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Volumn 19, Issue 24, 2013, Pages 6802-6811

Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE REGULATED PROTEIN 78; HEAT SHOCK PROTEIN 70; MONOCLONAL ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

EID: 84890705779     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-1106     Document Type: Article
Times cited : (155)

References (34)
  • 1
    • 10344222124 scopus 로고    scopus 로고
    • The role of the unfolded protein response in tumour development: Friend or foe?
    • DOI 10.1038/nrc1505
    • Ma Y, Hendershot LM. The role of the unfolded protein response in tumour development: friend or foe? Nat Rev Cancer 2004;4:966-77. (Pubitemid 39626220)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.12 , pp. 966-977
    • Ma, Y.1    Hendershot, L.M.2
  • 2
    • 84874112079 scopus 로고    scopus 로고
    • The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies
    • Luo B, Lee AS. The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies. Oncogene 2013;32:805-18.
    • (2013) Oncogene , vol.32 , pp. 805-818
    • Luo, B.1    Lee, A.S.2
  • 3
    • 33646171070 scopus 로고    scopus 로고
    • Stress induction of GRP78/BiP and its role in cancer
    • Li J, Lee AS. Stress induction of GRP78/BiP and its role in cancer. Curr Mol Med 2006;6:45-54.
    • (2006) Curr Mol Med , vol.6 , pp. 45-54
    • Li, J.1    Lee, A.S.2
  • 4
    • 34248571826 scopus 로고    scopus 로고
    • GRP78 induction in cancer: Therapeutic and prognostic implications
    • DOI 10.1158/0008-5472.CAN-07-0325
    • Lee AS. GRP78 induction in cancer: therapeutic and prognostic implications. Cancer Res 2007;67:3496-9. (Pubitemid 46762126)
    • (2007) Cancer Research , vol.67 , Issue.8 , pp. 3496-3499
    • Lee, A.S.1
  • 5
    • 84859112544 scopus 로고    scopus 로고
    • Glucose regulated protein 78: A critical link between tumor microenvironment and cancer hallmarks
    • Li Z, Li Z. Glucose regulated protein 78: a critical link between tumor microenvironment and cancer hallmarks. Biochim Biophys Acta 2012; 1826:13-22.
    • (2012) Biochim Biophys Acta , vol.1826 , pp. 13-22
    • Li, Z.1    Li, Z.2
  • 6
    • 35448967382 scopus 로고    scopus 로고
    • The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas
    • DOI 10.1158/0008-5472.CAN-07-0625
    • Pyrko P, Schonthal AH, Hofman FM, Chen TC, Lee AS. The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas. Cancer Res 2007;67:9809-16. (Pubitemid 47621228)
    • (2007) Cancer Research , vol.67 , Issue.20 , pp. 9809-9816
    • Pyrko, P.1    Schontha, A.H.2    Hofman, F.M.3    Chen, T.C.4    Lee, A.S.5
  • 7
    • 52449107266 scopus 로고    scopus 로고
    • Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells
    • Virrey JJ, Dong D, Stiles C, Patterson JB, Pen L, Ni M, et al. Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells. Mol Cancer Res 2008;6:1268-75.
    • (2008) Mol Cancer Res , vol.6 , pp. 1268-1275
    • Virrey, J.J.1    Dong, D.2    Stiles, C.3    Patterson, J.B.4    Pen, L.5    Ni, M.6
  • 9
    • 79954569520 scopus 로고    scopus 로고
    • A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis
    • Dong D, Stapleton C, Luo B, Xiong S, Ye W, Zhang Y, et al. A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis. Cancer Res 2011;71:2848-57.
    • (2011) Cancer Res , vol.71 , pp. 2848-2857
    • Dong, D.1    Stapleton, C.2    Luo, B.3    Xiong, S.4    Ye, W.5    Zhang, Y.6
  • 10
    • 58049209726 scopus 로고    scopus 로고
    • Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium
    • Fu Y, Wey S, Wang M, Ye R, Liao CP, Roy-Burman P, et al. Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium. Proc Natl Acad Sci USA 2008;105:19444-9.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19444-19449
    • Fu, Y.1    Wey, S.2    Wang, M.3    Ye, R.4    Liao, C.P.5    Roy-Burman, P.6
  • 11
    • 84862908844 scopus 로고    scopus 로고
    • Inducible knockout of GRP78/BiP in the hematopoietic system suppresses pten-null leukemogenesis and AKT oncogenic signaling
    • Wey S, Luo B, Tseng CC, Ni M, Zhou H, Fu Y, et al. Inducible knockout of GRP78/BiP in the hematopoietic system suppresses pten-null leukemogenesis and AKT oncogenic signaling. Blood 2012;119: 817-25.
