-
1
-
-
65349177200
-
AMPK: An emerging drug target for diabetes and the metabolic syndrome
-
Zhang BB, Zhou G, Li C. AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab. 2009; 9: 407-16.
-
(2009)
Cell Metab
, vol.9
, pp. 407-416
-
-
Zhang, B.B.1
Zhou, G.2
Li, C.3
-
3
-
-
55749090598
-
AMP-activated protein kinase agonist dose dependently improves function and reduces apoptosis in glucotoxic β-cells without changing triglyceride levels
-
Nyblom HK, Sargsyan E, Bergsten P. AMP-activated protein kinase agonist dose dependently improves function and reduces apoptosis in glucotoxic β-cells without changing triglyceride levels. J Mol Endocrinol. 2008; 41: 187-94.
-
(2008)
J Mol Endocrinol
, vol.41
, pp. 187-194
-
-
Nyblom, H.K.1
Sargsyan, E.2
Bergsten, P.3
-
4
-
-
33847009048
-
AICAR potentiates ROS production induced by chronic high glucose: Roles of AMPK in pancreatic β-cell apoptosis
-
Kim WH, Lee JW, Suh YH, Lee HJ, Lee SH, Oh YK, et al. AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic β-cell apoptosis. Cell Signal. 2007; 19: 791-805.
-
(2007)
Cell Signal
, vol.19
, pp. 791-805
-
-
Kim, W.H.1
Lee, J.W.2
Suh, Y.H.3
Lee, H.J.4
Lee, S.H.5
Oh, Y.K.6
-
5
-
-
84896731193
-
Metformin plays a dual role in MIN6 pancreatic β cell function through AMPK-dependent autophagy
-
Jiang Y, Huang W, Wang J, Xu Z, He J, Lin X, et al. Metformin plays a dual role in MIN6 pancreatic β cell function through AMPK-dependent autophagy. Int J Biol Sci. 2014; 10: 268-77.
-
(2014)
Int J Biol Sci
, vol.10
, pp. 268-277
-
-
Jiang, Y.1
Huang, W.2
Wang, J.3
Xu, Z.4
He, J.5
Lin, X.6
-
6
-
-
0038363852
-
AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase
-
Kefas BA, Cai Y, Ling Z, Heimberg H, Hue L, Pipeleers D, et al. AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase. J Mol Endocrinol. 2003; 30: 151-61.
-
(2003)
J Mol Endocrinol
, vol.30
, pp. 151-161
-
-
Kefas, B.A.1
Cai, Y.2
Ling, Z.3
Heimberg, H.4
Hue, L.5
Pipeleers, D.6
-
7
-
-
33751549094
-
Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimu- lation
-
Cai Y, Martens GA, Hinke SA, Heimberg H, Pipeleers D, Van de Casteele M. Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimu- lation. Free Radic Biol Med. 2007; 42: 64-78.
-
(2007)
Free Radic Biol Med
, vol.42
, pp. 64-78
-
-
Cai, Y.1
Martens, G.A.2
Hinke, S.A.3
Heimberg, H.4
Pipeleers, D.5
Van De Casteele, M.6
-
8
-
-
3042702709
-
Metfor-min-induced stimulation of AMP-activated protein kinase in β-cells impairs their glucose responsiveness and can lead to apoptosis
-
Kefas BA, Cai Y, Kerckhofs K, Ling Z, Martens G, Heimberg H, et al. Metfor-min-induced stimulation of AMP-activated protein kinase in β-cells impairs their glucose responsiveness and can lead to apoptosis. Biochem Pharmacol. 2004; 68: 409-16.
-
(2004)
Biochem Pharmacol
, vol.68
, pp. 409-416
-
-
Kefas, B.A.1
Cai, Y.2
Kerckhofs, K.3
Ling, Z.4
Martens, G.5
Heimberg, H.6
-
9
-
-
73349123190
-
Sterol regulatory element-binding protein-1c knockdown protected INS-1E cells from lipotoxicity
-
Li J, Liu X, Ran X, Chen J, Li X, Wu W, et al. Sterol regulatory element-binding protein-1c knockdown protected INS-1E cells from lipotoxicity. Diabetes Obes Metab. 2010; 12: 35-46.
