Cox-2 inhibition attenuates cardiovascular and inflammatory aspects in monosodium glutamate-induced obese rats

Life Sciences

Volumn 87, Issue 11-12, 2010, Pages 375-381

  Cunha, N V ^a   de Abreu, S B ^a   Panis, C ^a   Grassiolli, S ^a   Guarnier, F A ^a   Cecchini, R ^a   Mazzuco, T L ^a   Pinge Filho, P ^a   Martins Pinge, M C ^a  

^a STATE UNIVERSITY OF LONDRINA   (Brazil)

Author keywords

Heart rate; Hypertension; Nitric oxide; Obesity; Oxidative stress; Prostaglandins

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 2; GLUTAMATE SODIUM; NITRIC OXIDE; PROSTAGLANDIN DERIVATIVE; CYCLOOXYGENASE 2 INHIBITOR; LIPID PEROXIDE; NITRIC ACID DERIVATIVE; PROSTAGLANDIN E2; PTGS2 PROTEIN, RAT; PYRAZOLE DERIVATIVE; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CATHETERIZATION; ARTICLE; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; ENZYME INHIBITION; EPIDIDYMIS FAT; FATTY LIVER; FEMORAL ARTERY; HYPERTENSION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIPID PEROXIDATION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; OBESITY; PROSTAGLANDIN BLOOD LEVEL; RAT; RETROPERITONEAL FAT; ADIPOSE TISSUE; ANIMAL; BLOOD; BLOOD PRESSURE; CHEMICALLY INDUCED; COMPLICATION; DRUG EFFECTS; HEART; HEART MUSCLE; HEART RATE; LIVER; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; WISTAR RAT;

ADIPOSE TISSUE; ANIMALS; BLOOD; BLOOD PRESSURE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; HEART; HEART RATE; HYPERTENSION; INFLAMMATION; LIPID PEROXIDATION; LIPID PEROXIDES; LIVER; MALE; MYOCARDIUM; NITRATES; OBESITY; PYRAZOLES; RATS; RATS, WISTAR; SODIUM GLUTAMATE; SULFONAMIDES;

RATTUS;

EID: 77956412010     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2010.07.014     Document Type: Article

References (49)

