-
1
-
-
0034663085
-
Stimulation of AMP-activated protein kinase (AMPK) is associated with enhancement of Glut1-mediated glucose transport
-
Abbud W., et al. Stimulation of AMP-activated protein kinase (AMPK) is associated with enhancement of Glut1-mediated glucose transport. Arch. Biochem. Biophys. 2000, 380(2):347-352.
-
(2000)
Arch. Biochem. Biophys.
, vol.380
, Issue.2
, pp. 347-352
-
-
Abbud, W.1
-
2
-
-
0028700877
-
Insulinotropic action of AICA riboside. I. Insulin release by isolated islets and the perfused pancreas
-
Akkan A.G., Malaisse W.J. Insulinotropic action of AICA riboside. I. Insulin release by isolated islets and the perfused pancreas. Diabetes Res. 1994, 25(1):13-23.
-
(1994)
Diabetes Res.
, vol.25
, Issue.1
, pp. 13-23
-
-
Akkan, A.G.1
Malaisse, W.J.2
-
3
-
-
1542777034
-
Complete polarization of single intestinal epithelial cells upon activation of Lkb1 by STRAD
-
Baas A.F., et al. Complete polarization of single intestinal epithelial cells upon activation of Lkb1 by STRAD. Cell 2004, 116(3):457-466.
-
(2004)
Cell
, vol.116
, Issue.3
, pp. 457-466
-
-
Baas, A.F.1
-
4
-
-
34247511497
-
Lkb1 and SAD kinases define a pathway required for the polarization of cortical neurons
-
Barnes A.P., et al. Lkb1 and SAD kinases define a pathway required for the polarization of cortical neurons. Cell 2007, 129(3):549-563.
-
(2007)
Cell
, vol.129
, Issue.3
, pp. 549-563
-
-
Barnes, A.P.1
-
5
-
-
0036320801
-
Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation and AICAR, an activator of AMP-activated protein kinase
-
Barthel A., et al. Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation and AICAR, an activator of AMP-activated protein kinase. Endocrinology 2002, 143(8):3183-3186.
-
(2002)
Endocrinology
, vol.143
, Issue.8
, pp. 3183-3186
-
-
Barthel, A.1
-
6
-
-
77954737056
-
Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia
-
Beall C., et al. Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia. Biochem. J. 2010, 429(2):323-333.
-
(2010)
Biochem. J.
, vol.429
, Issue.2
, pp. 323-333
-
-
Beall, C.1
-
7
-
-
33751549094
-
Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation
-
Cai Y., et al. Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation. Free Radic. Biol. Med. 2007, 42(1):64-78.
-
(2007)
Free Radic. Biol. Med.
, vol.42
, Issue.1
, pp. 64-78
-
-
Cai, Y.1
-
8
-
-
34547651092
-
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
-
Claret M., et al. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J. Clin. Invest. 2007, 117(8):2325-2336.
-
(2007)
J. Clin. Invest.
, vol.117
, Issue.8
, pp. 2325-2336
-
-
Claret, M.1
-
9
-
-
0034636006
-
Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression
-
da Silva Xavier G., et al. Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression. Proc. Nat. Acad. Sci. USA 2000, 97(8):4023-4028.
-
(2000)
Proc. Nat. Acad. Sci. USA
, vol.97
, Issue.8
, pp. 4023-4028
-
-
da Silva Xavier, G.1
-
10
-
-
0038584871
-
Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression
-
da Silva Xavier G., et al. Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem. J. 2003, 371(3):761-774.
-
(2003)
Biochem. J.
, vol.371
, Issue.3
, pp. 761-774
-
-
da Silva Xavier, G.1
-
11
-
-
79960773090
-
Preservation of beta-cell function: the key to diabetes prevention
-
DeFronzo R.A., Abdul-Ghani M.A. Preservation of beta-cell function: the key to diabetes prevention. J. Clin. Endocrinol. Metab. 2011, 96(8):2354-2366.
