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Volumn , Issue , 2014, Pages 69-80

The aging adipose organ: Lipid redistribution, inflammation, and cellular senescence

Author keywords

Aging; Cellular senescence; Inflammation; White adipose tissue

Indexed keywords


EID: 84944457213     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-62703-770-9_5     Document Type: Chapter
Times cited : (15)

References (128)
  • 1
    • 33845864967 scopus 로고    scopus 로고
    • Adipocytes as regulators of energy balance and glucose homeostasis
    • Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature. 2006;444(7121):847-53.
    • (2006) Nature , vol.444 , Issue.7121 , pp. 847-853
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 2
    • 0034504237 scopus 로고    scopus 로고
    • Subcutaneous and visceral adipose tissue: Their relation to the metabolic syndrome
    • Wajchenberg BL. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev. 2000;21(6):697-738.
    • (2000) Endocr Rev , vol.21 , Issue.6 , pp. 697-738
    • Wajchenberg, B.L.1
  • 3
    • 75449094816 scopus 로고    scopus 로고
    • Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications
    • Fabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology. 2010;51(2):679-89.
    • (2010) Hepatology , vol.51 , Issue.2 , pp. 679-689
    • Fabbrini, E.1    Sullivan, S.2    Klein, S.3
  • 4
    • 34347351228 scopus 로고    scopus 로고
    • Abdominal visceral and subcutaneous adipose tissue compartments: Association with metabolic risk factors in the Framingham Heart Study
    • Fox CS, et al. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation. 2007;116(1):39-48.
    • (2007) Circulation , vol.116 , Issue.1 , pp. 39-48
    • Fox, C.S.1
  • 5
    • 34249883032 scopus 로고    scopus 로고
    • Waist circumference and cardiometabolic risk: A consensus statement from shaping America's health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association
    • Klein S, et al. Waist circumference and cardiometabolic risk: a consensus statement from shaping America's health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Diabetes Care. 2007;30(6):1647-52.
    • (2007) Diabetes Care , vol.30 , Issue.6 , pp. 1647-1652
    • Klein, S.1
  • 6
    • 1442282377 scopus 로고    scopus 로고
    • The metabolic syndrome and aging
    • Morley JE. The metabolic syndrome and aging. J Gerontol A Biol Sci Med Sci. 2004;59(2):139-42.
    • (2004) J Gerontol A Biol Sci Med Sci , vol.59 , Issue.2 , pp. 139-142
    • Morley, J.E.1
  • 7
    • 69449095173 scopus 로고    scopus 로고
    • The metabolic syndrome in older persons: A loosely defined constellation of symptoms or a distinct entity?
    • Morley JE, Sinclair A. The metabolic syndrome in older persons: a loosely defined constellation of symptoms or a distinct entity? Age Ageing. 2009;38(5):494-7.
    • (2009) Age Ageing , vol.38 , Issue.5 , pp. 494-497
    • Morley, J.E.1    Sinclair, A.2
  • 8
    • 34248550944 scopus 로고    scopus 로고
    • Aging in adipocytes: Potential impact of inherent, depot-specific mechanisms
    • Cartwright MJ, Tchkonia T, Kirkland JL. Aging in adipocytes: potential impact of inherent, depot-specific mechanisms. Exp Gerontol. 2007;42(6):463-71.
    • (2007) Exp Gerontol , vol.42 , Issue.6 , pp. 463-471
    • Cartwright, M.J.1    Tchkonia, T.2    Kirkland, J.L.3
  • 9
    • 0028205364 scopus 로고
    • Sexual dimorphism of age-related changes in whole-body fat distribution in the obese
    • Kotani K, et al. Sexual dimorphism of age-related changes in whole-body fat distribution in the obese. Int J Obes Relat Metab Disord. 1994;18(4):207-12.
    • (1994) Int J Obes Relat Metab Disord , vol.18 , Issue.4 , pp. 207-212
    • Kotani, K.1
  • 10
    • 69049093712 scopus 로고    scopus 로고
    • Age-related changes in total and regional fat distribution
    • Kuk JL, et al. Age-related changes in total and regional fat distribution. Ageing Res Rev. 2009;8(4):339-48.
    • (2009) Ageing Res Rev , vol.8 , Issue.4 , pp. 339-348
    • Kuk, J.L.1
  • 11
    • 0029366311 scopus 로고
    • Pathophysiology and pathogenesis of visceral fat obesity
    • Matsuzawa Y, et al. Pathophysiology and pathogenesis of visceral fat obesity. Obes Res. 1995;3 Suppl 2:187S-94.
    • (1995) Obes Res. , vol.3 , pp. 187S-194S
    • Matsuzawa, Y.1
  • 12
    • 33746041829 scopus 로고    scopus 로고
    • A 3-year longitudinal study on body composition changes in the elderly: Role of physical exercise
    • Raguso CA, et al. A 3-year longitudinal study on body composition changes in the elderly: role of physical exercise. Clin Nutr. 2006;25(4):573-80.
    • (2006) Clin Nutr , vol.25 , Issue.4 , pp. 573-580
    • Raguso, C.A.1
  • 13
    • 32644435114 scopus 로고    scopus 로고
    • Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice
    • Baker DJ, et al. Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. J Cell Biol. 2006;172(4):529-40.
    • (2006) J Cell Biol , vol.172 , Issue.4 , pp. 529-540
    • Baker, D.J.1
  • 14
    • 0035347211 scopus 로고    scopus 로고
    • Contribution of abdominal adiposity to age-related differences in insulin sensitivity and plasma lipids in healthy nonobese women
    • DeNino WF, et al. Contribution of abdominal adiposity to age-related differences in insulin sensitivity and plasma lipids in healthy nonobese women. Diabetes Care. 2001;24(5):925-32.
    • (2001) Diabetes Care , vol.24 , Issue.5 , pp. 925-932
    • DeNino, W.F.1
  • 15
    • 4344602911 scopus 로고    scopus 로고
    • Anthropometric assessment of 10-y changes in body composition in the elderly
    • Hughes VA, et al. Anthropometric assessment of 10-y changes in body composition in the elderly. Am J Clin Nutr. 2004;80(2):475-82.
    • (2004) Am J Clin Nutr , vol.80 , Issue.2 , pp. 475-482
    • Hughes, V.A.1
  • 16
    • 17644417472 scopus 로고    scopus 로고
    • Obesity, regional body fat distribution, and the metabolic syndrome in older men and women
    • Goodpaster BH, et al. Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med. 2005;165(7):777-83.
