Acute inducible ablation of GRP78 reveals its role in hematopoietic stem cell survival, lymphogenesis and regulation of stress signaling

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Wey, Shiuan ^a   Luo, Biquan ^a   Lee, Amy S ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; CASPASE; CHEMOKINE; CYTOKINE; GLUCOSE REGULATED PROTEIN 78;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL LINEAGE; CELL LOSS; CELL POPULATION; CELL STRESS; CELL SURVIVAL; CHEMOKINE BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE BLOOD LEVEL; DEVELOPMENT; ENZYME ACTIVATION; GENE; GENE DELETION; GRP78 GENE; HEMATOPOIETIC STEM CELL; KNOCKOUT MOUSE; LYMPHOCYTOPENIA; LYMPHOGENESIS; LYMPHOID PROGENITOR CELL; MOUSE; MUTANT; MYELOID PROGENITOR CELL; NONHUMAN; PLEIOTROPY; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; REGULATORY MECHANISM; RNA SPLICING; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; XBP 1 GENE;

ANIMALS; APOPTOSIS; BONE MARROW CELLS; CELL SURVIVAL; CYTOKINES; GENE DELETION; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; LYMPHOID PROGENITOR CELLS; LYMPHOPENIA; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; UNFOLDED PROTEIN RESPONSE;

EID: 84862488769     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039047     Document Type: Article

References (41)

