Tight Regulation of Memory CD8+ T Cells Limits Their Effectiveness during Sustained High Viral Load

Immunity

Volumn 35, Issue 2, 2011, Pages 285-298

  West, Erin E ^a   Youngblood, Ben ^a   Tan, Wendy G ^a   Jin, Hyun Tak ^a   Araki, Koichi ^a   Alexe, Gabriela ^b,c   Konieczny, Bogumila T ^a   Calpe, Silvia ^d   Freeman, Gordon J ^b,d   Terhorst, Cox ^d   Haining, W Nicholas ^b,e   Ahmed, Rafi ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD8+ T LYMPHOCYTE; CHRONIC DISEASE; CONTROLLED STUDY; FEMALE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA VIRUS INFECTION; VIRUS LOAD;

ACUTE DISEASE; ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD; ARENAVIRIDAE INFECTIONS; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; CHRONIC DISEASE; CYTOKINES; IMMUNOLOGIC MEMORY; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PARACRINE COMMUNICATION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, IMMUNOLOGIC; T-LYMPHOCYTE SUBSETS; VIRAL LOAD; VIRAL VACCINES;

EID: 80051882327     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2011.05.017     Document Type: Article

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