    • (2005) Arch Intern Med , vol.165 , Issue.7 , pp. 777-783
    • Goodpaster, B.H.1
  • 17
    • 0042810882 scopus 로고    scopus 로고
    • Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women
    • Goodpaster BH, et al. Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women. Diabetes Care. 2003;26(2):372-9.
    • (2003) Diabetes Care , vol.26 , Issue.2 , pp. 372-379
    • Goodpaster, B.H.1
  • 18
    • 33847764645 scopus 로고    scopus 로고
    • Aging, adiposity, and calorie restriction
    • Fontana L, Klein S. Aging, adiposity, and calorie restriction. JAMA. 2007;297(9):986-94.
    • (2007) JAMA , vol.297 , Issue.9 , pp. 986-994
    • Fontana, L.1    Klein, S.2
  • 19
    • 84856692288 scopus 로고    scopus 로고
    • Physical activity and exercise in the regulation of human adipose tissue physiology
    • Thompson D, et al. Physical activity and exercise in the regulation of human adipose tissue physiology. Physiol Rev. 2012;92(1):157-91.
    • (2012) Physiol Rev , vol.92 , Issue.1 , pp. 157-191
    • Thompson, D.1
  • 20
    • 69049096543 scopus 로고    scopus 로고
    • Adiposopathy and bariatric surgery: Is 'sick fat' a surgical disease?
    • Bays HE, et al. Adiposopathy and bariatric surgery: is 'sick fat' a surgical disease? Int J Clin Pract. 2009; 63(9):1285-300.
    • (2009) Int J Clin Pract. , vol.63 , Issue.9 , pp. 1285-1300
    • Bays, H.E.1
  • 21
    • 0033039097 scopus 로고    scopus 로고
    • Revisiting the role of fat mass in the life extension induced by caloric restriction
    • discussion
    • Barzilai N, Gupta G. Revisiting the role of fat mass in the life extension induced by caloric restriction. J Gerontol A Biol Sci Med Sci. 1999;54(3):B89-96. discussion B97-8.
    • (1999) J Gerontol A Biol Sci Med Sci. , vol.54 , Issue.3
    • Barzilai, N.1    Gupta, G.2
  • 22
    • 66249088672 scopus 로고    scopus 로고
    • Rapamycin protects against high fat diet-induced obesity in C57BL/6J mice
    • Chang GR, et al. Rapamycin protects against high fat diet-induced obesity in C57BL/6J mice. J Pharmacol Sci. 2009;109(4):496-503.
    • (2009) J Pharmacol Sci , vol.109 , Issue.4 , pp. 496-503
    • Chang, G.R.1
  • 23
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • Harrison DE, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009;460(7253):392-5.
    • (2009) Nature , vol.460 , Issue.7253 , pp. 392-395
    • Harrison, D.E.1
  • 24
    • 53249134458 scopus 로고    scopus 로고
    • Role of the GH/IGF-1 axis in lifespan and healthspan: Lessons from animal models
    • Berryman DE, et al. Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models. Growth Horm IGF Res. 2008;18(6):455-71.
    • (2008) Growth Horm IGF Res , vol.18 , Issue.6 , pp. 455-471
    • Berryman, D.E.1
  • 25
    • 0037942739 scopus 로고    scopus 로고
    • Extended longevity in mice lacking the insulin receptor in adipose tissue
    • Bluher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science. 2003;299(5606):572-4.
    • (2003) Science , vol.299 , Issue.5606 , pp. 572-574
    • Bluher, M.1    Kahn, B.B.2    Kahn, C.R.3
  • 26
    • 40449142493 scopus 로고    scopus 로고
    • Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
    • Selman C, et al. Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J. 2008;22(3):807-18.
    • (2008) FASEB J , vol.22 , Issue.3 , pp. 807-818
    • Selman, C.1
  • 27
    • 70349669095 scopus 로고    scopus 로고
    • Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
    • Selman C, et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science. 2009; 326(5949):140-4.
    • (2009) Science , vol.326 , Issue.5949 , pp. 140-144
    • Selman, C.1
  • 28
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
    • Um SH, et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature. 2004;431(7005):200-5.
    • (2004) Nature , vol.431 , Issue.7005 , pp. 200-205
    • Um, S.H.1
  • 29
    • 69949106282 scopus 로고    scopus 로고
    • Fatty acid metabolism in the elderly: Effects of dehydroepiandrosterone and testosterone replacement in hormonally deficient men and women
    • Koutsari C, et al. Fatty acid metabolism in the elderly: effects of dehydroepiandrosterone and testosterone replacement in hormonally deficient men and women. J Clin Endocrinol Metab. 2009;94(9):3414-23.
    • (2009) J Clin Endocrinol Metab , vol.94 , Issue.9 , pp. 3414-3423
    • Koutsari, C.1
  • 30
    • 78349299099 scopus 로고    scopus 로고
    • Fat tissue, aging, and cellular senescence
    • Tchkonia T, et al. Fat tissue, aging, and cellular senescence. Aging Cell. 2010;9(5):667-84.
    • (2010) Aging Cell , vol.9 , Issue.5 , pp. 667-684
    • Tchkonia, T.1
  • 31
    • 80855138775 scopus 로고    scopus 로고
    • Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
    • Baker DJ, et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature. 2011;479(7372):232-6.
    • (2011) Nature , vol.479 , Issue.7372 , pp. 232-236
    • Baker, D.J.1
  • 32
    • 80655145234 scopus 로고    scopus 로고
    • Clinical review#: Lipodystrophies: Genetic and acquired body fat disorders
    • Garg A. Clinical review#: lipodystrophies: genetic and acquired body fat disorders. J Clin Endocrinol Metab. 2011;96(11):3313-25.
    • (2011) J Clin Endocrinol Metab , vol.96 , Issue.11 , pp. 3313-3325
    • Garg, A.1
  • 33
    • 70350443275 scopus 로고    scopus 로고
    • Transdifferentiation properties of adipocytes in the adipose organ
    • Cinti S. Transdifferentiation properties of adipocytes in the adipose organ. Am J Physiol Endocrinol Metab. 2009; 297(5):E977-86.