1. Wagers AJ, Christensen JL, Weissman IL, (2002) Cell fate determination from stem cells. Gene Ther 9: 606-612.
2. Zon LI, (2008) Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal. Nature 453: 306-313.
3. Lee AS, (2001) The glucose-regulated proteins: stress induction and clinical applications. Trends Biochem Sci 26: 504-510.
4. Hendershot LM, (2004) The ER function BiP is a master regulator of ER function. Mt Sinai J Med 71: 289-297.
5. Ni M, Lee AS, (2007) ER chaperones in mammalian development and human diseases. FEBS Lett 581: 3641-3651.
6. Luo B, Lee AS, (2012) The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anti-cancer therapies. Oncogene In press.
7. Wu J, Kaufman RJ, (2006) From acute ER stress to physiological roles of the unfolded protein response. Cell Death Differ 13: 374-384.
8. Ron D, Walter P, (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8: 519-529.
9. Wang M, Wey S, Zhang Y, Ye R, Lee AS, (2009) Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders. Antioxid Redox Signal 11: 2307-2316.
10. Hetz C, (2009) The UPR as a survival factor of cancer cells: More than folding proteins? Leuk Res 33: 880-882.
11. Luo S, Mao C, Lee B, Lee AS, (2006) GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development. Mol Cell Biol 26: 5688-5697.
12. Ota J, Yamashita Y, Okawa K, Kisanuki H, Fujiwara S, et al. (2003) Proteomic analysis of hematopoietic stem cell-like fractions in leukemic disorders. Oncogene 22: 5720-5728.
13. Wey S, Luo B, Tseng CC, Ni M, Zhou H, et al. (2012) Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling. Blood 119: 817-825.
14. Fu Y, Wey S, Wang M, Ye R, Liao CP, et al. (2008) Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium. Proc Natl Acad Sci USA 105: 19444-19449.
15. Kuhn R, Schwenk F, Aguet M, Rajewsky K, (1995) Inducible gene targeting in mice. Science 269: 1427-1429.
16. Reddy RK, Mao C, Baumeister P, Austin RC, Kaufman RJ, et al. (2003) Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J Biol Chem 278: 20915-20924.
17. Dinarello CA, (1996) Biologic basis for interleukin-1 in disease. Blood 87: 2095-2147.
18. Zuniga-Pflucker JC, Jiang D, Lenardo MJ, (1995) Requirement for TNF-alpha and IL-1 alpha in fetal thymocyte commitment and differentiation. Science 268: 1906-1909.
19. Chandrasekar B, Melby PC, Sarau HM, Raveendran M, Perla RP, et al. (2003) Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway. J Biol Chem 278: 4675-4686.
20. Choong ML, Yong YP, Tan AC, Luo B, Lodish HF, (2004) LIX: a chemokine with a role in hematopoietic stem cells maintenance. Cytokine 25: 239-245.
21. von Freeden-Jeffry U, Vieira P, Lucian LA, McNeil T, Burdach SE, et al. (1995) Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 181: 1519-1526.
22. Tan JT, Dudl E, LeRoy E, Murray R, Sprent J, et al. (2001) IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci USA 98: 8732-8737.
23. Murray R, Suda T, Wrighton N, Lee F, Zlotnik A, (1989) IL-7 is a growth and maintenance factor for mature and immature thymocyte subsets. Int Immunol 1: 526-531.
24. Akashi K, Kondo M, von Freeden-Jeffry U, Murray R, Weissman IL, (1997) Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 89: 1033-1041.
25. Cerretti DP, McKereghan K, Larsen A, Cantrell MA, Anderson D, et al. (1986) Cloning, sequence, and expression of bovine interleukin 2. Proc Natl Acad Sci USA 83: 3223-3227.
26. Lee AS, (2007) GRP78 induction in cancer: therapeutic and prognostic implications. Cancer Res 67: 3496-3499.
27. Pfaffenbach KT, Lee AS, (2011) The critical role of GRP78 in physiologic and pathologic stress. Curr Opin Cell Biol 23: 150-156.
28. Matus S, Glimcher LH, Hetz C, (2011) Protein folding stress in neurodegenerative diseases: a glimpse into the ER. Curr Opin Cell Biol 23: 239-252.
29. Rosati E, Sabatini R, Rampino G, De Falco F, Di Ianni M, et al. (2010) Novel targets for endoplasmic reticulum stress-induced apoptosis in B-CLL. Blood 116: 2713-2723.
30. Uckun FM, Qazi S, Ozer Z, Garner AL, Pitt J, et al. (2011) Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network. Br J Haematol 153: 741-752.
31. Dorner AJ, Kaufman RJ, (1994) The levels of endoplasmic reticulum proteins and ATP affect folding and secretion of selective proteins. Biologicals 22: 103-112.
32. Bonnerot C, Marks MS, Cosson P, Robertson EJ, Bikoff EK, et al. (1994) Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain. EMBO J 13: 934-944.
33. Qian Y, Zheng Y, Weber D, Tiffany-Castiglioni E, (2007) A 78-kDa glucose-regulated protein is involved in the decrease of interleukin-6 secretion by lead treatment from astrocytes. Am J Physiol Cell Physiol 293: C897-905.
34. Ni M, Zhang Y, Lee AS, (2011) Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting. Biochem J 434: 181-188.
35. Miharada K, Karlsson G, Rehn M, Rorby E, Siva K, et al. (2011) Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78. Cell Stem Cell 9: 330-344.
36. Kobayashi Y, Yamamoto K, Saido T, Kawasaki H, Oppenheim JJ, et al. (1990) Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha. Proc Natl Acad Sci USA 87: 5548-5552.
37. Napolitano LA, Grant RM, Deeks SG, Schmidt D, De Rosa SC, et al. (2001) Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nat Med 7: 73-79.
38. Bolotin E, Annett G, Parkman R, Weinberg K, (1999) Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count. Bone Marrow Transplant 23: 783-788.
39. Luo B, Lam BS, Lee SH, Wey S, Zhou H, et al. (2011) The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche. PLoS One 6: e20364.
40. Ni M, Zhou H, Wey S, Baumeister P, Lee AS, (2009) Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP. PLoS One 4: e6868.
41. Koh YT, Gray A, Higgins SA, Hubby B, Kast WM, (2009) Androgen ablation augments prostate cancer vaccine immunogenicity only when applied after immunization. Prostate 69: 571-584.