-
(2011)
J. Clin. Endocrinol. Metab.
, vol.96
, Issue.8
, pp. 2354-2366
-
-
DeFronzo, R.A.1
Abdul-Ghani, M.A.2
-
12
-
-
0036537357
-
Obligatory role of membrane events in the regulatory effect of metformin on the respiratory chain function
-
Detaille D., et al. Obligatory role of membrane events in the regulatory effect of metformin on the respiratory chain function. Biochem. Pharmacol. 2002, 63(7):1259-1272.
-
(2002)
Biochem. Pharmacol.
, vol.63
, Issue.7
, pp. 1259-1272
-
-
Detaille, D.1
-
13
-
-
1642546212
-
Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)
-
Diraison F., et al. Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR). Biochem. J. 2004, 378(Pt 3):769-778.
-
(2004)
Biochem. J.
, vol.378
, Issue.PART 3
, pp. 769-778
-
-
Diraison, F.1
-
14
-
-
0034614420
-
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
-
El-Mir M.Y., et al. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J. Biol. Chem. 2000, 275(1):223-228.
-
(2000)
J. Biol. Chem.
, vol.275
, Issue.1
, pp. 223-228
-
-
El-Mir, M.Y.1
-
15
-
-
70349484214
-
Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice
-
Fu A., et al. Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice. Cell Metab. 2009, 10(4):285-295.
-
(2009)
Cell Metab.
, vol.10
, Issue.4
, pp. 285-295
-
-
Fu, A.1
-
16
-
-
74149083791
-
AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators
-
Garcia-Garcia C., et al. AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators. Biochem. Pharmacol. 2010, 79(6):853-863.
-
(2010)
Biochem. Pharmacol.
, vol.79
, Issue.6
, pp. 853-863
-
-
Garcia-Garcia, C.1
-
17
-
-
79952114408
-
The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 beta cells
-
Garcia-Haro L., et al. The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 beta cells. FASEB J. 2010, 24(12):5080-5091.
-
(2010)
FASEB J.
, vol.24
, Issue.12
, pp. 5080-5091
-
-
Garcia-Haro, L.1
-
18
-
-
34249850161
-
The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells
-
Gleason C.E., et al. The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells. J. Biol. Chem. 2007, 282(14):10341-10351.
-
(2007)
J. Biol. Chem.
, vol.282
, Issue.14
, pp. 10341-10351
-
-
Gleason, C.E.1
-
19
-
-
70349503932
-
Lkb1 regulates pancreatic beta cell size, polarity, and function
-
Granot Z., et al. Lkb1 regulates pancreatic beta cell size, polarity, and function. Cell Metab. 2009, 10(4):296-308.
-
(2009)
Cell Metab.
, vol.10
, Issue.4
, pp. 296-308
-
-
Granot, Z.1
-
20
-
-
68049108189
-
Plasma membrane depolarization as a determinant of the first phase of insulin secretion
-
Hatlapatka K., Willenborg M., Rustenbeck I. Plasma membrane depolarization as a determinant of the first phase of insulin secretion. Am. J. Physiol. Endocrinol. Metab. 2009, 297(2):E315-E322.
-
(2009)
Am. J. Physiol. Endocrinol. Metab.
, vol.297
, Issue.2
-
-
Hatlapatka, K.1
Willenborg, M.2
Rustenbeck, I.3
-
21
-
-
0029910018
-
Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase
-
Hawley S.A., et al. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J. Biol. Chem. 1996, 271(44):27879-27887.
-
(1996)
J. Biol. Chem.
, vol.271
, Issue.44
, pp. 27879-27887
-
-
Hawley, S.A.1
-
22
-
-
0345107247
-
Complexes between the Lkb1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
-
Hawley S.A., et al. Complexes between the Lkb1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2003, 2(4):28.
-
(2003)
J. Biol.
, vol.2
, Issue.4
, pp. 28
-
-
Hawley, S.A.1
-
23
-
-
23044432463
-
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase
-
Hawley S.A., et al. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2005, 2(1):9-19.
-
(2005)
Cell Metab.
