The C9orf72 repeat size correlates with onset age of disease, DNA methylation and transcriptional downregulation of the promoter

Molecular Psychiatry

Volumn 21, Issue 8, 2016, Pages 1112-1124

  Gijselinck, I ^a,b   Van Mossevelde, S ^a,b   Van Der Zee, J ^a,b   Sieben, A ^a,b,c   Engelborghs, S ^b,d   De Bleecker, J ^c   Ivanoiu, A ^e   Deryck, O ^f   Edbauer, D ^g,h   Zhang, M ⁱ   Heeman, B ^a,b   Baumer V ^a,b   Van Den Broeck, M ^a,b   Mattheijssens, M ^a,b   Peeters, K ^a,b   Rogaeva, E ^i,j   De Jonghe, P ^a,b,k   Cras, P ^b,k   Martin, J J ^b   De Deyn, P P ^b,d,l   Cruts, M ^a,b   Van Broeckhoven, C ^a,b   more..

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c GHENT UNIVERSITY HOSPITAL   (Belgium)

^d Hospital Network Antwerp Middelheim and Hoge Beuken   (Belgium)

^e CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^f General Hospital St Jan   (Belgium)

^g GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^h UNIVERSITY OF MUNICH   (Germany)

ⁱ UNIVERSITY OF TORONTO   (Canada)

^j UNIVERSITY OF TORONTO   (Canada)

^k ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^l UNIVERSITY OF GRONINGEN   (Netherlands)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CPG ISLAND; DNA FLANKING REGION; DNA METHYLATION; DOWN REGULATION; FRONTOTEMPORAL DEMENTIA; GENE DELETION; GENE INSERTION; HUMAN; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MOSAICISM; ONSET AGE; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION; ADULT; BELGIUM; EPIGENETICS; FEMALE; GENETIC EPIGENESIS; GENETIC PREDISPOSITION; GENETICS; MALE; METABOLISM; MIDDLE AGED; PROCEDURES;

C9ORF72 PROTEIN, HUMAN; PROTEIN;

ADULT; AGE OF ONSET; AMYOTROPHIC LATERAL SCLEROSIS; BELGIUM; CPG ISLANDS; DNA METHYLATION; DOWN-REGULATION; EPIGENESIS, GENETIC; EPIGENOMICS; FEMALE; FRONTOTEMPORAL LOBAR DEGENERATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; PROMOTER REGIONS, GENETIC; PROTEINS;

EID: 84944704005     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2015.159     Document Type: Article

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