    • (2009) Am J Physiol Endocrinol Metab , vol.297 , Issue.5 , pp. E977-E986
    • Cinti, S.1
  • 34
    • 2342644142 scopus 로고    scopus 로고
    • Comparison of proliferation and differentiation capacity of human adipocyte precursor cells from the omental and subcutaneous adipose tissue depot of obese subjects
    • Van Harmelen V, Rohrig K, Hauner H. Comparison of proliferation and differentiation capacity of human adipocyte precursor cells from the omental and subcutaneous adipose tissue depot of obese subjects. Metab Clin Exp. 2004;53(5):632-7.
    • (2004) Metab Clin Exp , vol.53 , Issue.5 , pp. 632-637
    • Van Harmelen, V.1    Rohrig, K.2    Hauner, H.3
  • 35
    • 0034972714 scopus 로고    scopus 로고
    • Altered expression of C/EBP family members results in decreased adipogenesis with aging
    • Karagiannides I, et al. Altered expression of C/EBP family members results in decreased adipogenesis with aging. Am J Physiol Regul Integr Comp Physiol. 2001;280(6):R1772-80.
    • (2001) Am J Physiol Regul Integr Comp Physiol. , vol.280 , Issue.6 , pp. R1772-R1780
    • Karagiannides, I.1
  • 36
    • 0025246162 scopus 로고
    • Age, anatomic site, and the replication and differentiation of adipocyte precursors
    • Kirkland JL, Hollenberg CH, Gillon WS. Age, anatomic site, and the replication and differentiation of adipocyte precursors. Am J Physiol. 1990;258(2 Pt 1):C206-10.
    • (1990) Am J Physiol. , vol.258 , Issue.2 , pp. C206-C210
    • Kirkland, J.L.1    Hollenberg, C.H.2    Gillon, W.S.3
  • 37
    • 0028091785 scopus 로고
    • Regional adiposity and morbidity
    • Kissebah AH, Krakower GR. Regional adiposity and morbidity. Physiol Rev. 1994;74(4):761-811.
    • (1994) Physiol Rev , vol.74 , Issue.4 , pp. 761-811
    • Kissebah, A.H.1    Krakower, G.R.2
  • 38
    • 41449114649 scopus 로고    scopus 로고
    • Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased visceral adiposity
    • Bays HE, et al. Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased visceral adiposity. Expert Rev Cardiovasc Ther. 2008;6(3):343-68.
    • (2008) Expert Rev Cardiovasc Ther , vol.6 , Issue.3 , pp. 343-368
    • Bays, H.E.1
  • 39
    • 0024271697 scopus 로고
    • Muscle and adipose tissue morphology and metabolism in Cushing's syndrome
    • Rebuffe-Scrive M, et al. Muscle and adipose tissue morphology and metabolism in Cushing's syndrome. J Clin Endocrinol Metab. 1988;67(6):1122-8.
    • (1988) J Clin Endocrinol Metab , vol.67 , Issue.6 , pp. 1122-1128
    • Rebuffe-Scrive, M.1
  • 40
    • 18844456342 scopus 로고    scopus 로고
    • Adiposopathy, metabolic syndrome, quantum physics, general relativity, chaos and the Theory of Everything
    • Bays H. Adiposopathy, metabolic syndrome, quantum physics, general relativity, chaos and the Theory of Everything. Expert Rev Cardiovasc Ther. 2005;3(3):393-404.
    • (2005) Expert Rev Cardiovasc Ther , vol.3 , Issue.3 , pp. 393-404
    • Bays, H.1
  • 41
    • 12444296524 scopus 로고    scopus 로고
    • Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus
    • Heilbronn L, Smith SR, Ravussin E. Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus. Int J Obes Relat Metab Disord. 2004;28 Suppl 4:S12-21.
    • (2004) Int J Obes Relat Metab Disord. , vol.28 , pp. S12-21
    • Heilbronn, L.1    Smith, S.R.2    Ravussin, E.3
  • 42
    • 0036298505 scopus 로고    scopus 로고
    • Lipids and insulin resistance: What we've learned at the Fourth International Smolenice Symposium
    • Ravussin E, et al. Lipids and insulin resistance: what we've learned at the Fourth International Smolenice Symposium. Ann N Y Acad Sci. 2002;967:576-80.
    • (2002) Ann N Y Acad Sci , vol.967 , pp. 576-580
    • Ravussin, E.1
  • 43
    • 33645521371 scopus 로고    scopus 로고
    • Induction of colitis causes inflammatory responses in fat depots: Evidence for substance P pathways in human mesenteric preadipocytes
    • Karagiannides I, et al. Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes. Proc Natl Acad Sci U S A. 2006;103(13):5207-12.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.13 , pp. 5207-5212
    • Karagiannides, I.1
  • 44
    • 70449475544 scopus 로고    scopus 로고
    • The influence of omentectomy on bacterial clearance: An experimental study
    • Uzunkoy A, Ozbilge H, Horoz M. The influence of omentectomy on bacterial clearance: an experimental study. TJTES. 2009;15(6):541-5.
    • (2009) TJTES , vol.15 , Issue.6 , pp. 541-545
    • Uzunkoy, A.1    Ozbilge, H.2    Horoz, M.3
  • 45
    • 34548531751 scopus 로고    scopus 로고
    • Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs and CTRPs
    • Schaffler A, Scholmerich J, Salzberger B. Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs and CTRPs. Trends Immunol. 2007;28(9):393-9.
    • (2007) Trends Immunol , vol.28 , Issue.9 , pp. 393-399
    • Schaffler, A.1    Scholmerich, J.2    Salzberger, B.3
  • 46
    • 79151484704 scopus 로고    scopus 로고
    • Adipokines in inflammation and metabolic disease
    • Ouchi N, et al. Adipokines in inflammation and metabolic disease. Nat Rev Immunol. 2011;11(2):85-97.
    • (2011) Nat Rev Immunol , vol.11 , Issue.2 , pp. 85-97
    • Ouchi, N.1
  • 47
    • 0031762908 scopus 로고    scopus 로고
    • Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: Depot difference and regulation by glucocorticoid
    • Fried SK, Bunkin DA, Greenberg AS. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab. 1998;83(3):847-50.
    • (1998) J Clin Endocrinol Metab , vol.83 , Issue.3 , pp. 847-850
    • Fried, S.K.1    Bunkin, D.A.2    Greenberg, A.S.3
  • 48
    • 77951665927 scopus 로고    scopus 로고
    • Subcutaneous and visceral adipose tissue gene expression of serum adipokines that predict type 2 diabetes
    • Samaras K, et al. Subcutaneous and visceral adipose tissue gene expression of serum adipokines that predict type 2 diabetes. Obesity. 2010;18(5):884-9.