, vol.2
, Issue.1
, pp. 9-19
-
-
Hawley, S.A.1
-
24
-
-
34247185346
-
Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer
-
Hinke S.A., et al. Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer. Br. J. Pharmacol. 2007, 150(8):1031-1043.
-
(2007)
Br. J. Pharmacol.
, vol.150
, Issue.8
, pp. 1031-1043
-
-
Hinke, S.A.1
-
25
-
-
34248357199
-
Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo
-
Hurov J.B., et al. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc. Natl. Acad. Sci. USA 2007, 104(13):5680-5685.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, Issue.13
, pp. 5680-5685
-
-
Hurov, J.B.1
-
26
-
-
33748153690
-
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
-
Inoki K., et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 2006, 126(5):955-968.
-
(2006)
Cell
, vol.126
, Issue.5
, pp. 955-968
-
-
Inoki, K.1
-
27
-
-
48249109104
-
Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2
-
Jansson D., et al. Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2. Proc. Natl. Acad. Sci. USA 2008, 105(29):10161-10166.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, Issue.29
, pp. 10161-10166
-
-
Jansson, D.1
-
28
-
-
0345832116
-
Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle
-
Jorgensen S.B., et al. Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle. J. Biol. Chem. 2004, 279(2):1070-1079.
-
(2004)
J. Biol. Chem.
, vol.279
, Issue.2
, pp. 1070-1079
-
-
Jorgensen, S.B.1
-
29
-
-
20844451123
-
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
-
Kahn B.B., et al. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 2005, 1(1):15-25.
-
(2005)
Cell Metab.
, vol.1
, Issue.1
, pp. 15-25
-
-
Kahn, B.B.1
-
30
-
-
0037301056
-
AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase
-
Kefas B.A., et al. AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase. Diabetologia 2003, 46(2):250-254.
-
(2003)
Diabetologia
, vol.46
, Issue.2
, pp. 250-254
-
-
Kefas, B.A.1
-
31
-
-
0038363852
-
AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase
-
Kefas B.A., et al. AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase. J. Mol. Endocrinol. 2003, 30(2):151-161.
-
(2003)
J. Mol. Endocrinol.
, vol.30
, Issue.2
, pp. 151-161
-
-
Kefas, B.A.1
-
32
-
-
33847009048
-
AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis
-
Kim W.H., et al. AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis. Cell. Signal. 2007, 19(4):791-805.
-
(2007)
Cell. Signal.
, vol.19
, Issue.4
, pp. 791-805
-
-
Kim, W.H.1
-
33
-
-
0032765396
-
5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle
-
Kurth-Kraczek E.J., et al. 5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle. Diabetes 1999, 48(8):1667-1671.
-
(1999)
Diabetes
, vol.48
, Issue.8
, pp. 1667-1671
-
-
Kurth-Kraczek, E.J.1
-
34
-
-
67651154419
-
Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations
-
Lamontagne J., et al. Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations. Endocrinology 2009, 150(8):3465-3474.
-
(2009)
Endocrinology
, vol.150
, Issue.8
, pp. 3465-3474
-
-
Lamontagne, J.1
-
35
-
-
33745869049
-
Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues
-
LeBrasseur N.K., et al. Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues. Am. J. Physiol. Endocrinol. Metab. 2006, 291(1):E175-E181.
-
(2006)
Am. J. Physiol. Endocrinol. Metab.
, vol.291
, Issue.1
-
-
LeBrasseur, N.K.1
-
36
-
-
9444249257
-
AMP-activated protein kinase: a new beta-cell glucose sensor? Regulation by amino acids and calcium ions
-
Leclerc I., Rutter G.A. AMP-activated protein kinase: a new beta-cell glucose sensor? Regulation by amino acids and calcium ions. Diabetes 2004, 53(Suppl 3):S67-S74.
-
(2004)
Diabetes
, vol.53
, Issue.SUPPL. 3
-
-
Leclerc, I.1
Rutter, G.A.2
-
37
-
-
0035406121
-
Hepatocyte nuclear factor-4alpha involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase
-
Leclerc I., et al. Hepatocyte nuclear factor-4alpha involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase. Diabetes 2001, 50(7):1515-1521.