    • (2012) Blood , vol.119 , pp. 817-825
    • Wey, S.1    Luo, B.2    Tseng, C.C.3    Ni, M.4    Zhou, H.5    Fu, Y.6
  • 12
    • 4544255170 scopus 로고    scopus 로고
    • Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands
    • DOI 10.1016/j.ccr.2004.08.018, PII S1535610804002405
    • Arap MA, Lahdenranta J, Mintz PJ, Hajitou A, Sarkis AS, Arap W, et al. Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands. Cancer Cell 2004;6: 275-84. (Pubitemid 39222040)
    • (2004) Cancer Cell , vol.6 , Issue.3 , pp. 275-284
    • Arap, M.A.1    Lahdenranta, J.2    Mintz, P.J.3    Hajitou, A.4    Sarkis, A.S.5    Arap, W.6    Pasqualini, R.7
  • 14
    • 79951537603 scopus 로고    scopus 로고
    • Beyond the endoplasmic reticulum: Atypical GRP78 in cell viability, signalling and therapeutic targeting
    • Ni M, Zhang Y, Lee AS. Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting. Biochem J 2011;434:181-8.
    • (2011) Biochem J , vol.434 , pp. 181-188
    • Ni, M.1    Zhang, Y.2    Lee, A.S.3
  • 15
    • 77952061607 scopus 로고    scopus 로고
    • Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP
    • Zhang Y, Liu R, Ni M, Gill P, Lee AS. Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP. J Biol Chem 2010;285:15065-75.
    • (2010) J Biol Chem , vol.285 , pp. 15065-15075
    • Zhang, Y.1    Liu, R.2    Ni, M.3    Gill, P.4    Lee, A.S.5
  • 16
    • 37849035474 scopus 로고    scopus 로고
    • GRP78 and cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth
    • Shani G, Fischer WH, Justice NJ, Kelber JA, Vale W, Gray PC. GRP78 and cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth. Mol Cell Biol 2008;28:666-77.
    • (2008) Mol Cell Biol , vol.28 , pp. 666-677
    • Shani, G.1    Fischer, W.H.2    Justice, N.J.3    Kelber, J.A.4    Vale, W.5    Gray, P.C.6
  • 18
    • 77956165188 scopus 로고    scopus 로고
    • GRP78 signaling hub a receptor for targeted tumor therapy
    • Sato M, Yao VJ, Arap W, Pasqualini R. GRP78 signaling hub a receptor for targeted tumor therapy. Adv Genet 2010;69:97-114.
    • (2010) Adv Genet , vol.69 , pp. 97-114
    • Sato, M.1    Yao, V.J.2    Arap, W.3    Pasqualini, R.4
  • 19
    • 84877098258 scopus 로고    scopus 로고
    • Inhibition of established micrometastases bytargeted drug delivery via cell surface-associated GRP78
    • Miao YR, Eckhardt BL, Cao Y, Pasqualini R, Argani P, Arap W, et al. Inhibition of established micrometastases bytargeted drug delivery via cell surface-associated GRP78. Clin Cancer Res 2013;19:2107-16.
    • (2013) Clin Cancer Res , vol.19 , pp. 2107-2116
    • Miao, Y.R.1    Eckhardt, B.L.2    Cao, Y.3    Pasqualini, R.4    Argani, P.5    Arap, W.6
  • 20
  • 21
    • 77950577414 scopus 로고    scopus 로고
    • Novel EphB4 monoclonal antibodies modulate angiogenesis and inhibit tumor growth
    • Krasnoperov V, Kumar SR, Ley E, Li X, Scehnet J, Liu R, et al. Novel EphB4 monoclonal antibodies modulate angiogenesis and inhibit tumor growth. Am J Pathol 2010;176:2029-38.
    • (2010) Am J Pathol , vol.176 , pp. 2029-2038
    • Krasnoperov, V.1    Kumar, S.R.2    Ley, E.3    Li, X.4    Scehnet, J.5    Liu, R.6
  • 24
    • 84887014432 scopus 로고    scopus 로고
    • The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells
    • Shin SY, Lee KS, Choi YK, Lim HJ, Lee HG, Lim Y, et al. The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells. Carcinogenesis 2013;34:2080-9.
