How obesity causes diabetes in Zucker diabetic fatty rats

Trends in Endocrinology and Metabolism

Volumn 8, Issue 7, 1997, Pages 276-282

  Unger, Roger H ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGUANIDINE; LONG CHAIN FATTY ACID; NICOTINAMIDE; TROGLITAZONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; BODY WEIGHT; CELL FUNCTION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ESTERIFICATION; EXPERIMENTAL DIABETES MELLITUS; GENE MUTATION; HYPERGLYCEMIA; INSULIN RESISTANCE; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; REVIEW;

EID: 0031239663     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(97)00094-5     Document Type: Review

References (32)

1. Capito K, Hansen SE, Hedeskov CJ, Islin H, Thams P: 1992. Fat-induced changes in mouse pancreatic islet insulin secretion, insulin biosynthesis and glucose metabolism. Acta Diabetol 28:103-108.
2. Caro JF, Sinha MK, Kolecznoki JW et al.: 1996, Leptin: the tale of an obesity gene. Diabetes 45:1455-1462.
3. DeFronzo RA: 1988. The triumvirate β-cell, muscle, liver: a collusion responsible for NIDDM. Diabetes 37:667-687.
4. Elks ML: 1993. Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release. Endocrinology 133:208-214.
5. Ferrannini E, Barrett EJ, Bovilacqua S, DeFronzo RA: 1983. Effect of fatty acids on glucose production and utilization in man. J Clin Invest 72:1737-1747.
6. Greenough WB, Crespin SR, Steinberg D: 1967. Hypoglycemia and hyperinsulinemia in response to raised free fatty acid levels. Lancet 2:1334-1336.
7. Groop LC, Salominia C, Shank M, Bonadonna RC, Ferrannini E, DeFronzo RA: 1991. The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 72:96-107.
8. Hirose H, Lee Y, Inman LR, Nagasawa Y, Johnson JH, Unger RH: 1996. Defective fatty acid-mediated β-cell compensation in Zucker diabetic fatty rats. J Biol Chem 271:5633-5637.
9. Iida M, Murakami T, Ishida K, Mizuno A, Kuwajima, Shima K: 1996. Substitution at Codon 269 (glutamine→proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat. Biochem Biophys Res Commun 224:597-604.
10. Kieffer T, Heller RS, Habener JF: 1996. Leptin receptors expressed on pancreatic β-cells. Biochem Biophys Res Commun 224:522-527.
11. Koyama K, Chen G, Wang M-Y, et al.: 1997a. β-Cell function in normal rats made hyperleptinemic by adenovirus-gene therapy. Diabetes (in press).
12. Koyama K, Chen G, Lee Y, et al.: 1997b. Relationships between tissue triglyceride content, insulin resistance and insulin secretion. Am J Physiol (in press).
13. Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH: 1994. β-Cell lipotoxicity in the pathogenesis of non-insulin dependent diabetes mellitus of obese rats: impairment in adipocyte β-cell relationships. Proc Natl Acad Sci USA 91:10,878-10,882.
14. Lee Y, Hirose H, Zhou Y-T, Easer V, McGarry JD, Unger RH: 1997. Increased lipogenic capacity of the islets of obese rats. Diabetes 46:408-413.
15. Madison LL, Scyffert WA, Unger RH, Barker B: 1968. Effect of plasma free fatty acids on plasma glucagon and serum insulin concentrations. Metabolism 17:301-304.
16. McDaniel ML, Kodon G, Hill JR, Marshall JA, Corbett JA: 1996. Cytokines and nitric oxide in islet inflammation and diabetes. Proc Soc Exp Biol Med 211:24-32.
17. McGarry JD: 1992. What if Minkowski had been ageusic? An alternative angle on diabetes. Science 258:766-774.
18. McGarry JD: 1994. Disordered metabolism in diabetes: have we underemphasized the fat cell component? J Cell Biochem 565:29-38.
19. Milburn JL, Hirose H, Lee YH, et al.: 1995. Pancreatic β-cells in obesity: evidence for induction of functional, morphologic and metabolic abnormalities by increased long-chain fatty acids. J Biol Chem 270:1295-1299.
20. National Center for Health Statistics: 1994. Cited in "An epidemic of obesity." Newsweek 1 Aug, p 62.
21. Ohneda M, Inman LR, Unger RH: 1995. Caloric restriction in obese prediabetic rats prevents β-cell depletion. Diabetologia 38:173-179.
22. Paolisso G, Tacunni FA, Foley JE, Bogardus C, Howard BV, Ravussin E: 1995. A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM. Diabetologia 38:1213-1217.
23. Peterson RG, Shaw WN, Neel M, Little LA, Eichberg J: 1990. Zucker diabetic fatty rat as a model for non-insulin-dependent diabetes mellitus. ILAR News 32:16-19.
24. Phillips MS, Liu A, Hammond HA, et al.: 1996. Leptin receptor missence mutation in the fatty Zucker rat. Nat Genet 13:18-19.
25. Randle PJ, Garland PF, Hales CN: 1963. The glucose fatty-acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1:785-789.
26. Reaven GM: 1995. The fourth musketeer: from Alexandre Dumas to Claude Bernard. Diabetologia 38:8-13.
27. Sako Y, Grill VE: 1990. A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and β-cell oxidation through a process likely coupled to fatty acid oxidation. Endocrinology 127:1580-1589.
28. Shimabukuro M, Koyama K, Chen G, et al.: 1997a. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA (in press).
29. Shimabukuro M, Ohneda M, Lee YH, Unger RH: 1997b. Role of nitric oxide in obesity-induced β-cell disease. J Clin Invest (in press).
30. Unger RH: 1995. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 44:863-870.
31. Weber G, Ilar Convery HJ, Lea MA, Stamm NB: 1966. Feedback inhibition of key glycolytic enzymes in liver: action of free fatty acids. Science 154:1357-1360.
32. Zierler KL: 1976. Fatty acids as substrates for heart and skeletal muscle. Circ Res 39:459-463.