-
(2001)
Diabetes
, vol.50
, Issue.7
, pp. 1515-1521
-
-
Leclerc, I.1
-
38
-
-
2442691889
-
Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion
-
Leclerc I., et al. Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion. Am. J. Physiol. Endocrinol. Metab. 2004, 286(6):E1023-E1031.
-
(2004)
Am. J. Physiol. Endocrinol. Metab.
, vol.286
, Issue.6
-
-
Leclerc, I.1
-
39
-
-
34250827107
-
Energy-dependent regulation of cell structure by AMP-activated protein kinase
-
Lee J.H., et al. Energy-dependent regulation of cell structure by AMP-activated protein kinase. Nature 2007, 447(7147):1017-1020.
-
(2007)
Nature
, vol.447
, Issue.7147
, pp. 1017-1020
-
-
Lee, J.H.1
-
40
-
-
20444399500
-
Regulation of SNARK activity in response to cellular stresses
-
Lefebvre D.L., Rosen C.F. Regulation of SNARK activity in response to cellular stresses. Biochim. Biophys. Acta 2005, 1724(1-2):71-85.
-
(2005)
Biochim. Biophys. Acta
, vol.1724
, Issue.1-2
, pp. 71-85
-
-
Lefebvre, D.L.1
Rosen, C.F.2
-
41
-
-
77957850112
-
Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis
-
Lennerz J.K., et al. Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis. Mol. Cell. Biol. 2010, 30(21):5043-5056.
-
(2010)
Mol. Cell. Biol.
, vol.30
, Issue.21
, pp. 5043-5056
-
-
Lennerz, J.K.1
-
42
-
-
79953755370
-
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
-
Li Y., et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 2011, 13(4):376-388.
-
(2011)
Cell Metab.
, vol.13
, Issue.4
, pp. 376-388
-
-
Li, Y.1
-
43
-
-
73249149131
-
Glucose deprivation regulates KATP channel trafficking via AMP-activated protein kinase in pancreatic beta-cells
-
Lim A., et al. Glucose deprivation regulates KATP channel trafficking via AMP-activated protein kinase in pancreatic beta-cells. Diabetes 2009, 58(12):2813-2819.
-
(2009)
Diabetes
, vol.58
, Issue.12
, pp. 2813-2819
-
-
Lim, A.1
-
44
-
-
12144287284
-
Lkb1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
-
Lizcano J.M., et al. Lkb1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J. 2004, 23(4):833-843.
-
(2004)
EMBO J.
, vol.23
, Issue.4
, pp. 833-843
-
-
Lizcano, J.M.1
-
45
-
-
30544441347
-
Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells
-
MacDonald P.E., Eliasson L., Rorsman P. Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells. J. Cell Sci. 2005, 118(Pt 24):5911-5920.
-
(2005)
J. Cell Sci.
, vol.118
, Issue.PART 24
, pp. 5911-5920
-
-
MacDonald, P.E.1
Eliasson, L.2
Rorsman, P.3
-
46
-
-
14644419552
-
Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells
-
MacDonald P.E., et al. Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells. Diabetes 2005, 54(3):736-743.
-
(2005)
Diabetes
, vol.54
, Issue.3
, pp. 736-743
-
-
MacDonald, P.E.1
-
47
-
-
0028685850
-
Insulinotropic action of AICA riboside. II. Secretory, metabolic and cationic aspects
-
Malaisse W.J., et al. Insulinotropic action of AICA riboside. II. Secretory, metabolic and cationic aspects. Diabetes Res 1994, 25(1):25-37.
-
(1994)
Diabetes Res
, vol.25
, Issue.1
, pp. 25-37
-
-
Malaisse, W.J.1
-
48
-
-
33748747706
-
Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro
-
Momcilovic M., Hong S.P., Carlson M. Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro. J. Biol. Chem. 2006, 281(35):25336-25343.
