T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 47, 2011, Pages 19001-19006

  Sharma, Shalini ^a   Sundararajan, Aarthi ^b   Suryawanshi, Amol ^a   Kumar, Naveen ^c   Veiga Parga, Tamara ^a   Kuchroo, Vijay K ^d   Thomas, Paul G ^e   Sangster, Mark Y ^b   Rouse, Barry T ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ECALECTIN; HYBRID PROTEIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; T CELL IMMUNOGLOBULIN AND MUCIN PROTEIN 3; UNCLASSIFIED DRUG;

ACUTE PHASE RESPONSE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; GENE INACTIVATION; HUMORAL IMMUNITY; IMMUNOREGULATION; INFLUENZA A; INFLUENZA VIRUS A; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; VIRAL CLEARANCE; WILD TYPE;

ACUTE-PHASE REACTION; ANALYSIS OF VARIANCE; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GALECTINS; IMMUNITY, HUMORAL; INFLUENZA A VIRUS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORTHOMYXOVIRIDAE INFECTIONS; RECEPTORS, VIRUS; SIGNAL TRANSDUCTION;

EID: 82755187758     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1107087108     Document Type: Article

References (38)

1. Rouse BT, Sehrawat S (2010) Immunity and immunopathology to viruses: What decides the outcome? Nat Rev Immunol 10:514-526.
2. Zinkernagel RM (1996) Immunology taught by viruses. Science 271:173-178.
3. Sehrawat S, et al. (2010) Galectin-9/TIM-3 interaction regulates virus-specific primary and memory CD8 T cell response. PLoS Pathog 6:e1000882.
4. Belkaid Y, Rouse BT (2005) Natural regulatory T cells in infectious disease. Nat Immunol 6:353-360. (Pubitemid 41716772)
5. Suvas S, Kumaraguru U, Pack CD, Lee S, Rouse BT (2003) CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses. J Exp Med 198:889-901. (Pubitemid 37152926)
6. Toka FN, Suvas S, Rouse BT (2004) CD4+ CD25+ T cells regulate vaccine-generated primary and memory CD8+ T-cell responses against herpes simplex virus type 1. J Virol 78:13082-13089. (Pubitemid 39507816)
7. Sun J, Madan R, Karp CL, Braciale TJ (2009) Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10. Nat Med 15:277-284.
8. Serhan CN, Krishnamoorthy S, Recchiuti A, Chiang N (2011) Novel anti-inflammatory-pro-resolving mediators and their receptors. Curr Top Med Chem 11:629-647.
9. Rabinovich GA, Toscano MA (2009) Turning 'sweet' on immunity: Galectin-glycan interactions in immune tolerance and inflammation. Nat Rev Immunol 9:338-352.
10. Kuchroo VK, Meyers JH, Umetsu DT, DeKruyff RH (2006) TIM family of genes in immunity and tolerance. Adv Immunol 91:227-249. (Pubitemid 44286997)
11. Sehrawat S, Suryawanshi A, Hirashima M, Rouse BT (2009) Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: Shifting the balance toward regulators. J Immunol 182:3191-3201.
12. Golden-Mason L, et al. (2009) Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells. J Virol 83:9122-9130.
13. Jones RB, et al. (2008) Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J Exp Med 205: 2763-2779.
14. Zhu C, et al. (2005) The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 6:1245-1252. (Pubitemid 43045636)
15. Chabot S, et al. (2002) Regulation of galectin-9 expression and release in Jurkat T cell line cells. Glycobiology 12:111-118. (Pubitemid 34428934)
16. Su EW, Bi S, Kane LP (2010) Galectin-9 regulates T helper cell function independently of Tim-3. Glycobiology 21:1258-1265.
17. Seder RA, Darrah PA, Roederer M (2008) T-cell quality in memory and protection: Implications for vaccine design. Nat Rev Immunol 8:247-258. (Pubitemid 351432801)
18. Swain SL, Dutton RW, Woodland DL (2004) T cell responses to influenza virus infection: Effector and memory cells. Viral Immunol 17:197-209. (Pubitemid 38880421)
19. Kuchroo VK, Dardalhon V, Xiao S, Anderson AC (2008) New roles for TIM family members in immune regulation. Nat Rev Immunol 8:577-580.
20. Haeryfar SM, DiPaolo RJ, Tscharke DC, Bennink JR, Yewdell JW (2005) Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities. J Immunol 174:3344-3351. (Pubitemid 40354038)
21. Sangster MY, et al. (2003) An early CD4+ T cell-dependent immunoglobulin A response to influenza infection in the absence of key cognate T-B interactions. J Exp Med 198:1011-1021. (Pubitemid 37248617)
22. Marshall D, Sealy R, Sangster M, Coleclough C (1999) TH cells primed during influenza virus infection provide help for qualitatively distinct antibody responses to subsequent immunization. J Immunol 163:4673-4682. (Pubitemid 29501227)
23. MacLeod MK, et al. (2011) Memory CD4 T cells that express CXCR5 provide accelerated help to B cells. J Immunol 186:2889-2896.
24. Rothaeusler K, Baumgarth N (2010) B-cell fate decisions following influenza virus infection. Eur J Immunol 40:366-377.
25. Dardalhon V, et al. (2010) Tim-3/galectin-9 pathway: Regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells. J Immunol 185:1383-1392.
26. Chang WL, et al. (2007) Influenza virus infection causes global respiratory tract B cell response modulation via innate immune signals. J Immunol 178:1457-1467. (Pubitemid 46154617)
27. Waffarn EE, Baumgarth N (2011) Protective B cell responses to flu-no fluke! J Immunol 186:3823-3829.
28. Joo HM, He Y, Sangster MY (2008) Broad dispersion and lung localization of virusspecific memory B cells induced by influenza pneumonia. Proc Natl Acad Sci USA 105: 3485-3490. (Pubitemid 351723579)
29. Persson CG, et al. (1998) Contribution of plasma-derived molecules to mucosal immune defence, disease and repair in the airways. Scand J Immunol 47:302-313. (Pubitemid 28206425)
30. Ulloa L, Doody J, Massagué J (1999) Inhibition of transforming growth factor-beta/ SMAD signalling by the interferon-gamma/STAT pathway. Nature 397:710-713.
31. Gajewski TF, Fitch FW (1988) Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J Immunol 140:4245-4252.
32. Cerutti A (2008) The regulation of IgA class switching. Nat Rev Immunol 8:421-434.
33. Joo HM, He Y, Sundararajan A, Huan L, Sangster MY (2010) Quantitative analysis of influenza virus-specific B cell memory generated by different routes of inactivated virus vaccination. Vaccine 28:2186-2194.
34. Nedrud JG, Liang XP, Hague N, Lamm ME (1987) Combined oral/nasal immunization protects mice from Sendai virus infection. J Immunol 139:3484-3492. (Pubitemid 18022005)
35. Kumar N, Xin ZT, Liang Y, Ly H, Liang Y (2008) NF-kappaB signaling differentially regulates influenza virus RNA synthesis. J Virol 82:9880-9889.
36. La Gruta NL, et al. (2010) Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion. J Clin Invest 120:1885-1894.
37. Townsend AR, Bastin J, Gould K, Brownlee GG (1986) Cytotoxic T lymphocytes recognize influenza haemagglutinin that lacks a signal sequence. Nature 324:575-577. (Pubitemid 17185072)
38. Kumaraguru U, Rouse BT (2000) Application of the intracellular gamma interferon assay to recalculate the potency of CD8(+) T-cell responses to herpes simplex virus. J Virol 74:5709-5711. (Pubitemid 30346606)