-
(2010)
Diabetes Obes Metab
, vol.12
, pp. 35-46
-
-
Li, J.1
Liu, X.2
Ran, X.3
Chen, J.4
Li, X.5
Wu, W.6
-
10
-
-
84884735588
-
AMPK regulates ER morphology and function in stressed pancreatic β-cells via phosphorylation of DRP1
-
Wikstrom JD, Israeli T, Bachar-Wikstrom E, Swisa A, Ariav Y, Waiss M, et al. AMPK regulates ER morphology and function in stressed pancreatic β-cells via phosphorylation of DRP1. Mol Endocrinol. 2013; 27: 1706-23.
-
(2013)
Mol Endocrinol
, vol.27
, pp. 1706-1723
-
-
Wikstrom, J.D.1
Israeli, T.2
Bachar-Wikstrom, E.3
Swisa, A.4
Ariav, Y.5
Waiss, M.6
-
11
-
-
43549108142
-
Glucolipotoxicity: Fuel excess and β-cell dysfunction
-
Poitout V, Robertson RP. Glucolipotoxicity: fuel excess and β-cell dysfunction. Endocr Rev. 2008; 29: 351-66.
-
(2008)
Endocr Rev
, vol.29
, pp. 351-366
-
-
Poitout, V.1
Robertson, R.P.2
-
12
-
-
77954595108
-
Gluco-lipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 β-cells
-
El-Assaad W, Joly E, Barbeau A, Sladek R, Buteau J, Maestre I, et al. Gluco-lipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 β-cells. Endocrinology. 2010; 151: 3061-73.
-
(2010)
Endocrinology
, vol.151
, pp. 3061-3073
-
-
El-Assaad, W.1
Joly, E.2
Barbeau, A.3
Sladek, R.4
Buteau, J.5
Maestre, I.6
-
13
-
-
76049113712
-
Gluco-lipotoxicity of the pancreatic beta cell
-
Poitout V, Amyot J, Semache M, Zarrouki B, Hagman D, Fontes G. Gluco-lipotoxicity of the pancreatic beta cell. Biochim Biophys Acta. 2010; 1801: 289-98.
-
(2010)
Biochim Biophys Acta
, vol.1801
, pp. 289-298
-
-
Poitout, V.1
Amyot, J.2
Semache, M.3
Zarrouki, B.4
Hagman, D.5
Fontes, G.6
-
14
-
-
0036896505
-
Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: Role in β-cell adaptation and failure in the etiology of diabetes
-
Prentki M, Joly E, El-Assaad W, Roduit R. Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in β-cell adaptation and failure in the etiology of diabetes. Diabetes. 2002; 51(Suppl 3): S405-13.
-
(2002)
Diabetes
, vol.51
, pp. S405-S413
-
-
Prentki, M.1
Joly, E.2
El-Assaad, W.3
Roduit, R.4
-
15
-
-
33745863033
-
Islet beta cell failure in type 2 diabetes
-
Prentki M, Nolan CJ. Islet beta cell failure in type 2 diabetes. J Clin Invest. 2006; 116: 1802-12.
-
(2006)
J Clin Invest
, vol.116
, pp. 1802-1812
-
-
Prentki, M.1
Nolan, C.J.2
-
16
-
-
79952836464
-
A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking
-
Boslem E, MacIntosh G, Preston AM, Bartley C, Busch AK, Fuller M, et al. A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking. Bio chem J. 2011; 435: 267-76.
-
(2011)
Bio Chem J
, vol.435
, pp. 267-276
-
-
Boslem, E.1
Macintosh, G.2
Preston, A.M.3
Bartley, C.4
Busch, A.K.5
Fuller, M.6
-
17
-
-
0037147215
-
Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic β-cells (INS-1)
-
Wrede CE, Dickson LM, Lingohr MK, Briaud I, Rhodes CJ. Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic β-cells (INS-1). J Biol Chem. 2002; 277: 49676-84.