-
(2006)
J. Biol. Chem.
, vol.281
, Issue.35
, pp. 25336-25343
-
-
Momcilovic, M.1
Hong, S.P.2
Carlson, M.3
-
49
-
-
55749090598
-
AMP-activated protein kinase agonist dose dependently improves function and reduces apoptosis in glucotoxic beta-cells without changing triglyceride levels
-
Nyblom H.K., Sargsyan E., Bergsten P. AMP-activated protein kinase agonist dose dependently improves function and reduces apoptosis in glucotoxic beta-cells without changing triglyceride levels. J. Mol. Endocrinol. 2008, 41(3):187-194.
-
(2008)
J. Mol. Endocrinol.
, vol.41
, Issue.3
, pp. 187-194
-
-
Nyblom, H.K.1
Sargsyan, E.2
Bergsten, P.3
-
50
-
-
79959338922
-
AMPK is a direct adenylate charge-regulated protein kinase
-
Oakhill J.S., et al. AMPK is a direct adenylate charge-regulated protein kinase. Science 2011, 332(6036):1433-1435.
-
(2011)
Science
, vol.332
, Issue.6036
, pp. 1433-1435
-
-
Oakhill, J.S.1
-
51
-
-
20144386698
-
Long-term AICAR administration and exercise prevents diabetes in ZDF rats
-
Pold R., et al. Long-term AICAR administration and exercise prevents diabetes in ZDF rats. Diabetes 2005, 54(4):928-934.
-
(2005)
Diabetes
, vol.54
, Issue.4
, pp. 928-934
-
-
Pold, R.1
-
52
-
-
48249146208
-
Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner
-
Rachdi L., et al. Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner. Proc. Natl. Acad. Sci. USA 2008, 105(27):9250-9255.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, Issue.27
, pp. 9250-9255
-
-
Rachdi, L.1
-
53
-
-
28044464932
-
Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo
-
Richards S.K., et al. Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo. J. Endocrinol. 2005, 187(2):225-235.
-
(2005)
J. Endocrinol.
, vol.187
, Issue.2
, pp. 225-235
-
-
Richards, S.K.1
-
54
-
-
47249099357
-
Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism
-
Ronnebaum S.M., et al. Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism. J. Biol. Chem. 2008, 283(21):14248-14256.
-
(2008)
J. Biol. Chem.
, vol.283
, Issue.21
, pp. 14248-14256
-
-
Ronnebaum, S.M.1
-
55
-
-
0032946302
-
Malonyl-CoA, fuel sensing, and insulin resistance
-
Ruderman N.B., et al. Malonyl-CoA, fuel sensing, and insulin resistance. Am. J. Physiol. 1999, 276(1 Pt 1):E1-E18.
-
(1999)
Am. J. Physiol.
, vol.276
, Issue.1 PART 1
-
-
Ruderman, N.B.1
-
56
-
-
0141905919
-
Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis
-
Rutter G.A., Da Silva Xavier G., Leclerc I. Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochem. J. 2003, 375(Pt 1):1-16.
-
(2003)
Biochem. J.
, vol.375
, Issue.PART 1
, pp. 1-16
-
-
Rutter, G.A.1
Da Silva Xavier, G.2
Leclerc, I.3
-
57
-
-
0032529139
-
AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform
-
Salt I., et al. AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. Biochem. J. 1998, 334(Pt 1):177-187.
-
(1998)
Biochem. J.
, vol.334
, Issue.PART 1
, pp. 177-187
-
-
Salt, I.1
-
58
-
-
0032213768
-
AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release
-
Salt I.P., et al. AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release. Biochem. J. 1998, 335(Pt 3):533-539.
-
(1998)
Biochem. J.
, vol.335
, Issue.PART 3
, pp. 533-539
-
-
Salt, I.P.1
-
59
-
-
77958198168
-
AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells
-
Santidrian A.F., et al. AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells. Blood 2010, 116(16):3023-3032.
-
(2010)
Blood
, vol.116
, Issue.16
, pp. 3023-3032
-
-
Santidrian, A.F.1
-
60
-
-
78650961108
-
SIK2 is a key regulator for neuronal survival after ischemia via TORC1-CREB
-
Sasaki T., et al. SIK2 is a key regulator for neuronal survival after ischemia via TORC1-CREB. Neuron 2011, 69(1):106-119.