    • (2010) Obesity , vol.18 , Issue.5 , pp. 884-889
    • Samaras, K.1
  • 49
    • 48349101968 scopus 로고    scopus 로고
    • The endocrine profile of subcutaneous and visceral adipose tissue of obese patients
    • Dolinkova M, et al. The endocrine profile of subcutaneous and visceral adipose tissue of obese patients. Mol Cell Endocrinol. 2008;291(1-2):63-70.
    • (2008) Mol Cell Endocrinol. , vol.291 , Issue.1-2 , pp. 63-70
    • Dolinkova, M.1
  • 50
    • 34347233419 scopus 로고    scopus 로고
    • Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass
    • Kloting N, et al. Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metab. 2007;6(1):79-87.
    • (2007) Cell Metab , vol.6 , Issue.1 , pp. 79-87
    • Kloting, N.1
  • 51
    • 0030849674 scopus 로고    scopus 로고
    • Adipose tissue-derived tumor necrosis factor-alpha activity is elevated in older rats
    • Morin CL, et al. Adipose tissue-derived tumor necrosis factor-alpha activity is elevated in older rats. J Gerontol A Biol Sci Med Sci. 1997;52(4):B190-5.
    • (1997) J Gerontol A Biol Sci Med Sci. , vol.52 , Issue.4 , pp. B190-B500
    • Morin, C.L.1
  • 52
    • 67649653963 scopus 로고    scopus 로고
    • Age-associated increase in cytokine production during systemic inflammation: Adipose tissue as a major source of IL-6
    • Starr ME, Evers BM, Saito H. Age-associated increase in cytokine production during systemic inflammation:adipose tissue as a major source of IL-6. J Gerontol A Biol Sci Med Sci. 2009;64(7):723-30.
    • (2009) J Gerontol A Biol Sci Med Sci , vol.64 , Issue.7 , pp. 723-730
    • Starr, M.E.1    Evers, B.M.2    Saito, H.3
  • 53
    • 41249098290 scopus 로고    scopus 로고
    • Aging up-regulates expression of inflammatory mediators in mouse adipose tissue
    • Wu D, et al. Aging up-regulates expression of inflammatory mediators in mouse adipose tissue. J Immunol. 2007;179(7):4829-39.
    • (2007) J Immunol , vol.179 , Issue.7 , pp. 4829-4839
    • Wu, D.1
  • 54
    • 53549130485 scopus 로고    scopus 로고
    • White fat progenitor cells reside in the adipose vasculature
    • Tang W, et al. White fat progenitor cells reside in the adipose vasculature. Science. 2008;322(5901):583-6.
    • (2008) Science , vol.322 , Issue.5901 , pp. 583-586
    • Tang, W.1
  • 55
    • 84856954303 scopus 로고    scopus 로고
    • The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells
    • Tran KV, et al. The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells. Cell Metab. 2012;15(2):222-9.
    • (2012) Cell Metab , vol.15 , Issue.2 , pp. 222-229
    • Tran, K.V.1
  • 56
    • 33845299821 scopus 로고    scopus 로고
    • Rosiglitazone promotes development of a novel adipocyte population from bone marrowderived circulating progenitor cells
    • Crossno Jr JT, et al. Rosiglitazone promotes development of a novel adipocyte population from bone marrowderived circulating progenitor cells. J Clin Invest. 2006;116(12):3220-8.
    • (2006) J Clin Invest , vol.116 , Issue.12 , pp. 3220-3228
    • Crossno, J.T.1
  • 57
    • 28744437374 scopus 로고    scopus 로고
    • Characterization of human fibrocytes as circulating adipocyte progenitors and the formation of human adipose tissue in SCID mice
    • Hong KM, et al. Characterization of human fibrocytes as circulating adipocyte progenitors and the formation of human adipose tissue in SCID mice. FASEB J. 2005;19(14):2029-31.
    • (2005) FASEB J , vol.19 , Issue.14 , pp. 2029-2031
    • Hong, K.M.1
  • 58
    • 0036081705 scopus 로고    scopus 로고
    • Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes
    • Tchkonia T, et al. Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes. Am J Physiol Regul Integr Comp Physiol. 2002;282(5):R1286-96.
    • (2002) Am J Physiol Regul Integr Comp Physiol. , vol.282 , Issue.5 , pp. R1286-R1296
    • Tchkonia, T.1
  • 59
    • 33750596340 scopus 로고    scopus 로고
    • Fat depot-specific characteristics are retained in strains derived from single human preadipocytes
    • Tchkonia T, et al. Fat depot-specific characteristics are retained in strains derived from single human preadipocytes. Diabetes. 2006;55(9):2571-8.
    • (2006) Diabetes , vol.55 , Issue.9 , pp. 2571-2578
    • Tchkonia, T.1
  • 60
    • 0034808972 scopus 로고    scopus 로고
    • Different fat depots are distinct mini-organs
    • Tchkonia T, et al. Different fat depots are distinct mini-organs. Curr Opin Endocrinol Diabetes Obes. 2001; 8(5):227-34.
    • (2001) Curr Opin Endocrinol Diabetes Obes , vol.8 , Issue.5 , pp. 227-234
    • Tchkonia, T.1
  • 61
    • 33846032618 scopus 로고    scopus 로고
    • Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns
    • Tchkonia T, et al. Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns. Am J Physiol Endocrinol Metab. 2007;292(1):E298-307.
    • (2007) Am J Physiol Endocrinol Metab. , vol.292 , Issue.1 , pp. E298-307
    • Tchkonia, T.1
  • 62
    • 77951667655 scopus 로고    scopus 로고
    • Adipose depots possess unique developmental gene signatures
    • Yamamoto Y, et al. Adipose depots possess unique developmental gene signatures. Obesity. 2010;18(5):872-8.
    • (2010) Obesity , vol.18 , Issue.5 , pp. 872-878
    • Yamamoto, Y.1
  • 63
    • 77955266460 scopus 로고    scopus 로고
    • Brown vs white adipocytes: The PPAR gamma coregulator story
    • Koppen A, Kalkhoven E. Brown vs white adipocytes: the PPAR gamma coregulator story. FEBS Lett. 2010;584(15):3250-9.
