, Hou X, Kanel G, Zeng N, Galicia V, Wang Y et al. The critical role of AKT2 in hepatic steatosis induced by PTEN loss. Am J Pathol 2010; 176: 2302-2308.
    • (2010) Am J Pathol , vol.176 , pp. 2302-2308
    • He, L.1    Hou, X.2    Kanel, G.3    Zeng, N.4    Galicia, V.5    Wang, Y.6
  • 12
    • 84896699712 scopus 로고    scopus 로고
    • Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis
    • Chen WT, Tseng CC, Pfaffenbach K, Kanel G, Luo B, Stiles BL et al. Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis. Hepatology 2014; 59: 947-957.
    • (2014) Hepatology , vol.59 , pp. 947-957
    • Chen, W.T.1    Tseng, C.C.2    Pfaffenbach, K.3    Kanel, G.4    Luo, B.5    Stiles, B.L.6
  • 13
    • 34447558236 scopus 로고    scopus 로고
    • ER chaperones in mammalian development and human diseases
    • Ni M, Lee AS. ER chaperones in mammalian development and human diseases. FEBS Lett 2007; 581: 3641-3651.
    • (2007) FEBS Lett , vol.581 , pp. 3641-3651
    • Ni, M.1    Lee, A.S.2
  • 14
    • 84897036337 scopus 로고    scopus 로고
    • Glucose-regulated proteins in cancer: Molecular mechanisms and therapeutic potential
    • Lee AS. Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential. Nat Rev Cancer 2014; 14: 263-276.
    • (2014) Nat Rev Cancer , vol.14 , pp. 263-276
    • Lee, A.S.1
  • 15
    • 84874112079 scopus 로고    scopus 로고
    • The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies
    • Luo B, Lee AS. The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies. Oncogene 2013; 32: 805-818.
    • (2013) Oncogene , vol.32 , pp. 805-818
    • Luo, B.1    Lee, A.S.2
  • 16
  • 18
    • 33748076770 scopus 로고    scopus 로고
    • GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer
    • Lee E, Nichols P, Spicer D, Groshen S, Yu MC, Lee AS. GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer. Cancer Res 2006; 66: 7849-7853.
    • (2006) Cancer Res , vol.66 , pp. 7849-7853
    • Lee, E.1    Nichols, P.2    Spicer, D.3    Groshen, S.4    Yu, M.C.5    Lee, A.S.6
  • 19
    • 84876694384 scopus 로고    scopus 로고
    • AKT inhibition mitigates GRP78 (glucose-regulated protein) expression and contribution to chemoresistance in endometrial cancers
    • Gray MJ, Mhawech-Fauceglia P, Yoo E, Yang W, Wu E, Lee AS et al. AKT inhibition mitigates GRP78 (glucose-regulated protein) expression and contribution to chemoresistance in endometrial cancers. Int J Cancer 2013; 133: 21-30.
    • (2013) Int J Cancer , vol.133 , pp. 21-30
    • Gray, M.J.1    Mhawech-Fauceglia, P.2    Yoo, E.3    Yang, W.4    Wu, E.5    Lee, A.S.6
  • 20
    • 81855170040 scopus 로고    scopus 로고
    • Understanding obesity and endometrial cancer risk: Opportunities for prevention
    • Schmandt RE, Iglesias DA, Co NN, Lu KH. Understanding obesity and endometrial cancer risk: opportunities for prevention. Am J Obstet Gynecol 2011; 205: 518-525.
    • (2011) Am J Obstet Gynecol , vol.205 , pp. 518-525
    • Schmandt, R.E.1    Iglesias, D.A.2    Co, N.N.3    Lu, K.H.4
  • 21
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010; 140: 900-917.
    • (2010) Cell , vol.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 22
    • 84873729773 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival
    • Matsuo K, Gray MJ, Yang DY, Srivastava SA, Tripathi PB, Sonoda LA et al. The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival. Gynecol Oncol 2013; 128: 552-559.