1. Balbo S.L., Mathias P.C., Bonfleur M.L., Alves H.F., Siroti F.J., Monteiro O.G., Ribeiro F.B., Souza A.C. Vagotomy reduces obesity in MSG-treated rats. Research Communications in Molecular Pathology and Pharmacology 2000, 108(5-6):291-296.
2. Bolduc C., Larose M., Lafond Adipose tissue transcriptome by serial análisis of gene expresión. Obesity Research 2004, 12:750-757.
3. Bourgoin F., Bachelard H., Badeau M., Mélançon S., Pitre M., Larivière R., Nadeau A. Endothelial and vascular dysfunctions and insulin resistance in rats fed a high-fat, high-sucrose diet. The American Journal of Physiology 2008, 295(3):H1044-H1055.
4. Choudhury K.R., Yagle K.J., Swanson P.E., Krohn K.A., Rajendran J.G. A robust automated measure of average antibody staining in immunohistochemistry images. The Journal of Histochemistry and Cytochemistry 2010, 58:95-107.
5. Da Silva A.A., do Carmo J., Dubinion J., Hall J.E. The role of the sympathetic nervous system in obesity-related hypertension. Current Hypertension Reports 2009, 11(3):206-211.
6. Dawson R., Pelleymounter M.A., Millard W.J., Liu S., Eppler B. Attenuation of leptin-mediated effects by monosodium glutamate-induced arcuate nucleus damage. The American Journal of Physiology 1997, 273(1 Pt 1):E202-E206.
7. De Abreu S.B., Lenhard A., Mehanna A., de Souza H.C., Correa F.M., Hasser E.M., Martins-Pinge M.C. Role of paraventricular nucleus in exercise training-induced autonomic modulation in conscious rats. Autonomic Neuroscience 2009, 148(1-2):28-35.
8. De Carvalho Papa P., Vargas A.M., Da Silva J.L., Nunes M.T., Machado U.F. GLUT4 protein is differently modulated during development of obesity in monosodium glutamate-treated mice. Life Sciences 2002, 71(16):1917-1928.
9. Dolnikoff M., Martin-Hidalgo A., Machado U.F., Lima F.B., Herrera E. Decreased lipolysis and enhanced glycerol and glucose utilization by adipose tissue prior to development of obesity in monosodium glutamate (MSG) treated-rats. International Journal of Obesity Related Metabolism Disorders 2001, 25(3):426-433.
10. Ericsson A., Arias C., Sawchenko P.E. Evidence for an intramedullary prostaglandin-dependent mechanism in the activation of stress-related neuroendocrine circuitry by intravenous interleukin-1. The Journal of Neuroscience 1997, 17:7166-7179.
11. Fain J.N., Kanu A., Bahouth S.W. Comparison of PGE2, prostacyclin and leptin release by human adipocytes versus explants of adipose tissue in primary culture. Prostaglandins Leukotrienes and Essential Fatty Acids 2002, 67:467-473.
12. Ferri C.C., Ferguson A.V. Prostaglandin E2 mediates cellular effects of interleukin-1 on parvocellular neurones in the paraventricular nucleus of the hypothalamus. Journal of Neuroendocrinology 2005, 17:498-508.
13. Fontes M.A., Martins-Pinge M.C., Naves V., Campagnole-Santos M.J., Lopes O.U., Khosla M.C., Santos R.A. Cardiovascular effects produced by microinjection of angiotensins and angiotensin antagonists into the ventrolateral medulla of freely moving rats. Brain Research 1997, 750:305-310.
14. Grassi G. Sympathetic overdrive and cardiovascular risk in the metabolic syndrome. Hypertension Research 2006, 29:839-847.
15. Grassi G., Arenare F., Quarti-Trevano F., Seravalle G., Mancia G. Heart rate, sympathetic cardiovascular influences, and the metabolic syndrome. Progress in Cardiovascular Disease 2009, 52(1):31-37.
16. Hirata A.E., Andrade I.S., Vaskevicius P., Dolnikoff M.S. Monosodium glutamate (MSG)-obese rats develop glucose intolerance and insulin resistance to peripheral glucose uptake. Brazilian Journal of Medical and Biological Research 1997, 30(5):671-674.
17. Hoffman W.E., Schmid P.G. Cardiovascular and antidiuretic effects of central prostaglandin E2. The Journal of Physiology 1979, 288:159-169.
18. Hotamisligil G.S. Inflammation and metabolic disorders. Nature 2006, 444(7121):860-867. 14.
19. Hsieh P.S., Jin J.S., Chiang C.F., Chan P.C., Chen C.H., Shih K.C. COX-2-mediated inflammation in fat is crucial for obesity-linked insulin resistance and fatty liver. Obesity 2009, 17(6):1150-1157.
20. Jonk A.M., Houben A.J., De Jongh R.T., Serné E.H., Schaper N.C., Stehouwer C.D. Microvascular dysfuncition in obesity: a potential mechanism in the pathogenesis of obesity associated insulin resistance and hypertension. Physiology 2007, 22:252-260.
21. Kizer J.S., Nemeroff C.B., Youngblood W.W. Neurotoxic amino acids and structurally related analogs. Pharmacological Reviews 1978, 29(4):301-318.
22. Macho L., Jezova D., Zorad S., Fickova M. Postnatal monosodium glutamate treatment results in attenuation of corticosterone metabolic rate in adult rats. Endocrine Regulations 1999, 33:61-67.
23. Macho L., Fickova M., Jezova R., Zorad S. Late effects of postnatal administration of monosodium glutamate on insulin action in adult rats. Physiological Research 2000, 49(Suppl 1):S79-S85.
24. Martins A.C., Souza K.L., Shio M.T., Mathias P.C., Lelkes P.I., Garcia R.M. Adrenal medullary function and expression of catecholamine-synthesizing enzymes in mice with hypothalamic obesity. Life Sciences 2004, 74(26):3211-3222.
25. Martins-Pinge M.C., Baraldi-Passy I., Lopes O.U. Excitatory effects of nitric oxide within the rostral ventrolateral medulla of freely moving rats. Hypertension 1997, 30(3 Pt 2):704-707.
