Immunomodulatory effects of soybeans and processed soy food compounds

Recent Patents on Food, Nutrition and Agriculture

Volumn 7, Issue 2, 2015, Pages 92-99

  Tezuka, Hiroyuki ^a   Imai, Shinjiro ^b  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF TECHNOLOGY   (Japan)

Author keywords

Anti inflammatory; Flavonoid; Inflammation; Isoflavone; Saponin; Soybean

Indexed keywords

IMMUNOLOGIC FACTOR; ISOFLAVONE DERIVATIVE; PLANT MEDICINAL PRODUCT; SAPONIN;

ANIMAL; CHEMISTRY; FOOD HANDLING; HUMAN; HYPERSENSITIVITY; INFLAMMATION; PATENT; PATHOLOGY; SOY FOOD; SOYBEAN;

ANIMALS; FOOD HANDLING; HUMANS; HYPERSENSITIVITY; IMMUNOLOGIC FACTORS; INFLAMMATION; ISOFLAVONES; PATENTS AS TOPIC; PHYTOCHEMICALS; SAPONINS; SOY FOODS; SOYBEANS;

EID: 84945261949     PISSN: 22127984     EISSN: 18761429     Source Type: Journal    
DOI: 10.2174/2212798407666150629123957     Document Type: Article

References (78)