    • (2010) FEBS Lett , vol.584 , Issue.15 , pp. 3250-3259
    • Koppen, A.1    Kalkhoven, E.2
  • 64
    • 0027526301 scopus 로고
    • Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor
    • Gearing KL, et al. Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor. Proc Natl Acad Sci U S A. 1993;90(4):1440-4.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , Issue.4 , pp. 1440-1444
    • Gearing, K.L.1
  • 65
    • 0027314960 scopus 로고
    • The retinoid X receptor enhances the function of the peroxisome proliferator activated receptor
    • Issemann I, et al. The retinoid X receptor enhances the function of the peroxisome proliferator activated receptor. Biochimie. 1993;75(3-4):251-6.
    • (1993) Biochimie , vol.75 , Issue.3-4 , pp. 251-256
    • Issemann, I.1
  • 66
    • 0029102676 scopus 로고
    • Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: Alternative promoter use and different splicing yield two mPPAR gamma isoforms
    • Zhu Y, et al. Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms. Proc Natl Acad Sci U S A. 1995;92(17):7921-5.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , Issue.17 , pp. 7921-7925
    • Zhu, Y.1
  • 67
    • 0033546003 scopus 로고    scopus 로고
    • Role of PPAR gamma in regulating a cascade expression of cyclin-dependent kinase inhibitors, p18(INK4c) and p21(Waf1/Cip1), during adipogenesis
    • Morrison RF, Farmer SR. Role of PPAR gamma in regulating a cascade expression of cyclin-dependent kinase inhibitors, p18(INK4c) and p21(Waf1/Cip1), during adipogenesis. J Biol Chem. 1999;274(24):17088-97.
    • (1999) J Biol Chem , vol.274 , Issue.24 , pp. 17088-17097
    • Morrison, R.F.1    Farmer, S.R.2
  • 68
    • 28944446431 scopus 로고    scopus 로고
    • The many faces of PPAR gamma
    • Lehrke M, Lazar MA. The many faces of PPAR gamma. Cell. 2005;123(6):993-9.
    • (2005) Cell , vol.123 , Issue.6 , pp. 993-999
    • Lehrke, M.1    Lazar, M.A.2
  • 69
    • 33748942837 scopus 로고    scopus 로고
    • Transcriptional control of adipocyte formation
    • Farmer SR. Transcriptional control of adipocyte formation. Cell Metab. 2006;4(4):263-73.
    • (2006) Cell Metab , vol.4 , Issue.4 , pp. 263-273
    • Farmer, S.R.1
  • 70
    • 33244480814 scopus 로고    scopus 로고
    • Temporal recruitment of CCAAT/enhancer-binding proteins to early and late adipogenic promoters in vivo
    • Salma N, Xiao H, Imbalzano AN. Temporal recruitment of CCAAT/enhancer-binding proteins to early and late adipogenic promoters in vivo. J Mol Endocrinol. 2006;36(1):139-51.
    • (2006) J Mol Endocrinol , vol.36 , Issue.1 , pp. 139-151
    • Salma, N.1    Xiao, H.2    Imbalzano, A.N.3
  • 71
    • 0036007024 scopus 로고    scopus 로고
    • C/EBP alpha induces adipogenesis through PPAR gamma: A unified pathway
    • Rosen ED, et al. C/EBP alpha induces adipogenesis through PPAR gamma: a unified pathway. Genes Dev. 2002;16(1):22-6.
    • (2002) Genes Dev , vol.16 , Issue.1 , pp. 22-26
    • Rosen, E.D.1
  • 72
    • 0033083803 scopus 로고    scopus 로고
    • Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity
    • Wu Z, et al. Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol Cell. 1999;3(2):151-8.
    • (1999) Mol Cell , vol.3 , Issue.2 , pp. 151-158
    • Wu, Z.1
  • 73
    • 0028036212 scopus 로고
    • Effects of age and anatomic site on preadipocyte number in rat fat depots
    • Kirkland JL, et al. Effects of age and anatomic site on preadipocyte number in rat fat depots. J Gerontol. 1994;49(1):B31-5.
    • (1994) J Gerontol. , vol.49 , Issue.1 , pp. B31-B35
    • Kirkland, J.L.1
  • 74
    • 0038660699 scopus 로고    scopus 로고
    • Preadipocyte conversion to macrophage. Evidence of plasticity
    • Charriere G, et al. Preadipocyte conversion to macrophage. Evidence of plasticity. J Biol Chem. 2003; 278(11):9850-5.
    • (2003) J Biol Chem , vol.278 , Issue.11 , pp. 9850-9855
    • Charriere, G.1
  • 75
    • 33751235259 scopus 로고    scopus 로고
    • Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes
    • Chung S, et al. Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes. Endocrinology. 2006;147(11):5340-51.
    • (2006) Endocrinology , vol.147 , Issue.11 , pp. 5340-5351
    • Chung, S.1
  • 76
    • 0034637439 scopus 로고    scopus 로고
    • The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes
    • Lin Y, et al. The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem. 2000;275(32):24255-63.
    • (2000) J Biol Chem , vol.275 , Issue.32 , pp. 24255-24263
    • Lin, Y.1
  • 77
    • 42949109139 scopus 로고    scopus 로고
    • Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue
    • Vitseva OI, et al. Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue. Obesity. 2008;16(5):932-7.
    • (2008) Obesity , vol.16 , Issue.5 , pp. 932-937
    • Vitseva, O.I.1
  • 78
    • 70350462403 scopus 로고    scopus 로고
    • Inflammation and impaired adipogenesis in hypertrophic obesity in man
    • Gustafson B, et al. Inflammation and impaired adipogenesis in hypertrophic obesity in man. Am J Physiol Endocrinol Metab. 2009;297(5):E999-1003.
    • (2009) Am J Physiol Endocrinol Metab. , vol.297 , Issue.5 , pp. E999-1003
    • Gustafson, B.1
  • 79
    • 67650242164 scopus 로고    scopus 로고
    • Impaired preadipocyte differentiation in human abdominal obesity: Role of Wnt, tumor necrosis factor-alpha, and inflammation
    • Isakson P, et al. Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation. Diabetes. 2009;58(7):1550-7.
    • (2009) Diabetes , vol.58 , Issue.7 , pp. 1550-1557
    • Isakson, P.1
  • 80
    • 69049111145 scopus 로고    scopus 로고
    • Functional analyses reveal the greater potency of preadipocytes compared with adipocytes as endothelial cell activator under normoxia, hypoxia, and TNFalpha exposure
    • Mack I, et al. Functional analyses reveal the greater potency of preadipocytes compared with adipocytes as endothelial cell activator under normoxia, hypoxia, and TNFalpha exposure. Am J Physiol Endocrinol Metab. 2009;297(3):E735-48.