-
(2011)
Neuron
, vol.69
, Issue.1
, pp. 106-119
-
-
Sasaki, T.1
-
61
-
-
28844433635
-
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
-
Shaw R.J., et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 2005, 310(5754):1642-1646.
-
(2005)
Science
, vol.310
, Issue.5754
, pp. 1642-1646
-
-
Shaw, R.J.1
-
62
-
-
42349086872
-
Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice
-
Shigeyama Y., et al. Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice. Mol. Cell. Biol. 2008, 28(9):2971-2979.
-
(2008)
Mol. Cell. Biol.
, vol.28
, Issue.9
, pp. 2971-2979
-
-
Shigeyama, Y.1
-
63
-
-
0036165489
-
5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice
-
Song X.M., et al. 5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice. Diabetologia 2002, 45(1):56-65.
-
(2002)
Diabetologia
, vol.45
, Issue.1
, pp. 56-65
-
-
Song, X.M.1
-
64
-
-
77952587385
-
Lkb1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo
-
Sun G., et al. Lkb1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo. Am. J. Physiol. Endocrinol. Metab. 2010, 298(6):E1261-E1273.
-
(2010)
Am. J. Physiol. Endocrinol. Metab.
, vol.298
, Issue.6
-
-
Sun, G.1
-
65
-
-
77952095690
-
Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo
-
Sun G., et al. Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo. Diabetologia 2010, 53(5):924-936.
-
(2010)
Diabetologia
, vol.53
, Issue.5
, pp. 924-936
-
-
Sun, G.1
-
66
-
-
33744933422
-
Alpha-lipoic acid regulates AMP-activated protein kinase and inhibits insulin secretion from beta cells
-
Targonsky E.D., et al. Alpha-lipoic acid regulates AMP-activated protein kinase and inhibits insulin secretion from beta cells. Diabetologia 2006, 49(7):1587-1598.
-
(2006)
Diabetologia
, vol.49
, Issue.7
, pp. 1587-1598
-
-
Targonsky, E.D.1
-
67
-
-
0346732321
-
5'-AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics
-
Tsuboi T., et al. 5'-AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics. J. Biol. Chem. 2003, 278(52):52042-52051.
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.52
, pp. 52042-52051
-
-
Tsuboi, T.1
-
68
-
-
0345171412
-
Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc
-
Van de Casteele M., et al. Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc. Biochem. Biophys. Res. Commun. 2003, 312(4):937-944.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.312
, Issue.4
, pp. 937-944
-
-
Van de Casteele, M.1
-
69
-
-
0026063181
-
Inhibition by AICA riboside of gluconeogenesis in isolated rat hepatocytes
-
Vincent M.F., et al. Inhibition by AICA riboside of gluconeogenesis in isolated rat hepatocytes. Diabetes 1991, 40(10):1259-1266.
-
(1991)
Diabetes
, vol.40
, Issue.10
, pp. 1259-1266
-
-
Vincent, M.F.1
-
70
-
-
0037326307
-
Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models
-
Viollet B., et al. Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models. Biochem. Soc. Trans. 2003, 31(Pt 1):216-219.
-
(2003)
Biochem. Soc. Trans.
, vol.31
, Issue.PART 1
, pp. 216-219
-
-
Viollet, B.1
-
71
-
-
17044377065
-
5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways
-
Wang C.Z., et al. 5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways. Biochem. Biophys. Res. Commun. 2005, 330(4):1073-1079.
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.330
, Issue.4
, pp. 1073-1079
-
-
Wang, C.Z.1
-
72
-
-
34250665869
-
Troglitazone acutely activates AMP-activated protein kinase and inhibits insulin secretion from beta cells
-
Wang X., et al. Troglitazone acutely activates AMP-activated protein kinase and inhibits insulin secretion from beta cells. Life Sci. 2007, 81(2):160-165.
-
(2007)
Life Sci.
