Hypolipidemic and antiinflammation activities of fermented soybean fibers from meju in C57BL/6 J mice

Phytotherapy Research

Volumn 28, Issue 9, 2014, Pages 1335-1341

  Kim, Jong Ho ^a   Jia, Yaoyao ^a   Lee, Jung Gyu ^a   Nam, Bora ^a   Lee, Ji Hae ^a   Shin, Kwang Soon ^b   Hurh, Byung Serk ^c   Choi, Yong Ho ^c   Lee, Sung Joon ^a  

^a Korea University   (South Korea)

^b Kyonggi University   (South Korea)

^c SEMPIO FOODS COMPANY   (South Korea)

Author keywords

Inflammation; Lipid metabolism; Meju; Soybean fibers

Indexed keywords

C REACTIVE PROTEIN; CD36 ANTIGEN; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INTERLEUKIN 6; LIVER X RECEPTOR ALPHA; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; ANTILIPEMIC AGENT; CYTOKINE; SOYBEAN PROTEIN;

ACOX1 GENE; ACS GENE; ADIPOCYTE; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BODY WEIGHT; CD36 GENE; CELL SIZE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CONTROLLED STUDY; CPT1ALPHA GENE; CYP7A1 GENE; FATP5 GENE; FATTY ACID OXIDATION; FATTY ACID TRANSPORT; FERMENTED PRODUCT; FERMENTED SOYBEAN FIBER; FERMENTED SOYBEAN PEPTIDE AND AMINO ACID; GENE; GENE EXPRESSION; HYPOLIPIDEMIC ACTIVITY; IN VIVO STUDY; INSIG 2A GENE; LIPID STORAGE; LXRALPHA GENE; MALE; MEJU; MOUSE; NONHUMAN; OBESITY; PROTEIN EXPRESSION; PROTEIN INDUCTION; SOYBEAN; SREBP1C GENE; THERAPY EFFECT; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; ANIMAL; BLOOD; C57BL MOUSE; CHEMISTRY; DIETARY FIBER; DRUG EFFECT; FERMENTATION; INFLAMMATION; LIPID METABOLISM; SOYBEAN FIBERS;

INFLAMMATION; LIPID METABOLISM; MEJU; SOYBEAN FIBERS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CYTOKINES; DIETARY FIBER; FERMENTATION; HYPOLIPIDEMIC AGENTS; LIPID METABOLISM; MALE; MICE, INBRED C57BL; SOYBEAN PROTEINS; SOYBEANS;

EID: 84907922758     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5134     Document Type: Article

References (30)

1. Andreozzi F, Laratta E, Cardellini M, et al. 2006. Plasma interleukin-6 levels are independently associated with insulin secretion in a cohort of Italian-Caucasian nondiabetic subjects. Diabetes 55: 2021-2024.
2. Beaglehole R. 1990. International trends in coronary heart disease mortality, morbidity, and risk factors. Epidemiol Rev 12: 1-15.
3. Birketvedt GS, Shimshi M, Erling T, et al. 2005. Experiences with three different fiber supplements in weight reduction. Med Sci Monit 11: 8.
4. Brown L, Rosner B, Willett WW, et al. 1999. Cholesterol-lowering effects of dietary fiber: ameta-analysis. Am J Clin Nutr 69: 30-42.
5. Byung-Suk Hur Y-HC, Kim K O, Baik E J. 2013. Production of fermentation microorganisms with starch-hydrolysing activities. Republic of Korea Patent.
6. Jia Y, Kim JY, Jun HJ, et al. 2012. The natural carotenoid astaxanthin, a PPAR-alpha agonist and PPAR-gamma antagonist, reduces hepatic lipid accumulation by rewiring the transcriptome in lipid-loaded hepatocytes. Mol Nutr Food Res 56: 878-888.
7. Kern PA, Ranganathan S, Li C, et al. 2001. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 280: E745-E751.
8. Kershaw EE, Flier JS. 2004. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89: 2548-2556.
9. Kim D-H, Kim S-H, Kwon S-W, et al. 2013. Mycoflora of soybeans used for meju fermentation. Mycobiology 41: 100-107.
10. King DE. 2005. Dietary fiber, inflammation, and cardiovascular disease. Mol Nutr Food Res 49: 594-600.
11. King DE, Egan BM, Geesey ME. 2003. Relation of dietary fat and fiber to elevation of C-reactive protein. Am J Cardiol 92: 1335-1339.
12. Kromhout D. 2001. Epidemiology of cardiovascular diseases in Europe. Public Health Nutr 4: 441-457.
13. Lee SY, Kim HY, Lee S, et al. 2012. Mass spectrometry-based metabolite profiling and bacterial diversity characterization of Korean traditional meju during fermentation. J Microbiol Biotechnol 22: 1523-1531.
14. Liu S, Stampfer MJ, Hu FB, et al. 1999. Whole-grain consumption and risk of coronary heart disease: results from the Nurses' Health Study. Am J Clin Nutr 70: 412-419.
15. Lo G. 1989. Nutritional and physical properties of dietary fiber from soybeans. Cereal foods world 34: 530-534.
16. Lo GS, Goldberg AP, Lim A, et al. 1986. Soy fiber improves lipid and carbohydrate metabolism in primary hyperlipidemic subjects. Atherosclerosis 62: 239-248.
17. Rader DJ. 2000. Inflammatory markers of coronary risk. N Engl J Med 343: 1179-1182.
18. Ridker PM. 2003. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation 107: 363-369.
19. Rui L, Aguirre V, Kim JK, et al. 2001. Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. J Clin Invest 107: 181-189.
20. Schwenk RW, Holloway GP, Luiken JJFP, et al. 2010. Fatty acid transport across the cell membrane: Regulation by fatty acid transporters. Prostaglandins Leukot Essent Fatty Acids 82: 149-154.
21. Sethi JK, Hotamisligil GS. 1999. The role of TNF in adipocytemetabolism. In: Seminars in Cell and Developmental Biology, 19-30.
22. Steffen LM, Jacobs DR, Stevens J, et al. 2003. Associations of whole-grain, refined-grain, and fruit and vegetable consumption with risks of all-cause mortality and incident coronary artery disease and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Clin Nutr 78: 383-390.
23. Suh HJ, Yang HS, Ra KS, et al. 2013. Peyer's patch-mediated intestinal immune system modulating activity of pectic-type polysaccharide from peel of Citrus unshiu. Food Chem 138: 1079-1086.
24. Unit ES. 2005. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins. Lancet 366: 1267-1278.
25. Watzl B, Girrbach S, Roller M. 2005. Inulin, oligofructose and immunomodulation. Br J Nutr 93: 49-56.
26. Wellen KE, Hotamisligil GS. 2005. Inflammation, stress, and diabetes. J Clin Invest 115: 1111-1119.
27. Yecies JL, Zhang HH, Menon S, et al. 2011. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab 14: 21-32.
28. Yellaturu CR, Deng X, Park EA, et al. 2009. Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2a and its dissociation from SREBP cleavage-activating protein (SCAP). SREBP-1c complex. J Biol Chem 284: 31726-31734.
29. Yudkin JS, Stehouwer C, Emeis J, et al. 1999. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 19: 972-978.
30. Zhang Y, Mangelsdorf DJ. 2002. LuXuRies of lipid homeostasis: the unity of nuclear hormone receptors, transcription regulation, and cholesterol sensing. Mol Interv 2: 78-87.