26. Martins-Pinge M.C., Becker L.K., Garcia M.R.L., Zoccal D.B., Neto R.V., Basso L.S., Souza H.C., Lopes O.U. Attenuated pressor responses to amino acids in the rostral ventrolateral medulla after swimming training in conscious rats. Autonomic Neuroscience 2005, 122(1-2):21-28.
27. Martins-Pinge M.C., Garcia M.R.L., Zoccal D.B., Crestani C.C., Pinge-Filho P. Differential influence of iNOS and nNOS inhibitors on rostral ventrolateral medullary mediated cardiovascular control in conscious rats. Autonomic Neuroscience 2007, 131:65-69.
28. Mathias P.C., Grassiolli S., Rocha D.N., Scomparin D.X., Gravena C. Transplantation of pancreatic islets from hypothalamic obese rats corrects hyperglycemia of diabetic rats. Transplantation Procedings 2007, 39(1):193-195.
29. Mehanna A., Vitorino D.C., Panis C., Blanco E.E., Pinge Filho P., Martins-Pinge M.C. Cardiovascular and pulmonary effects of NOS inhibition in endotoxemic conscious rats subjected to swimming training. Life Sciences 2007, 81(16):1301-1308.
30. Messina M.M., Evans S.A., Swoap S.J., Overton J.M. Perinatal MSG treatment attenuates fasting-induced bradycardia and metabolic suppression. Physiology & Behavior 2005, 86(3):324-330.
31. Nakanishi Y., Tsuneyama K., Fujimoto M., Salunga T.L., Nomoto K., An J.L., Takano Y., Iizuka S., Nagata M., Suzuki W., Shimada T., Aburada M., Nakano M., Selmi C., Gershwin M.E. Monosodium glutamate (MSG): a villain and promoter of liver inflammation and dysplasia. Journal of Autoimmunity 2008, 30(1-2):42-50.
32. Navarro-Gonzálvez J.A., Garcia-Bentayas C., Arenas J. Semiautomated measurement of nitrate in biological fluids. Clinical Chemistry 1998, 44:679-681.
33. Okuno T., Lindheimer M.D., Oparil S. Central effects of prostaglandin E2 on blood pressure and plasma renin activity in rats. Role of the sympathoadrenal system and vasopressin. Hypertension 1982, 4:809-816.
34. Olney J.W. Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science 1969, 164(880):719-721.
35. Pacher P., Beckman J.S., Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiological Reviews 2007, 87:315-424.
36. Perello M., Gaillard R.C., Chisari A., Spinedi E. Adrenal enucleation in MSG-damaged hyperleptinemic male rats transiently restores adrenal sensitivity to leptin. Neuroendocrinology 2003, 78(3):176-184.
37. Perello M., Castrogiovanni D., Giovambattista A., Gaillard R.C., Spinedi E. Prolonged but not short negative energy condition restored corticoadrenal leptin sensitivity in the hypothalamic obese rat. Neuroendocrinology 2009, 89(3):276-287.
38. Perelló M., Moreno G., Gaillard R.C., Spinedi E. Glucocorticoid-dependency of increased adiposity in a model of hypothalamic obesity. Neuro Endocrinology Letters 2004, 25(1-2):119-126.
39. Pinge-Filho P., Tadokoro C.E., Abrahamsohn I.A. Prostaglandins mediate suppression of lymphocyte proliferation and cytokine synthesis in acute Trypanosoma cruzi infection. Cellular Immunology 1999, 193(1):90-98.
40. Pinterova L., Zelezna B., Fickova M., Macho L., Krizanova O., Jezova D., Zorad S. Elevated AT1 receptor protein but lower angiotensin II-binding in adipose tissue of rats with monosodium glutamate-induced obesity. Hormone and Metabolic Research 2001, 33:708-712.
41. Rana J.S., Nieuwdorp M., Jukema J.W., Kastelein J.J. Cardiovascular metabolic syndrome - an interplay of obesity inflammation, diabetes and coronary heart disease. Diabetes, Obesity & Metabolism 2007, 9:218-232.
42. Rivest S., Lacroix S., Vallieres L., Nadeau S., Zhang J., Laflamme N. How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli. Proceedings of the Society of Experimental Biology and Medicine 2000, 223:22-38.
43. Romagnano M.A., Pilcher W.H., Bennett-Clarke C., Chafel T.L., Joseph S.A. Distribution of somatostatin in the mouse brain: effects of neonatal MSG treatment. Brain Research 1982, 234(2):387-398.
44. Souza H.C., Martins-Pinge M.C., Dias da Silva V.J., Borghi-Silva A., Gastaldi A.C., Blanco J.H., Tezini G.C. Heart rate and arterial pressure variability in the experimental renovascular hypertension model in rats. Autonomic Neuroscience 2008, 139(1-2):38-45.
45. Tatakihara V.L.H., Cecchini R., Borges C.L., Malvezi A.D., Souza V.K.G., Yamada-Ogatta S.F., Rizzo L.V., Pinge-Filho P. Effects of cyclooxygenase inhibitors on parasite burden, anemia and oxidative stress in murine Trypanosoma cruzi infection. FEMS Immunology and Medical Microbiology 2008, 52(1):47-58.
46. Tentolouris N., Liatis S., Katsilambros N. Sympathetic system activity in obesity and metabolic syndrome. Annals of the New York Academy of Sciences 2006, 1083:129-152.
47. Voltera A.F., Cesaretti M.L.R., Ginoza M., Kohlmann O. Effects of neuroendocrine obesity induction on systemic hemodynamics and left ventricular function of normotensive rats. Arquivos Brasileiros de Endocrinologia e Metabolismo 2008, 52:47-54.
48. Zhang Z.H., Wei S.G., Francis J., Felder R.B. Cardiovascular and renal sympathetic activation by blood-borne TNF-alpha in rat: the role of central prostaglandins. The American Journal of Physiology 2003, 284:R916-R927.
49. Zimiani K., Guarnier F.A., Miranda H.C., Watanabe M.A., Cecchini R. Nitric oxide mediated oxidative stress injury in rat skeletal muscle subjected to ischemia/reperfusion as evaluated by chemiluminescence. Nitric Oxide 2005, 13(3):196-203.