Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis

EMBO Journal

Volumn 34, Issue 20, 2015, Pages 2506-2521

  Kumar, Atul ^a   Aguirre, Jacob D ^b   Condos, Tara E C ^b   Martinez Torres, R Julio ^a   Chaugule, Viduth K ^a   Toth, Rachel ^a   Sundaramoorthy, Ramasubramanian ^a   Mercier, Pascal ^b   Knebel, Axel ^a   Spratt, Donald E ^b   Barber, Kathryn R ^b   Shaw, Gary S ^b   Walden, Helen ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b WESTERN UNIVERSITY   (Canada)

Author keywords

enzyme mechanism; Parkinson's disease; phosphorylation; ubiquitin ligase; ubiquitination

Indexed keywords

PARKIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; BINDING AFFINITY; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; HUMAN; HYDROGEN BOND; ISOTHERMAL TITRATION CALORIMETRY; LIGHT SCATTERING; MOLECULAR MODEL; NONHUMAN; PEDICULUS HUMANUS; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; SIZE EXCLUSION CHROMATOGRAPHY; SURFACE AREA; UBIQUITINATION; BINDING SITE; BIOLOGICAL MODEL; CALORIMETRY; CHEMISTRY; CRYSTALLIZATION; GENETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PHOSPHORYLATION; PROTEIN CONFORMATION;

BINDING SITES; CALORIMETRY; CATALYSIS; CHROMATOGRAPHY, GEL; CRYSTALLIZATION; ENZYME ACTIVATION; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHORYLATION; PROTEIN CONFORMATION; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 84944441665     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201592337     Document Type: Article

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