Acute viral respiratory infection rapidly induces a CD8+ T cell exhaustion-like phenotype

Journal of Immunology

Volumn 195, Issue 9, 2015, Pages 4319-4330

  Erickson, John J ^a   Lu, Pengcheng ^b   Wen, Sherry ^a   Hastings, Andrew K ^a   Gilchuk, Pavlo ^a   Joyce, Sebastian ^a,c   Shyr, Yu ^b   Williams, John V ^a,d  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2B4; EPITOPE; GAMMA INTERFERON; MEMBRANE PROTEIN; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN LAG 3; PROTEIN TIM 3; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; PDCD1 PROTEIN, MOUSE; TRANSCRIPTOME;

2B4 GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CELL MATURATION; CELL MIGRATION; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE COURSE; DOWN REGULATION; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN METAPNEUMOVIRUS INFECTION; IMMUNOPHENOTYPING; INFECTION; INTRACELLULAR SIGNALING; LAG 3 GENE; LEUKOCYTE FUNCTION AND CHARACTERISTICS; LOWER RESPIRATORY TRACT INFECTION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTIC CHORIOMENINGITIS; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SPLEEN CELL; T CELL EXHAUSTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TIM 3 GENE; UPREGULATION; VIRAL RESPIRATORY TRACT INFECTION; WILD TYPE; ACUTE DISEASE; ANIMAL; C57BL MOUSE; CLUSTER ANALYSIS; CONGENIC STRAIN; DNA MICROARRAY; GENETICS; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; LUNG; METABOLISM; METAPNEUMOVIRUS; PARAMYXOVIRUS INFECTION; PHENOTYPE; PHYSIOLOGY; PROCEDURES; RESPIRATORY TRACT INFECTION; SPLEEN; VIROLOGY;

ACUTE DISEASE; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CLUSTER ANALYSIS; GENE EXPRESSION PROFILING; HOST-PATHOGEN INTERACTIONS; HUMANS; LUNG; METAPNEUMOVIRUS; MICE, CONGENIC; MICE, INBRED C57BL; MICE, KNOCKOUT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PARAMYXOVIRIDAE INFECTIONS; PHENOTYPE; PROGRAMMED CELL DEATH 1 RECEPTOR; RESPIRATORY TRACT INFECTIONS; SPLEEN; TRANSCRIPTOME;

EID: 84945156924     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1403004     Document Type: Article

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