, vol.81
, Issue.2
, pp. 160-165
-
-
Wang, X.1
-
73
-
-
0034090975
-
The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry
-
Watts J.L., et al. The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. Development 2000, 127(7):1467-1475.
-
(2000)
Development
, vol.127
, Issue.7
, pp. 1467-1475
-
-
Watts, J.L.1
-
74
-
-
78049446505
-
Conditional gene targeting in mouse pancreatic ss-Cells: analysis of ectopic Cre transgene expression in the brain
-
Wicksteed B., et al. Conditional gene targeting in mouse pancreatic ss-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes 2010, 59(12):3090-3098.
-
(2010)
Diabetes
, vol.59
, Issue.12
, pp. 3090-3098
-
-
Wicksteed, B.1
-
75
-
-
44949196953
-
Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell
-
Wiederkehr A., Wollheim C.B. Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell. Cell Calcium 2008, 44(1):64-76.
-
(2008)
Cell Calcium
, vol.44
, Issue.1
, pp. 64-76
-
-
Wiederkehr, A.1
Wollheim, C.B.2
-
76
-
-
10744230065
-
Lkb1 is the upstream kinase in the AMP-activated protein kinase cascade
-
Woods A., et al. Lkb1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr. Biol. 2003, 13(22):2004-2008.
-
(2003)
Curr. Biol.
, vol.13
, Issue.22
, pp. 2004-2008
-
-
Woods, A.1
-
77
-
-
23044437445
-
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells
-
Woods A., et al. Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab. 2005, 2(1):21-33.
-
(2005)
Cell Metab.
, vol.2
, Issue.1
, pp. 21-33
-
-
Woods, A.1
-
78
-
-
79954517977
-
Structure of mammalian AMPK and its regulation by ADP
-
Xiao B., et al. Structure of mammalian AMPK and its regulation by ADP. Nature 2011, 472(7342):230-233.
-
(2011)
Nature
, vol.472
, Issue.7342
, pp. 230-233
-
-
Xiao, B.1
-
79
-
-
33745204479
-
AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues
-
Xue B., Kahn B.B. AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J. Physiol. 2006, 574(Pt 1):73-83.
-
(2006)
J. Physiol.
, vol.574
, Issue.PART 1
, pp. 73-83
-
-
Xue, B.1
Kahn, B.B.2
-
80
-
-
0029081369
-
Glucose activation of acetyl-CoA carboxylase in association with insulin secretion in a pancreatic beta-cell line
-
Zhang S., Kim K.H. Glucose activation of acetyl-CoA carboxylase in association with insulin secretion in a pancreatic beta-cell line. J. Endocrinol. 1995, 147(1):33-41.
-
(1995)
J. Endocrinol.
, vol.147
, Issue.1
, pp. 33-41
-
-
Zhang, S.1
Kim, K.H.2
-
81
-
-
65349177200
-
AMPK: an emerging drug target for diabetes and the metabolic syndrome
-
Zhang B.B., Zhou G., Li C. AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab. 2009, 9(5):407-416.
-
(2009)
Cell Metab.
, vol.9
, Issue.5
, pp. 407-416
-
-
Zhang, B.B.1
Zhou, G.2
Li, C.3
-
82
-
-
65249085779
-
AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cells
-
Zhang X., et al. AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cells. J. Cell Mol. Med. 2009, 13(4):758-770.
-
(2009)
J. Cell Mol. Med.
, vol.13
, Issue.4
, pp. 758-770
-
-
Zhang, X.1
-
83
-
-
50449090523
-
Berberine acutely inhibits insulin secretion from beta-cells through 3',5'-cyclic adenosine 5'-monophosphate signaling pathway
-
Zhou L., et al. Berberine acutely inhibits insulin secretion from beta-cells through 3',5'-cyclic adenosine 5'-monophosphate signaling pathway. Endocrinology 2008, 149(9):4510-4518.
-
(2008)
Endocrinology
, vol.149
, Issue.9
, pp. 4510-4518
-
-
Zhou, L.1
|