    • (2013) Gynecol Oncol , vol.128 , pp. 552-559
    • Matsuo, K.1    Gray, M.J.2    Yang, D.Y.3    Srivastava, S.A.4    Tripathi, P.B.5    Sonoda, L.A.6
  • 23
    • 10344222124 scopus 로고    scopus 로고
    • The role of the unfolded protein response in tumour development: Friend or foe?
    • Ma Y, Hendershot LM. The role of the unfolded protein response in tumour development: friend or foe? Nat Rev Cancer 2004; 4: 966-977.
    • (2004) Nat Rev Cancer , vol.4 , pp. 966-977
    • Ma, Y.1    Hendershot, L.M.2
  • 24
    • 33645156429 scopus 로고    scopus 로고
    • From acute ER stress to physiological roles of the unfolded protein response
    • Wu J, Kaufman RJ. From acute ER stress to physiological roles of the unfolded protein response. Cell Death Differ 2006; 13: 374-384.
    • (2006) Cell Death Differ , vol.13 , pp. 374-384
    • Wu, J.1    Kaufman, R.J.2
  • 25
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 2007; 8: 519-529.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 26
    • 79951537603 scopus 로고    scopus 로고
    • Beyond the endoplasmic reticulum: Atypical GRP78 in cell viability, signalling and therapeutic targeting
    • Ni M, Zhang Y, Lee AS. Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting. Biochem J 2011; 434: 181-188.
    • (2011) Biochem J , vol.434 , pp. 181-188
    • Ni, M.1    Zhang, Y.2    Lee, A.S.3
  • 27
    • 77952061607 scopus 로고    scopus 로고
    • Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP
    • Zhang Y, Liu R, Ni M, Gill P, Lee AS. Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP. J Biol Chem 2010; 285: 15065-15075.
    • (2010) J Biol Chem , vol.285 , pp. 15065-15075
    • Zhang, Y.1    Liu, R.2    Ni, M.3    Gill, P.4    Lee, A.S.5
  • 28
    • 84893205768 scopus 로고    scopus 로고
    • Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 production
    • Zhang Y, Tseng CC, Tsai YL, Fu X, Schiff R, Lee A. Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 production. PLoS One 2013; 8: e80071.
    • (2013) PLoS One , vol.8
    • Zhang, Y.1    Tseng, C.C.2    Tsai, Y.L.3    Fu, X.4    Schiff, R.5    Lee, A.6
  • 30
    • 77956165188 scopus 로고    scopus 로고
    • GRP78 signaling hub a receptor for targeted tumor therapy
    • Sato M, Yao VJ, Arap W, Pasqualini R. GRP78 signaling hub a receptor for targeted tumor therapy. Adv Genet 2010; 69: 97-114.
    • (2010) Adv Genet , vol.69 , pp. 97-114
    • Sato, M.1    Yao, V.J.2    Arap, W.3    Pasqualini, R.4
  • 31
    • 4544255170 scopus 로고    scopus 로고
    • Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands
    • Arap MA, Lahdenranta J, Mintz PJ, Hajitou A, Sarkis AS, Arap W et al. Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands. Cancer Cell 2004; 6: 275-284.
    • (2004) Cancer Cell , vol.6 , pp. 275-284
    • Arap, M.A.1    Lahdenranta, J.2    Mintz, P.J.3    Hajitou, A.4    Sarkis, A.S.5    Arap, W.6
  • 32
    • 84890705779 scopus 로고    scopus 로고
    • Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth and metastasis
    • Liu R, Li X, Gao W, Zhou Y, Wey S, Mitra SK et al. Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth and metastasis. Clin Cancer Res 2013; 19: 6802-6811.
    • (2013) Clin Cancer Res , vol.19 , pp. 6802-6811
    • Liu, R.1    Li, X.2    Gao, W.3    Zhou, Y.4    Wey, S.5    Mitra, S.K.6
  • 33
    • 84862488769 scopus 로고    scopus 로고
    • Acute inducible ablation of GRP78 reveals its role in hematopoietic stem cell survival, lymphogenesis and regulation of stress signaling
    • Wey S, Luo B, Lee AS. Acute inducible ablation of GRP78 reveals its role in hematopoietic stem cell survival, lymphogenesis and regulation of stress signaling. PLoS One 2012; 7: e39047.
