Protein hydrolysates from β-Conglycinin enriched soybean genotypes inhibit lipid accumulation and inflammation in vitro

Molecular Nutrition and Food Research

Volumn 53, Issue 8, 2009, Pages 1007-1018

  Martinez Villaluenga, Cristina ^a   Dia, Vermont P ^a   Berhow, Mark ^b   Bringe, Neal A ^c   de Mejia, Elvira Gonzalez ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b AGRICULTURAL RESEARCH SERVICE   (United States)

^c MONSANTO COMPANY   (United States)

Author keywords

conglycinin; Biomarkers; Inflammation; Lipid metabolism; Soy protein hydrolysates

Indexed keywords

BETA CONGLYCININ PROTEIN, GLYCINE MAX; BETA-CONGLYCININ PROTEIN, GLYCINE MAX; CYCLOOXYGENASE 2 INHIBITOR; FATTY ACID SYNTHASE; GLOBULIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPROTEIN LIPASE; NITRIC OXIDE; PLANT ANTIGEN; PROSTAGLANDIN E2; SEED STORAGE PROTEIN; SOYBEAN PROTEIN; VEGETABLE PROTEIN;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL STRAIN 3T3; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; GENOTYPE; INFLAMMATION; LIPID METABOLISM; MOUSE; SOYBEAN;

3T3-L1 CELLS; ANIMALS; ANTIGENS, PLANT; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; FATTY ACID SYNTHETASE COMPLEX; GENOTYPE; GLOBULINS; INFLAMMATION; LIPID METABOLISM; LIPOPROTEIN LIPASE; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PLANT PROTEINS; SEED STORAGE PROTEINS; SOYBEAN PROTEINS; SOYBEANS;

GLYCINE MAX;

EID: 69149094546     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200800473     Document Type: Article

References (53)

