Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 production

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Tseng, Yi Zhang Chun Chih ^a   Tsai, Yuan Li ^a   Fu, Xiaoyong ^b   Schiff, Rachel ^b   Lee, Amy S ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ESTROGEN; GLUCOSE REGULATED PROTEIN 78; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN KINASE B; PROTEIN P85; TAMOXIFEN;

ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER CELL; CELL SURFACE; COMPLEX FORMATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HORMONAL THERAPY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; THERAPY RESISTANCE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS, HORMONAL; CELL LINE, TUMOR; CELL MEMBRANE; DRUG RESISTANCE, NEOPLASM; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAT-SHOCK PROTEINS; HUMANS; MICE; MUTATION; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHATIDYLINOSITOLS; PLASMIDS; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SOLUBILITY; TAMOXIFEN; TRANSFECTION;

EID: 84893205768     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0080071     Document Type: Article

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