    • (2009) Am J Physiol Endocrinol Metab. , vol.297 , Issue.3 , pp. E735-E748
    • Mack, I.1
  • 81
    • 0033007024 scopus 로고    scopus 로고
    • A role for preadipocytes as macrophage-like cells
    • Cousin B, et al. A role for preadipocytes as macrophage-like cells. FASEB J. 1999;13(2):305-12.
    • (1999) FASEB J , vol.13 , Issue.2 , pp. 305-312
    • Cousin, B.1
  • 82
    • 0032233184 scopus 로고    scopus 로고
    • Inhibitors of preadipocyte replication: Opportunities for the treatment of obesity
    • Kirkland JL, Hollenberg CH. Inhibitors of preadipocyte replication: opportunities for the treatment of obesity. Prog Mol Subcell Biol. 1998;20:177-95.
    • (1998) Prog Mol Subcell Biol , vol.20 , pp. 177-195
    • Kirkland, J.L.1    Hollenberg, C.H.2
  • 83
    • 42549164595 scopus 로고    scopus 로고
    • Regional anatomic and age effects on cell function of human adipose-derived stem cells
    • Schipper BM, et al. Regional anatomic and age effects on cell function of human adipose-derived stem cells. Ann Plast Surg. 2008;60(5):538-44.
    • (2008) Ann Plast Surg , vol.60 , Issue.5 , pp. 538-544
    • Schipper, B.M.1
  • 84
    • 33747338275 scopus 로고    scopus 로고
    • Increased CUG triplet repeat-binding protein-1 predisposes to impaired adipogenesis with aging
    • Karagiannides I, et al. Increased CUG triplet repeat-binding protein-1 predisposes to impaired adipogenesis with aging. J Biol Chem. 2006;281(32):23025-33.
    • (2006) J Biol Chem , vol.281 , Issue.32 , pp. 23025-23033
    • Karagiannides, I.1
  • 85
    • 77949525237 scopus 로고    scopus 로고
    • Aging, depot origin, and preadipocyte gene expression
    • Cartwright MJ, et al. Aging, depot origin, and preadipocyte gene expression. J Gerontol A Biol Sci Med Sci. 2010;65(3):242-51.
    • (2010) J Gerontol A Biol Sci Med Sci , vol.65 , Issue.3 , pp. 242-251
    • Cartwright, M.J.1
  • 86
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003;112(12):1821-30.
    • (2003) J Clin Invest , vol.112 , Issue.12 , pp. 1821-1830
    • Xu, H.1
  • 87
    • 0038516918 scopus 로고    scopus 로고
    • One- and two-year change in body composition as measured by DXA in a population-based cohort of older men and women
    • Visser M, et al. One- and two-year change in body composition as measured by DXA in a population-based cohort of older men and women. J Appl Physiol. 2003;94(6):2368-74.
    • (2003) J Appl Physiol , vol.94 , Issue.6 , pp. 2368-2374
    • Visser, M.1
  • 88
    • 0034891673 scopus 로고    scopus 로고
    • Age-related differences in fat-free mass, skeletal muscle, body cell mass and fat mass between 18 and 94 years
    • Kyle UG, et al. Age-related differences in fat-free mass, skeletal muscle, body cell mass and fat mass between 18 and 94 years. Eur J Clin Nutr. 2001;55(8):663-72.
    • (2001) Eur J Clin Nutr , vol.55 , Issue.8 , pp. 663-672
    • Kyle, U.G.1
  • 89
    • 34247397526 scopus 로고    scopus 로고
    • Epicardial fat: Properties, function and relationship to obesity
    • Rabkin SW. Epicardial fat: properties, function and relationship to obesity. Obes Rev. 2007;8(3):253-61.
    • (2007) Obes Rev , vol.8 , Issue.3 , pp. 253-261
    • Rabkin, S.W.1
  • 90
    • 33646806826 scopus 로고    scopus 로고
    • Lipotoxicity, overnutrition and energy metabolism in aging
    • Slawik M, Vidal-Puig AJ. Lipotoxicity, overnutrition and energy metabolism in aging. Ageing Res Rev. 2006;5(2):144-64.
    • (2006) Ageing Res Rev , vol.5 , Issue.2 , pp. 144-164
    • Slawik, M.1    Vidal-Puig, A.J.2
  • 91
    • 0028299585 scopus 로고
    • Waist circumference and abdominal sagittal diameter: Best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women
    • Pouliot MC, et al. Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. Am J Cardiol. 1994;73(7):460-8.
    • (1994) Am J Cardiol , vol.73 , Issue.7 , pp. 460-468
    • Pouliot, M.C.1
  • 92
    • 0032938719 scopus 로고    scopus 로고
    • Surgical removal of visceral fat reverses hepatic insulin resistance
    • Barzilai N, et al. Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes. 1999;48(1):94-8.
    • (1999) Diabetes , vol.48 , Issue.1 , pp. 94-98
    • Barzilai, N.1
  • 93
    • 0036787345 scopus 로고    scopus 로고
    • Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: An adipokinemediated process?
    • Gabriely I, et al. Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokinemediated process? Diabetes. 2002;51(10):2951-8.
    • (2002) Diabetes , vol.51 , Issue.10 , pp. 2951-2958
    • Gabriely, I.1
  • 94
    • 0033203137 scopus 로고    scopus 로고
    • Surgical removal of visceral fat decreases plasma free fatty acid and increases insulin sensitivity on liver and peripheral tissue in monosodium glutamate (MSG)-obese rats
    • Kim YW, Kim JY, Lee SK. Surgical removal of visceral fat decreases plasma free fatty acid and increases insulin sensitivity on liver and peripheral tissue in monosodium glutamate (MSG)-obese rats. J Korean Med Sci. 1999;14(5):539-45.
    • (1999) J Korean Med Sci , vol.14 , Issue.5 , pp. 539-545
    • Kim, Y.W.1    Kim, J.Y.2    Lee, S.K.3
  • 95
    • 84859041004 scopus 로고    scopus 로고
    • Hepatic and peripheral insulin sensitivity and diabetes remission at 1 month after Roux-en-Y gastric bypass surgery in patients randomized to omentectomy
    • Dunn JP, et al. Hepatic and peripheral insulin sensitivity and diabetes remission at 1 month after Roux-en-Y gastric bypass surgery in patients randomized to omentectomy. Diabetes Care. 2012;35(1):137-42.