1. Mateos-Aparicio I., Redondo CA, Villanueva-Suárez MJ, Zapata-Revilla MA. Soybean, a promising health source. Nutr Hosp 2008; 23: 305-12.
2. Deng R. Food and food supplements with hypocholesterolemic effects. Rec Pat Food Nutr Agric 2009; 1: 15-24.
3. Hall WL, Vafeiadou K, Hallund J., Bugel S, Reimann M, Koebnick C., et al. Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: Interactions with genotype and equol production. Am J Clin Nutr 2006; 83: 592-600.
4. Lund CO, Mortensen A, Nilas L., Breinholt VM, Larsen JJ, Ottesen B. Estrogen and phytoestrogens: Effect on eNOS expression and in vitro vasodilation in cerebral arteries in ovariectomized Watanabe heritable hyperlipidemic rabbits. Eur J Obstet Gynecol Reprod Biol 2007; 130: 84-92.
5. Andres S, Abraham K, Appel K.E., Lampen, A. Risks and benefits of dietary isoflavones for cancer. Crit Rev Toxicol 2011; 41: 463-506.
6. Song WO, Chun OK, Hwang I, Shin H.S., Kim BG, Kim KS, et al. Soy isoflavones as safe functional ingredients. Inflammation 1999; 23: 231-9.
7. Tsai CY, Chen YH, Chien Y.W., Huang WH, Lin SH. Effect of soy saponin on the growth of human colon cancer cells. World J Gastroenterol 2010; 16: 3371-6.
8. Moon YJ, Wang X, Morris ME Dietary flavonoids: Effects on xenobiotic and carcinogen metabolism. Toxicol In vitro 2006; 20: 187-210.
9. Katayanagi Y, Yasui K, Ikemoto H., Taguchi K, Fukutomi R, Isemura M., et al. The study evaluating the clinical and immunomodulatory effects of green soybean extracts. Food Chem 2013; 138: 2300-5.
10. Gilroy DW, Lawrence T, Perretti M., Rossi AG. Inflammatory resolution: New opportunities for drug discovery. Nat Rev Drug Discov 2004; 3: 401-16.
11. Kundu JK, Surh YJ Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with antiinflammatory phytochemicals. Mutat Res 2005; 591: 123-46.
12. Barnes S. The biochemistry, chemistry and physiology of the isoflavones in soybeans and their food products. Lymphat Res Biol 2010; 8: 89-98.
13. Hur HG, Lay JO Jr, Beger RD, Freeman JP, Rafii F. Isolation of human intestinal bacteria metabolizing the natural isoflavone glycosides daidzin and genistin. Arch Microbiol 2000; 174: 422-8.
14. Woclawek-Potocka I., Okuda K, Acosta T.J., Korzekwa A., Pilawski W, Skarzynski DJ. Phytoestrogen metabolites are much more active than phytoestrogens themselves in increasing prostaglandin F (2alpha) synthesis via prostaglanin F (2alpha) synthase-like 2 stimulation in bovine endometrium. Prostaglandins Other Lipid Mediat 2005; 78: 202-17.
15. King RA, Bursill DB Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans. Am J Clin Nutr 1998; 67: 867-72.
16. Masilamani M, Wei J, Sampson HA Regulation of the immune response by soybean isoflavones. Immunol Res 2012; 54: 95-110.
17. Xiao CW. Health effects of soy protein and isoflavones in humans. J Nutr 2008; 138: 1244S-9S.
18. Vitale DC, Piazza C, Melilli B., Drago F, Salomone S. Isoflavones: Estrogenic activity, biological effect and bioavailability. Eur J Drug Metab Pharmacokinet 2013; 38: 15-25.
19. Jia Z, Babu PV, Si H, Nallasamy P., Zhu H, Zhen W, et al Genistein inhibits TNF-a-induced endothelial inflammation through the protein kinase pathway A and improves vascular inflammation in C57BL/6 mice. Int J Cardiol 2013; 168: 2637-45.
20. Mohammad-Shahi M., Haidari F, Rashidi B., Saei AA, Mahboob S, Rashidi MR. Comparison of the effects of genistein and daidzein with dexamethasone and soy protein on rheumatoid arthritis in rats. Bioimpacts 2011; 1: 161-70.
21. Ng TB, Ye XJ, Wong J.H., Fang EF, Chan YS, Pan W, et al Glyceollin, a soybean phytoalexin with medicinal properties. Appl Microbiol Biotechnol 2011; 90: 59-68.
22. Simons R, Vincken JP, Roidos N, Bovee T.F., van Iersel M, Verbruggen MA, et al Increasing soy isoflavonoid content and diversity by simultaneous malting and challenging by a fungus to modulate estrogenicity. Agric Food Chem 2011; 59: 6748-58.
