Screening a UK amyotrophic lateral sclerosis cohort provides evidence of multiple origins of the C9orf72 expansion

Neurobiology of Aging

Volumn 36, Issue 1, 2015, Pages 546.e1-546.e7

  Fratta, Pietro ^a   Polke, James M ^b   Newcombe, Jia ^c   Mizielinska, Sarah ^a   Lashley, Tammaryn ^a   Poulter, Mark ^a   Beck, Jon ^a   Preza, Elisavet ^a   Devoy, Anny ^a   Sidle, Katie ^a,d   Howard, Robin ^d   Malaspina, Andrea ^d,e   Orrell, Richard W ^a,d   Clarke, Jan ^d   Lu, Ching Hua ^c,e   Mok, Kin ^c   Collins, Toby ^a   Shoaii, Maryam ^a   Nanji, Tina ^b   Wray, Selina ^a   Adamson, Gary ^a   Pittman, Alan ^a   Renton, Alan E ^f   Traynor, Bryan J ^f   Sweeney, Mary G ^b   Revesz, Tamas ^a   Houlden, Henry ^a,b   Mead, Simon ^a   Isaacs, Adrian M ^a   Fisher, Elizabeth M C ^a   more..

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b Neurogenetics Group   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

^e QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^f NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Amyotrophic lateral sclerosis; Frontotemporal dementia; Somatic instability

Indexed keywords

ADULT; ALLELE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BRAIN ATROPHY; C9ORF72 GENE; CEREBELLUM; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; FRONTAL CORTEX; GENE; GENETIC RISK; GENETIC SCREENING; GENOMIC INSTABILITY; HAPLOTYPE; HEXANUCLEOTIDE REPEAT EXPANSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE REPEAT; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC INSTABILITY; SPINAL CORD; SPINAL CORD DISEASE; UNITED KINGDOM; FRONTOTEMPORAL DEMENTIA; GENETICS; GREAT BRITAIN;

C9ORF72 PROTEIN, HUMAN; PROTEIN; REPETITIVE DNA;

AMYOTROPHIC LATERAL SCLEROSIS; COHORT STUDIES; DNA REPEAT EXPANSION; FRONTOTEMPORAL DEMENTIA; GREAT BRITAIN; HUMANS; PROTEINS;

EID: 84920417120     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2014.07.037     Document Type: Article

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