-
(2002)
J Biol Chem
, vol.277
, pp. 49676-49684
-
-
Wrede, C.E.1
Dickson, L.M.2
Lingohr, M.K.3
Briaud, I.4
Rhodes, C.J.5
-
18
-
-
35148833815
-
Regulation of beta-cell mass and function by the Akt/protein kinase B signalling path-way
-
Elghazi L, Rachdi L, Weiss AJ, Cras-Meneur C, Bernal-Mizrachi E. Regulation of beta-cell mass and function by the Akt/protein kinase B signalling path-way. Diabetes Obes Metab. 2007; 9 (Suppl 2): 147-57.
-
(2007)
Diabetes Obes Metab
, vol.9
, pp. 147-157
-
-
Elghazi, L.1
Rachdi, L.2
Weiss, A.J.3
Cras-Meneur, C.4
Bernal-Mizrachi, E.5
-
19
-
-
2342562556
-
Mitogen-activated protein kinases in apoptosis regulation
-
Wada T, Penninger JM. Mitogen-activated protein kinases in apoptosis regulation. Oncogene. 2004; 23: 2838-49.
-
(2004)
Oncogene
, vol.23
, pp. 2838-2849
-
-
Wada, T.1
Penninger, J.M.2
-
20
-
-
84885856271
-
Exendin-4 protects pancreatic beta cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway
-
Natalicchio A, Labarbuta R, Tortosa F, Biondi G, Marrano N, Peschechera A, et al. Exendin-4 protects pancreatic beta cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway. Diabetologia. 2013; 56: 2456-66.
-
(2013)
Diabetologia
, vol.56
, pp. 2456-2466
-
-
Natalicchio, A.1
Labarbuta, R.2
Tortosa, F.3
Biondi, G.4
Marrano, N.5
Peschechera, A.6
-
21
-
-
0037301056
-
AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase
-
Kefas BA, Heimberg H, Vaulont S, Meisse D, Hue L, Pipeleers D, et al. AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase. Diabetologia. 2003; 46: 250-4.
-
(2003)
Diabetologia
, vol.46
, pp. 250-254
-
-
Kefas, B.A.1
Heimberg, H.2
Vaulont, S.3
Meisse, D.4
Hue, L.5
Pipeleers, D.6
-
22
-
-
33745116619
-
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic β-cell apoptosis
-
Karaskov E, Scott C, Zhang L, Teodoro T, Ravazzola M, Volchuk A. Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic β-cell apoptosis. Endocrinology. 2006; 147: 3398-407.
-
(2006)
Endocrinology
, vol.147
, pp. 3398-3407
-
-
Karaskov, E.1
Scott, C.2
Zhang, L.3
Teodoro, T.4
Ravazzola, M.5
Volchuk, A.6
-
23
-
-
84862558716
-
Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice
-
Huang SL, Yu RT, Gong J, Feng Y, Dai YL, Hu F, et al. Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice. Diabetologia. 2012; 55: 1469-81.
-
(2012)
Diabetologia
, vol.55
, pp. 1469-1481
-
-
Huang, S.L.1
Yu, R.T.2
Gong, J.3
Feng, Y.4
Dai, Y.L.5
Hu, F.6
-
24
-
-
1642546212
-
Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: Modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)
-
Diraison F, Parton L, Ferre P, Foufelle F, Briscoe CP, Leclerc I, et al. Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR). Biochem J. 2004; 378: 769-78.
-
(2004)
Biochem J
, vol.378
, pp. 769-778
-
-
Diraison, F.1
Parton, L.2
Ferre, P.3
Foufelle, F.4
Briscoe, C.P.5
Leclerc, I.6
-
25
-
-
0031239663
-
How obesity causes diabetes in Zucker diabetic fatty rats
-
Unger RH. How obesity causes diabetes in Zucker diabetic fatty rats. Trends Endocrin Met. 1997; 8: 276-82.
-
(1997)
Trends Endocrin Met
, vol.8
, pp. 276-282
-
-
Unger, R.H.1
-
26
-
-
0035130102
-
Diseases of liporegulation: New perspective on obesity and related disorders
-
Unger RH, Orci L. Diseases of liporegulation: new perspective on obesity and related disorders. Faseb J. 2001; 15: 312-21.
-
(2001)
Faseb J
, vol.15
, pp. 312-321
-
-
Unger, R.H.1
Orci, L.2
-
27
-
-
79960977229
-
Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents beta cell failure in rodent models of type 2 diabetes
-
Tiano JP, Delghingaro-Augusto V, Le May C, Liu S, Kaw MK, Khuder SS, et al. Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents beta cell failure in rodent models of type 2 diabetes. J Clin Invest. 2011; 121: 3331-42.