    • (2013) Carcinogenesis , vol.34 , pp. 2080-2089
    • Shin, S.Y.1    Lee, K.S.2    Choi, Y.K.3    Lim, H.J.4    Lee, H.G.5    Lim, Y.6
  • 25
  • 26
    • 0026503190 scopus 로고
    • Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor
    • Aslakson CJ, Miller FR. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res 1992;52:1399-405.
    • (1992) Cancer Res , vol.52 , pp. 1399-1405
    • Aslakson, C.J.1    Miller, F.R.2
  • 27
    • 79951841266 scopus 로고    scopus 로고
    • Increased expression of P-glycoprotein is associated with doxorubicin chemore-sistance in the metastatic 4T1 breast cancer model
    • Bao L, Haque A, Jackson K, Hazari S, Moroz K, Jetly R, et al. Increased expression of P-glycoprotein is associated with doxorubicin chemore-sistance in the metastatic 4T1 breast cancer model. Am J Pathol 2011;178:838-52.
    • (2011) Am J Pathol , vol.178 , pp. 838-852
    • Bao, L.1    Haque, A.2    Jackson, K.3    Hazari, S.4    Moroz, K.5    Jetly, R.6
  • 28
    • 33646376411 scopus 로고    scopus 로고
    • Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    • DOI 10.1038/nature04703, PII NATURE04703
    • Yilmaz OH, Valdez R, Theisen BK, Guo W, Ferguson DO, Wu H, et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 2006;441:475-82. (Pubitemid 44050144)
    • (2006) Nature , vol.441 , Issue.7092 , pp. 475-482
    • Yilmaz, O.H.1    Valdez, R.2    Theisen, B.K.3    Guo, W.4    Ferguson, D.O.5    Wu, H.6    Morrison, S.J.7
  • 29
    • 84866984516 scopus 로고    scopus 로고
    • A peptidic unconjugated GRP78/BiP ligand modulates the unfolded protein response and induces prostate cancer cell death
    • Maddalo D, Neeb A, Jehle K, Schmitz K, Muhle-Goll C, Shatkina L, et al. A peptidic unconjugated GRP78/BiP ligand modulates the unfolded protein response and induces prostate cancer cell death. PLoS One 2012;7:e45690.
    • (2012) PLoS One , vol.7
    • Maddalo, D.1    Neeb, A.2    Jehle, K.3    Schmitz, K.4    Muhle-Goll, C.5    Shatkina, L.6
  • 31
    • 0036828823 scopus 로고    scopus 로고
    • 2-macroglobulin-induced signal transduction: Evidence from RNA interference that the low density lipoprotein receptor-related protein is associated with, but not necessary for, GRP 78-mediated signal transduction
    • DOI 10.1074/jbc.M206174200
    • Misra UK, Gonzalez-Gronow M, Gawdi G, Hart JP, Johnson CE, Pizzo SV. The role of grp 78 in alpha 2-macroglobulin-induced signal trans-duction. evidence from RNA interference that the low density lipopro-tein receptor-related protein is associated with, but not necessary for, GRP 78-mediated signal transduction. J Biol Chem 2002;277: 42082-7. (Pubitemid 35257523)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.44 , pp. 42082-42087
    • Misra, U.K.1    Gonzalez-Gronow, M.2    Gawdi, G.3    Hart, J.P.4    Johnson, C.E.5    Pizzo, S.V.6
  • 32
    • 84871271221 scopus 로고    scopus 로고
    • Receptor-recognized alpha(2)-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells
    • Misra UK, Pizzo SV. Receptor-recognized alpha(2)-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells. PLoS One 2012;7:e51735.
    • (2012) PLoS One , vol.7
    • Misra, U.K.1    Pizzo, S.V.2
  • 33
    • 84860778806 scopus 로고    scopus 로고
    • A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice
    • de Ridder GG, Ray R, Pizzo SV. A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice. Melanoma Res 2012;22:225-35.
    • (2012) Melanoma Res , vol.22 , pp. 225-235
    • De Ridder, G.G.1    Ray, R.2    Pizzo, S.V.3
  • 34
    • 11344268358 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance to therapies targeting the epidermal growth factor receptor
    • Camp ER, Summy J, Bauer TW, Liu W, Gallick GE, Ellis LM. Molecular mechanisms of resistance to therapies targeting the epidermal growth factor receptor. Clin Cancer Res 2005;11:397-405. (Pubitemid 40075820)
    • (2005) Clinical Cancer Research , vol.11 , Issue.1 , pp. 397-405
    • Camp, E.R.1    Summy, J.2    Bauer, T.W.3    Liu, W.4    Gallick, G.E.5    Ellis, L.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.