C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits

Science

Volumn 348, Issue 6239, 2015, Pages 1151-1154

  Chew, Jeannie ^a,b   Gendron, Tania F ^a   Prudencio, Mercedes ^a   Sasaguri, Hiroki ^a   Zhang, Yong Jie ^a   Castanedes Casey, Monica ^a   Lee, Chris W ^a   Jansen West, Karen ^a   Kurti, Aishe ^a   Murray, Melissa E ^a   Bieniek, Kevin F ^a,b   Bauer, Peter O ^a   Whitelaw, Ena C ^a   Rousseau, Linda ^a   Stankowski, Jeannette N ^a   Stetler, Caroline ^a   Daughrity, Lillian M ^a   Perkerson, Emilie A ^a   Desaro, Pamela ^c   Johnston, Amelia ^c   Overstreet, Karen ^c   Edbauer, Dieter ^d,e,f   Rademakers, Rosa ^a,b   Boylan, Kevin B ^c   Dickson, Dennis W ^a,b   Fryer, John D ^a,b   Petrucelli, Leonard ^a,b   more..

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

^c MAYO CLINIC   (United States)

^d GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^e UNIVERSITY OF MUNICH   (Germany)

^f Germany 3 Munich Cluster for Systems Neurology   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ARGININE; DIPEPTIDE; GLYCINE; C9ORF72 PROTEIN, HUMAN; DNA BINDING PROTEIN; GLYCYLPROLINE; N-GLYCYLALANINE; NUCLEAR RNA; PROTEIN; PROTEIN TDP-43;

GENE EXPRESSION; NERVOUS SYSTEM; NEUROLOGY; RODENT; SYMPTOM;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTOSIS; BEHAVIOR DISORDER; CONTROLLED STUDY; MOUSE; MOUSE MODEL; NERVE CELL; NONHUMAN; OPEN READING FRAME; PHENOTYPE; PRIORITY JOURNAL; PURKINJE CELL; TDP 43 PROTEINOPATHY; TRANSGENICS; WEIGHT REDUCTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL; ANTISOCIAL PERSONALITY DISORDER; BRAIN CORTEX; DEPENDOPARVOVIRUS; DISEASE MODEL; FRONTOTEMPORAL DEMENTIA; GENE TRANSFER; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; PATHOLOGY;

ADENO-ASSOCIATED VIRUS; ANIMALIA; MURINAE; MUS;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANTISOCIAL PERSONALITY DISORDER; CEREBRAL CORTEX; DEPENDOVIRUS; DIPEPTIDES; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; FRONTOTEMPORAL DEMENTIA; GENE TRANSFER TECHNIQUES; HEK293 CELLS; HUMANS; MICE; PROTEINS; PURKINJE CELLS; RNA, NUCLEAR;

EID: 84930637080     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaa9344     Document Type: Article

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