23. Kim HJ, Lim JS, Kim W.K., Kim JS. Soyabean glyceollins: Biological effects and relevance to human health. Proc Nutr Soc 2012; 71: 166-74.
24. Kim HJ, Cha BY, Choi B, Lim J.S., Woo JT, Kim JS. Glyceollins inhibit platelet-derived growth factor-mediated human arterial smooth muscle cell proliferation and migration. Br J Nutr 2012; 107: 24-35.
25. Kim HJ, Sung MK, Kim JS Anti-inflammatory effects of glyceollins derived from soybean by elicitation with Aspergillus sojae. Inflamm Res 2011; 60: 909-17.
26. Tanaka K, Ohgo Y, Katayanagi Y., Yasui K, Hiramoto S, Ikemoto H., et al. Anti-inflammatory effects of green soybean extract irradiated with visible light. Sci Rep 2014; 4: 4732.
27. Lee TH, Do MH, Oh Y.L., Cho DW, Kim SH, Kim SY. Dietary fermented soybean suppresses UVB-induced skin inflammation in hairless mice via regulation of the MAPK signaling pathway. J Agric Food Chem 2014; 62: 8962-72.
28. Regal JF, Fraser DG, Weeks C.E., Greenberg NA. Dietary phytoestrogens have anti-inflammatory activity in a guinea pig model of asthma. Proc Soc Exp Biol Med 2000; 223: 372-8.
29. Masilamani M, Wei J, Bhatt S., Paul M, Yakir S, Sampson HA Soybean isoflavones regulate dendritic cell function and suppress allergic sensitization to peanut. J Allergy Clin Immunol 2011; 128: 1242-50.
30. Kinoshita S, Noda K, Tagawa Y., Inafuku S, Dong Y, Fukuhara J., et al. Genistein attenuates choroidal neovascularization. J Nutr Biochem 2014; 25: 1177-82.
31. MacDonald RS, Guo J, Copeland J., Browning JD Jr, Sleper D, Rottinghaus GE, et al Environmental influences on isoflavones and saponins in soybeans and their role in colon cancer. J Nutr 2005; 135: 1239-42.
32. Berhow MA, Duval SM, Dobbins T.A., Maynes J. Analysis and quantitative determination of group B saponins in processed soybean products. Phytochem Anal 2002; 13: 343-8.
33. Berhow MA, Wagner ED, Vaughn S.F., Plewa MJ. Characterization and antimutagenic activity of soybean saponins. Mutat Res 2000; 448: 11-22.
34. Kitagawa I, Wang HK, Taniyama T, Yoshikawa AM Saponin and sapogenol A, soy sapogenol B, and soy sapogenol E oleanene sapogenols from soybean Glycine-Max. Structures of soy saponin I, soy saponin II, and soy saponin III. Chem Pharm Bull 1998; 36: 153-61.
35. Kitagawa I, Yoshikawa M, Wang H.K., Saito M., Tosirisuk V, Fujiwara T, et al Revised structures of soy sapogenol A, soy sapogenol B, and soy sapogenol E oleanene sapogenols from soybean Glycine Max. Structures of soy saponin I, soy saponin II and soy saponin III. Chem Pharm Bull 1988; 30: 2294-7.
36. Dia VP, Berhow MA, Gonzalez De Mejia E. Bowman-Birk inhibitor and genistein among soy compounds that synergistically inhibit nitric oxide and prostaglandin E2 pathways in lipopolysaccharide-induced macrophages. J Agric Food Chem 2008; 56:11707-17.
37. Lee IA, Park YJ, Joh E.H., Kim DH. Soyasaponin Ab ameliorates colitis by inhibiting the binding of lipopolysaccharide (LPS) to Toll-like receptor (TLR)4 on macrophages. J Agric Food Chem 2011; 59: 13165-72.
38. Kim HY, Yu R, Kim J.S., Kim YK, Sung MK. Antiproliferative crude soy saponin extract modulates the expression of IkappaBalpha, protein kinase C, and cyclooxygenase-2 in human colon cancer cells. Cancer Lett 2004; 210: 1-6.
39. Zha L, Chen J, Sun S., Mao L, Chu X, Deng H., et al. Soyasaponins can blunt inflammation by inhibiting the reactive oxygen speciesmediated activation of PI3K/Akt/NF-KB pathway. PLoS One 2014; 9: e107655.
40. Marzocchella L, Fantini M, Benvenuto M., Masuelli L, Tresoldi I, Modesti A., et al. Dietary flavonoids: Molecular mechanisms of action as antiinflammatory agents. Rec Pat Inflamm Allergy Drug Discov 2011; 5: 200-20.