1. Singh, P., Kumar, R., Sabapathy, S. N., Bawa, A. S., Functional and edible uses of soy protein products, Compr. Rev. Food Sci. Food Saf. 2008, 7, 14-28.
2. Möller, N. P., Scholz-Ahrens, K. E., Roos, N., Schrezenmeir, J., Bioactive peptides and proteins from foods: Indication for health effects, Eur. J. Nutr. 2008, 47, 171-182.
3. Wang, W., Gonzalez de Mejia, E., A new frontier in soy bioactive peptides that may prevent age-related chronic diseases, Compr. Rev. Food Sci. Food Saf. 2005, 4, 63-78.
4. Flegal, K. M., Graubard, B. I., Williamson, D. F., Gail, M. H., Excess deaths associated with underweight, overweight, and obesity, JAMA 2005, 293, 861-1867.
5. Shimomura, I., Hammer, R. E., Richardson, J. A., Ikemoto, S., Bashmakov, Y., Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: Model for congenital generalized lipodystrophy, Genes Dev. 1998, 12, 3182-3194.
6. Rahman, Md. A., Kumar, S. G., Kim, S. W., Hwang, H. J., et al., Proteomic analysis for inhibitory effect of chitosan oligosaccharides on 3T3-L1 adipocyte differentiation, Proteomics 2008,8,569-581.
7. Jing-Jing, L., Chang, J. H., Dong, X., Anti-obesity effects of conjugated linoleic acid, docosahexaenoic acid, and eicosapentaenoic acid, Mol. Nutr. Food Res. 2008, 52, 631-645.
8. Kuhajda, F. P., Landree, L. E., Ronnett, G. V., The connections between C75 and obesity drug-target pathways, Trends Pharmacol. Sci. 2005, 26, 541-54
9. Kridel, S. J., Axelrod, F., Rozenkrantz, N., Smith, J. W., Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity, Cancer Res. 2004, 64, 2070-2075.
10. Hotamisligil, G. S., Inflammation and metabolic disorders, Nature 2006, 444, 860-867.
11. Van Gaal, L. F., Mertens, I. L., De Block, C. E., Mechanisms linking obesity with cardiovascular disease, Nature 2006, 444,875-880.
12. Weisberg, S. P., Hunter, D., Huber, R., Lemieux, J., et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding, J. Clin. Invest. 2006, 116, 115-124.
13. Guha, M., Mackman, N., Lipopolysaccharide induction of gene expression in human monocytes, Cell. Signal. 2001, 13, 85-94.
14. Nagai, H., Kumamoto, H., Fukuda, M., Takahashi, T., Inducible nitric oxide synthase and apoptosis-related factors in the synovial tissues of temporomandibular joints with internal derangement and osteoarthritis, J. Oral Maxillofac. Surg. 2003,61,801-907.
15. Boota, A., Zar, H., Kim, Y. M., Johnson, B., et al.,IL-1 beta stimulates superoxide and delayed peroxynitrite production by pulmonary vascular smooth muscle cell, Am. J. Physiol. 1996,271,932-938.
16. Ringseis, R., Matthes, B., Lehmann, V., Becker, K., et al., Peptides and hydrolysates from casein and soy protein modulate the release of vasoactive substances from human aortic endothelial cells, Biochim. Biophys. Acta 2005, 1721, 89-97
17. Martinez-Villaluenga, C., Bringe, N. A., Berhow, M. A., Gonzalez de Mejia, E., β-Conglycinin embeds active peptides that inhibit lipid accumulation in 3T3-L1 adipocytes in vitro, J. Agric. Food Chem. 2008, 56, 10533-10543.
18. Wang, W., Bringe, N. A., Berhow, M. A., Gonzalez de Mejia, E., β-conglycinins among sources of bioactives in hydrolysates of different soybean varieties that inhibit leukemia cells invitro, J. Agric. Food Chem. 2008, 56, 4012-4020.
19. Hou, S. H. J., Chang, S. K. C., Structural characteristics of purified glycinin from soybeans stored under various conditions, J. Agric. Food Chem. 2004, 52, 3792-3800.
20. Bennett, J. O., Krishman, A. H., Wiebold, W. J., Krishman, H. B., Positional effect on protein and oil content and composition of soybeans, J. Agric. Food Chem. 2003, 51, 6882-6886.
21. Kim, L. M., Soy and tea components inhibit in vitro adipogenesis, Master Thesis, University of Illinois, Urbana-Champaign, 2007, p. 120.
22. Hsu, C.-L., Yen, G.-C., Effects of flavonoids and phenolic acids on the inhibition of adipogenesis in 3T3-L1 adipocytes, J. Agric. Food Chem. 2007, 55, 8404-8410.
23. Gonzales, M. M., Orlando, R. A., Role of adipocyte-derived lipoprotein lipase in adipocyte hypertrophy, Nutr. Metab. 2007,4,22-31.
24. Koo, H.-Y., Wallig, M. A., Chung, B. H., Nara, T. Y., et al., Dietary fructose induces a wide range of genes with distinct shift in carbohydrate and lipid metabolism in fed and fasted rat liver, Biochim. Biophys. Acta 2008, 1782, 341-348.
25. Green, L. C., Wagner, D. A., Glogowski, J., Skipper, P. L., et al., Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids, Anal. Biochem. 1982, 26, 131-138.
26. Vaughn, N., Rizzo, A., Doane, D., Beverly, J. L., Gonzalez de Mejia, E., Intracerebroventricular administration of soy protein hydrolysates reduces body weight without affecting food intake in rats, Plant Foods Hum. Nutr. 2008, 63, 41-46.
27. Lo, W. M. Y., Li-Chan, E. C. Y., Angiotensin I converting enzyme inhibitory peptides from in vitro pepsin-pancreatin digestion of soy protein, J. Agric. Food Chem. 2005, 53, 3369-3376.
