Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

Brain Research

Volumn 1584, Issue , 2014, Pages 15-21

  Belzil, Veronique V ^a   Bauer, Peter O ^a   Gendron, Tania F ^a   Murray, Melissa E ^a   Dickson, Dennis ^a   Petrucelli, Leonard ^a  

^a MAYO CLINIC   (United States)

Author keywords

Amyotrophic lateral sclerosis; C9orf72; DNA methylation; Epigenetics; Frontotemporal dementia; Repeat expansion

Indexed keywords

HISTONE H3; HISTONE H4; LYSINE; C9ORF72 PROTEIN, HUMAN; HISTONE; PROTEIN;

5' UNTRANSLATED REGION; ADOLESCENT; ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BLOOD; CEREBELLUM; CLINICAL ARTICLE; COGNITIVE DEFECT; COHORT ANALYSIS; CONTROLLED STUDY; CPG ISLAND; DEMENTIA; DISEASE DURATION; DNA DETERMINATION; DNA METHYLATION; FEMALE; FRONTAL CORTEX; FRONTOTEMPORAL DEMENTIA; HISTONE METHYLATION; HUMAN; MALE; NERVE DEGENERATION; ONSET AGE; POLYMERASE CHAIN REACTION; PROTEIN METHYLATION; SPINAL CORD; GENETICS; METABOLISM; MIDDLE AGED; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AMYOTROPHIC LATERAL SCLEROSIS; CEREBELLUM; CPG ISLANDS; DNA METHYLATION; FEMALE; FRONTOTEMPORAL LOBAR DEGENERATION; HISTONES; HUMANS; MALE; MIDDLE AGED; PROTEINS;

EID: 84907681995     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2014.02.015     Document Type: Article

References (20)

1. S. Almeida Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons Acta Neuropathol. 126 2013 385 399
2. P.E. Ash Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS Neuron 77 2013 639 646
3. V.V. Belzil, T.F. Gendron, and L. Petrucelli RNA-mediated toxicity in neurodegenerative disease Mol. Cell. Neurosci. 56C 2012 406 419
4. V.V. Belzil Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood Acta Neuropathol. 126 2013 895 905
5. V.V. Belzil Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood Acta Neuropathol. 126 2013 895 905
6. C. Cencioni Oxidative stress and epigenetic regulation in ageing and age-related diseases Int. J. Mol. Sci. 14 2013 17643 17663
7. B.A. Chestnut Epigenetic regulation of motor neuron cell death through DNA methylation J. Neurosci. 31 2011 16619 16636
8. S. Ciura Loss of function of C9orf72 causes motor deficits in a zebrafish model of amyotrophic lateral sclerosis Ann. Neurol. 2013 (Epub ahead of print)
9. C.J. Donnelly RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention Neuron 80 2013 415 428
10. P. Fratta Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia Acta Neuropathol. 126 2013 401 409
11. D. Galimberti, and E. Scarpini Genetics and biology of Alzheimers disease and frontotemporal lobar degeneration Int. J. Clin. Exp. Med. 3 2010 129 143
12. T.F. Gendron Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS Acta Neuropathol. 126 2013 829 844
13. T.F. Gendron, V. Belzil, Y.J. Zhang, and L. Petrucelli Mechanisms of toxicity in C9FTLD/ALS Acta Neuropathol. 127 2014 359 376
14. I. Gijselinck A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study Lancet Neurol. 11 2012 54 65
15. C.A. Johnston Amyotrophic lateral sclerosis in an urban setting: a population based study of inner city London J. Neurol. 253 2006 1642 1643
16. H. Lu, X. Liu, Y. Deng, and H. Qing DNA methylation, a hand behind neurodegenerative diseases Front. Aging Neurosci. 5 2013 85
17. K. Mori The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS Science 339 2013 1335 1338
18. T. Prell, and J. Grosskreutz The involvement of the cerebellum in amyotrophic lateral sclerosis Amyotroph. Lateral Scler. Frontotempor. Degener. 14 2013 507 515
19. N. Suzuki The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD Nat. Neurosci. 16 2013 1725 1727
20. Z. Xi Hypermethylation of the CpG island near the GC repeat in ALS with a C9orf72 expansion Am. J. Hum. Genet 92 2013 981 989