41. Kim JM, Kim JS, Yoo H, Choung M.G., Sung MK. Effects of black soybean [Glycine max (L.) Merr.] seed coats and its anthocyanidins on colonic inflammation and cell proliferation in vitro and in vivo. J Agric Food Chem 2008; 56: 8427-33.
42. Tsoyi K, Park HB, Kim Y.M., Chung JI, Shin SC, Lee WS, et al Anthocyanins from black soybean seed coats inhibit UVB-induced inflammatory cylooxygenase-2 gene expression and PGE2 production through regulation of the nuclear factor-kappaB and phosphatidylinositol 3-kinase/Akt pathway. J Agric Food Chem 2008; 56: 8969-74.
43. Kim JM, Kim KM, Park E.H., Seo JH, Song JY, Shin SC, et al Anthocyanins from black soybean inhibit Helicobacter pyloriinduced inflammation in human gastric epithelial AGS cells. Microbiol Immunol 2013; 57: 366-73.
44. Bime C, Wei CY, Holbrook J, Smith L.J., Wise RA. Association of dietary soy genistein intake with lung function and asthma control: A post-hoc analysis of patients enrolled in a prospective multicentre clinical trial. Prim Care Respir J 2012; 21: 398-404.
45. Mizushina Y, Kuriyama I, Yoshida H. Inhibition of DNA polymerase X and associated inflammatory activities of extracts from steamed germinated soybeans. Food Funct 2014; 5: 696-704.
46. Yang X, Zhu J, Tung C.Y., Gardiner G., Wang Q, Chang HC, et al Lunasin alleviates allergic airway inflammation while increases antigen-specific tregs. PLoS One 2015; 10: e0115330.
47. Moussa L, Bézirard V, Salvador-Cartier C, Bacquié V, Lencina C, Lévêque M, et al. A low dose of fermented soy germ alleviates gut barrier injury, hyperalgesia and faecal protease activity in a rat model of inflammatory bowel disease. PLoS One 2012; 7: e49547.
48. Ibuki, M., Hasegawa, Y., Mine Y. Anti-inflammatory agent for oral application, and anti-inflammatory peptide for oral application. US20120157395 (2012).
49. Kovacs-Nolan J., Zhang H, Ibuki M., Nakamori T, Yoshiura K, Turner P.V., et al. The PepT1-transportable soy tripeptide VPY reduces intestinal inflammation. Biochim Biophys Acta 2012; 1820: 1753-63.
50. Ibuki, M., Hasegawa, Y., Mine, Y. Anti-inflammatory agent for oral application, and anti-inflammatory peptide for oral application. WO2011007612 (2011).
51. Martinez-Villaluenga C., Dia VP, Berhow M, Bringe N.A., Gonzalez de Mejia E. Protein hydrolysates from beta-conglycinin enriched soybean genotypes inhibit lipid accumulation and inflammation in vitro. Mol Nutr Food Res. 2009; 53: 1007-18
52. Motoyama, T. Anti-inflammatory agent. WO2011145553 (2011)
53. Oskoueian E, Abdullah N, Hendra R., Karimi E. Bioactive compounds, antioxidant, xanthine oxidase inhibitory, tyrosinase inhibitory and anti-inflammatory activities of selected agro-industrial byproducts. Int J Mol Sci 2011; 12: 8610-25.
54. Choi YH, Lim H, Heo M.Y., Kwon DY, Kim HP. Antiinflammatory activity of the ethanol extract of Chungkukjang, Korean fermented bean: 5-lipoxygenase inhibition. J Med Food 2008; 11: 539-43.
55. Holick FM. Vitamin D deficiency. N Engl J Med 2007; 357: 266-81.
56. Aoki H, Sukegawa K, Daikokuya Y. Effects of ultraviolet-A irradiation on the quality of harvested agricultural products during the drying process. Acta Horticulturae 2011; 907: 101-4.
57. Imai, S., Tanaka, K. Anti-inflammatory agent. WO2011093290 (2011).
58. Katayanagi Y, Yasui K, Ikemoto H., Taguchi K, Fukutomi R, Isemura M., et al. The clinical and immunomodulatory effects of green soybean extracts. Food Chem 2013; 138(4): 2300-5.
59. Isemura, M., Kaneko, A., Yasui, K. Anti-allergic agent. WO2011080825 (2011).
60. Kim JH, Jia Y, Lee J.G., Nam B., Lee JH, Shin KS, et al. Hypolipidemic and antiinflammation activities of fermented soybean fibers from meju in C57BL/6J mice. Phytother Res 2014; 28: 1335-41
