Saikosaponin a inhibits lipopolysaccharide-oxidative stress and inflammation in Human umbilical vein endothelial cells via preventing TLR4 translocation into lipid rafts

Free Radical Biology and Medicine

Volumn 89, Issue , 2015, Pages 777-785

  Fu, Yunhe ^a   Hu, Xiaoyu ^a   Cao, Yongguo ^a   Zhang, Zecai ^a   Zhang, Naisheng ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

ABCA1; cholesterol; lipid raft; NF B; ROS

Indexed keywords

ABC TRANSPORTER A1; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CHOLESTEROL; CYCLOOXYGENASE 2; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 8; LIVER X RECEPTOR ALPHA; REACTIVE OXYGEN METABOLITE; SAIKOSAPONIN A; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; LIPOPOLYSACCHARIDE; OLEANOLIC ACID; SAIKOSAPONIN; SAPONIN; SMALL INTERFERING RNA; TLR4 PROTEIN, HUMAN;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL STIMULATION; CELL VIABILITY; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENSITY GRADIENT CENTRIFUGATION; DIMERIZATION; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INFLAMMATION; LIPID RAFT; OLIGOMERIZATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; CELL CULTURE; CELL MEMBRANE; DRUG EFFECTS; GENETIC TRANSFECTION; METABOLISM; PROTEIN TRANSPORT;

ANTI-INFLAMMATORY AGENTS; BLOTTING, WESTERN; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; MEMBRANE MICRODOMAINS; OLEANOLIC ACID; OXIDATIVE STRESS; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SAPONINS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TRANSFECTION;

EID: 84944753877     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.10.407     Document Type: Article

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