-
(2011)
J Clin Invest
, vol.121
, pp. 3331-3342
-
-
Tiano, J.P.1
Delghingaro-Augusto, V.2
Le May, C.3
Liu, S.4
Kaw, M.K.5
Khuder, S.S.6
-
28
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001; 108: 1167-74.
-
(2001)
J Clin Invest
, vol.108
, pp. 1167-1174
-
-
Zhou, G.1
Myers, R.2
Li, Y.3
Chen, Y.4
Shen, X.5
Fenyk-Melody, J.6
-
29
-
-
9144271181
-
AMP-activated protein kinase is required for the lipid-lowering effect of met-formin in insulin-resistant human HepG2 cells
-
Zang M, Zuccollo A, Hou X, Nagata D, Walsh K, Herscovitz H, et al. AMP-activated protein kinase is required for the lipid-lowering effect of met-formin in insulin-resistant human HepG2 cells. J Biol Chem. 2004; 279: 47898-905.
-
(2004)
J Biol Chem
, vol.279
, pp. 47898-47905
-
-
Zang, M.1
Zuccollo, A.2
Hou, X.3
Nagata, D.4
Walsh, K.5
Herscovitz, H.6
-
30
-
-
84878366989
-
The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding
-
Henriksen BS, Curtis ME, Fillmore N, Cardon BR, Thomson DM, Hancock CR. The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding. Diabetol Metab Syndr. 2013; 5: 29.
-
(2013)
Diabetol Metab Syndr
, vol.5
, pp. 29
-
-
Henriksen, B.S.1
Curtis, M.E.2
Fillmore, N.3
Cardon, B.R.4
Thomson, D.M.5
Hancock, C.R.6
-
31
-
-
0033613181
-
Troglitazone prevents mitochondrial alterations, β cell destruction, and diabetes in obese prediabetic rats
-
Higa M, Zhou YT, Ravazzola M, Baetens D, Orci L, Unger RH. Troglitazone prevents mitochondrial alterations, β cell destruction, and diabetes in obese prediabetic rats. Proc Natl Acad Sci U S A. 1999; 96: 11513-8.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 11513-11518
-
-
Higa, M.1
Zhou, Y.T.2
Ravazzola, M.3
Baetens, D.4
Orci, L.5
Unger, R.H.6
-
32
-
-
12144271041
-
Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: Prevention of diabetes and ectopic lipid deposition
-
Yu X, McCorkle S, Wang M, Lee Y, Li J, Saha AK, et al. Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. Diabetologia. 2004; 47: 2012-21.
-
(2004)
Diabetologia
, vol.47
, pp. 2012-2021
-
-
Yu, X.1
McCorkle, S.2
Wang, M.3
Lee, Y.4
Li, J.5
Saha, A.K.6
-
33
-
-
0036318319
-
Lipotoxicity in human pancreatic islets and the protective effect of metformin
-
Lupi R, Del Guerra S, Fierabracci V, Marselli L, Novelli M, Patane G, et al. Lipotoxicity in human pancreatic islets and the protective effect of metformin. Diabetes. 2002; 51 (Suppl 1): S134-7.
-
(2002)
Diabetes
, vol.51
, pp. S134-S137
-
-
Lupi, R.1
Del Guerra, S.2
Fierabracci, V.3
Marselli, L.4
Novelli, M.5
Patane, G.6
-
34
-
-
84855765351
-
Metformin prevents endoplasmic reticulum stress-induced apoptosis through AMPK-PI3K-c-Jun NH2 pathway
-
Jung TW, Lee MW, Lee YJ, Kim SM. Metformin prevents endoplasmic reticulum stress-induced apoptosis through AMPK-PI3K-c-Jun NH2 pathway. Biochem Biophys Res Commun. 2012; 417: 147-52.
-
(2012)
Biochem Biophys Res Commun
, vol.417
, pp. 147-152
-
-
Jung, T.W.1
Lee, M.W.2
Lee, Y.J.3
Kim, S.M.4
|