    • (2012) PLoS One , vol.7
    • Wey, S.1    Luo, B.2    Lee, A.S.3
  • 35
    • 33750706551 scopus 로고    scopus 로고
    • Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer
    • Pootrakul L, Datar RH, Shi SR, Cai J, Hawes D, Groshen SG et al. Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer. Clin Cancer Res 2006; 12: 5987-5993.
    • (2006) Clin Cancer Res , vol.12 , pp. 5987-5993
    • Pootrakul, L.1    Datar, R.H.2    Shi, S.R.3    Cai, J.4    Hawes, D.5    Groshen, S.G.6
  • 36
    • 33646171070 scopus 로고    scopus 로고
    • Stress induction of GRP78/BiP and its role in cancer
    • Li J, Lee AS. Stress induction of GRP78/BiP and its role in cancer. Curr Mol Med 2006; 6: 45-54.
    • (2006) Curr Mol Med , vol.6 , pp. 45-54
    • Li, J.1    Lee, A.S.2
  • 37
    • 78649874180 scopus 로고    scopus 로고
    • GRP78 as potential predictor for breast cancer response to adjuvant taxane therapy
    • Lee E, Nichols P, Groshen S, Spicer D, Lee AS. GRP78 as potential predictor for breast cancer response to adjuvant taxane therapy. Int J Cancer 2011; 128: 726-731.
    • (2011) Int J Cancer , vol.128 , pp. 726-731
    • Lee, E.1    Nichols, P.2    Groshen, S.3    Spicer, D.4    Lee, A.S.5
  • 38
    • 62149147508 scopus 로고    scopus 로고
    • Expression of glucose-regulated stress protein GRP78 is related to progression of melanoma
    • Zhuang L, Scolyer RA, Lee CS, McCarthy SW, Cooper WA, Zhang XD et al. Expression of glucose-regulated stress protein GRP78 is related to progression of melanoma. Histopathology 2009; 54: 462-470.
    • (2009) Histopathology , vol.54 , pp. 462-470
    • Zhuang, L.1    Scolyer, R.A.2    Lee, C.S.3    McCarthy, S.W.4    Cooper, W.A.5    Zhang, X.D.6
  • 39
    • 78651366118 scopus 로고    scopus 로고
    • Association of elevated GRP78 expression with increased astrocytoma malignancy via Akt and ERK pathways
    • Zhang LH, Yang XL, Zhang X, Cheng JX, Zhang W. Association of elevated GRP78 expression with increased astrocytoma malignancy via Akt and ERK pathways. Brain Res 2011; 1371: 23-31.
    • (2011) Brain Res , vol.1371 , pp. 23-31
    • Zhang, L.H.1    Yang, X.L.2    Zhang, X.3    Cheng, J.X.4    Zhang, W.5
  • 40
    • 33744962234 scopus 로고    scopus 로고
    • Activation and cross-talk between Akt, NF-{kappa}B, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78
    • Misra UK, Deedwania R, Pizzo SV. Activation and cross-talk between Akt, NF-{kappa}B, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78. J Biol Chem 2006; 281: 13694-13707.
    • (2006) J Biol Chem , vol.281 , pp. 13694-13707
    • Misra, U.K.1    Deedwania, R.2    Pizzo, S.V.3
  • 41
    • 0037470247 scopus 로고    scopus 로고
    • Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function
    • Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH et al. Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. J Biol Chem 2003; 278: 7607-7616.
    • (2003) J Biol Chem , vol.278 , pp. 7607-7616
    • Shin, B.K.1    Wang, H.2    Yim, A.M.3    Le Naour, F.4    Brichory, F.5    Jang, J.H.6
  • 43
    • 0021916744 scopus 로고
    • Can primary endometrial carcinoma stage i be cured without surgery and radiation therapy?
    • Bokhman JV, Chepick OF, Volkova AT, Vishnevsky AS. Can primary endometrial carcinoma stage I be cured without surgery and radiation therapy? Gynecol Oncol 1985; 20: 139-155.
    • (1985) Gynecol Oncol , vol.20 , pp. 139-155
    • Bokhman, J.V.1    Chepick, O.F.2    Volkova, A.T.3    Vishnevsky, A.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.