    • (2012) Diabetes Care , vol.35 , Issue.1 , pp. 137-142
    • Dunn, J.P.1
  • 96
    • 77955485237 scopus 로고    scopus 로고
    • Surgical removal of omental fat does not improve insulin sensitivity and cardiovascular risk factors in obese adults
    • Fabbrini E, et al. Surgical removal of omental fat does not improve insulin sensitivity and cardiovascular risk factors in obese adults. Gastroenterology. 2010;139(2):448-55.
    • (2010) Gastroenterology , vol.139 , Issue.2 , pp. 448-455
    • Fabbrini, E.1
  • 97
    • 77958159597 scopus 로고    scopus 로고
    • Is visceral fat responsible for the metabolic abnormalities associated with obesity?: Implications of omentectomy
    • Klein S. Is visceral fat responsible for the metabolic abnormalities associated with obesity?: implications of omentectomy. Diabetes Care. 2010;33(7):1693-4.
    • (2010) Diabetes Care , vol.33 , Issue.7 , pp. 1693-1694
    • Klein, S.1
  • 98
    • 78649955475 scopus 로고    scopus 로고
    • Body fat distribution and inflammation among obese older adults with and without metabolic syndrome
    • Koster A, et al. Body fat distribution and inflammation among obese older adults with and without metabolic syndrome. Obesity. 2010;18(12):2354-61.
    • (2010) Obesity , vol.18 , Issue.12 , pp. 2354-2361
    • Koster, A.1
  • 99
    • 0035019558 scopus 로고    scopus 로고
    • Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes
    • Caserta F, et al. Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes. Am J Physiol Endocrinol Metab. 2001;280(2):E238-47.
    • (2001) Am J Physiol Endocrinol Metab. , vol.280 , Issue.2 , pp. E238-E247
    • Caserta, F.1
  • 100
    • 0020629370 scopus 로고
    • Influence of anatomic site and age on the replication and differentiation of rat adipocyte precursors in culture
    • Djian P, Roncari AK, Hollenberg CH. Influence of anatomic site and age on the replication and differentiation of rat adipocyte precursors in culture. J Clin Invest. 1983;72(4):1200-8.
    • (1983) J Clin Invest , vol.72 , Issue.4 , pp. 1200-1208
    • Djian, P.1    Roncari, A.K.2    Hollenberg, C.H.3
  • 101
    • 0027697061 scopus 로고
    • Ageing, differentiation, and gene expression in rat epididymal preadipocytes
    • Kirkland JL, Hollenberg CH, Gillon WS. Ageing, differentiation, and gene expression in rat epididymal preadipocytes. Biochem Cell Biol. 1993;71(11-12):556-61.
    • (1993) Biochem Cell Biol. , vol.71 , Issue.11-12 , pp. 556-561
    • Kirkland, J.L.1    Hollenberg, C.H.2    Gillon, W.S.3
  • 102
    • 37149033176 scopus 로고    scopus 로고
    • Increased TNFalpha and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis
    • Tchkonia T, et al. Increased TNFalpha and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis. Am J Physiol Endocrinol Metab. 2007;293(6):E1810-9.
    • (2007) Am J Physiol Endocrinol Metab. , vol.293 , Issue.6 , pp. E1810-E1819
    • Tchkonia, T.1
  • 103
    • 0024522450 scopus 로고
    • Varying capacities for replication of rat adipocyte precursor clones and adipose tissue growth
    • Wang H, Kirkland JL, Hollenberg CH. Varying capacities for replication of rat adipocyte precursor clones and adipose tissue growth. J Clin Invest. 1989;83(5):1741-6.
    • (1989) J Clin Invest , vol.83 , Issue.5 , pp. 1741-1746
    • Wang, H.1    Kirkland, J.L.2    Hollenberg, C.H.3
  • 104
    • 0032977513 scopus 로고    scopus 로고
    • Age-related adipose tissue mRNA expression of ADD1/SREBP1, PPAR gamma, lipoprotein lipase, and GLUT4 glucose transporter in rhesus monkeys
    • Hotta K, et al. Age-related adipose tissue mRNA expression of ADD1/SREBP1, PPAR gamma, lipoprotein lipase, and GLUT4 glucose transporter in rhesus monkeys. J Gerontol A Biol Sci Med Sci. 1999;54(5):B183-8.
    • (1999) J Gerontol A Biol Sci Med Sci. , vol.54 , Issue.5 , pp. B183-B188
    • Hotta, K.1
  • 105
    • 0026546365 scopus 로고
    • CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription
    • Ron D, Habener JF. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev. 1992;6(3):439-53.
    • (1992) Genes Dev , vol.6 , Issue.3 , pp. 439-453
    • Ron, D.1    Habener, J.F.2
  • 106
    • 0037931782 scopus 로고    scopus 로고
    • Expression of the pro-apoptotic gene gadd153/chop is elevated in liver with aging and sensitizes cells to oxidant injury
    • Ikeyama S, et al. Expression of the pro-apoptotic gene gadd153/chop is elevated in liver with aging and sensitizes cells to oxidant injury. J Biol Chem. 2003;278(19):16726-31.
    • (2003) J Biol Chem , vol.278 , Issue.19 , pp. 16726-16731
    • Ikeyama, S.1
  • 107
    • 0033570899 scopus 로고    scopus 로고
    • CUG repeat binding protein (CUGBP1) interacts with the 5' region of C/EBP beta mRNA and regulates translation of C/EBP beta isoforms
    • Timchenko NA, et al. CUG repeat binding protein (CUGBP1) interacts with the 5' region of C/EBP beta mRNA and regulates translation of C/EBP beta isoforms. Nucleic Acids Res. 1999;27(22):4517-25.
    • (1999) Nucleic Acids Res , vol.27 , Issue.22 , pp. 4517-4525
    • Timchenko, N.A.1
  • 108
    • 23944453915 scopus 로고    scopus 로고
    • A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein beta and NF-(kappa)B activity in Hodgkin and anaplastic large cell lymphomas
    • Jundt F, et al. A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein beta and NF-(kappa)B activity in Hodgkin and anaplastic large cell lymphomas. Blood. 2005;106(5):1801-7.