28. Kohno, M., Hirotsuka, M., Kito, M., Matsuzawa, Y., Decreases in serum triacylglycerol and visceral fat mediated by dietary soybean β-conglycinin, J. Atheroscler. Thromb. 2006,13,247-255.
29. Moriyama, T., Kishomoto, K., Nagai, K., Urade, R. l., et al., Soybean beta-conglycinin diet suppresses serum triglyceride levels in normal and genetically obese mice by induction of beta-oxidation, downregulation of fatty acid synthase, and inhibition of triglyceride absorption, Biosci. Biotechnol. Biochem. 2004, 68, 352-359.
30. Fukui, K., Kojima, M., Tachibana, N., Kohno, M., et al., Effects of soybean β-conglycinin on hepatic lipid metabolism and fecal lipid excretion in normal adult rats, Biosci. Biotechnol. Biochem. 2004, 68, 1153-1155.
31. Jang, E.-H., Moon, J.-S., Ko, J. H., Ahn, C.-W., et al., Novel black soy peptides with antiobesity effects: activation of leptin-like signaling and AMP-activated protein kinase, Int. J. Obes. 2008, 32, 1161-1170.
32. Yang, S.-C., Liu, S.-M., Yang, H.-Y., Lin, Y.-H., Chen, J.-R., Soybean protein hydrolysates improves plasma and liver lipid profiles in rats fed high-Cholesterol diet, J. Am. Coll. Nutr. 2007,26,416-423.
33. Cho, S.-J., Juillerat, M. A., Lee, C.-H., Cholesterol lowering mechanism of soybean protein hydrolysate, J. Agric. Food Chem. 2007, 55, 10599-10604.
34. Zhao, W.-H., Zhao, C.-Y., Gao, L.-F., Feng, F.-F., et al., The nobel inhibitory effect of Pangdahain on fatty acid synthase, Life 2008, 60, 185-194.
35. Berdnt, J., Kovacs, P., Ruschke, K., Kloting, N., et al., Fatty acid synthase gene expression in human adipose tissue association with obesity and type 2 diabetes, Diabetologia 2007, 50,1472-1480.
36. Mobbs, C. V., Makimura, H., Block the FAS, lose the fat, Nat. Med. 2002, 8, 335-336.
37. Loftus, T. M., Jaworsky, D. E., Frehywot, G. L., Townsend, C. A., et al., Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors, Science 2000, 288, 2379-2381.
38. Kumar, M. V., Shimokawa, T., Nagy, T. R., Lane, M. D., Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice, Proc. Natl. Acad. Sci. U. S. A. 2002,99,1921-1925.
39. Dridi, S., Ververken, C., Hillgartner, F. B., Lutgarde, A., et al., FAS inhibitor cerulenin reduces food intake and melanocortin receptor gene expression without modulating the other (an)orexigenic neuropeptides in chickens, Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 291, 138-147.
40. Velasquez, M. T., Bhathena, S. J., Role of dietary soy protein in obesity, Int. J. Med. Sci. 2007, 4, 72-82.
41. Kalhan, R., Smith, L. J., Nlend, M. C., Nair, A., et al., A mechanism of soy genistein in asthma: Inhibition of eosinophil p-38 dependent leukotriene synthesis, Clin. Exp. Allergy 2008,38,103-112.
42. Kao, T. H., Wu, W. M., Hung, C. F., Wu, W. B., Chen, B. H., Anti-inflammatory effects of isoflavone powder produced from soybean cake, J. Agric. Food Chem. 2007, 55, 11068-11079.
43. Hooshmand, S., Soung, D. Y., Lucas, E. A., Madihally, S. V., et al., Genistein reduces the production of pro-inflammatory molecules in human chondrocytes, J. Nutr. Biochem. 2007, 18,609-614.
44. Kang, J. H., Sung, M. K., Kawada, T., Yoo, H. et al., Soybean saponins suppress the release of proinflammatory mediators by LPS-stimulated peritoneal macrophages, Cancer Lett. 2005,230,219-227.
45. Dia, V. P., Wang, W., Oh, V. L., de Lumen, B. O., Gonzalez de Mejia, E., Isolation, purification and characterization of lunasin from defatted soybean flour and in vitro evaluation of its anti-inflammatory activity, Food Chem. 2009, 114, 108-115.
46. Takamatsu, K., in: Sugano, M. (Ed.), Soy and Health and Disease Prevention, CRC Press LLC, Boca Raton, Florida 2006, pp. 235-249.
47. Korhonen, H., Pihlanto, A., Food-derived bioactive peptides opportunities for designing future foods, Curr. Pharm. Des. 2003,9,1297-308.
48. Brandsch, M., Knutter, I., Bosse-Doenecke, E., Pharmaceutical and pharmacological importance of peptide transporters, J. Pharm. Pharmacol. 2008, 60, 543-85.
49. Kim, J. Y., Kim, T. H., Kim, S. S., Anti-inflammatory effect of a human prothrombin fragment-2-derived peptide, NSA9, in EOC microglia, Biochem. Biophys. Res. Commun. 2008, 368,779-785.
50. Gonzalez-Rey, E., Delgado, M., Vasoactive intestinal peptide inhibits cyclooxygenase-2 expression in activated macrophages, microglia and dendritic cells, Brain Behav. Immun. 2008,22,35-41.
51. 2 increases growth and motility of colorectal carcinoma cells, J. Biol. Chem. 2001, 276, 18075-18081.
52. Shao, J., Evers, B. M., Sheng, H., Prostagladin E2 synergistically enhances receptor tyrosine kinase-dependent signaling system in colon cancer cells, J. Biol. Chem. 2004, 279, 14287-14293.
53. Sinicrope, F. A., Targeting cycloxygenase-2 for prevention and therapy of colorectal cancer, Mol. Carcinog. 2006, 45, 447-454.