61. Lee YJ, Kim JE, Kwak M.H., Go J., Kim DS, Son HJ, et al. Quantitative evaluation of the therapeutic effect of fermented soybean products containing a high concentration of GABA on phthalic anhydride-induced atopic dermatitis in IL-4/Luc/CNS-1 Tg mice. Int J Mol Med 2014; 33: 1185-94.
62. Bae MJ, Shin HS, See H.J., Chai OH, Shon DH. Cheonggukjang ethanol extracts inhibit a murine allergic asthma via suppression of mast cell-dependent anaphylactic reactions. J Med Food 2014; 17: 142-9.
63. Kubow, S., Sheppard, J. Use of soy kefir powder for reducing pain, blood pressure and inflammation. US20090221469 (2009).
64. Maheu E, Cadet C, Marty M., Moyse D, Kerloch I, Coste P., et al. Randomised, controlled trial of avocado-soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: The ERADIAS study. Ann Rheum Dis 2014; 73: 376-84.
65. Frondoza, C, Henderson, T.R., Grzanna, R. Orally administrable compositions comprising avocado/soybean unsaponifiables and lipoic acid and methods of administration. US20120294960 (2012).
66. Jeong JW, Lee HH, Han M.H., Kim GY, Kim WJ, Choi YH. Antiinflammatory effects of genistein via suppression of the toll-like receptor 4-mediated signaling pathway in lipopolysaccharide-stimulated BV2 microglia. Chem Biol Interact 2014; 212: 30-9.
67. Dijsselbloem N, Goriely S, Albarani V., Gerlo S, Francoz S, Marine J-C, et al. A critical role for p53 in the control of NF-KB-dependent gene expression in TLR4-stimulated dendritic cells exposed to genistein. J Immunol 2007; 178: 5048-57.
68. Satsu H, Hyun JS, Shin H.S., Shimizu M. Suppressive effect of an isoflavone fraction on tumor necrosis factor-alpha-induced interleukin-8 production in human intestinal epithelial Caco-2 cells. J Nutr Sci Vitaminol 2009; 55: 442-6.
69. Chiu TM, Huang CC, Lin T.J., Fang JY, Wu NL, Hung CF. In vitro and in vivo anti-photoaging effects of an isoflavone extract from soybean cake. J Ethnopharmacol 2009; 126: 108-13.
70. Valsecchi AE, Franchi S, Panerai A.E., Sacerdote P., Trovato AE, Colleoni M. Genistein, a natural phytoestrogen from soy, relieves neuropathic pain following chronic constriction sciatic nerve injury in mice: Anti-inflammatory and antioxidant activity. J Neurochem 2008; 107: 230-40.
71. Verdrengh M, Jonsson IM, Holmdahl R, Tarkowski A. Genistein as an anti-inflammatory agent. Inflamm Res 2003; 52: 341-6.
72. Morimoto M, Watanabe T, Yamori M., Takebe M, Wakatsuki Y. Isoflavones regulate innate immunity and inhibit experimental colitis. J Gastroenterol Hepatol 2009; 24: 1123-9.
73. Kang JS, Yoon YD, Han M.H., Han SB, Lee K, Kang MR, et al Estrogen receptor-independent inhibition of tumor necrosis factor-alpha gene expression by phytoestrogen equol is mediated by blocking nuclear factor-kappaB activation in mouse macrophages. Biochem Pharmacol 2005; 71: 136-43.
74. Sakai T, Furoku S, Nakamoto M., Shuto E, Hosaka T, Nishioka Y., et al. Soy isoflavone equol perpetuates dextran sulfate sodiuminduced acute colitis in mice. Biosci Biotechnol Biochem 2011; 75: 593-5.
75. Paradkar PN, Blum PS, Berhow M.A., Baumann H., Kuo S-M. Dietary isoflavones suppress endotoxin-induced inflammatory reaction in liver and intestine. Cancer Lett 2004; 215: 21-8.
76. Davis JN, Kucuk O, Djuric Z., Sarkar FH. Soy isoflavone supplementation in healthy men prevents NF-kappa B activation by TNF-alpha in blood lymphocytes. Free Radic Biol Med 2001; 30: 1293-302.
77. Huang Y, Cao S, Nagamani M., Anderson KE, Grady JJ, Lu L-JW. Decreased circulating levels of tumor necrosis factor-{alpha} in postmenopausal women during consumption of soycontaining isoflavones. J Clin Endocrinol Metab 2005; 90: 3956-62.
78. Lee IA, Park YJ, Yeo H.K., Han MJ, Kim DH. Soyasaponin I attenuates TNBS-Induced colitis in mice by inhibiting NF-KB pathway. J Agric Food Chem 2010; 58: 10929-34.