    • (2005) Blood , vol.106 , Issue.5 , pp. 1801-1807
    • Jundt, F.1
  • 109
    • 0037330932 scopus 로고    scopus 로고
    • Inhibition of phosphatidylcholine synthesis induces expression of the endoplasmic reticulum stress and apoptosis-related protein CCAAT/enhancer-binding protein-homologous protein (CHOP/GADD153)
    • van der Sanden MH, et al. Inhibition of phosphatidylcholine synthesis induces expression of the endoplasmic reticulum stress and apoptosis-related protein CCAAT/enhancer-binding protein-homologous protein (CHOP/GADD153). Biochem J. 2003;369(Pt 3):643-50.
    • (2003) Biochem J. , vol.369 , pp. 643-650
    • van der Sanden, M.H.1
  • 110
    • 8944259440 scopus 로고    scopus 로고
    • Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153)
    • Wang XZ, et al. Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153). Mol Cell Biol. 1996;16(8):4273-80.
    • (1996) Mol Cell Biol , vol.16 , Issue.8 , pp. 4273-4280
    • Wang, X.Z.1
  • 111
    • 0033134682 scopus 로고    scopus 로고
    • Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
    • Harris TB, et al. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med. 1999;106(5):506-12.
    • (1999) Am J Med , vol.106 , Issue.5 , pp. 506-512
    • Harris, T.B.1
  • 112
    • 69949150673 scopus 로고    scopus 로고
    • A crucial role for adipose tissue p53 in the regulation of insulin resistance
    • Minamino T, et al. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med. 2009; 15(9):1082-7.
    • (2009) Nat Med , vol.15 , Issue.9 , pp. 1082-1087
    • Minamino, T.1
  • 113
    • 33749167092 scopus 로고    scopus 로고
    • Ageing: Balancing regeneration and cancer
    • Beausejour CM, Campisi J. Ageing: balancing regeneration and cancer. Nature. 2006;443(7110):404-5.
    • (2006) Nature , vol.443 , Issue.7110 , pp. 404-405
    • Beausejour, C.M.1    Campisi, J.2
  • 114
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res. 1961;25:585-621.
    • (1961) Exp Cell Res , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 115
    • 45449084795 scopus 로고    scopus 로고
    • Cellular senescence and organismal aging
    • Jeyapalan JC, Sedivy JM. Cellular senescence and organismal aging. Mech Ageing Dev. 2008;129(7-8):467-74.
    • (2008) Mech Ageing Dev. , vol.129 , Issue.7-8 , pp. 467-474
    • Jeyapalan, J.C.1    Sedivy, J.M.2
  • 116
    • 24744454582 scopus 로고    scopus 로고
    • Senescence comes of age
    • Narita M, Lowe SW. Senescence comes of age. Nat Med. 2005;11(9):920-2.
    • (2005) Nat Med , vol.11 , Issue.9 , pp. 920-922
    • Narita, M.1    Lowe, S.W.2
  • 117
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
    • Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell. 2005;120(4):513-22.
    • (2005) Cell , vol.120 , Issue.4 , pp. 513-522
    • Campisi, J.1
  • 118
    • 2342435511 scopus 로고    scopus 로고
    • Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span
    • Martin-Ruiz C, et al. Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span. J Biol Chem. 2004;279(17):17826-33.
    • (2004) J Biol Chem , vol.279 , Issue.17 , pp. 17826-17833
    • Martin-Ruiz, C.1
  • 119
    • 0037667702 scopus 로고    scopus 로고
    • Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
    • Narita M, et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell. 2003;113(6):703-16.
    • (2003) Cell , vol.113 , Issue.6 , pp. 703-716
    • Narita, M.1
  • 120
    • 0034682721 scopus 로고    scopus 로고
    • Cellular senescence: Mitotic clock or culture shock?
    • Sherr CJ, DePinho RA. Cellular senescence: mitotic clock or culture shock? Cell. 2000;102(4):407-10.
    • (2000) Cell. , vol.102 , Issue.4 , pp. 407-410
    • Sherr, C.J.1    DePinho, R.A.2
  • 121
    • 0034069237 scopus 로고    scopus 로고
    • Cancer, aging and cellular senescence
    • Campisi J. Cancer, aging and cellular senescence. In Vivo. 2000;14(1):183-8.
    • (2000) In Vivo , vol.14 , Issue.1 , pp. 183-188
    • Campisi, J.1
  • 122
    • 2342516817 scopus 로고    scopus 로고
    • Fragile fugue: P53 in aging, cancer and IGF signaling
    • Campisi J. Fragile fugue: p53 in aging, cancer and IGF signaling. Nat Med. 2004;10(3):231-2.
    • (2004) Nat Med , vol.10 , Issue.3 , pp. 231-232
    • Campisi, J.1
  • 123
    • 33846937033 scopus 로고    scopus 로고
    • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    • Xue W, et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature. 2007;445(7128):656-60.
    • (2007) Nature , vol.445 , Issue.7128 , pp. 656-660
    • Xue, W.1
  • 124
    • 33646946746 scopus 로고    scopus 로고
    • Senescence-associated beta-galactosidase is lysosomal beta-galactosidase
    • Lee BY, et al. Senescence-associated beta-galactosidase is lysosomal beta-galactosidase. Aging Cell. 2006; 5(2):187-95.
    • (2006) Aging Cell , vol.5 , Issue.2 , pp. 187-195
    • Lee, B.Y.1
  • 125
    • 66149167336 scopus 로고    scopus 로고
    • DNA damage response and cellular senescence in tissues of aging mice
    • Wang C, et al. DNA damage response and cellular senescence in tissues of aging mice. Aging Cell. 2009; 8(3):311-23.
    • (2009) Aging Cell , vol.8 , Issue.3 , pp. 311-323
    • Wang, C.1
  • 126
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
    • Coppe JP, et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008;6(12):2853-68.
    • (2008) PLoS Biol , vol.6 , Issue.12 , pp. 2853-2868
    • Coppe, J.P.1
  • 127
    • 77952105389 scopus 로고    scopus 로고
    • Inflammatory networks during cellular senescence: Causes and consequences
    • Freund A, et al. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med. 2010;16(5):238-46.
    • (2010) Trends Mol Med , vol.16 , Issue.5 , pp. 238-246
    • Freund, A.1
  • 128
    • 13944260728 scopus 로고    scopus 로고
    • Stromal-epithelial interactions in aging and cancer: Senescent fibroblasts alter epithelial cell differentiation
    • Parrinello S, et al. Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J Cell Sci. 2005;118(Pt 3):485-96.
    • (2005) J Cell Sci. , vol.118 , pp. 485-496
    • Parrinello, S.1


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